DOI: 10.1016/s0092-8674(01)00227-6. Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

10.1016/s0092-8674(01)00227-6

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Myung, K., Datta, A., & Kolodner, R. D. (2001). Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae. Cell, 104(3), 397â408.

Authors 3

Kyungjae Myung (first)
Abhijit Datta (additional)
Richard D Kolodner (additional)

References 100 Referenced 265

10.1101/gad.8.20.2401 / Genes Dev. / The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast by Allen (1994)
10.1016/S0959-437X(99)80010-0 / Curr. Opin. Genet. Dev. / The spindle checkpoint by Amon (1999)
10.1073/pnas.92.25.11791 / Proc. Natl. Acad. Sci. USA / Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint by Araki (1995)
10.1128/MCB.20.12.4393-4404.2000 / Mol. Cell Biol. / DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints by Bashkirov (2000)
10.1126/science.286.5449.2528 / Science / Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome by Bell (1999)
10.1093/emboj/17.6.1819 / EMBO J. / Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing by Boulton (1998)
10.1101/gad.14.4.397 / Genes Dev. / ATR disruption leads to chromosomal fragmentation and early embryonic lethality by Brown (2000)
10.1073/pnas.93.26.15075 / Proc. Natl. Acad. Sci. USA / The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast by Brush (1996)
10.1073/pnas.86.13.5044 / Proc. Natl. Acad. Sci. USA / Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene by Canning (1989)
10.1016/S0092-8674(00)81175-7 / Cell / The hMRE11/hRad50 protein complex and Nijmegen Breakage Syndrome by Carney (1998)
10.1038/12687 / Nat. Genet. / Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants by Chen (1999)
10.1016/S1097-2765(00)80109-4 / Mol. Cell / Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair by Chen (1998)
10.1128/MCB.19.11.7801 / Mol. Cell Biol. / Saccharomyces cerevisiae pol30 (Proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair by Chen (1999)
10.1016/0378-1119(92)90454-W / Gene / Multifunctional yeast high-copy-number shuttle vectors by Christianson (1992)
10.1016/S0960-9822(99)80163-8 / Curr. Biol. / The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast by Clarke (1999)
{'key': '10.1016/S0092-8674(01)00227-6_BIB16', 'first-page': '4645', 'article-title': 'The role of genomic instability in human carcinogenesis', 'volume': '19', 'author': 'Coleman', 'year': '1999', 'journal-title': 'Anticancer Res.'} / Anticancer Res. / The role of genomic instability in human carcinogenesis by Coleman (1999)
10.1038/5991 / Nat. Genet. / Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions by Corda (1999)
10.1128/MCB.20.7.2378-2384.2000 / Mol. Cell Biol. / Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae by Craven (2000)
10.1016/S1097-2765(00)00058-7 / Mol. Cell / Checkpoint dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants by Datta (2000)
10.1101/gad.12.18.2956 / Genes Dev. / Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway by Desany (1998)
10.1016/S0092-8674(00)81670-0 / Cell / Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and δ by Diede (1999)
10.1074/jbc.274.28.19513 / J. Biol. Chem. / The Nijmegen Breakage Syndrome protein is essential for Mre11 phosphorylation upon DNA damage by Dong (1999)
10.1126/science.274.5293.1664 / Science / Cell cycle checkpoints by Elledge (1996)
10.1073/pnas.93.24.13825 / Proc. Natl. Acad. Sci. USA / The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells by Freid (1996)
10.1093/emboj/18.11.3173 / EMBO J. / RAD53, DUN1, and PDS1 define two parallel G2/M checkpoint pathways in budding yeast by Gardner (1999)
10.1038/75508 / Nat. Genet. / ATM-dependent phosphorylation of nibrin in response to radiation exposure by Gatei (2000)
10.1016/0378-1119(88)90185-0 / Gene / New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites by Gietz (1988)
10.1016/0092-8674(95)90479-4 / Cell / TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human Ataxia Telangiectasia gene by Greenwell (1995)
{'key': '10.1016/S0092-8674(01)00227-6_BIB29', 'first-page': '859', 'article-title': 'BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability', 'volume': '58', 'author': 'Gretarsdottir', 'year': '1998', 'journal-title': 'Cancer Res.'} / Cancer Res. / BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability by Gretarsdottir (1998)
10.1083/jcb.131.3.709 / J. Cell Biol. / Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast by Hardwick (1995)
10.1016/0092-8674(92)90586-2 / Cell / Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells by Hartwell (1992)
10.1016/S0046-8177(96)90106-9 / Hum. Pathol. / Comparative genomic hybridization by Hermsen (1996)
