DOI: 10.1016/s0092-8674(00)81632-3. A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing

A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing

10.1016/s0092-8674(00)81632-3

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Pellizzoni, L., Kataoka, N., Charroux, B., & Dreyfuss, G. (1998). A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing. Cell, 95(5), 615â624.

Authors 4

Livio Pellizzoni (first)
Naoyuki Kataoka (additional)
Bernard Charroux (additional)
Gideon Dreyfuss (additional)

References 58 Referenced 437

10.1084/jem.173.6.1407 / J. Exp. Med. / Human auto antibody to a novel protein of the nuclear coiled body by Andrade (1991)
10.1073/pnas.90.5.1947 / Proc. Natl. Acad. Sci. USA / Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation by Andrade (1993)
10.1073/pnas.94.22.11798 / Proc. Natl. Acad. Sci. USA / Prp43 by Arenas (1997)
10.1083/jcb.131.4.817 / J. Cell Biol. / Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus by Bohmann (1995)
10.1038/344540a0 / Nature / Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2–13.3 by Brzustowicz (1990)
10.1086/513913 / Am. J. Hum. Genet. / When is a deletion not a deletion? When it is converted by Burghes (1997)
10.1038/ng1195-335 / Nature Genet. / A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients by Bussaglia (1995)
10.1002/j.1460-2075.1991.tb07936.x / EMBO J. / Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery by Carmo-Fonseca (1991)
{'key': '10.1016/S0092-8674(00)81632-3_BIB9', 'first-page': '1503', 'article-title': 'Molecular basis of spinal muscular atrophy in Chinese', 'volume': '57', 'author': 'Chang', 'year': '1995', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Molecular basis of spinal muscular atrophy in Chinese by Chang (1995)
10.1083/jcb.99.6.1997 / J. Cell. Biol. / Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells by Choi (1984)
{'key': '10.1016/S0092-8674(00)81632-3_BIB11', 'first-page': '805', 'article-title': 'Deletions of the survival motor neuron gene in unaffected siblings of patients with spinal muscular atrophy', 'volume': '57', 'author': 'Cobben', 'year': '1995', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Deletions of the survival motor neuron gene in unaffected siblings of patients with spinal muscular atrophy by Cobben (1995)
10.1038/349487a0 / Nature / Requirement of the RNA helicase-like protein PRP22 for the release of messenger RNA from spliceosomes by Company (1991)
10.1093/hmg/6.8.1205 / Hum. Mol. Gen. / The survival motor neuron protein in spinal muscular atrophy by Coovert (1997)
10.1136/jmg.26.12.761 / J. Med. Genet. / A Hungarian study on Werdnig-Hoffmann disease by Czeizel (1989)
10.1093/nar/11.5.1475 / Nucleic Acids Res. / Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei by Dignam (1983)
10.1126/science.2143847 / Science / An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus by Fischer (1990)
10.1016/S0092-8674(00)80368-2 / Cell / The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis by Fischer (1997)
10.1006/bbrc.1995.2135 / Biochem. Biophys. Res. Commun. / Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients by Gennarelli (1995)
