DOI: 10.1016/s0092-8674(00)80851-x. Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

10.1016/s0092-8674(00)80851-x

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Plotnikov, A. N., Hubbard, S. R., Schlessinger, J., & Mohammadi, M. (2000). Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity. Cell, 101(4), 413â424.

Authors 4

Alexander N Plotnikov (first)
Stevan R Hubbard (additional)
Joseph Schlessinger (additional)
Moosa Mohammadi (additional)

References 44 Referenced 337

10.1093/hmg/7.9.1475 / Hum. Mol. Genet. / Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand by Anderson (1998)
10.1016/S0065-230X(08)60305-X / Adv. Cancer Res. / The FGF family of growth factors and oncogenes by Basilico (1992)
10.1021/bi9521755 / Biochemistry / X-ray crystal structure of human acidic fibroblast growth factor by Blaber (1996)
10.1016/S0021-9258(18)98331-6 / J. Biol. Chem. / A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site by Bottaro (1993)
10.1107/S0907444998003254 / Acta. Crystallogr. D / Crystallography and NMR system by Brünger (1998)
10.1146/annurev.bi.58.070189.003043 / Annu. Rev. Biochem. / The heparin-binding (fibroblast) growth factor family of proteins by Burgess (1989)
10.1016/S0968-0004(97)01170-5 / Trends Biochem. Sci. / Fibroblast growth factor receptors by Burke (1998)
10.1074/jbc.274.49.34785 / J. Biol. Chem. / Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity by Chellaiah (1999)
10.1016/S0021-9258(19)36821-8 / J. Biol. Chem. / A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity by Dell (1992)
10.1073/pnas.88.8.3441 / Proc. Natl. Acad. Sci. / Three-dimensional structure of human basic fibroblast growth factor by Eriksson (1991)
10.1016/S0959-440X(98)80147-4 / Curr. Opin. Struct. Biol. / Diversity does make a difference by Faham (1998)
10.1021/bi00033a002 / Biochemistry / Molecular modeling based mutagenesis defines ligand binding and specificity determining regions of fibroblast growth factor receptors by Gray (1995)
10.1021/bi961942c / Biochemistry / Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor by Gray (1996)
10.1016/0022-2836(92)90226-A / J. Mol. Biol. / X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 Å resolution by Holden (1992)
10.1126/science.1699274 / Science / Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence by Imamura (1990)
10.1016/0167-4889(92)90136-Y / Biochim. Biophys. Acta / Fibroblast growth factor receptor tyrosine kinases by Jaye (1992)
10.1016/S0065-230X(08)60821-0 / Adv. Cancer Res. / Structural and functional diversity in the FGF receptor multigene family by Johnson (1993)
10.1107/S0108767390010224 / Acta Crystallogr. A / Improved methods for binding protein models in electron density maps and the location of errors in these models by Jones (1991)
10.1107/S0021889891004399 / J. Appl. Crystallogr. / MOLSCRIPT by Kraulis (1991)
10.1107/S0021889892009944 / J. Appl. Cryst. / PROCHECK by Laskowski (1993)
{'key': '10.1016/S0092-8674(00)80851-X_BIB21', 'first-page': '505', 'article-title': 'Raster3D', 'volume': '277', 'author': 'Merrit', 'year': '1997', 'journal-title': 'Methods Enzymol.'} / Methods Enzymol. / Raster3D by Merrit (1997)
