DOI: 10.1016/s0092-8674(01)00598-0. Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation

Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation

10.1016/s0092-8674(01)00598-0

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Heard, E., Rougeulle, C., Arnaud, D., Avner, P., Allis, C. D., & Spector, D. L. (2001). Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation. Cell, 107(6), 727â738.

Authors 6

Edith Heard (first)
Claire Rougeulle (additional)
Danielle Arnaud (additional)
Philip Avner (additional)
C.David Allis (additional)
David L. Spector (additional)

References 46 Referenced 393

10.1093/emboj/18.7.1923 / EMBO J. / Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3–9 encode centromere-associated proteins which complex with the heterochromatin component M31 by Aagaard (1999)
10.1038/35047580 / Nat. Rev. Genet. / X-chromosome inactivation by Avner (2001)
10.1007/BF02524648 / Chromosoma / Reduced levels of histone H3 acetylation on the inactive X chromosome in human females by Boggs (1996)
{'key': '10.1016/S0092-8674(01)00598-0_BIB4', 'article-title': 'Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes', 'volume': 'in press', 'author': 'Boggs', 'year': '2001', 'journal-title': 'Nat. Genet.'} / Nat. Genet. / Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes by Boggs (2001)
10.1073/pnas.95.23.13887 / Proc. Natl. Acad. Sci. USA / c-Myc target gene specificity is determined by a post-DNA binding mechanism by Boyd (1998)
10.1038/351329a0 / Nature / Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome by Brockdorff (1991)
10.1016/0092-8674(92)90520-M / Cell / The human XIST gene by Brown (1992)
10.1016/S0092-8674(00)00118-5 / Cell / Signaling to chromatin through histone modifications by Cheung (2000)
10.1038/924 / Nat. Genet. / Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation by Clerc (1998)
10.1038/31275 / Nature / Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals by Costanzi (1998)
10.1083/jcb.153.4.773 / J. Cell. Biol. / Synergism of Xist RNA, DNA methylation and histone hypoacetylation in maintaining X chromosome inactivation by Csankovszki (2001)
10.1101/gad.13.22.2940 / Genes Dev. / The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. by Dudley (1999)
10.1016/S0959-437X(00)00058-7 / Curr. Opin. Genet. Dev. / The HP1 protein family by Eissenberg (2000)
10.1073/pnas.96.24.13825 / Natl. Acad. Sci. USA / Promoter-specific hypoacetylation of X-inactivated genes Proc by Gilbert (1999)
10.1128/MCB.19.4.3156 / Mol. Cell. Biol. / Xist yeast artificial chromosome transgenes functions as X-inactivation centers only in multicopy arrays and not as single copies by Heard (1999)
10.1002/(SICI)1521-1878(199807)20:7<532::AID-BIES3>3.0.CO;2-M / Bioessays / Conspiracy of silence among repeated transgenes by Henikoff (1998)
{'key': '10.1016/S0092-8674(01)00598-0_BIB17', 'series-title': 'Manipulating the Mouse Embryo', 'author': 'Hogan', 'year': '1994'} / Manipulating the Mouse Embryo by Hogan (1994)
10.1126/science.1063127 / Science / Translating the histone code by Jenuwein (2001)
10.1016/0092-8674(93)90419-Q / Cell / The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression by Jeppesen (1993)
10.1093/emboj/20.9.2236 / EMBO J. / Association and spreading of the Drosophila dosage compensation complex from a discrete roX1 chromatin entry site by Kageyama (2001)
10.1016/S0959-437X(00)00127-1 / Curr. Opin. Genet. Dev. / The role of chromosomal RNAs in marking the X for dosage compensation by Kelley (2000)