10.1093/hmg/4.10.1927 / Hum. Mol. Genet. / Molecular analysis of SMA candidate genes (SMN and NAIP) in autosomal recessive spinal muscular atrophy on 5q13 by Hahnen (1995)
{'key': '10.1016/S0092-8674(00)81632-3_BIB20', 'first-page': '1057', 'article-title': 'Hybrid Survival Motor Neurons genes in patients with autosomal recessive spinal muscular atrophy', 'volume': '59', 'author': 'Hahnen', 'year': '1996', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Hybrid Survival Motor Neurons genes in patients with autosomal recessive spinal muscular atrophy by Hahnen (1996)
10.1073/pnas.89.1.305 / Proc. Natl. Acad. Sci. USA / U1 and U2 small nuclear RNAs are present in nuclear speckles by Huang (1992)
10.1016/0076-6879(89)80116-8 / Methods Enzymol. / Analysis of splicing complexes and small nuclear ribonucleoprotein particles by native gel electrophoresis by Konarska (1989)
10.1016/0092-8674(84)90268-X / Cell / Recognition of cap structure in splicing in vitro of mRNA precursors by Konarska (1984)
10.1093/nar/16.20.9415 / Nucleic Acids Res. / Pre-mRNA splicing by complementation with purified U1, U2, U4/U6 snRNPs by Krainer (1988)
10.1016/0962-8924(93)90214-L / Trends Cell Biol. / The coiled body by Lamond (1993)
10.1126/science.280.5363.547 / Science / Structure and function in the nucleus by Lamond (1998)
10.1016/0092-8674(95)90460-3 / Cell / Identification and characterization of a spinal muscular atrophy-determining gene by Lefebvre (1995)
10.1038/ng0797-265 / Nature Genet. / Correlation between severity and SMN protein level in spinal muscular atrophy by Lefebvre (1997)
10.1073/pnas.78.5.2737 / Proc. Natl. Acad. Sci. USA / Monoclonal antibodies to nucleic acid-containing cellular constituents by Lerner (1981)
10.1002/j.1460-2075.1996.tb00725.x / EMBO J. / A novel nuclear structure containing the survival of motor neuron proteins by Liu (1996)
10.1016/S0092-8674(00)80367-0 / Cell / The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins by Liu (1997)
10.1038/ng0598-63 / Nature Genet. / SMN oligomerization defect correlates with spinal muscular atrophy severity by Lorson (1998)
10.1016/0167-4781(90)90001-I / Biochim. Biophys. Acta / Structure of spliceosomal snRNPs and their role in pre-mRNA splicing by Luhrmann (1990)
10.1083/jcb.121.4.715 / J. Cell Biol. / Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells by Matera (1993)
10.1016/0092-8674(86)90072-3 / Cell / Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding by Mattaj (1986)
Mattaj, I.W. (1988). UsnRNP assembly and transport. In Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles, M. Birnstiel, ed. (Berlin: Springer-Verlag), pp. 100–114. (10.1007/978-3-642-73020-7_4)
10.1016/S0960-9822(98)70055-7 / Curr. Biol. / Ribonucleoprotein assembly by Mattaj (1998)
10.1016/0092-8674(85)90314-9 / Cell / Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins by Mattaj (1985)
10.1038/344767a0 / Nature / Gene for chronic spinal muscular atrophies maps to chromosome 5q by Melki (1990)
10.1128/MCB.10.7.3365 / Mol. Cell. Biol. / Nucleocytoplasmic transport and processing of small nuclear RNA precursors by Neuman de Vegvar (1990)
