DOI: 10.1016/s0092-8674(00)80875-2. Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

10.1016/s0092-8674(00)80875-2

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Dobles, M., Liberal, V., Scott, M. L., Benezra, R., & Sorger, P. K. (2000). Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2. Cell, 101(6), 635â645.

Authors 5

Max Dobles (first)
Vasco Liberal (additional)
Martin L Scott (additional)
Robert Benezra (additional)
Peter K Sorger (additional)

References 61 Referenced 422

10.1093/emboj/18.10.2707 / EMBO J. / Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage by Alexandru (1999)
10.1016/0012-1606(80)90048-2 / Dev. Biol. / Polyadenylated RNA of mouse ova and loss of maternal RNA in early development by Bachvarova (1980)
10.1007/s004120050321 / Chromosoma / Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod by Basu (1998)
10.1083/jcb.146.1.13 / J. Cell Biol. / Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila by Basu (1999)
10.1083/jcb.143.7.1775 / J. Cell Biol. / Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis by Bernard (1998)
10.1038/32688 / Nature / Mutations of mitotic checkpoint genes in human cancers by Cahill (1998)
10.1126/science.2660260 / Science / Altering the genome by homologous recombination by Capecchi (1989)
10.1083/jcb.143.1.49 / J. Cell Biol. / Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1 by Chan (1998)
10.1083/jcb.146.5.941 / J. Cell Biol. / Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC by Chan (1999)
10.1126/science.274.5285.242 / Science / Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores by Chen (1996)
10.1083/jcb.143.2.283 / J. Cell Biol. / Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores by Chen (1998)
10.1091/mbc.10.8.2607 / Mol. Biol. Cell / The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins by Chen (1999)
10.1038/10049 / Nat. Cell Biol. / Temporal and spatial control of cyclin B1 destruction in metaphase by Clute (1999)
10.1101/gad.10.24.3081 / Genes Dev. / Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p by Cohen-Fix (1996)
10.1101/gad.12.12.1871 / Genes Dev. / The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation by Fang (1998)
10.1083/jcb.145.5.979 / J. Cell Biol. / Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2 by Fraschini (1999)
10.1083/jcb.119.3.493 / J. Cell Biol. / Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation by Gavrieli (1992)
10.1083/jcb.121.3.503 / J. Cell Biol. / NDC10 by Goh (1993)
10.1083/jcb.141.5.1193 / J. Cell Biol. / Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase by Gorbsky (1998)
10.1073/pnas.83.23.9065 / Proc. Natl. Acad. Sci. USA / Transgenesis by means of blastocyst-derived embryonic stem cell lines by Gossler (1986)
10.1126/science.273.5277.953 / Science / Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption by Hardwick (1996)
10.1083/jcb.148.5.871 / J. Cell Biol. / MAD3 encodes a novel component of the spindle checkpoint which interacts with bub3p, cdc20p, and mad2p by Hardwick (2000)
10.1126/science.7997877 / Science / Cell cycle control and cancer by Hartwell (1994)
10.1126/science.2683079 / Science / Checkpoints by Hartwell (1989)
{'key': '10.1016/S0092-8674(00)80875-2_BIB25', 'first-page': '28', 'article-title': 'The fidelity of mitotic chromosome reproduction in S. cerevisiae', 'volume': '1', 'author': 'Hartwell', 'year': '1982', 'journal-title': 'Rec. Adv. Yeast Mol. Biol.'} / Rec. Adv. Yeast Mol. Biol. / The fidelity of mitotic chromosome reproduction in S. cerevisiae by Hartwell (1982)
10.1073/pnas.94.15.7965 / Proc. Natl. Acad. Sci. USA / The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex by He (1997)
{'key': '10.1016/S0092-8674(00)80875-2_BIB27', 'series-title': 'Manipulating the Mouse Embryo', 'author': 'Hogan', 'year': '1994'} / Manipulating the Mouse Embryo by Hogan (1994)
10.1016/0092-8674(81)90014-3 / Cell / S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function by Hoyt (1991)
10.1126/science.279.5353.1041 / Science / Budding yeast Cdc20 by Hwang (1998)