10.1006/dbio.1996.0333 / Dev. Biol. / X-inactivation and H4 acetylation in embryonic stem cells by Keohane (1996)
10.1016/S0092-8674(00)80061-6 / Cell. / Targeted mutagenesis of Tsix leads to nonrandom X inactivation by Lee (1999)
10.1016/S0092-8674(00)80079-3 / Cell / A 450 kb transgene displays properties of the mammalian X-inactivation center by Lee (1996)
10.1038/190372a0 / Nature / Gene action in the X chromosome of the mouse (Mus musculus L.) by Lyon (1961)
10.1159/000014969 / Cytogenet. Cell Genet. / X-chromosome inactivation by Lyon (1998)
10.1101/gad.11.2.156 / Genes Dev. / Xist-deficient mice are defective in dosage compensation but not spermatogenesis by Marahrens (1997)
10.1093/hmg/10.20.2225 / Hum. Mol. Gen. / Forty years of decoding the silence in X-chromosome inactivation by Maxfield Boumil (2001)
10.1002/bies.950090211 / BioEssays / X chromosome inactivation by McBurney (1988)
10.1083/jcb.147.7.1399 / J. Cell Biol. / Histone macroH2A relocates to the inactive X chromosome after initiation and propagation of X-inactivation by Mermoud (1999)
10.1093/hmg/10.13.1403 / Hum. Mol. Gen. / Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation by Morey (2001)
10.1126/science.1060118 / Science / Role of histone H3 Lysine 9 methylation in epigenetic control of heterochromatin assembly by Nakayama (2001)
10.1016/S0092-8674(00)81769-9 / Cell / Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 by Nichols (1998)
10.1038/35087620 / Nature / Rb targets histone H3 methylation and HP1 to promoters by Nielsen (2001)
10.1126/science.1064150 / Science / Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries by Noma (2001)
10.1093/emboj/18.10.2897 / EMBO J. / A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation by O'Neill (1999)
10.1016/S0092-8674(00)80355-4 / Cell / X chromosome inactivation is mediated by Xist RNA stabilization by Panning (1997)
10.1038/379131a0 / Nature / Requirement for Xist in X chromosome inactivation by Penny (1996)
10.1083/jcb.150.5.1189 / J. Cell Biol. / Dynamic relocalization of histone macroH2A1 from centrosomes to inactive X chromosomes during X inactivation by Rasmussen (2000)
{'key': '10.1016/S0092-8674(01)00598-0_BIB40', 'first-page': '379', 'article-title': 'X chromosome deletions in embryo-derived (EK) cell lines associated with the lack of X chromosome inactivation', 'volume': '90', 'author': 'Rastan', 'year': '1985', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / X chromosome deletions in embryo-derived (EK) cell lines associated with the lack of X chromosome inactivation by Rastan (1985)
10.1038/35020506 / Nature / Regulation of chromatin structure by site-specific histone H3 methyltransferases by Rea (2000)
{'key': '10.1016/S0092-8674(01)00598-0_BIB42', 'series-title': 'Biochemistry and Biology of DNA Methylation', 'article-title': 'Methylation of the PGK promoter and an enhancer way-station model for X-chromosome inactivation', 'author': 'Riggs', 'year': '1985'} / Biochemistry and Biology of DNA Methylation / Methylation of the PGK promoter and an enhancer way-station model for X-chromosome inactivation by Riggs (1985)
10.1016/S0092-8674(01)80012-X / Cell / Stabilization of Xist RNA mediates initiation of X chromosome inactivation by Sheardown (1997)
10.1007/BF01666137 / J. Tiss. Cult. Meth. / Culture and differentiation of embryonic stem cells by Smith (1991)
10.1038/47412 / Nature / The language of covalent histone modifications by Strahl (2000)
10.1016/S1097-2765(00)80248-8 / Mol. Cell / A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation by Wutz (2000)