10.1101/gad.10.8.997 / Genes Dev. / A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome by Ohno (1996)
10.1083/jcb.124.3.249 / J. Cell Biol. / Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors by O’Keefe (1994)
10.1016/0092-8674(83)90212-X / Cell / Splicing of messenger RNA precursor is inhibited by antisera to small nuclear ribonucleoprotein by Padgett (1983)
10.1136/jmg.10.3.260 / J. Med. Genet. / The gene frequency of acute Werdnig-Hoffmann disease (SMA type I) by Pearn (1973)
10.1136/jmg.15.6.409 / J. Med. Genet. / Incidence, prevalence and gene frequency studies of chronic childhood spinal muscular atrophy by Pearn (1978)
10.1126/science.279.5352.857 / Science / A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoproteins particles by Raghunathan (1998)
{'key': '10.1016/S0092-8674(00)81632-3_BIB47', 'first-page': '129', 'article-title': 'Un sencillo metodo de coloracion seletiva del reticulo protoplasmico y sus efectos en los diversos organos nerviosos de vertebrados y invertebrados', 'volume': '2', 'author': 'Ramón y Cajal', 'year': '1903', 'journal-title': 'Trab. Lab. Invest. Biol.'} / Trab. Lab. Invest. Biol. / Un sencillo metodo de coloracion seletiva del reticulo protoplasmico y sus efectos en los diversos organos nerviosos de vertebrados y invertebrados by Ramón y Cajal (1903)
10.1016/1047-8477(90)90066-L / J. Struct. Biol. / Association between the nucleolus and the coiled body by Raska (1990)
10.1136/adc.45.239.33 / Arch. Dis. Child. / The genetic component in child mortality by Roberts (1970)
10.1093/hmg/4.4.631 / Hum. Mol. Genet. / Deletions in the survival motor neuron gene on 5q13 in autosomal recessive spinal muscular atrophy by Rodrigues (1995)
10.1016/0955-0674(95)80086-7 / Curr. Opin. Cell Biol. / Spheres, coiled bodies and nuclear bodies by Roth (1995)
10.1073/pnas.94.18.9920 / Proc. Natl. Acad. Sci. USA / Inactivation of the survival of motor neuron gene, a candidate gene for human muscular atrophy, leads to massive cell death in early mouse embryos by Schrank (1997)
10.1083/jcb.129.3.551 / J. Cell Biol. / A nuclear localization domain in the hnRNP A1 protein by Siomi (1995)
10.1016/S0092-8674(00)80925-3 / Cell / Mechanical devices of the spliceosome by Staley (1998)
10.1093/hmg/5.2.257 / Hum. Mol. Genet. / Molecular analysis of the SMN and NAIP gene in Spanish spinal muscular atrophy (SMA) families and correlation between number of copies of BCD54l and SMN phenotype by Velasco (1996)
{'key': '10.1016/S0092-8674(00)81632-3_BIB56', 'first-page': '3432', 'article-title': 'Structural analysis of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function', 'volume': '11', 'author': 'Wassarman', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Structural analysis of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function by Wassarman (1991)
10.1093/emboj/16.6.1401 / EMBO J. / Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity by Zeng (1997)
10.3109/10409239009090604 / Crit. Rev. Biochem. Mol. Biol. / Cell biology of the snRNP particles by Zieve (1990)