10.1073/pnas.89.1.246 / Proc. Natl. Acad. Sci. / Determination of ligand-binding specificity by alternative splicing by Miki (1992)
10.2741/A321 / Front Biosci. / FGF signaling in skeletal development by Naski (1998)
10.1107/S0108767393007597 / Acta Cryst. A / AMoRe by Navaza (1994)
10.1128/MCB.12.1.240 / Mol. Cell. Biol. / Heparin is required for cell-free binding of βFGF to a soluble receptor and for mitogenesis in whole cells by Ornitz (1992)
10.1074/jbc.271.25.15292 / J. Biol. Chem. / Receptor specificity of the fibroblast growth factor family by Ornitz (1996)
{'key': '10.1016/S0092-8674(00)80851-X_BIB27', 'series-title': 'Proceedings of the CCP4 Study Weekend', 'article-title': 'Oscillation data reduction program', 'author': 'Otwinowski', 'year': '1993'} / Proceedings of the CCP4 Study Weekend / Oscillation data reduction program by Otwinowski (1993)
10.1016/S0092-8674(00)80051-3 / Cell / Structural basis for FGF receptor dimerization and activation by Plotnikov (1999)
10.1074/jbc.270.50.29813 / J. Biol. Chem. / Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities by Reich-Slotky (1995)
10.1016/S0021-9258(18)53334-2 / J. Biol. Chem. / Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor by Ron (1993)
10.1016/0092-8674(94)90032-9 / Cell / Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation by Spivak-Kroizman (1994)
10.1016/S0021-9258(18)47101-3 / J. Biol. Chem. / Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis by Springer (1994)
10.1073/pnas.97.1.49 / Proc. Natl. Acad. Sci. / Structural interactions of fibroblast growth factor receptor with its ligands by Stauber (2000)
10.1093/nar/22.22.4673 / Nucleic Acids Res. / CLUSTAL W by Thompson (1994)
10.1002/j.1460-2075.1992.tb05526.x / EMBO J. / Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction by Vainikka (1992)
10.1074/jbc.270.17.10222 / J. Biol. Chem. / Ligand-specific structural domains in the fibroblast growth factor receptor by Wang (1995)
10.1021/bi981758m / Biochemistry / Common and specific determinants for fibroblast growth factors in the ectodomain of the receptor kinase complex by Wang (1999)
10.1016/0092-8674(91)90512-W / Cell / Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor by Yayon (1991)
10.1002/j.1460-2075.1992.tb05240.x / EMBO J. / A confined variable region confers ligand specificity on fibroblast growth factor receptors by Yayon (1992)
10.1073/pnas.90.22.10643 / Proc. Natl. Acad. Sci. / Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library by Yayon (1993)
Zhu, X., Komiya, H., Chirino, A., Faham, S., Fox, G.M., Arakawa, T., Hsu, B.T., and Rees, D.C. (1991). Science 251, 90–93. (10.1126/science.1702556)
10.1074/jbc.270.37.21869 / J. Biol. Chem. / Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Identification by structure-based site-directed mutagenesis by Zhu (1995)
10.1093/protein/10.4.417 / Protein Eng. / Analysis of high-affinity binding determinants in the receptor binding epitope of basic fibroblast growth factor by Zhu (1997)
10.1093/protein/11.10.937 / Protein Eng. / Identification of two new hydrophobic residues on basic fibroblast growth factor important for fibroblast growth factor receptor binding by Zhu (1998)

