DOI: 10.1016/s0092-8674(01)00520-7. CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

10.1016/s0092-8674(01)00520-7

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Gumienny, T. L., Brugnera, E., Tosello-Trampont, A.-C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., Schedl, T., Qin, Y., Van Aelst, L., Hengartner, M. O., & Ravichandran, K. S. (2001). CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration. Cell, 107(1), 27â41.

Authors 15

Tina L. Gumienny (first)
Enrico Brugnera (additional)
Annie-Carole Tosello-Trampont (additional)
Jason M. Kinchen (additional)
Lisa B. Haney (additional)
Kiyoji Nishiwaki (additional)
Scott F. Walk (additional)
Michael E. Nemergut (additional)
Ian G. Macara (additional)
Ross Francis (additional)
Tim Schedl (additional)
Yi Qin (additional)
Linda Van Aelst (additional)
Michael O. Hengartner (additional)
Kodimangalam S. Ravichandran (additional)

References 46 Referenced 477

10.1038/35046549 / Nat. Cell Biol. / αvβ5 integrin recruits the CrkII-Dock180-Rac1 complex for phagocytosis of apoptotic cells by Albert (2000)
10.1016/0092-8674(87)90593-9 / Cell / A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant by Avery (1987)
10.1042/0264-6021:3480241 / Biochem. J. / Rho GTPases and their effector proteins by Bishop (2000)
10.1126/science.282.5394.1717 / Science / Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases by Caron (1998)
10.1083/jcb.146.5.1107 / J. Cell Biol. / Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells by Cheresh (1999)
10.1038/35036454 / Nat. Cell Biol. / Function of rho family proteins in actin dynamics during phagocytosis and engulfment by Chimini (2000)
10.1038/35046585 / Nat. Cell Biol. / A common set of engulfment genes mediates the removal of both apoptotic and necrotic cells in C. elegans by Chung (2000)
10.1093/genetics/129.1.79 / Genetics / Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans by Ellis (1991)
10.1083/jcb.138.3.589 / J. Cell Biol. / Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization by Erickson (1997)
10.1128/MCB.16.4.1770 / Mol. Cell. Biol. / DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane by Hasegawa (1996)
10.1126/science.6857247 / Science / Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans by Hedgecock (1983)
{'key': '10.1016/S0092-8674(01)00520-7_BIB12', 'first-page': '213', 'article-title': 'Programmed cell death in the nematode C. elegans', 'volume': '54', 'author': 'Hengartner', 'year': '1999', 'journal-title': 'Recent Prog. Horm. Res.'} / Recent Prog. Horm. Res. / Programmed cell death in the nematode C. elegans by Hengartner (1999)
10.1016/S0092-8674(01)00219-7 / Cell / Apoptosis by Hengartner (2001)
10.1016/0092-8674(94)90506-1 / Cell / C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 by Hengartner (1994)
10.1146/annurev.genet.33.1.229 / Annu. Rev. Genet. / Mechanisms of mRNA surveillance in eukaryotes by Hilleren (1999)
{'key': '10.1016/S0092-8674(01)00520-7_BIB16', 'series-title': 'The Nematode Caenorhabditis elegans', 'article-title': 'List of mapped genes and mutant phenotypes', 'author': 'Hodgkin', 'year': '1988'} / The Nematode Caenorhabditis elegans / List of mapped genes and mutant phenotypes by Hodgkin (1988)
10.1002/(SICI)1097-0177(200005)218:1<2::AID-DVDY2>3.0.CO;2-W / Dev. Dyn. / The Caenorhabditis elegans gonad by Hubbard (2000)
10.1615/CritRevOncog.v8.i4.30 / Crit Rev Oncog / Role of Crk oncogene product in physiologic signaling by Kiyokawa (1997)
10.1101/gad.12.21.3331 / Genes Dev. / Activation of Rac1 by a Crk SH3-binding protein, DOCK180 by Kiyokawa (1998)
10.1074/jbc.273.38.24479 / J. Biol. Chem. / Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex by Kiyokawa (1998)
10.1016/0012-1606(76)90002-6 / Dev. Biol. / Development of the male reproductive system and sexual transformation in the nematode Caenorhabditis elegans by Klass (1976)