Dates

Type	When
Created	21 years, 4 months ago (April 10, 2004, 5:39 a.m.)
Deposited	2 years, 4 months ago (April 28, 2023, 3:16 a.m.)
Indexed	2 days, 18 hours ago (Aug. 31, 2025, 6:11 a.m.)
Issued	26 years, 10 months ago (Nov. 1, 1998)
Published	26 years, 10 months ago (Nov. 1, 1998)
Published Print	26 years, 10 months ago (Nov. 1, 1998)

Funders 0

None

BibTeX

@article{Pellizzoni_1998, title={A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing}, volume={95}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)81632-3}, DOI={10.1016/s0092-8674(00)81632-3}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Pellizzoni, Livio and Kataoka, Naoyuki and Charroux, Bernard and Dreyfuss, Gideon}, year={1998}, month=nov, pages={615–624} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        31
      ]
    ],
    "date-time": "2025-08-31T10:11:32Z",
    "timestamp": 1756635092199
  },
  "reference-count": 58,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            11,
            1
          ]
        ],
        "date-time": "1998-11-01T00:00:00Z",
        "timestamp": 909878400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2001,
            4,
            11
          ]
        ],
        "date-time": "2001-04-11T00:00:00Z",
        "timestamp": 986947200000
      },
      "content-version": "vor",
      "delay-in-days": 892,
      "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        11
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(00)81632-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        10
      ]
    ],
    "date-time": "2004-04-10T09:39:29Z",
    "timestamp": 1081589969000
  },
  "page": "615-624",
  "source": "Crossref",
  "is-referenced-by-count": 437,
  "title": "A Novel Function for SMN, the Spinal Muscular Atrophy Disease Gene Product, in Pre-mRNA Splicing",
  "prefix": "10.1016",
  "volume": "95",
  "author": [
    {
      "given": "Livio",
      "family": "Pellizzoni",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Naoyuki",
      "family": "Kataoka",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bernard",
      "family": "Charroux",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gideon",
      "family": "Dreyfuss",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1407",
      "DOI": "10.1084/jem.173.6.1407",
      "article-title": "Human auto antibody to a novel protein of the nuclear coiled body",
      "volume": "173",
      "author": "Andrade",
      "year": "1991",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "1947",
      "DOI": "10.1073/pnas.90.5.1947",
      "article-title": "Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation",
      "volume": "90",
      "author": "Andrade",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "11798",
      "DOI": "10.1073/pnas.94.22.11798",
      "article-title": "Prp43",
      "volume": "94",
      "author": "Arenas",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1083/jcb.131.4.817",
      "article-title": "Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus",
      "volume": "131",
      "author": "Bohmann",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "540",
      "DOI": "10.1038/344540a0",
      "article-title": "Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2\u201313.3",
      "volume": "344",
      "author": "Brzustowicz",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1086/513913",
      "article-title": "When is a deletion not a deletion? When it is converted",
      "volume": "61",
      "author": "Burghes",
      "year": "1997",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1038/ng1195-335",
      "article-title": "A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients",
      "volume": "11",
      "author": "Bussaglia",
      "year": "1995",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1002/j.1460-2075.1991.tb07936.x",
      "article-title": "Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery",
      "volume": "10",
      "author": "Carmo-Fonseca",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB9",
      "first-page": "1503",
      "article-title": "Molecular basis of spinal muscular atrophy in Chinese",
      "volume": "57",
      "author": "Chang",
      "year": "1995",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1997",
      "DOI": "10.1083/jcb.99.6.1997",
      "article-title": "Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells",
      "volume": "99",
      "author": "Choi",
      "year": "1984",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB11",
      "first-page": "805",
      "article-title": "Deletions of the survival motor neuron gene in unaffected siblings of patients with spinal muscular atrophy",
      "volume": "57",
      "author": "Cobben",
      "year": "1995",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1038/349487a0",
      "article-title": "Requirement of the RNA helicase-like protein PRP22 for the release of messenger RNA from spliceosomes",
      "volume": "349",
      "author": "Company",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1205",
      "DOI": "10.1093/hmg/6.8.1205",
      "article-title": "The survival motor neuron protein in spinal muscular atrophy",
      "volume": "6",
      "author": "Coovert",
      "year": "1997",
      "journal-title": "Hum. Mol. Gen."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "761",
      "DOI": "10.1136/jmg.26.12.761",
      "article-title": "A Hungarian study on Werdnig-Hoffmann disease",
      "volume": "26",
      "author": "Czeizel",
      "year": "1989",
      "journal-title": "J. Med. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1475",
      "DOI": "10.1093/nar/11.5.1475",
      "article-title": "Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei",
      "volume": "11",
      "author": "Dignam",