Dates

Type	When
Created	21 years, 4 months ago (April 17, 2004, 2:47 p.m.)
Deposited	6 years, 6 months ago (Feb. 13, 2019, 6:27 a.m.)
Indexed	2 days, 16 hours ago (Sept. 3, 2025, 6:25 a.m.)
Issued	23 years, 9 months ago (Dec. 1, 2001)
Published	23 years, 9 months ago (Dec. 1, 2001)
Published Print	23 years, 9 months ago (Dec. 1, 2001)

Funders 0

None

BibTeX

@article{Heard_2001, title={Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation}, volume={107}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(01)00598-0}, DOI={10.1016/s0092-8674(01)00598-0}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Heard, Edith and Rougeulle, Claire and Arnaud, Danielle and Avner, Philip and Allis, C.David and Spector, David L.}, year={2001}, month=dec, pages={727–738} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:25:49Z",
    "timestamp": 1756895149173
  },
  "reference-count": 46,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            12,
            1
          ]
        ],
        "date-time": "2001-12-01T00:00:00Z",
        "timestamp": 1007164800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4246,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(01)00598-0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        17
      ]
    ],
    "date-time": "2004-04-17T18:47:25Z",
    "timestamp": 1082227645000
  },
  "page": "727-738",
  "source": "Crossref",
  "is-referenced-by-count": 393,
  "title": "Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation",
  "prefix": "10.1016",
  "volume": "107",
  "author": [
    {
      "given": "Edith",
      "family": "Heard",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Claire",
      "family": "Rougeulle",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Danielle",
      "family": "Arnaud",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Philip",
      "family": "Avner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C.David",
      "family": "Allis",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David L.",
      "family": "Spector",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1923",
      "DOI": "10.1093/emboj/18.7.1923",
      "article-title": "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3\u20139 encode centromere-associated proteins which complex with the heterochromatin component M31",
      "volume": "18",
      "author": "Aagaard",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1038/35047580",
      "article-title": "X-chromosome inactivation",
      "volume": "1",
      "author": "Avner",
      "year": "2001",
      "journal-title": "Nat. Rev. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1007/BF02524648",
      "article-title": "Reduced levels of histone H3 acetylation on the inactive X chromosome in human females",
      "volume": "105",
      "author": "Boggs",
      "year": "1996",
      "journal-title": "Chromosoma"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB4",
      "article-title": "Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes",
      "volume": "in press",
      "author": "Boggs",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "13887",
      "DOI": "10.1073/pnas.95.23.13887",
      "article-title": "c-Myc target gene specificity is determined by a post-DNA binding mechanism",
      "volume": "95",
      "author": "Boyd",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1038/351329a0",
      "article-title": "Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome",
      "volume": "351",
      "author": "Brockdorff",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1016/0092-8674(92)90520-M",
      "article-title": "The human XIST gene",
      "volume": "71",
      "author": "Brown",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1016/S0092-8674(00)00118-5",
      "article-title": "Signaling to chromatin through histone modifications",
      "volume": "103",
      "author": "Cheung",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1038/924",
      "article-title": "Role of the region 3\u2032 to Xist exon 6 in the counting process of X-chromosome inactivation",
      "volume": "19",
      "author": "Clerc",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1038/31275",
      "article-title": "Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals",
      "volume": "393",
      "author": "Costanzi",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "773",
      "DOI": "10.1083/jcb.153.4.773",
      "article-title": "Synergism of Xist RNA, DNA methylation and histone hypoacetylation in maintaining X chromosome inactivation",
      "volume": "153",
      "author": "Csankovszki",
      "year": "2001",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "2940",
      "DOI": "10.1101/gad.13.22.2940",
      "article-title": "The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo.",
      "volume": "13",
      "author": "Dudley",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "204",
      "DOI": "10.1016/S0959-437X(00)00058-7",
      "article-title": "The HP1 protein family",
      "volume": "2",
      "author": "Eissenberg",
      "year": "2000",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "13825",
      "DOI": "10.1073/pnas.96.24.13825",
      "article-title": "Promoter-specific hypoacetylation of X-inactivated genes Proc",
      "volume": "96",
      "author": "Gilbert",
      "year": "1999",
      "journal-title": "Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "3156",
      "DOI": "10.1128/MCB.19.4.3156",
      "article-title": "Xist yeast artificial chromosome transgenes functions as X-inactivation centers only in multicopy arrays and not as single copies",
      "volume": "19",
      "author": "Heard",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "532",
      "DOI": "10.1002/(SICI)1521-1878(199807)20:7<532::AID-BIES3>3.0.CO;2-M",
      "article-title": "Conspiracy of silence among repeated transgenes",
      "volume": "20",
      "author": "Henikoff",
      "year": "1998",
      "journal-title": "Bioessays"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB17",
      "series-title": "Manipulating the Mouse Embryo",
      "author": "Hogan",
      "year": "1994"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1074",
      "DOI": "10.1126/science.1063127",
      "article-title": "Translating the histone code",
      "volume": "293",
      "author": "Jenuwein",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1016/0092-8674(93)90419-Q",
      "article-title": "The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression",
      "volume": "74",
      "author": "Jeppesen",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "2236",
      "DOI": "10.1093/emboj/20.9.2236",
      "article-title": "Association and spreading of the Drosophila dosage compensation complex from a discrete roX1 chromatin entry site",
      "volume": "20",
      "author": "Kageyama",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1016/S0959-437X(00)00127-1",
      "article-title": "The role of chromosomal RNAs in marking the X for dosage compensation",
      "volume": "10",
      "author": "Kelley",
      "year": "2000",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "618",