Dates

Type	When
Created	21 years, 4 months ago (April 10, 2004, 5:39 a.m.)
Deposited	4 years, 2 months ago (June 15, 2021, 9:45 a.m.)
Indexed	2 weeks, 6 days ago (Aug. 2, 2025, 12:43 a.m.)
Issued	25 years, 3 months ago (May 1, 2000)
Published	25 years, 3 months ago (May 1, 2000)
Published Print	25 years, 3 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Plotnikov_2000, title={Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity}, volume={101}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80851-x}, DOI={10.1016/s0092-8674(00)80851-x}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Plotnikov, Alexander N and Hubbard, Stevan R and Schlessinger, Joseph and Mohammadi, Moosa}, year={2000}, month=may, pages={413–424} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:43:35Z",
    "timestamp": 1754109815646
  },
  "reference-count": 44,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            5,
            1
          ]
        ],
        "date-time": "2000-05-01T00:00:00Z",
        "timestamp": 957139200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 4825,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(00)80851-x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        10
      ]
    ],
    "date-time": "2004-04-10T09:39:29Z",
    "timestamp": 1081589969000
  },
  "page": "413-424",
  "source": "Crossref",
  "is-referenced-by-count": 337,
  "title": "Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity",
  "prefix": "10.1016",
  "volume": "101",
  "author": [
    {
      "given": "Alexander N",
      "family": "Plotnikov",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Stevan R",
      "family": "Hubbard",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joseph",
      "family": "Schlessinger",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Moosa",
      "family": "Mohammadi",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1475",
      "DOI": "10.1093/hmg/7.9.1475",
      "article-title": "Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand",
      "volume": "7",
      "author": "Anderson",
      "year": "1998",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/S0065-230X(08)60305-X",
      "article-title": "The FGF family of growth factors and oncogenes",
      "volume": "59",
      "author": "Basilico",
      "year": "1992",
      "journal-title": "Adv. Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "2086",
      "DOI": "10.1021/bi9521755",
      "article-title": "X-ray crystal structure of human acidic fibroblast growth factor",
      "volume": "35",
      "author": "Blaber",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "9180",
      "DOI": "10.1016/S0021-9258(18)98331-6",
      "article-title": "A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site",
      "volume": "268",
      "author": "Bottaro",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "article-title": "Crystallography and NMR system",
      "volume": "54",
      "author": "Br\u00fcnger",
      "year": "1998",
      "journal-title": "Acta. Crystallogr. D"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "575",
      "DOI": "10.1146/annurev.bi.58.070189.003043",
      "article-title": "The heparin-binding (fibroblast) growth factor family of proteins",
      "volume": "58",
      "author": "Burgess",
      "year": "1989",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1016/S0968-0004(97)01170-5",
      "article-title": "Fibroblast growth factor receptors",
      "volume": "23",
      "author": "Burke",
      "year": "1998",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "34785",
      "DOI": "10.1074/jbc.274.49.34785",
      "article-title": "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity",
      "volume": "49",
      "author": "Chellaiah",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "21225",
      "DOI": "10.1016/S0021-9258(19)36821-8",
      "article-title": "A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity",
      "volume": "267",
      "author": "Dell",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "3441",
      "DOI": "10.1073/pnas.88.8.3441",
      "article-title": "Three-dimensional structure of human basic fibroblast growth factor",
      "volume": "88",
      "author": "Eriksson",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "578",
      "DOI": "10.1016/S0959-440X(98)80147-4",
      "article-title": "Diversity does make a difference",
      "volume": "8",
      "author": "Faham",
      "year": "1998",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "10325",
      "DOI": "10.1021/bi00033a002",
      "article-title": "Molecular modeling based mutagenesis defines ligand binding and specificity determining regions of fibroblast growth factor receptors",
      "volume": "34",
      "author": "Gray",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "15640",
      "DOI": "10.1021/bi961942c",
      "article-title": "Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor",
      "volume": "35",
      "author": "Gray",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "840",
      "DOI": "10.1016/0022-2836(92)90226-A",
      "article-title": "X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 \u00c5 resolution",
      "volume": "227",
      "author": "Holden",
      "year": "1992",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1567",
      "DOI": "10.1126/science.1699274",
      "article-title": "Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence",
      "volume": "249",
      "author": "Imamura",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "185",
      "DOI": "10.1016/0167-4889(92)90136-Y",
      "article-title": "Fibroblast growth factor receptor tyrosine kinases",
      "volume": "1135",
      "author": "Jaye",
      "year": "1992",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/S0065-230X(08)60821-0",
      "article-title": "Structural and functional diversity in the FGF receptor multigene family",
      "volume": "60",
      "author": "Johnson",
      "year": "1993",
      "journal-title": "Adv. Cancer Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "article-title": "Improved methods for binding protein models in electron density maps and the location of errors in these models",
