DOI: 10.1016/s0092-8674(00)81410-5. A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

10.1016/s0092-8674(00)81410-5

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998). A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis. Cell, 92(6), 829â839.

Authors 6

Pere Puigserver (first)
Zhidan Wu (additional)
Cheol Won Park (additional)
Reed Graves (additional)
Margaret Wright (additional)
Bruce M Spiegelman (additional)

References 57 Referenced 3,174

10.1126/science.277.5328.965 / Science / AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer by Anzick (1997)
10.1038/384641a0 / Nature / The CBP co-activator is a histone acetyltransferase by Bannister (1996)
10.1016/S0014-5793(97)00384-0 / FEBS Lett. / Uncoupling protein-3 by Boss (1997)
10.1016/S0021-9258(17)35962-8 / J. Biol. Chem. / Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein by Bouillaud (1986)
{'key': '10.1016/S0092-8674(00)81410-5_BIB5', 'first-page': 'R1291', 'article-title': 'Increase in cytochrome oxidase capacity of BAT and other tissues in cold-acclimated gerbils', 'volume': '258', 'author': 'Bourhim', 'year': '1990', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Increase in cytochrome oxidase capacity of BAT and other tissues in cold-acclimated gerbils by Bourhim (1990)
10.1042/bst0240407 / Biochem. Soc. Trans. / Adrenergic regulation of brown adipocyte differentiation by Cannon (1996)
10.1016/S0021-9258(19)51087-0 / J. Biol. Chem. / In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein by Cassard-Doulcier (1994)
10.1002/j.1460-2075.1995.tb00044.x / EMBO J. / Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor by Cavailles (1995)
10.1038/383099a0 / Nature / Role of CBP/P300 in nuclear receptor signaling by Chakravarti (1996)
10.1073/pnas.88.23.10774 / Proc. Natl. Acad. Sci. USA / Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs by Champigny (1991)
10.1016/S0092-8674(00)80516-4 / Cell / Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex by Chen (1997)
10.1038/ng0397-269 / Nat. Genet. / Uncoupling protein-2 by Fleury (1997)
10.1038/ng0397-223 / Nat. Genet. / Obesity research springs a proton leak by Flier (1997)
10.1016/0006-2952(96)00345-0 / Biochem. Pharmacol. / Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent by Foellmi-Adams (1996)
{'key': '10.1016/S0092-8674(00)81410-5_BIB15', 'first-page': '383', 'article-title': 'Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans', 'volume': '16', 'author': 'Garruti', 'year': '1992', 'journal-title': 'Int. J. Obes. Relat. Metab. Disord.'} / Int. J. Obes. Relat. Metab. Disord. / Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans by Garruti (1992)
10.2337/diab.46.5.900 / Diabetes / Cloning and characterization of an uncoupling protein homolog by Gimeno (1997)
10.1016/S0955-0674(97)80066-X / Curr. Opin. Cell Biol. / Nuclear receptor coactivators by Glass (1997)
10.1074/jbc.272.39.24129 / J. Biol. Chem. / Uncoupling protein-3 by Gong (1997)
10.1016/S0092-8674(01)80010-6 / Cell / Transcription properties of a cell type–specific TATA-binding protein, TRF by Hansen (1997)
10.1038/42750 / Nature / A signature motif in transcriptional co-activators mediates binding to nuclear receptors by Heery (1997)
10.1139/y89-063 / Can. J. Physiol. Pharmacol. / Role of thermogenesis in the regulation of energy balance in relation to obesity by Himms-Hagen (1989)
10.3181/00379727-208-43847A / Proc. Soc. Exp. Biol. Med. / Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats by Himms-Hagen (1995)
10.1038/377397a0 / Nature / Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor by Horlein (1995)
10.1126/science.274.5295.2100 / Science / Inhibition of adipogenesis through MAP kinase mediates phosphorylation of PPARγ by Hu (1996)
10.1016/S0021-9258(17)36228-2 / J. Biol. Chem. / Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression by Jacobsson (1985)
10.1016/S0092-8674(00)81118-6 / Cell / A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors by Kamei (1996)
10.1101/gad.10.9.1096 / Genes Dev. / ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism by Kim (1996)
10.1042/bj3160607 / Biochem. J. / Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation by Klingenspor (1996)