10.1016/0092-8674(81)90014-3 / Cell / S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function by Hoyt (1991)
10.1016/S0959-8049(99)00298-1 / Eur. J. Cancer / Genetic pathways in colorectal and other cancers by Ilyas (1999)
10.1093/emboj/17.22.6427 / EMBO J. / Replication errors by Jiricny (1998)
10.1093/nar/22.15.3104 / Nucleic Acids Res. / An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae by Kato (1994)
10.1074/jbc.274.53.37538 / J. Biol. Chem. / Substrate specificities and identification of putative substrates of ATM kinase family members by Kim (1999)
10.1126/science.280.5366.1036 / Science / Landscaping the cancer terrain by Kinzler (1998)
10.1073/pnas.96.8.4494 / Proc. Natl. Acad. Sci. USA / Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells by Klein (1999)
10.1093/dnares/3.6.421 / DNA Res. / Breakpoint junction of interstitial homozygous deletion at chromosome 2q33 in a small cell lung carcinoma by Kohno (1996)
10.1101/gad.10.12.1433 / Genes Dev. / Biochemistry and genetics of eukaryotic mismatch repair by Kolodner (1996)
10.1016/S0959-437X(99)80013-6 / Curr. Opin. Genet. Dev. / Eukaryotic DNA mismatch repair by Kolodner (1999)
10.1111/j.1365-2958.1995.tb02403.x / Mol. Microbiol. / Collapse and repair of replication forks in Escherichia coli by Kuzminov (1995)
{'key': '10.1016/S0092-8674(01)00227-6_BIB44', 'first-page': '1201', 'article-title': 'Atm', 'volume': '75', 'author': 'Lavin', 'year': '1999', 'journal-title': 'Int. J. Radiat. Biol.'} / Int. J. Radiat. Biol. / Atm by Lavin (1999)
10.1007/BF02986080 / J. Genet. / The distribution of the numbers of mutants in bacterial populations by Lea (1948)
10.1016/S0092-8674(00)81482-8 / Cell / Saccharomyces Ku70, Mre11/Rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage by Lee (1998)
10.1038/25292 / Nature / Genetic instabilities in human cancers by Lengauer (1998)
10.1016/S0092-8674(00)81871-1 / Cell / p53, the cellular gatekeeper for growth and division by Levine (1997)
{'key': '10.1016/S0092-8674(01)00227-6_BIB49', 'first-page': '393', 'article-title': 'The role of mismatch repair in DNA damage-induced apoptosis', 'volume': '11', 'author': 'Li', 'year': '1999', 'journal-title': 'Oncology Res.'} / Oncology Res. / The role of mismatch repair in DNA damage-induced apoptosis by Li (1999)
10.1038/35007091 / Nature / ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway by Lim (2000)
10.1007/PL00008656 / Mol. Gen. Genet. / Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest by Liu (2000)
{'key': '10.1016/S0092-8674(01)00227-6_BIB52', 'first-page': '3075', 'article-title': 'Mutator phenotype may be required for multistage carcinogenesis', 'volume': '51', 'author': 'Loeb', 'year': '1991', 'journal-title': 'Cancer Res.'} / Cancer Res. / Mutator phenotype may be required for multistage carcinogenesis by Loeb (1991)
10.1128/MCB.16.7.3235 / Mol. Cell Biol. / Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase by Longhese (1996)
10.1073/pnas.83.5.1398 / Proc. Natl. Acad. Sci. USA / Identification of yeast mutants with altered telomere structure by Lustig (1986)
10.1073/pnas.93.14.7131 / Proc. Natl. Acad. Sci. USA / Double-strand break repair in the absence of RAD51 in yeast by Malkova (1996)
10.1016/S0960-9822(00)00450-4 / Curr. Biol. / Cell cycle restriction of telomere elongation by Marcand (2000)
10.1128/MCB.17.10.6087 / Mol. Cell Biol. / hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double strand breaks by Maser (1997)
10.1016/S0960-9822(99)80424-2 / Curr. Biol. / DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p by McAinsh (1999)
10.1016/S0968-0004(00)01560-7 / Trends Biochem. Sci. / Replication fork arrest and DNA recombination by Michel (2000)
10.1016/0092-8674(95)90480-8 / Cell / TEL1, an S. cerevisiae homolog of the human gene mutated in Ataxia Telangiectasia, is functionally related to the yeast checkpoint gene MEC1 by Morrow (1995)
10.1038/83673 / Nat. Genet. / SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, functions in the suppression of genome instability and homeologous recombination by Myung (2001)
10.1128/MCB.20.16.5888-5896.2000 / Mol. Cell Biol. / Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae. by Naiki (2000)
10.1016/0092-8674(95)90448-4 / Cell / DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint by Navas (1995)
10.1101/gad.14.16.2046 / Genes Dev. / The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast by Paciotti (2000)
10.1016/S1097-2765(00)80035-0 / Mol. Cell / Involvement of Brca2 in DNA repair by Patel (1998)
10.1016/S0092-8674(00)81870-X / Cell / When checkpoints fail by Paulovich (1997)
Ponder, B.A.J., and Cavenee, W.K. (1995). Genetics and cancer: a second look, C.S. Harbor, ed. (NY: Cold Spring Harbor Press). (10.1007/978-94-011-0677-1)