      "year": "1983",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.1126/science.2143847",
      "article-title": "An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus",
      "volume": "249",
      "author": "Fischer",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1023",
      "DOI": "10.1016/S0092-8674(00)80368-2",
      "article-title": "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis",
      "volume": "90",
      "author": "Fischer",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "342",
      "DOI": "10.1006/bbrc.1995.2135",
      "article-title": "Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients",
      "volume": "213",
      "author": "Gennarelli",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1927",
      "DOI": "10.1093/hmg/4.10.1927",
      "article-title": "Molecular analysis of SMA candidate genes (SMN and NAIP) in autosomal recessive spinal muscular atrophy on 5q13",
      "volume": "4",
      "author": "Hahnen",
      "year": "1995",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB20",
      "first-page": "1057",
      "article-title": "Hybrid Survival Motor Neurons genes in patients with autosomal recessive spinal muscular atrophy",
      "volume": "59",
      "author": "Hahnen",
      "year": "1996",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1073/pnas.89.1.305",
      "article-title": "U1 and U2 small nuclear RNAs are present in nuclear speckles",
      "volume": "89",
      "author": "Huang",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "442",
      "DOI": "10.1016/0076-6879(89)80116-8",
      "article-title": "Analysis of splicing complexes and small nuclear ribonucleoprotein particles by native gel electrophoresis",
      "volume": "180",
      "author": "Konarska",
      "year": "1989",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.1016/0092-8674(84)90268-X",
      "article-title": "Recognition of cap structure in splicing in vitro of mRNA precursors",
      "volume": "38",
      "author": "Konarska",
      "year": "1984",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "9415",
      "DOI": "10.1093/nar/16.20.9415",
      "article-title": "Pre-mRNA splicing by complementation with purified U1, U2, U4/U6 snRNPs",
      "volume": "16",
      "author": "Krainer",
      "year": "1988",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1016/0962-8924(93)90214-L",
      "article-title": "The coiled body",
      "volume": "3",
      "author": "Lamond",
      "year": "1993",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "547",
      "DOI": "10.1126/science.280.5363.547",
      "article-title": "Structure and function in the nucleus",
      "volume": "280",
      "author": "Lamond",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "155",
      "DOI": "10.1016/0092-8674(95)90460-3",
      "article-title": "Identification and characterization of a spinal muscular atrophy-determining gene",
      "volume": "89",
      "author": "Lefebvre",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1038/ng0797-265",
      "article-title": "Correlation between severity and SMN protein level in spinal muscular atrophy",
      "volume": "16",
      "author": "Lefebvre",
      "year": "1997",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "2737",
      "DOI": "10.1073/pnas.78.5.2737",
      "article-title": "Monoclonal antibodies to nucleic acid-containing cellular constituents",
      "volume": "78",
      "author": "Lerner",
      "year": "1981",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "3555",
      "DOI": "10.1002/j.1460-2075.1996.tb00725.x",
      "article-title": "A novel nuclear structure containing the survival of motor neuron proteins",
      "volume": "15",
      "author": "Liu",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1013",
      "DOI": "10.1016/S0092-8674(00)80367-0",
      "article-title": "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins",
      "volume": "90",
      "author": "Liu",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1038/ng0598-63",
      "article-title": "SMN oligomerization defect correlates with spinal muscular atrophy severity",
      "volume": "19",
      "author": "Lorson",
      "year": "1998",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1016/0167-4781(90)90001-I",
      "article-title": "Structure of spliceosomal snRNPs and their role in pre-mRNA splicing",
      "volume": "1087",
      "author": "Luhrmann",
      "year": "1990",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "715",
      "DOI": "10.1083/jcb.121.4.715",
      "article-title": "Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells",
      "volume": "121",
      "author": "Matera",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1016/0092-8674(86)90072-3",
      "article-title": "Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding",
      "volume": "46",
      "author": "Mattaj",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB36",
      "doi-asserted-by": "crossref",
      "unstructured": "Mattaj, I.W. (1988). UsnRNP assembly and transport. In Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles, M. Birnstiel, ed. (Berlin: Springer-Verlag), pp. 100\u2013114.",
      "DOI": "10.1007/978-3-642-73020-7_4"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/S0960-9822(98)70055-7",
      "article-title": "Ribonucleoprotein assembly",
      "volume": "8",
      "author": "Mattaj",
      "year": "1998",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1016/0092-8674(85)90314-9",
      "article-title": "Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins",
      "volume": "40",
      "author": "Mattaj",
      "year": "1985",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1038/344767a0",
      "article-title": "Gene for chronic spinal muscular atrophies maps to chromosome 5q",