10.1083/jcb.140.4.961 / J. Cell Biol. / CAS/Crk coupling serves as a “molecular switch” for induction of cell migration by Klemke (1998)
10.1016/S0960-9822(01)00047-1 / Curr. Biol. / Requirement for Rho GTPases and PI-3 kinase during apoptotic cell phagocytosis by macrophages by Leverrier (2001)
10.1016/S0092-8674(00)81202-7 / Cell / Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans by Liu (1998)
10.1002/j.1460-2075.1996.tb00353.x / EMBO J. / The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death by Luciani (1996)
10.1093/emboj/17.21.6219 / EMBO J. / Fc receptor-mediated phagocytosis requires CDC42 and Rac1 by Massol (1998)
10.1038/332272a0 / Nature / A novel viral oncogene with structural similarity to phospholipase C by Mayer (1988)
10.1016/S0091-679X(08)61399-0 / Methods Cell Biol. / DNA transformation by Mello (1995)
10.1242/dev.126.14.3035 / Development / The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development by Montell (1999)
10.1126/science.292.5521.1540 / Science / Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B by Nemergut (2001)
10.1016/S0167-4889(99)00133-0 / Biochim. Biophys. Acta / Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins by Nishihara (1999)
10.1093/genetics/152.3.985 / Genetics / Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans by Nishiwaki (1999)
10.1083/jcb.144.6.1235 / J. Cell Biol. / Rho GTPases control polarity, protrusion, and adhesion during cell movement by Nobes (1999)
10.1101/gad.12.21.3337 / Genes Dev. / Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes by Nolan (1998)
10.1038/35004000 / Nat. Cell Biol. / CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans by Reddien (2000)
10.1016/0092-8674(92)90164-8 / Cell / The small GTP-binding protein rac regulates growth factor-induced membrane ruffling by Ridley (1992)
{'key': '10.1016/S0092-8674(01)00520-7_BIB37', 'first-page': '89', 'article-title': 'Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae', 'volume': '67', 'author': 'Robertson', 'year': '1982', 'journal-title': 'J. Embryol. Exp. Morph.'} / J. Embryol. Exp. Morph. / Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae by Robertson (1982)
10.1038/35037722 / Nature / Corpse clearance defines the meaning of cell death by Savill (2000)
10.1091/mbc.3.2.221 / Mol. Biol. Cell / Temporal and spatial expression patterns of the small heat shock (hsp16) proteins in transgenic Caenorhabditis elegans by Stringham (1992)
10.1016/0012-1606(77)90158-0 / Dev. Biol. / Post-embryonic cell lineages of the nematode, Caenorhabditis elegans by Sulston (1977)
10.1128/MCB.15.12.6829 / Mol. Cell. Biol. / Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins by Tanaka (1995)
{'key': '10.1016/S0092-8674(01)00520-7_BIB42', 'article-title': 'Evidence for a conserved role for CrkII and Rac in engulfment of apoptotic cells', 'volume': 'in press', 'author': 'Tosello-Trampont', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Evidence for a conserved role for CrkII and Rac in engulfment of apoptotic cells by Tosello-Trampont (2001)
10.1101/gad.11.18.2295 / Genes Dev. / Rho GTPases and signaling networks by Van Aelst (1997)
10.1016/S0092-8674(00)81201-5 / Cell / The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters by Wu (1998)
10.1038/32195 / Nature / C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 by Wu (1998)
10.1016/S0092-8674(01)00190-8 / Cell / CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans by Zhou (2001)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 12:29 p.m.)
Indexed	2 days, 15 hours ago (Aug. 26, 2025, 3:10 a.m.)
Issued	23 years, 10 months ago (Oct. 1, 2001)
Published	23 years, 10 months ago (Oct. 1, 2001)
Published Print	23 years, 10 months ago (Oct. 1, 2001)