10.1093/genetics/155.1.475 / Genetics / The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast by Ritchie (2000)
10.1128/MCB.19.9.6065 / Mol. Cell Biol. / Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae by Ritchie (1999)
10.1128/MCB.14.12.8282 / Mol. Cell Biol. / The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase by Roberts (1994)
10.1126/science.271.5247.357 / Science / Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways by Sanchez (1996)
10.1126/science.286.5442.1166 / Science / Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms by Sanchez (1999)
10.1038/27001 / Nature / A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication by Santocanale (1998)
10.1023/A:1018788132560 / J. Mam. Gland. Biol. Neoplasia / Functional characterization of BRCA1 and BRCA2 by Sharan (1998)
10.1038/386804a0 / Nature / Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 by Sharan (1997)
10.1146/annurev.genet.31.1.635 / Anuu. Rev. Genet. / Ataxia-telangiectasia and the Nijmegen breakage syndrome by Shiloh (1997)
10.1038/27007 / Nature / Regulation of DNA-replication origins during cell-cycle progression by Shirahige (1998)
10.1126/science.7545955 / Science / TLC1 by Singer (1994)
10.1016/S0092-8674(00)81547-0 / Cell / The DNA double-strand break repair gene hMRE11 is mutated in individuals with an Ataxia-Telangiectasia-like disorder by Stewart (1999)
10.1128/MCB.17.10.5905 / Mol. Cell Biol. / Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway by Sugimoto (1997)
10.1101/gad.10.4.395 / Genes Dev. / Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways by Sun (1996)
10.1016/S0960-9822(99)80355-8 / Curr. Biol. / Chromosome segregation by Taylor (1999)
10.1016/S0092-8674(00)81846-2 / Cell / A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair by Tishkoff (1997)
10.1073/pnas.93.25.14800 / Proc. Natl. Acad. Sci. USA / The mutation rate and cancer by Tomlinson (1996)
10.1016/S0960-9822(99)80479-5 / Curr. Biol. / Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification by Tutt (1999)
10.1016/S0092-8674(00)81174-5 / Cell / Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen Breakage Syndrome by Varon (1998)
10.1016/S0079-6603(08)60723-0 / Prog. Nucleic Acid Res. Mol. Biol. / Genetic disorders associated with cancer predisposition and genomic instability by Vessey (1999)
10.1093/emboj/17.19.5679 / EMBO J. / The budding yesat Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage by Vialard (1998)
10.1002/yea.320101310 / Yeast / New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. by Wach (1994)
10.1128/MCB.15.12.6838 / Mol. Cell Biol. / Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae by Wang (1995)
10.1073/pnas.96.7.3824 / Proc. Natl. Acad. Sci. USA / DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae by Wang (1999)
10.1016/S0092-8674(00)81597-4 / Cell / DNA damage and checkpoint pathways by Weinert (1998)
10.1016/S0959-437X(98)80140-8 / Curr. Opin. Genet. Dev. / DNA damage checkpoints update by Weinert (1998)
10.1101/gad.8.6.652 / Genes Dev. / Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair by Weinert (1994)
10.1038/8743 / Nat. Genet. / Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation by Xu (1999)
10.1083/jcb.133.1.85 / J. Cell Biol. / Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. by Yamamoto (1996)
10.1111/j.1365-2141.1995.tb03392.x / Br. J. Haematol. / Characterization of genomic BCR-ABL breakpoints in chronic myeloid leukaemia by PCR by Zhang (1995)
10.1016/S1097-2765(00)80277-4 / Mol. Cell / A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools by Zhao (1998)
10.1126/science.285.5428.747 / Science / Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response by Zhong (1999)
10.1016/0092-8674(93)90321-G / Cell / DUN1 encodes a protein kinase that controls the DNA damage response in yeast by Zhou (1993)

Dates

Type	When
Created	21 years, 4 months ago (April 15, 2004, 5:36 a.m.)
Deposited	8 months, 2 weeks ago (Dec. 15, 2024, 4:11 p.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 7:06 a.m.)
Issued	24 years, 7 months ago (Feb. 1, 2001)
Published	24 years, 7 months ago (Feb. 1, 2001)
Published Print	24 years, 7 months ago (Feb. 1, 2001)

Funders 0

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BibTeX

@article{Myung_2001, title={Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae}, volume={104}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(01)00227-6}, DOI={10.1016/s0092-8674(01)00227-6}, number={3}, journal={Cell}, publisher={Elsevier BV}, author={Myung, Kyungjae and Datta, Abhijit and Kolodner, Richard D}, year={2001}, month=feb, pages={397–408} }

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      "author": "Bashkirov",