10.1016/S0092-8674(00)81148-4 / Cell / Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 by Jin (1998)
{'key': '10.1016/S0092-8674(00)80875-2_BIB31', 'first-page': '816', 'article-title': 'Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death', 'volume': '56', 'author': 'Jordan', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death by Jordan (1996)
10.1126/science.279.5353.1045 / Science / Fission yeast Slp1 by Kim (1998)
10.1016/S0092-8674(00)81333-1 / Cell / Lessons from hereditary colorectal cancer by Kinzler (1996)
10.1038/70309 / Nat. Cell Biol. / Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans by Kitagawa (1999)
10.1128/MCB.18.2.1055 / Mol. Cell. Biol. / Characterization of the p53-dependent postmitotic checkpoint following spindle disruption by Lanni (1998)
10.1038/386623a0 / Nature / Genetic instability in colorectal cancers by Lengauer (1997)
10.1016/0092-8674(92)90561-P / Cell / A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei by Leonhardt (1992)
10.1073/pnas.96.9.4989 / Proc. Natl. Acad. Sci. USA / Bifurcation of the mitotic checkpoint pathway in budding yeast by Li (1999)
10.1126/science.274.5285.246 / Science / Identification of a human mitotic checkpoint gene by Li (1996)
10.1016/0092-8674(81)90015-5 / Cell / Feedback control of mitosis in budding yeast by Li (1991)
10.1038/373630a0 / Nature / Mitotic forces control a cell-cycle checkpoint by Li (1995)
10.1073/pnas.94.23.12431 / Proc. Natl. Acad. Sci. USA / MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity by Li (1997)
10.1016/0092-8674(91)90385-C / Cell / Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors by Mahadevan (1991)
10.1073/pnas.96.15.8493 / Proc. Natl. Acad. Sci. USA / Retention of the BUB3 checkpoint protein on lagging chromosomes by Martinez-Exposito (1999)
10.1091/mbc.3.12.1443 / Mol. Biol. Cell / Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae by McGrew (1992)
10.1111/j.1601-5223.1971.tb02431.x / Hereditas / The chromosomes of fifty primary Rous rat sarcomas by Mitelman (1971)
10.1042/bj3430673 / Biochem. J. / Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta by Nelson (1999)
10.1038/sj.onc.1203141 / Oncogene / Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers by Nomoto (1999)
10.1074/jbc.270.38.22077 / J. Biol. Chem. / Regulation of gene expression at the beginning of mammalian development by Nothias (1995)
10.1074/jbc.272.15.10035 / J. Biol. Chem. / Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation by O'Neill (1997)
10.1083/jcb.127.5.1301 / J. Cell Biol. / Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle by Rieder (1994)
10.1083/jcb.130.4.941 / J. Cell. Biol. / The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores by Rieder (1995)
{'key': '10.1016/S0092-8674(00)80875-2_BIB53', 'series-title': 'Normal development of the mouse. In The Mouse', 'author': 'Rugh', 'year': '1990'} / Normal development of the mouse. In The Mouse by Rugh (1990)
10.1093/emboj/17.5.1336 / EMBO J. / The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae by Shirayama (1998)
{'key': '10.1016/S0092-8674(00)80875-2_BIB55', 'first-page': '293', 'article-title': 'Gastrulation in the mouse', 'volume': '42', 'author': 'Snow', 'year': '1977', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / Gastrulation in the mouse by Snow (1977)
10.1083/jcb.142.1.1 / J. Cell Biol. / The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase by Taylor (1998)
10.1016/S0092-8674(00)80255-X / Cell / Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage by Taylor (1997)
10.1126/science.278.5337.460 / Science / CDC20 and CDH1 by Visintin (1997)
10.1073/pnas.95.19.11193 / Proc. Natl. Acad. Sci. USA / Mad2 transiently associates with an APC/p55Cdc complex during mitosis by Wassmann (1998)
10.1007/BF03401588 / Mol. Med. / Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway by Woods (1995)
10.1083/jcb.133.1.85 / J. Cell Biol. / Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae by Yamamoto (1996)

