DOI: 10.1016/s0092-8674(02)00626-8. The Role of PML in Tumor Suppression

The Role of PML in Tumor Suppression

10.1016/s0092-8674(02)00626-8

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Salomoni, P., & Pandolfi, P. P. (2002). The Role of PML in Tumor Suppression. Cell, 108(2), 165â170.

Authors 2

Paolo Salomoni (first)
Pier Paolo Pandolfi (additional)

References 29 Referenced 445

10.1128/MCB.18.2.1084 / Mol. Cell. Biol. / The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein by Alcalay (1998)
10.1101/gad.14.16.2015 / Genes Dev. / PML is induced by oncogenic ras and promotes premature senescence by Ferbeyre (2000)
{'key': '10.1016/S0092-8674(02)00626-8_BIB3', 'first-page': '185', 'article-title': 'Regulation of p53 activity in nuclear bodies by a specific PML isoform', 'volume': '6', 'author': 'Fogal', 'year': '2000', 'journal-title': 'EMBO J.'} / EMBO J. / Regulation of p53 activity in nuclear bodies by a specific PML isoform by Fogal (2000)
10.1016/S0092-8674(00)80521-8 / Cell / Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain by Gu (1997)
10.1038/35036365 / Nat. Cell Biol. / The function of PML in p53-dependent apoptosis by Guo (2000)
10.1038/ncb715 / Nat. Cell Biol. / Regulation of p53 activity by its interaction with homeodomain-interacting protein by Hofmann (2002)
10.1038/sj.onc.1204765 / Oncogene / PML protein isoforms and the RBCC/TRIM motif by Jensen (2001)
10.1016/S1097-2765(01)00257-X / Mol. Cell / Role of PML and PML-RARα in Mad-mediated transcriptional repression by Khan (2001)
10.1074/jbc.C100532200 / J. Biol. Chem. / PML-RARα alleviates the transcriptional repression mediated by tumor suppressor Rb by Khan (2001)
10.1084/jem.193.12.1361 / J. Exp. Med. / Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation by Lallemand-Breitenbach (2001)
10.1038/sj.onc.1201705 / Oncogene / Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis by Le (1998)
10.1128/MCB.20.5.1784-1796.2000 / Mol. Cell. Biol. / Sequestration and inhibition of Daxx-mediated transcriptional repression by PML by Li (2000)
10.1182/blood.V93.10.3167.410k44_3167_3215 / Blood / Deconstructing a disease by Melnick (1999)
10.1038/ncb714 / Nat. Cell Biol. / Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis by Orazi (2002)
10.1038/sj.onc.1204600 / Oncogene / The theory of APL by Pandolfi (2001)
10.1038/35021000 / Nature / PML regulates p53 acetylation and premature senescence induced by oncogenic Ras by Pearson (2000)
10.1038/35087019 / Nat. Cell Biol. / TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation by Perlman (2001)
10.1038/3068 / Nat. Genet. / PML induces a novel caspase-independent death process by Quignon (1998)
10.1073/pnas.96.26.15103 / Proc. Natl. Acad. Sci. USA / A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia by Pollock (1999)
10.1146/annurev.immunol.17.1.781 / Annu. Rev. Immunol. / The central effectors of cell death in the immune system by Rathmell (1999)
10.1084/jem.193.4.521 / J. Exp. Med. / Role of promyelocytic leukemia (PML) protein in tumor suppression by Rego (2001)
10.1101/gad.944801 / Genes Dev. / PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies by Sachdev (2001)
10.1016/S1097-2765(01)00255-6 / Mol. Cell / Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes by Turelli (2001)
10.1126/science.279.5356.1547 / Science / Role of PML in cell growth and the retinoic acid pathway by Wang (1998)
10.1038/3030 / Nat. Genet. / PML is essential for multiple apoptotic pathways by Wang (1998)
10.1038/sj.onc.1203367 / Oncogene / A role for PML and the nuclear body in genomic stability by Zhong (1999)
10.1182/blood.V95.9.2748.009k31a_2748_2752 / Blood / Role of SUMO-1-modified PML in nuclear body formation by Zhong (2000)
10.1038/35010583 / Nat. Cell Biol. / The transcriptional role of PML and the nuclear body by Zhong (2000)
10.1084/jem.191.4.631 / J. Exp. Med. / Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis by Zhong (2000)