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      "volume": "286",
      "author": "Bell",
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      "volume": "17",
      "author": "Boulton",
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      "author": "Brown",
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      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "first-page": "9",
      "DOI": "10.1016/S1097-2765(00)80109-4",
      "article-title": "Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair",
      "volume": "2",
      "author": "Chen",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "7801",
      "DOI": "10.1128/MCB.19.11.7801",
      "article-title": "Saccharomyces cerevisiae pol30 (Proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair",
      "volume": "19",
      "author": "Chen",
      "year": "1999",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/0378-1119(92)90454-W",
      "article-title": "Multifunctional yeast high-copy-number shuttle vectors",
      "volume": "110",
      "author": "Christianson",
      "year": "1992",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/S0960-9822(99)80163-8",
      "article-title": "The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast",
      "volume": "9",
      "author": "Clarke",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB16",
      "first-page": "4645",
      "article-title": "The role of genomic instability in human carcinogenesis",
      "volume": "19",
      "author": "Coleman",
      "year": "1999",
      "journal-title": "Anticancer Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "204",
      "DOI": "10.1038/5991",
      "article-title": "Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions",
      "volume": "21",
      "author": "Corda",
      "year": "1999",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "2378",
      "DOI": "10.1128/MCB.20.7.2378-2384.2000",
      "article-title": "Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae",
      "volume": "20",
      "author": "Craven",
      "year": "2000",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1016/S1097-2765(00)00058-7",
      "article-title": "Checkpoint dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants",
      "volume": "6",
      "author": "Datta",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "2958",
      "DOI": "10.1101/gad.12.18.2956",
      "article-title": "Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway",
      "volume": "12",
      "author": "Desany",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1016/S0092-8674(00)81670-0",
      "article-title": "Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases \u03b1 and \u03b4",
      "volume": "99",
      "author": "Diede",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "19513",
      "DOI": "10.1074/jbc.274.28.19513",
      "article-title": "The Nijmegen Breakage Syndrome protein is essential for Mre11 phosphorylation upon DNA damage",
      "volume": "274",
      "author": "Dong",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1664",
      "DOI": "10.1126/science.274.5293.1664",
      "article-title": "Cell cycle checkpoints",
      "volume": "274",
      "author": "Elledge",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "13825",
      "DOI": "10.1073/pnas.93.24.13825",
      "article-title": "The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells",
      "volume": "93",
      "author": "Freid",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "3173",
      "DOI": "10.1093/emboj/18.11.3173",
      "article-title": "RAD53, DUN1, and PDS1 define two parallel G2/M checkpoint pathways in budding yeast",
      "volume": "18",
      "author": "Gardner",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1038/75508",
      "article-title": "ATM-dependent phosphorylation of nibrin in response to radiation exposure",
      "volume": "25",
      "author": "Gatei",
      "year": "2000",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1016/0378-1119(88)90185-0",
      "article-title": "New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites",
      "volume": "74",
      "author": "Gietz",
      "year": "1988",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "823",
      "DOI": "10.1016/0092-8674(95)90479-4",
      "article-title": "TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human Ataxia Telangiectasia gene",
      "volume": "82",
      "author": "Greenwell",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB29",
      "first-page": "859",
      "article-title": "BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability",
      "volume": "58",
      "author": "Gretarsdottir",
      "year": "1998",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1083/jcb.131.3.709",