{'key': '10.1016/S0092-8674(00)81410-5_BIB29', 'first-page': '59', 'article-title': 'An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene', 'volume': '14', 'author': 'Kozak', 'year': '1994', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene by Kozak (1994)
10.1016/0092-8674(91)90620-E / Cell / Functional activity of myogenic HLH proteins requires heter-oligomerization with E12/E47-like proteins in vivo by Lassar (1991)
10.1038/366740a0 / Nature / Development of obesity in transgenic mice following the genetic ablation of brown adipose tissue by Lowell (1993)
10.1016/0092-8674(92)90352-D / Cell / A novel B cell–derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors by Luo (1992)
{'key': '10.1016/S0092-8674(00)81410-5_BIB33', 'series-title': 'Molecular Cloning', 'author': 'Maniatis', 'year': '1989'} / Molecular Cloning by Maniatis (1989)
10.1042/bj3080749 / Biochem. J. / Co-ordinate decrease in the expression of mitochondrial genome and nuclear genes for mitochondrial proteins in the lactation-induced mitochondrial hypotrophy of rat brown fat by Martin (1995)
10.1016/S0092-8674(00)80218-4 / Cell / Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase by Nagy (1997)
10.1042/bst0140223 / Biochem. Soc. Trans. / Mechanisms of thermogenesis in brown adipose tissue by Nicholls (1986)
10.1126/science.270.5240.1354 / Science / Sequence and characterization of a coactivator for the steroid hormone receptor superfamily by Onate (1995)
10.1016/S0092-8674(00)80211-1 / Cell / What is up and down with histone aceylation and transcription by Pazin (1997)
10.1073/pnas.90.18.8392 / Proc. Natl. Acad. Sci. USA / Production of high titre, helper-free retroviruses by transient transfection by Pear (1993)
10.1530/eje.0.1360231 / Eur. J. Endocrinol. / Thyroid hormone and gene expression in the regulation of mitochondrial respiratory function by Pillar (1997)
10.1042/bj3170827 / Biochem. J. / In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid by Puigserver (1996)
10.1016/S0021-9258(17)46245-4 / J. Biol. Chem. / Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture by Rehnmark (1990)
10.1128/MCB.16.7.3410 / Mol. Cell. Biol. / Differentiation-dependent expression of the brown adipocyte uncoupling protein gene by Sears (1996)
{'key': '10.1016/S0092-8674(00)81410-5_BIB44', 'first-page': '141', 'article-title': 'Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action', 'volume': '52', 'author': 'Shibata', 'year': '1997', 'journal-title': 'Recent Prog. Horm. Res.'} / Recent Prog. Horm. Res. / Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action by Shibata (1997)
10.1089/thy.1995.5.481 / Thyroid / Thyroid hormone control of thermogenesis and energy balance by Silva (1995)
10.1530/eje.0.1360251 / Eur. J. Endocrinol. / Regulation of the uncoupling protein gene expression by Silva (1997)
10.1038/38304 / Nature / Steroid receptor coactivator-1 is a histone acetyltransferase by Spencer (1997)
10.1016/S0092-8674(00)81359-8 / Cell / Adipogenesis and obesity by Spiegelman (1996)
10.1074/jbc.271.47.29909 / J. Biol. Chem. / Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation by Tai (1996)
{'key': '10.1016/S0092-8674(00)81410-5_BIB50', 'first-page': '1271', 'article-title': 'Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor', 'volume': '43', 'author': 'Tontonoz', 'year': '1994', 'journal-title': 'Cell'} / Cell / Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor by Tontonoz (1994)
10.1101/gad.8.10.1224 / Genes Dev. / mPPARγ2 by Tontonoz (1994)
10.1038/42652 / Nature / The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function by Torchia (1997)
10.1006/bbrc.1997.6740 / Biochem. Biophys. Res. Commun. / UCP3 by Vidal-Puig (1997)
10.1002/j.1460-2075.1996.tb00736.x / EMBO J. / TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors by Voegel (1996)
10.1074/jbc.270.27.16347 / J. Biol. Chem. by Wrutniak (1995)
10.1073/pnas.93.14.6975 / Proc. Natl. Acad. Sci. USA / The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins by Yuryev (1996)
10.1074/jbc.272.41.25500 / J. Biol. Chem. / Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor by Zhu (1997)