Funders 0

None

BibTeX

@article{Gumienny_2001, title={CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration}, volume={107}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(01)00520-7}, DOI={10.1016/s0092-8674(01)00520-7}, number={1}, journal={Cell}, publisher={Elsevier BV}, author={Gumienny, Tina L. and Brugnera, Enrico and Tosello-Trampont, Annie-Carole and Kinchen, Jason M. and Haney, Lisa B. and Nishiwaki, Kiyoji and Walk, Scott F. and Nemergut, Michael E. and Macara, Ian G. and Francis, Ross and Schedl, Tim and Qin, Yi and Van Aelst, Linda and Hengartner, Michael O. and Ravichandran, Kodimangalam S.}, year={2001}, month=oct, pages={27–41} }

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      "author": "Albert",
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      "article-title": "A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant",
      "volume": "51",
      "author": "Avery",
      "year": "1987",
      "journal-title": "Cell"
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      "article-title": "Rho GTPases and their effector proteins",
      "volume": "348",
      "author": "Bishop",
      "year": "2000",
      "journal-title": "Biochem. J."
    },
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      "first-page": "1717",
      "DOI": "10.1126/science.282.5394.1717",
      "article-title": "Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases",
      "volume": "282",
      "author": "Caron",
      "year": "1998",
      "journal-title": "Science"
    },
    {
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      "article-title": "Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells",
      "volume": "146",
      "author": "Cheresh",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB6",
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      "first-page": "E191",
      "DOI": "10.1038/35036454",
      "article-title": "Function of rho family proteins in actin dynamics during phagocytosis and engulfment",
      "volume": "2",
      "author": "Chimini",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "931",
      "DOI": "10.1038/35046585",
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      "volume": "2",
      "author": "Chung",
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      "article-title": "Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans",
      "volume": "129",
      "author": "Ellis",
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      "year": "1997",
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      "author": "Hedgecock",
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      "author": "Hubbard",
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      "volume": "8",
      "author": "Kiyokawa",
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      "author": "Kiyokawa",
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      "volume": "273",
      "author": "Kiyokawa",
      "year": "1998",
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      "year": "1976",
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      "volume": "140",
      "author": "Klemke",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
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      "article-title": "Requirement for Rho GTPases and PI-3 kinase during apoptotic cell phagocytosis by macrophages",
      "volume": "11",
      "author": "Leverrier",
      "year": "2001",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "961",
      "DOI": "10.1016/S0092-8674(00)81202-7",
      "article-title": "Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans",
      "volume": "93",
      "author": "Liu",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "226",
      "DOI": "10.1002/j.1460-2075.1996.tb00353.x",
      "article-title": "The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death",
      "volume": "15",
      "author": "Luciani",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "6219",
      "DOI": "10.1093/emboj/17.21.6219",
      "article-title": "Fc receptor-mediated phagocytosis requires CDC42 and Rac1",
      "volume": "17",
      "author": "Massol",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "272",
      "DOI": "10.1038/332272a0",
      "article-title": "A novel viral oncogene with structural similarity to phospholipase C",
      "volume": "332",
      "author": "Mayer",
      "year": "1988",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/S0091-679X(08)61399-0",
      "article-title": "DNA transformation",
      "volume": "48",
      "author": "Mello",
      "year": "1995",
      "journal-title": "Methods Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "3035",
      "DOI": "10.1242/dev.126.14.3035",
      "article-title": "The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development",
      "volume": "126",
      "author": "Montell",
      "year": "1999",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1540",
      "DOI": "10.1126/science.292.5521.1540",
      "article-title": "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B",
      "volume": "292",
      "author": "Nemergut",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/S0167-4889(99)00133-0",
      "article-title": "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins",
      "volume": "1452",
      "author": "Nishihara",
      "year": "1999",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "985",
      "DOI": "10.1093/genetics/152.3.985",
      "article-title": "Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans",
      "volume": "152",
      "author": "Nishiwaki",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1235",
      "DOI": "10.1083/jcb.144.6.1235",
      "article-title": "Rho GTPases control polarity, protrusion, and adhesion during cell movement",
      "volume": "144",
      "author": "Nobes",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "3337",
      "DOI": "10.1101/gad.12.21.3337",
      "article-title": "Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes",
      "volume": "12",
      "author": "Nolan",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1038/35004000",
      "article-title": "CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans",
      "volume": "2",
      "author": "Reddien",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1016/0092-8674(92)90164-8",
      "article-title": "The small GTP-binding protein rac regulates growth factor-induced membrane ruffling",
      "volume": "70",
      "author": "Ridley",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB37",
      "first-page": "89",
      "article-title": "Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae",
      "volume": "67",
      "author": "Robertson",
      "year": "1982",
      "journal-title": "J. Embryol. Exp. Morph."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1038/35037722",
      "article-title": "Corpse clearance defines the meaning of cell death",
      "volume": "407",
      "author": "Savill",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1091/mbc.3.2.221",
      "article-title": "Temporal and spatial expression patterns of the small heat shock (hsp16) proteins in transgenic Caenorhabditis elegans",
      "volume": "3",
      "author": "Stringham",
      "year": "1992",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1016/0012-1606(77)90158-0",
      "article-title": "Post-embryonic cell lineages of the nematode, Caenorhabditis elegans",
      "volume": "56",
      "author": "Sulston",
      "year": "1977",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "6829",
      "DOI": "10.1128/MCB.15.12.6829",
      "article-title": "Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins",
      "volume": "15",
      "author": "Tanaka",
      "year": "1995",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB42",
      "article-title": "Evidence for a conserved role for CrkII and Rac in engulfment of apoptotic cells",
      "volume": "in press",
      "author": "Tosello-Trampont",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "2295",
      "DOI": "10.1101/gad.11.18.2295",
      "article-title": "Rho GTPases and signaling networks",
      "volume": "11",
      "author": "Van Aelst",
      "year": "1997",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "951",
      "DOI": "10.1016/S0092-8674(00)81201-5",
      "article-title": "The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters",
      "volume": "93",
      "author": "Wu",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1038/32195",
      "article-title": "C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180",
      "volume": "392",
      "author": "Wu",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00520-7_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/S0092-8674(01)00190-8",
      "article-title": "CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans",
      "volume": "104",
      "author": "Zhou",
      "year": "2001",
      "journal-title": "Cell"
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