      "article-title": "Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast",
      "volume": "131",
      "author": "Hardwick",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1016/0092-8674(92)90586-2",
      "article-title": "Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells",
      "volume": "71",
      "author": "Hartwell",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1016/S0046-8177(96)90106-9",
      "article-title": "Comparative genomic hybridization",
      "volume": "27",
      "author": "Hermsen",
      "year": "1996",
      "journal-title": "Hum. Pathol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1016/0092-8674(81)90014-3",
      "article-title": "S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function",
      "volume": "66",
      "author": "Hoyt",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1986",
      "DOI": "10.1016/S0959-8049(99)00298-1",
      "article-title": "Genetic pathways in colorectal and other cancers",
      "volume": "35",
      "author": "Ilyas",
      "year": "1999",
      "journal-title": "Eur. J. Cancer"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "6427",
      "DOI": "10.1093/emboj/17.22.6427",
      "article-title": "Replication errors",
      "volume": "17",
      "author": "Jiricny",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "3104",
      "DOI": "10.1093/nar/22.15.3104",
      "article-title": "An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae",
      "volume": "22",
      "author": "Kato",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "37538",
      "DOI": "10.1074/jbc.274.53.37538",
      "article-title": "Substrate specificities and identification of putative substrates of ATM kinase family members",
      "volume": "274",
      "author": "Kim",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1036",
      "DOI": "10.1126/science.280.5366.1036",
      "article-title": "Landscaping the cancer terrain",
      "volume": "280",
      "author": "Kinzler",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "4494",
      "DOI": "10.1073/pnas.96.8.4494",
      "article-title": "Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells",
      "volume": "96",
      "author": "Klein",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "421",
      "DOI": "10.1093/dnares/3.6.421",
      "article-title": "Breakpoint junction of interstitial homozygous deletion at chromosome 2q33 in a small cell lung carcinoma",
      "volume": "3",
      "author": "Kohno",
      "year": "1996",
      "journal-title": "DNA Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1433",
      "DOI": "10.1101/gad.10.12.1433",
      "article-title": "Biochemistry and genetics of eukaryotic mismatch repair",
      "volume": "10",
      "author": "Kolodner",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/S0959-437X(99)80013-6",
      "article-title": "Eukaryotic DNA mismatch repair",
      "volume": "9",
      "author": "Kolodner",
      "year": "1999",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1111/j.1365-2958.1995.tb02403.x",
      "article-title": "Collapse and repair of replication forks in Escherichia coli",
      "volume": "16",
      "author": "Kuzminov",
      "year": "1995",
      "journal-title": "Mol. Microbiol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB44",
      "first-page": "1201",
      "article-title": "Atm",
      "volume": "75",
      "author": "Lavin",
      "year": "1999",
      "journal-title": "Int. J. Radiat. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "264",
      "DOI": "10.1007/BF02986080",
      "article-title": "The distribution of the numbers of mutants in bacterial populations",
      "volume": "49",
      "author": "Lea",
      "year": "1948",
      "journal-title": "J. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "399",
      "DOI": "10.1016/S0092-8674(00)81482-8",
      "article-title": "Saccharomyces Ku70, Mre11/Rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage",
      "volume": "94",
      "author": "Lee",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "643",
      "DOI": "10.1038/25292",
      "article-title": "Genetic instabilities in human cancers",
      "volume": "396",
      "author": "Lengauer",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1016/S0092-8674(00)81871-1",
      "article-title": "p53, the cellular gatekeeper for growth and division",
      "volume": "88",
      "author": "Levine",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB49",
      "first-page": "393",
      "article-title": "The role of mismatch repair in DNA damage-induced apoptosis",
      "volume": "11",
      "author": "Li",
      "year": "1999",