Dates

Type	When
Created	21 years, 4 months ago (April 10, 2004, 5:39 a.m.)
Deposited	3 years, 2 months ago (June 16, 2022, 5:11 a.m.)
Indexed	59 minutes ago (Sept. 7, 2025, 12:28 p.m.)
Issued	27 years, 6 months ago (March 1, 1998)
Published	27 years, 6 months ago (March 1, 1998)
Published Print	27 years, 6 months ago (March 1, 1998)

Funders 0

None

BibTeX

@article{Puigserver_1998, title={A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis}, volume={92}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)81410-5}, DOI={10.1016/s0092-8674(00)81410-5}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Puigserver, Pere and Wu, Zhidan and Park, Cheol Won and Graves, Reed and Wright, Margaret and Spiegelman, Bruce M}, year={1998}, month=mar, pages={829–839} }

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      "DOI": "10.1016/S0021-9258(17)36228-2",
      "article-title": "Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression",
      "volume": "260",
      "author": "Jacobsson",
      "year": "1985",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1016/S0092-8674(00)81118-6",
      "article-title": "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors",
      "volume": "85",
      "author": "Kamei",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB27",
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      "first-page": "1096",
      "DOI": "10.1101/gad.10.9.1096",
      "article-title": "ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism",
      "volume": "10",
      "author": "Kim",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "607",
      "DOI": "10.1042/bj3160607",
      "article-title": "Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation",
      "volume": "316",
      "author": "Klingenspor",
      "year": "1996",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB29",
      "first-page": "59",
      "article-title": "An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene",
      "volume": "14",
      "author": "Kozak",
      "year": "1994",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "305",
      "DOI": "10.1016/0092-8674(91)90620-E",
      "article-title": "Functional activity of myogenic HLH proteins requires heter-oligomerization with E12/E47-like proteins in vivo",
      "volume": "66",
      "author": "Lassar",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "740",
      "DOI": "10.1038/366740a0",
      "article-title": "Development of obesity in transgenic mice following the genetic ablation of brown adipose tissue",
      "volume": "366",
      "author": "Lowell",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1016/0092-8674(92)90352-D",
      "article-title": "A novel B cell\u2013derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors",
      "volume": "71",
      "author": "Luo",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB33",
      "series-title": "Molecular Cloning",
      "author": "Maniatis",
      "year": "1989"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "749",
      "DOI": "10.1042/bj3080749",
      "article-title": "Co-ordinate decrease in the expression of mitochondrial genome and nuclear genes for mitochondrial proteins in the lactation-induced mitochondrial hypotrophy of rat brown fat",
      "volume": "308",
      "author": "Martin",
      "year": "1995",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1016/S0092-8674(00)80218-4",
      "article-title": "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase",
      "volume": "89",
      "author": "Nagy",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1042/bst0140223",
      "article-title": "Mechanisms of thermogenesis in brown adipose tissue",
      "volume": "14",
      "author": "Nicholls",
      "year": "1986",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "1354",
      "DOI": "10.1126/science.270.5240.1354",
      "article-title": "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily",
      "volume": "270",
      "author": "Onate",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1016/S0092-8674(00)80211-1",
      "article-title": "What is up and down with histone aceylation and transcription",
      "volume": "89",
      "author": "Pazin",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "8392",
      "DOI": "10.1073/pnas.90.18.8392",
      "article-title": "Production of high titre, helper-free retroviruses by transient transfection",
      "volume": "90",
      "author": "Pear",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "231",
      "DOI": "10.1530/eje.0.1360231",
      "article-title": "Thyroid hormone and gene expression in the regulation of mitochondrial respiratory function",
      "volume": "136",