Dates

Type	When
Created	21 years, 3 months ago (May 11, 2004, 6:35 a.m.)
Deposited	4 years, 2 months ago (June 17, 2021, 8:45 a.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:53 p.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Dobles_2000, title={Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2}, volume={101}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80875-2}, DOI={10.1016/s0092-8674(00)80875-2}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Dobles, Max and Liberal, Vasco and Scott, Martin L and Benezra, Robert and Sorger, Peter K}, year={2000}, month=jun, pages={635–645} }

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      "journal-title": "Chromosoma"
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      "volume": "146",
      "author": "Basu",
      "year": "1999",
      "journal-title": "J. Cell Biol."
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      "volume": "143",
      "author": "Bernard",
      "year": "1998",
      "journal-title": "J. Cell Biol."
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      "doi-asserted-by": "publisher",
      "first-page": "300",
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      "volume": "143",
      "author": "Chan",
      "year": "1998",
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      "author": "Chan",
      "year": "1999",
      "journal-title": "J. Cell Biol."
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      "volume": "145",
      "author": "Fraschini",
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      "author": "Gorbsky",
      "year": "1998",
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      "author": "Hardwick",
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      "volume": "148",
      "author": "Hardwick",
      "year": "2000",
      "journal-title": "J. Cell Biol."
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      "first-page": "629",
      "DOI": "10.1126/science.2683079",
      "article-title": "Checkpoints",
      "volume": "246",
      "author": "Hartwell",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB25",
      "first-page": "28",
      "article-title": "The fidelity of mitotic chromosome reproduction in S. cerevisiae",
      "volume": "1",
      "author": "Hartwell",
      "year": "1982",
      "journal-title": "Rec. Adv. Yeast Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB26",
      "doi-asserted-by": "publisher",
      "first-page": "7965",
      "DOI": "10.1073/pnas.94.15.7965",
      "article-title": "The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex",
      "volume": "94",
      "author": "He",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB27",
      "series-title": "Manipulating the Mouse Embryo",
      "author": "Hogan",
      "year": "1994"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB28",
      "doi-asserted-by": "publisher",
      "first-page": "507",
      "DOI": "10.1016/0092-8674(81)90014-3",
      "article-title": "S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function",
      "volume": "66",
      "author": "Hoyt",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB29",
      "doi-asserted-by": "publisher",
      "first-page": "1041",
      "DOI": "10.1126/science.279.5353.1041",
      "article-title": "Budding yeast Cdc20",
      "volume": "279",
      "author": "Hwang",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB30",
      "doi-asserted-by": "publisher",
      "first-page": "81",
      "DOI": "10.1016/S0092-8674(00)81148-4",
      "article-title": "Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1",
      "volume": "93",
      "author": "Jin",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB31",
      "first-page": "816",
      "article-title": "Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death",
      "volume": "56",
      "author": "Jordan",
      "year": "1996",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB32",
      "doi-asserted-by": "publisher",
      "first-page": "1045",
      "DOI": "10.1126/science.279.5353.1045",
      "article-title": "Fission yeast Slp1",
      "volume": "279",
      "author": "Kim",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB33",
      "doi-asserted-by": "publisher",
      "first-page": "159",
      "DOI": "10.1016/S0092-8674(00)81333-1",
      "article-title": "Lessons from hereditary colorectal cancer",
      "volume": "87",
      "author": "Kinzler",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB34",
      "doi-asserted-by": "publisher",
      "first-page": "514",
      "DOI": "10.1038/70309",
      "article-title": "Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans",
      "volume": "1",
      "author": "Kitagawa",
      "year": "1999",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB35",
      "doi-asserted-by": "publisher",
      "first-page": "1055",
      "DOI": "10.1128/MCB.18.2.1055",
      "article-title": "Characterization of the p53-dependent postmitotic checkpoint following spindle disruption",
      "volume": "18",
      "author": "Lanni",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB36",
      "doi-asserted-by": "publisher",
      "first-page": "623",
      "DOI": "10.1038/386623a0",
      "article-title": "Genetic instability in colorectal cancers",
      "volume": "386",
      "author": "Lengauer",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB37",
      "doi-asserted-by": "publisher",
      "first-page": "865",
      "DOI": "10.1016/0092-8674(92)90561-P",
      "article-title": "A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei",
      "volume": "71",
      "author": "Leonhardt",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB38",
      "doi-asserted-by": "publisher",
      "first-page": "4989",
      "DOI": "10.1073/pnas.96.9.4989",
      "article-title": "Bifurcation of the mitotic checkpoint pathway in budding yeast",
      "volume": "96",
      "author": "Li",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB39",
      "doi-asserted-by": "publisher",
      "first-page": "246",
      "DOI": "10.1126/science.274.5285.246",
      "article-title": "Identification of a human mitotic checkpoint gene",
      "volume": "274",
      "author": "Li",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB40",
      "doi-asserted-by": "publisher",
      "first-page": "519",
      "DOI": "10.1016/0092-8674(81)90015-5",
      "article-title": "Feedback control of mitosis in budding yeast",
      "volume": "66",