Dates

Type	When
Created	21 years, 4 months ago (April 17, 2004, 2:47 p.m.)
Deposited	2 years, 4 months ago (April 28, 2023, 4:46 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 7, 2025, 4:59 p.m.)
Issued	23 years, 7 months ago (Jan. 1, 2002)
Published	23 years, 7 months ago (Jan. 1, 2002)
Published Print	23 years, 7 months ago (Jan. 1, 2002)

Funders 0

None

BibTeX

@article{Salomoni_2002, title={The Role of PML in Tumor Suppression}, volume={108}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(02)00626-8}, DOI={10.1016/s0092-8674(02)00626-8}, number={2}, journal={Cell}, publisher={Elsevier BV}, author={Salomoni, Paolo and Pandolfi, Pier Paolo}, year={2002}, month=jan, pages={165–170} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        7
      ]
    ],
    "date-time": "2025-08-07T20:59:39Z",
    "timestamp": 1754600379562
  },
  "reference-count": 29,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2002,
            1,
            1
          ]
        ],
        "date-time": "2002-01-01T00:00:00Z",
        "timestamp": 1009843200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4215,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        1
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(02)00626-8",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        17
      ]
    ],
    "date-time": "2004-04-17T18:47:25Z",
    "timestamp": 1082227645000
  },
  "page": "165-170",
  "source": "Crossref",
  "is-referenced-by-count": 445,
  "title": "The Role of PML in Tumor Suppression",
  "prefix": "10.1016",
  "volume": "108",
  "author": [
    {
      "given": "Paolo",
      "family": "Salomoni",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Pier Paolo",
      "family": "Pandolfi",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1084",
      "DOI": "10.1128/MCB.18.2.1084",
      "article-title": "The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein",
      "volume": "18",
      "author": "Alcalay",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "2015",
      "DOI": "10.1101/gad.14.16.2015",
      "article-title": "PML is induced by oncogenic ras and promotes premature senescence",
      "volume": "14",
      "author": "Ferbeyre",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB3",
      "first-page": "185",
      "article-title": "Regulation of p53 activity in nuclear bodies by a specific PML isoform",
      "volume": "6",
      "author": "Fogal",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1016/S0092-8674(00)80521-8",
      "article-title": "Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain",
      "volume": "90",
      "author": "Gu",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "730",
      "DOI": "10.1038/35036365",
      "article-title": "The function of PML in p53-dependent apoptosis",
      "volume": "2",
      "author": "Guo",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1038/ncb715",
      "article-title": "Regulation of p53 activity by its interaction with homeodomain-interacting protein",
      "volume": "4",
      "author": "Hofmann",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "7223",
      "DOI": "10.1038/sj.onc.1204765",
      "article-title": "PML protein isoforms and the RBCC/TRIM motif",
      "volume": "20",
      "author": "Jensen",
      "year": "2001",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1233",
      "DOI": "10.1016/S1097-2765(01)00257-X",
      "article-title": "Role of PML and PML-RAR\u03b1 in Mad-mediated transcriptional repression",
      "volume": "7",
      "author": "Khan",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "43491",
      "DOI": "10.1074/jbc.C100532200",
      "article-title": "PML-RAR\u03b1 alleviates the transcriptional repression mediated by tumor suppressor Rb",
      "volume": "276",
      "author": "Khan",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1361",
      "DOI": "10.1084/jem.193.12.1361",
      "article-title": "Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor \u03b1 degradation",
      "volume": "193",
      "author": "Lallemand-Breitenbach",
      "year": "2001",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "1839",
      "DOI": "10.1038/sj.onc.1201705",
      "article-title": "Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis",
      "volume": "16",
      "author": "Le",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1784",
      "DOI": "10.1128/MCB.20.5.1784-1796.2000",
      "article-title": "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML",
      "volume": "20",
      "author": "Li",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "3167",
      "DOI": "10.1182/blood.V93.10.3167.410k44_3167_3215",