      "author": "Pillar",
      "year": "1997",
      "journal-title": "Eur. J. Endocrinol."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "827",
      "DOI": "10.1042/bj3170827",
      "article-title": "In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid",
      "volume": "317",
      "author": "Puigserver",
      "year": "1996",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "16464",
      "DOI": "10.1016/S0021-9258(17)46245-4",
      "article-title": "Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture",
      "volume": "25",
      "author": "Rehnmark",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "3410",
      "DOI": "10.1128/MCB.16.7.3410",
      "article-title": "Differentiation-dependent expression of the brown adipocyte uncoupling protein gene",
      "volume": "16",
      "author": "Sears",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB44",
      "first-page": "141",
      "article-title": "Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action",
      "volume": "52",
      "author": "Shibata",
      "year": "1997",
      "journal-title": "Recent Prog. Horm. Res."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "481",
      "DOI": "10.1089/thy.1995.5.481",
      "article-title": "Thyroid hormone control of thermogenesis and energy balance",
      "volume": "5",
      "author": "Silva",
      "year": "1995",
      "journal-title": "Thyroid"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1530/eje.0.1360251",
      "article-title": "Regulation of the uncoupling protein gene expression",
      "volume": "136",
      "author": "Silva",
      "year": "1997",
      "journal-title": "Eur. J. Endocrinol."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1038/38304",
      "article-title": "Steroid receptor coactivator-1 is a histone acetyltransferase",
      "volume": "389",
      "author": "Spencer",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1016/S0092-8674(00)81359-8",
      "article-title": "Adipogenesis and obesity",
      "volume": "87",
      "author": "Spiegelman",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "29909",
      "DOI": "10.1074/jbc.271.47.29909",
      "article-title": "Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation",
      "volume": "271",
      "author": "Tai",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB50",
      "first-page": "1271",
      "article-title": "Stimulation of adipogenesis in fibroblasts by PPAR\u03b32, a lipid-activated transcription factor",
      "volume": "43",
      "author": "Tontonoz",
      "year": "1994",
      "journal-title": "Cell"
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    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "1224",
      "DOI": "10.1101/gad.8.10.1224",
      "article-title": "mPPAR\u03b32",
      "volume": "8",
      "author": "Tontonoz",
      "year": "1994",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "677",
      "DOI": "10.1038/42652",
      "article-title": "The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function",
      "volume": "387",
      "author": "Torchia",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1006/bbrc.1997.6740",
      "article-title": "UCP3",
      "volume": "235",
      "author": "Vidal-Puig",
      "year": "1997",
      "journal-title": "Biochem. Biophys. Res. Commun."
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    {
      "key": "10.1016/S0092-8674(00)81410-5_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "3667",
      "DOI": "10.1002/j.1460-2075.1996.tb00736.x",
      "article-title": "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors",
      "volume": "15",
      "author": "Voegel",
      "year": "1996",
      "journal-title": "EMBO J."
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      "key": "10.1016/S0092-8674(00)81410-5_BIB55",
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      "first-page": "16347",
      "DOI": "10.1074/jbc.270.27.16347",
      "volume": "270",
      "author": "Wrutniak",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
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      "doi-asserted-by": "crossref",
      "first-page": "6975",
      "DOI": "10.1073/pnas.93.14.6975",
      "article-title": "The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins",
      "volume": "93",
      "author": "Yuryev",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "DOI": "10.1074/jbc.272.41.25500",
      "article-title": "Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor",
      "volume": "272",
      "author": "Zhu",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
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