      "journal-title": "Oncology Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1038/35007091",
      "article-title": "ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway",
      "volume": "404",
      "author": "Lim",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1132",
      "DOI": "10.1007/PL00008656",
      "article-title": "Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest",
      "volume": "262",
      "author": "Liu",
      "year": "2000",
      "journal-title": "Mol. Gen. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB52",
      "first-page": "3075",
      "article-title": "Mutator phenotype may be required for multistage carcinogenesis",
      "volume": "51",
      "author": "Loeb",
      "year": "1991",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "3235",
      "DOI": "10.1128/MCB.16.7.3235",
      "article-title": "Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase",
      "volume": "16",
      "author": "Longhese",
      "year": "1996",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "1398",
      "DOI": "10.1073/pnas.83.5.1398",
      "article-title": "Identification of yeast mutants with altered telomere structure",
      "volume": "83",
      "author": "Lustig",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "7131",
      "DOI": "10.1073/pnas.93.14.7131",
      "article-title": "Double-strand break repair in the absence of RAD51 in yeast",
      "volume": "93",
      "author": "Malkova",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1016/S0960-9822(00)00450-4",
      "article-title": "Cell cycle restriction of telomere elongation",
      "volume": "10",
      "author": "Marcand",
      "year": "2000",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "6087",
      "DOI": "10.1128/MCB.17.10.6087",
      "article-title": "hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double strand breaks",
      "volume": "17",
      "author": "Maser",
      "year": "1997",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "963",
      "DOI": "10.1016/S0960-9822(99)80424-2",
      "article-title": "DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p",
      "volume": "9",
      "author": "McAinsh",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/S0968-0004(00)01560-7",
      "article-title": "Replication fork arrest and DNA recombination",
      "volume": "25",
      "author": "Michel",
      "year": "2000",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1016/0092-8674(95)90480-8",
      "article-title": "TEL1, an S. cerevisiae homolog of the human gene mutated in Ataxia Telangiectasia, is functionally related to the yeast checkpoint gene MEC1",
      "volume": "82",
      "author": "Morrow",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1038/83673",
      "article-title": "SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, functions in the suppression of genome instability and homeologous recombination",
      "volume": "27",
      "author": "Myung",
      "year": "2001",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "5888",
      "DOI": "10.1128/MCB.20.16.5888-5896.2000",
      "article-title": "Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae.",
      "volume": "20",
      "author": "Naiki",
      "year": "2000",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "29",
      "DOI": "10.1016/0092-8674(95)90448-4",
      "article-title": "DNA polymerase \u03f5 links the DNA replication machinery to the S phase checkpoint",
      "volume": "80",
      "author": "Navas",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "2046",
      "DOI": "10.1101/gad.14.16.2046",
      "article-title": "The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast",
      "volume": "14",
      "author": "Paciotti",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1016/S1097-2765(00)80035-0",
      "article-title": "Involvement of Brca2 in DNA repair",
      "volume": "1",
      "author": "Patel",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
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      "first-page": "315",
      "DOI": "10.1016/S0092-8674(00)81870-X",
      "article-title": "When checkpoints fail",
      "volume": "88",
      "author": "Paulovich",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB67",
      "doi-asserted-by": "crossref",
      "unstructured": "Ponder, B.A.J., and Cavenee, W.K. (1995). Genetics and cancer: a second look, C.S. Harbor, ed. (NY: Cold Spring Harbor Press).",
      "DOI": "10.1007/978-94-011-0677-1"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB68",
      "doi-asserted-by": "crossref",
      "first-page": "475",
      "DOI": "10.1093/genetics/155.1.475",
      "article-title": "The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast",