      "DOI": "10.1006/dbio.1996.0333",
      "article-title": "X-inactivation and H4 acetylation in embryonic stem cells",
      "volume": "180",
      "author": "Keohane",
      "year": "1996",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1016/S0092-8674(00)80061-6",
      "article-title": "Targeted mutagenesis of Tsix leads to nonrandom X inactivation",
      "volume": "99",
      "author": "Lee",
      "year": "1999",
      "journal-title": "Cell."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/S0092-8674(00)80079-3",
      "article-title": "A 450 kb transgene displays properties of the mammalian X-inactivation center",
      "volume": "86",
      "author": "Lee",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "372",
      "DOI": "10.1038/190372a0",
      "article-title": "Gene action in the X chromosome of the mouse (Mus musculus L.)",
      "volume": "190",
      "author": "Lyon",
      "year": "1961",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1159/000014969",
      "article-title": "X-chromosome inactivation",
      "volume": "80",
      "author": "Lyon",
      "year": "1998",
      "journal-title": "Cytogenet. Cell Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1101/gad.11.2.156",
      "article-title": "Xist-deficient mice are defective in dosage compensation but not spermatogenesis",
      "volume": "11",
      "author": "Marahrens",
      "year": "1997",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "2225",
      "DOI": "10.1093/hmg/10.20.2225",
      "article-title": "Forty years of decoding the silence in X-chromosome inactivation",
      "volume": "10",
      "author": "Maxfield Boumil",
      "year": "2001",
      "journal-title": "Hum. Mol. Gen."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1002/bies.950090211",
      "article-title": "X chromosome inactivation",
      "volume": "9",
      "author": "McBurney",
      "year": "1988",
      "journal-title": "BioEssays"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1399",
      "DOI": "10.1083/jcb.147.7.1399",
      "article-title": "Histone macroH2A relocates to the inactive X chromosome after initiation and propagation of X-inactivation",
      "volume": "147",
      "author": "Mermoud",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1093/hmg/10.13.1403",
      "article-title": "Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation",
      "volume": "10",
      "author": "Morey",
      "year": "2001",
      "journal-title": "Hum. Mol. Gen."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1126/science.1060118",
      "article-title": "Role of histone H3 Lysine 9 methylation in epigenetic control of heterochromatin assembly",
      "volume": "292",
      "author": "Nakayama",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1016/S0092-8674(00)81769-9",
      "article-title": "Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4",
      "volume": "95",
      "author": "Nichols",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1038/35087620",
      "article-title": "Rb targets histone H3 methylation and HP1 to promoters",
      "volume": "412",
      "author": "Nielsen",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "1150",
      "DOI": "10.1126/science.1064150",
      "article-title": "Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries",
      "volume": "293",
      "author": "Noma",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "2897",
      "DOI": "10.1093/emboj/18.10.2897",
      "article-title": "A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation",
      "volume": "18",
      "author": "O'Neill",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "907",
      "DOI": "10.1016/S0092-8674(00)80355-4",
      "article-title": "X chromosome inactivation is mediated by Xist RNA stabilization",
      "volume": "90",
      "author": "Panning",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1038/379131a0",
      "article-title": "Requirement for Xist in X chromosome inactivation",
      "volume": "379",
      "author": "Penny",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "1189",
      "DOI": "10.1083/jcb.150.5.1189",
      "article-title": "Dynamic relocalization of histone macroH2A1 from centrosomes to inactive X chromosomes during X inactivation",
      "volume": "150",
      "author": "Rasmussen",
      "year": "2000",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB40",
      "first-page": "379",
      "article-title": "X chromosome deletions in embryo-derived (EK) cell lines associated with the lack of X chromosome inactivation",
      "volume": "90",
      "author": "Rastan",
      "year": "1985",
      "journal-title": "J. Embryol. Exp. Morphol."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1038/35020506",
      "article-title": "Regulation of chromatin structure by site-specific histone H3 methyltransferases",
      "volume": "406",
      "author": "Rea",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB42",
      "series-title": "Biochemistry and Biology of DNA Methylation",
      "article-title": "Methylation of the PGK promoter and an enhancer way-station model for X-chromosome inactivation",
      "author": "Riggs",
      "year": "1985"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1016/S0092-8674(01)80012-X",
      "article-title": "Stabilization of Xist RNA mediates initiation of X chromosome inactivation",
      "volume": "91",
      "author": "Sheardown",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1007/BF01666137",
      "article-title": "Culture and differentiation of embryonic stem cells",
      "volume": "13",
      "author": "Smith",
      "year": "1991",
      "journal-title": "J. Tiss. Cult. Meth."
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1038/47412",
      "article-title": "The language of covalent histone modifications",
      "volume": "316",
      "author": "Strahl",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00598-0_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1016/S1097-2765(00)80248-8",
      "article-title": "A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation",
      "volume": "5",
      "author": "Wutz",
      "year": "2000",
      "journal-title": "Mol. Cell"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867401005980?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867401005980?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        2,
        13
      ]
    ],
    "date-time": "2019-02-13T11:27:01Z",
    "timestamp": 1550057221000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867401005980"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  },
  "references-count": 46,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2001,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867401005980"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(01)00598-0",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1003107.46154",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1003107.34007",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1003107.30654",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  }
}