      "author": "Li",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB41",
      "doi-asserted-by": "publisher",
      "first-page": "630",
      "DOI": "10.1038/373630a0",
      "article-title": "Mitotic forces control a cell-cycle checkpoint",
      "volume": "373",
      "author": "Li",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB42",
      "doi-asserted-by": "publisher",
      "first-page": "12431",
      "DOI": "10.1073/pnas.94.23.12431",
      "article-title": "MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity",
      "volume": "94",
      "author": "Li",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB43",
      "doi-asserted-by": "publisher",
      "first-page": "775",
      "DOI": "10.1016/0092-8674(91)90385-C",
      "article-title": "Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors",
      "volume": "65",
      "author": "Mahadevan",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB44",
      "doi-asserted-by": "publisher",
      "first-page": "8493",
      "DOI": "10.1073/pnas.96.15.8493",
      "article-title": "Retention of the BUB3 checkpoint protein on lagging chromosomes",
      "volume": "96",
      "author": "Martinez-Exposito",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB45",
      "doi-asserted-by": "publisher",
      "first-page": "1443",
      "DOI": "10.1091/mbc.3.12.1443",
      "article-title": "Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae",
      "volume": "3",
      "author": "McGrew",
      "year": "1992",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB46",
      "doi-asserted-by": "publisher",
      "first-page": "155",
      "DOI": "10.1111/j.1601-5223.1971.tb02431.x",
      "article-title": "The chromosomes of fifty primary Rous rat sarcomas",
      "volume": "69",
      "author": "Mitelman",
      "year": "1971",
      "journal-title": "Hereditas"
    },
    {
      "issue": "Pt 3",
      "key": "10.1016/S0092-8674(00)80875-2_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "673",
      "DOI": "10.1042/bj3430673",
      "article-title": "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta",
      "volume": "343",
      "author": "Nelson",
      "year": "1999",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB48",
      "doi-asserted-by": "publisher",
      "first-page": "7180",
      "DOI": "10.1038/sj.onc.1203141",
      "article-title": "Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers",
      "volume": "18",
      "author": "Nomoto",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB49",
      "doi-asserted-by": "publisher",
      "first-page": "22077",
      "DOI": "10.1074/jbc.270.38.22077",
      "article-title": "Regulation of gene expression at the beginning of mammalian development",
      "volume": "270",
      "author": "Nothias",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB50",
      "doi-asserted-by": "publisher",
      "first-page": "10035",
      "DOI": "10.1074/jbc.272.15.10035",
      "article-title": "Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation",
      "volume": "272",
      "author": "O'Neill",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB51",
      "doi-asserted-by": "publisher",
      "first-page": "1301",
      "DOI": "10.1083/jcb.127.5.1301",
      "article-title": "Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle",
      "volume": "127",
      "author": "Rieder",
      "year": "1994",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB52",
      "doi-asserted-by": "publisher",
      "first-page": "941",
      "DOI": "10.1083/jcb.130.4.941",
      "article-title": "The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores",
      "volume": "130",
      "author": "Rieder",
      "year": "1995",
      "journal-title": "J. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB53",
      "series-title": "Normal development of the mouse. In The Mouse",
      "author": "Rugh",
      "year": "1990"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB54",
      "doi-asserted-by": "publisher",
      "first-page": "1336",
      "DOI": "10.1093/emboj/17.5.1336",
      "article-title": "The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae",
      "volume": "17",
      "author": "Shirayama",
      "year": "1998",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB55",
      "first-page": "293",
      "article-title": "Gastrulation in the mouse",
      "volume": "42",
      "author": "Snow",
      "year": "1977",
      "journal-title": "J. Embryol. Exp. Morphol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB56",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1083/jcb.142.1.1",
      "article-title": "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase",
      "volume": "142",
      "author": "Taylor",
      "year": "1998",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB57",
      "doi-asserted-by": "publisher",
      "first-page": "727",
      "DOI": "10.1016/S0092-8674(00)80255-X",
      "article-title": "Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage",
      "volume": "89",
      "author": "Taylor",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80875-2_BIB58",
      "doi-asserted-by": "publisher",
      "first-page": "460",
      "DOI": "10.1126/science.278.5337.460",
      "article-title": "CDC20 and CDH1",
      "volume": "278",
      "author": "Visintin",
      "year": "1997",
      "journal-title": "Science"
    },
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      "doi-asserted-by": "publisher",
      "first-page": "11193",
      "DOI": "10.1073/pnas.95.19.11193",
      "article-title": "Mad2 transiently associates with an APC/p55Cdc complex during mitosis",
      "volume": "95",
      "author": "Wassmann",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
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      "first-page": "506",
      "DOI": "10.1007/BF03401588",
      "article-title": "Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway",
      "volume": "1",
      "author": "Woods",
      "year": "1995",
      "journal-title": "Mol. Med."
    },
    {
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      "doi-asserted-by": "publisher",
      "first-page": "85",
      "DOI": "10.1083/jcb.133.1.85",
      "article-title": "Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae",
      "volume": "133",
      "author": "Yamamoto",
      "year": "1996",
      "journal-title": "J. Cell Biol."
    }
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