      "volume": "155",
      "author": "Ritchie",
      "year": "2000",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "6065",
      "DOI": "10.1128/MCB.19.9.6065",
      "article-title": "Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae",
      "volume": "19",
      "author": "Ritchie",
      "year": "1999",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "8282",
      "DOI": "10.1128/MCB.14.12.8282",
      "article-title": "The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase",
      "volume": "14",
      "author": "Roberts",
      "year": "1994",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1126/science.271.5247.357",
      "article-title": "Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways",
      "volume": "271",
      "author": "Sanchez",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB72",
      "doi-asserted-by": "crossref",
      "first-page": "1166",
      "DOI": "10.1126/science.286.5442.1166",
      "article-title": "Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms",
      "volume": "286",
      "author": "Sanchez",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "615",
      "DOI": "10.1038/27001",
      "article-title": "A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication",
      "volume": "395",
      "author": "Santocanale",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB74",
      "doi-asserted-by": "crossref",
      "first-page": "413",
      "DOI": "10.1023/A:1018788132560",
      "article-title": "Functional characterization of BRCA1 and BRCA2",
      "volume": "3",
      "author": "Sharan",
      "year": "1998",
      "journal-title": "J. Mam. Gland. Biol. Neoplasia"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "804",
      "DOI": "10.1038/386804a0",
      "article-title": "Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2",
      "volume": "386",
      "author": "Sharan",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB76",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1146/annurev.genet.31.1.635",
      "article-title": "Ataxia-telangiectasia and the Nijmegen breakage syndrome",
      "volume": "31",
      "author": "Shiloh",
      "year": "1997",
      "journal-title": "Anuu. Rev. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB77",
      "doi-asserted-by": "crossref",
      "first-page": "618",
      "DOI": "10.1038/27007",
      "article-title": "Regulation of DNA-replication origins during cell-cycle progression",
      "volume": "395",
      "author": "Shirahige",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "404",
      "DOI": "10.1126/science.7545955",
      "article-title": "TLC1",
      "volume": "266",
      "author": "Singer",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1016/S0092-8674(00)81547-0",
      "article-title": "The DNA double-strand break repair gene hMRE11 is mutated in individuals with an Ataxia-Telangiectasia-like disorder",
      "volume": "99",
      "author": "Stewart",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB80",
      "doi-asserted-by": "crossref",
      "first-page": "5905",
      "DOI": "10.1128/MCB.17.10.5905",
      "article-title": "Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway",
      "volume": "17",
      "author": "Sugimoto",
      "year": "1997",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB81",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1101/gad.10.4.395",
      "article-title": "Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways",
      "volume": "10",
      "author": "Sun",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB82",
      "doi-asserted-by": "crossref",
      "first-page": "562",
      "DOI": "10.1016/S0960-9822(99)80355-8",
      "article-title": "Chromosome segregation",
      "volume": "9",
      "author": "Taylor",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB83",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1016/S0092-8674(00)81846-2",
      "article-title": "A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair",
      "volume": "88",
      "author": "Tishkoff",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB84",
      "doi-asserted-by": "crossref",
      "first-page": "14800",
      "DOI": "10.1073/pnas.93.25.14800",
      "article-title": "The mutation rate and cancer",
      "volume": "93",
      "author": "Tomlinson",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB85",
      "doi-asserted-by": "crossref",
      "first-page": "1107",
      "DOI": "10.1016/S0960-9822(99)80479-5",
      "article-title": "Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification",
      "volume": "9",
      "author": "Tutt",