      "article-title": "Deconstructing a disease",
      "volume": "93",
      "author": "Melnick",
      "year": "1999",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1038/ncb714",
      "article-title": "Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis",
      "volume": "4",
      "author": "Orazi",
      "year": "2002",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "5726",
      "DOI": "10.1038/sj.onc.1204600",
      "article-title": "The theory of APL",
      "volume": "20",
      "author": "Pandolfi",
      "year": "2001",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1038/35021000",
      "article-title": "PML regulates p53 acetylation and premature senescence induced by oncogenic Ras",
      "volume": "406",
      "author": "Pearson",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "708",
      "DOI": "10.1038/35087019",
      "article-title": "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation",
      "volume": "3",
      "author": "Perlman",
      "year": "2001",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1038/3068",
      "article-title": "PML induces a novel caspase-independent death process",
      "volume": "20",
      "author": "Quignon",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "15103",
      "DOI": "10.1073/pnas.96.26.15103",
      "article-title": "A bcr-3 isoform of RAR\u03b1-PML potentiates the development of PML-RAR\u03b1-driven acute promyelocytic leukemia",
      "volume": "96",
      "author": "Pollock",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "781",
      "DOI": "10.1146/annurev.immunol.17.1.781",
      "article-title": "The central effectors of cell death in the immune system",
      "volume": "17",
      "author": "Rathmell",
      "year": "1999",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1084/jem.193.4.521",
      "article-title": "Role of promyelocytic leukemia (PML) protein in tumor suppression",
      "volume": "23",
      "author": "Rego",
      "year": "2001",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "3088",
      "DOI": "10.1101/gad.944801",
      "article-title": "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies",
      "volume": "15",
      "author": "Sachdev",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1245",
      "DOI": "10.1016/S1097-2765(01)00255-6",
      "article-title": "Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes",
      "volume": "7",
      "author": "Turelli",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1547",
      "DOI": "10.1126/science.279.5356.1547",
      "article-title": "Role of PML in cell growth and the retinoic acid pathway",
      "volume": "279",
      "author": "Wang",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1038/3030",
      "article-title": "PML is essential for multiple apoptotic pathways",
      "volume": "20",
      "author": "Wang",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "7941",
      "DOI": "10.1038/sj.onc.1203367",
      "article-title": "A role for PML and the nuclear body in genomic stability",
      "volume": "18",
      "author": "Zhong",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "2748",
      "DOI": "10.1182/blood.V95.9.2748.009k31a_2748_2752",
      "article-title": "Role of SUMO-1-modified PML in nuclear body formation",
      "volume": "95",
      "author": "Zhong",
      "year": "2000",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "E85",
      "DOI": "10.1038/35010583",
      "article-title": "The transcriptional role of PML and the nuclear body",
      "volume": "2",
      "author": "Zhong",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(02)00626-8_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "631",
      "DOI": "10.1084/jem.191.4.631",
      "article-title": "Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis",
      "volume": "191",
      "author": "Zhong",
      "year": "2000",
      "journal-title": "J. Exp. Med."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867402006268?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867402006268?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        28
      ]
    ],
    "date-time": "2023-04-28T08:46:35Z",
    "timestamp": 1682671595000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867402006268"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        1
      ]
    ]
  },
  "references-count": 29,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2002,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867402006268"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(02)00626-8",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2002,
        1
      ]
    ]
  }
}