      "volume": "344",
      "author": "Melki",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "3365",
      "DOI": "10.1128/MCB.10.7.3365",
      "article-title": "Nucleocytoplasmic transport and processing of small nuclear RNA precursors",
      "volume": "10",
      "author": "Neuman de Vegvar",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "997",
      "DOI": "10.1101/gad.10.8.997",
      "article-title": "A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome",
      "volume": "10",
      "author": "Ohno",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1083/jcb.124.3.249",
      "article-title": "Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors",
      "volume": "124",
      "author": "O\u2019Keefe",
      "year": "1994",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1016/0092-8674(83)90212-X",
      "article-title": "Splicing of messenger RNA precursor is inhibited by antisera to small nuclear ribonucleoprotein",
      "volume": "35",
      "author": "Padgett",
      "year": "1983",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1136/jmg.10.3.260",
      "article-title": "The gene frequency of acute Werdnig-Hoffmann disease (SMA type I)",
      "volume": "10",
      "author": "Pearn",
      "year": "1973",
      "journal-title": "J. Med. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1136/jmg.15.6.409",
      "article-title": "Incidence, prevalence and gene frequency studies of chronic childhood spinal muscular atrophy",
      "volume": "15",
      "author": "Pearn",
      "year": "1978",
      "journal-title": "J. Med. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "857",
      "DOI": "10.1126/science.279.5352.857",
      "article-title": "A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoproteins particles",
      "volume": "279",
      "author": "Raghunathan",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB47",
      "first-page": "129",
      "article-title": "Un sencillo metodo de coloracion seletiva del reticulo protoplasmico y sus efectos en los diversos organos nerviosos de vertebrados y invertebrados",
      "volume": "2",
      "author": "Ram\u00f3n y Cajal",
      "year": "1903",
      "journal-title": "Trab. Lab. Invest. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1016/1047-8477(90)90066-L",
      "article-title": "Association between the nucleolus and the coiled body",
      "volume": "104",
      "author": "Raska",
      "year": "1990",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1136/adc.45.239.33",
      "article-title": "The genetic component in child mortality",
      "volume": "45",
      "author": "Roberts",
      "year": "1970",
      "journal-title": "Arch. Dis. Child."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "631",
      "DOI": "10.1093/hmg/4.4.631",
      "article-title": "Deletions in the survival motor neuron gene on 5q13 in autosomal recessive spinal muscular atrophy",
      "volume": "4",
      "author": "Rodrigues",
      "year": "1995",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1016/0955-0674(95)80086-7",
      "article-title": "Spheres, coiled bodies and nuclear bodies",
      "volume": "7",
      "author": "Roth",
      "year": "1995",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "9920",
      "DOI": "10.1073/pnas.94.18.9920",
      "article-title": "Inactivation of the survival of motor neuron gene, a candidate gene for human muscular atrophy, leads to massive cell death in early mouse embryos",
      "volume": "94",
      "author": "Schrank",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1083/jcb.129.3.551",
      "article-title": "A nuclear localization domain in the hnRNP A1 protein",
      "volume": "129",
      "author": "Siomi",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1016/S0092-8674(00)80925-3",
      "article-title": "Mechanical devices of the spliceosome",
      "volume": "92",
      "author": "Staley",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1093/hmg/5.2.257",
      "article-title": "Molecular analysis of the SMN and NAIP gene in Spanish spinal muscular atrophy (SMA) families and correlation between number of copies of BCD54l and SMN phenotype",
      "volume": "5",
      "author": "Velasco",
      "year": "1996",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB56",
      "first-page": "3432",
      "article-title": "Structural analysis of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function",
      "volume": "11",
      "author": "Wassarman",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "1401",
      "DOI": "10.1093/emboj/16.6.1401",
      "article-title": "Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity",
      "volume": "16",
      "author": "Zeng",
      "year": "1997",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)81632-3_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.3109/10409239009090604",
      "article-title": "Cell biology of the snRNP particles",
      "volume": "25",
      "author": "Zieve",
      "year": "1990",
      "journal-title": "Crit. Rev. Biochem. Mol. Biol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400816323?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400816323?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        28
      ]
    ],
    "date-time": "2023-04-28T07:16:48Z",
    "timestamp": 1682666208000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867400816323"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        11
      ]
    ]
  },
  "references-count": 58,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1998,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867400816323"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(00)81632-3",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1998,
        11
      ]
    ]
  }
}