      "year": "1999",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB86",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1016/S0092-8674(00)81174-5",
      "article-title": "Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen Breakage Syndrome",
      "volume": "93",
      "author": "Varon",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB87",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1016/S0079-6603(08)60723-0",
      "article-title": "Genetic disorders associated with cancer predisposition and genomic instability",
      "volume": "63",
      "author": "Vessey",
      "year": "1999",
      "journal-title": "Prog. Nucleic Acid Res. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB88",
      "doi-asserted-by": "crossref",
      "first-page": "5679",
      "DOI": "10.1093/emboj/17.19.5679",
      "article-title": "The budding yesat Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage",
      "volume": "17",
      "author": "Vialard",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB89",
      "doi-asserted-by": "crossref",
      "first-page": "1793",
      "DOI": "10.1002/yea.320101310",
      "article-title": "New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae.",
      "volume": "10",
      "author": "Wach",
      "year": "1994",
      "journal-title": "Yeast"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB90",
      "doi-asserted-by": "crossref",
      "first-page": "6838",
      "DOI": "10.1128/MCB.15.12.6838",
      "article-title": "Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae",
      "volume": "15",
      "author": "Wang",
      "year": "1995",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB91",
      "doi-asserted-by": "crossref",
      "first-page": "3824",
      "DOI": "10.1073/pnas.96.7.3824",
      "article-title": "DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae",
      "volume": "96",
      "author": "Wang",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB92",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1016/S0092-8674(00)81597-4",
      "article-title": "DNA damage and checkpoint pathways",
      "volume": "94",
      "author": "Weinert",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB93",
      "doi-asserted-by": "crossref",
      "first-page": "185",
      "DOI": "10.1016/S0959-437X(98)80140-8",
      "article-title": "DNA damage checkpoints update",
      "volume": "8",
      "author": "Weinert",
      "year": "1998",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB94",
      "doi-asserted-by": "crossref",
      "first-page": "652",
      "DOI": "10.1101/gad.8.6.652",
      "article-title": "Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair",
      "volume": "8",
      "author": "Weinert",
      "year": "1994",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB95",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1038/8743",
      "article-title": "Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation",
      "volume": "22",
      "author": "Xu",
      "year": "1999",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB96",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1083/jcb.133.1.85",
      "article-title": "Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.",
      "volume": "133",
      "author": "Yamamoto",
      "year": "1996",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB97",
      "doi-asserted-by": "crossref",
      "first-page": "138",
      "DOI": "10.1111/j.1365-2141.1995.tb03392.x",
      "article-title": "Characterization of genomic BCR-ABL breakpoints in chronic myeloid leukaemia by PCR",
      "volume": "90",
      "author": "Zhang",
      "year": "1995",
      "journal-title": "Br. J. Haematol."
    },
    {
      "key": "10.1016/S0092-8674(01)00227-6_BIB98",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1016/S1097-2765(00)80277-4",
      "article-title": "A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools",
      "volume": "2",
      "author": "Zhao",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
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      "first-page": "747",
      "DOI": "10.1126/science.285.5428.747",
      "article-title": "Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response",
      "volume": "285",
      "author": "Zhong",
      "year": "1999",
      "journal-title": "Science"
    },
    {
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      "first-page": "1119",
      "DOI": "10.1016/0092-8674(93)90321-G",
      "article-title": "DUN1 encodes a protein kinase that controls the DNA damage response in yeast",
      "volume": "75",
      "author": "Zhou",
      "year": "1993",
      "journal-title": "Cell"
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