      "volume": "47",
      "author": "Jones",
      "year": "1991",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "946",
      "DOI": "10.1107/S0021889891004399",
      "article-title": "MOLSCRIPT",
      "volume": "24",
      "author": "Kraulis",
      "year": "1991",
      "journal-title": "J. Appl. Crystallogr."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1107/S0021889892009944",
      "article-title": "PROCHECK",
      "volume": "26",
      "author": "Laskowski",
      "year": "1993",
      "journal-title": "J. Appl. Cryst."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB21",
      "first-page": "505",
      "article-title": "Raster3D",
      "volume": "277",
      "author": "Merrit",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "246",
      "DOI": "10.1073/pnas.89.1.246",
      "article-title": "Determination of ligand-binding specificity by alternative splicing",
      "volume": "89",
      "author": "Miki",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "D781",
      "DOI": "10.2741/A321",
      "article-title": "FGF signaling in skeletal development",
      "volume": "3",
      "author": "Naski",
      "year": "1998",
      "journal-title": "Front Biosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1107/S0108767393007597",
      "article-title": "AMoRe",
      "volume": "50",
      "author": "Navaza",
      "year": "1994",
      "journal-title": "Acta Cryst. A"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1128/MCB.12.1.240",
      "article-title": "Heparin is required for cell-free binding of \u03b2FGF to a soluble receptor and for mitogenesis in whole cells",
      "volume": "12",
      "author": "Ornitz",
      "year": "1992",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "15292",
      "DOI": "10.1074/jbc.271.25.15292",
      "article-title": "Receptor specificity of the fibroblast growth factor family",
      "volume": "271",
      "author": "Ornitz",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB27",
      "series-title": "Proceedings of the CCP4 Study Weekend",
      "article-title": "Oscillation data reduction program",
      "author": "Otwinowski",
      "year": "1993"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1016/S0092-8674(00)80051-3",
      "article-title": "Structural basis for FGF receptor dimerization and activation",
      "volume": "98",
      "author": "Plotnikov",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "29813",
      "DOI": "10.1074/jbc.270.50.29813",
      "article-title": "Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities",
      "volume": "270",
      "author": "Reich-Slotky",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "5388",
      "DOI": "10.1016/S0021-9258(18)53334-2",
      "article-title": "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor",
      "volume": "268",
      "author": "Ron",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1015",
      "DOI": "10.1016/0092-8674(94)90032-9",
      "article-title": "Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation",
      "volume": "79",
      "author": "Spivak-Kroizman",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "26879",
      "DOI": "10.1016/S0021-9258(18)47101-3",
      "article-title": "Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis",
      "volume": "269",
      "author": "Springer",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1073/pnas.97.1.49",
      "article-title": "Structural interactions of fibroblast growth factor receptor with its ligands",
      "volume": "97",
      "author": "Stauber",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "4673",
      "DOI": "10.1093/nar/22.22.4673",
      "article-title": "CLUSTAL W",
      "volume": "22",
      "author": "Thompson",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "4273",
      "DOI": "10.1002/j.1460-2075.1992.tb05526.x",
      "article-title": "Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction",
      "volume": "11",
      "author": "Vainikka",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "10222",
      "DOI": "10.1074/jbc.270.17.10222",
      "article-title": "Ligand-specific structural domains in the fibroblast growth factor receptor",
      "volume": "270",
      "author": "Wang",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "160",
      "DOI": "10.1021/bi981758m",
      "article-title": "Common and specific determinants for fibroblast growth factors in the ectodomain of the receptor kinase complex",
      "volume": "38",
      "author": "Wang",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "841",
      "DOI": "10.1016/0092-8674(91)90512-W",
      "article-title": "Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor",
      "volume": "64",
      "author": "Yayon",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "1885",
      "DOI": "10.1002/j.1460-2075.1992.tb05240.x",
      "article-title": "A confined variable region confers ligand specificity on fibroblast growth factor receptors",
      "volume": "11",
      "author": "Yayon",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "10643",
      "DOI": "10.1073/pnas.90.22.10643",
      "article-title": "Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library",
      "volume": "90",
      "author": "Yayon",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB41",
      "doi-asserted-by": "crossref",
      "unstructured": "Zhu, X., Komiya, H., Chirino, A., Faham, S., Fox, G.M., Arakawa, T., Hsu, B.T., and Rees, D.C. (1991). Science 251, 90\u201393.",
      "DOI": "10.1126/science.1702556"
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "21869",
      "DOI": "10.1074/jbc.270.37.21869",
      "article-title": "Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Identification by structure-based site-directed mutagenesis",
      "volume": "270",
      "author": "Zhu",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1093/protein/10.4.417",
      "article-title": "Analysis of high-affinity binding determinants in the receptor binding epitope of basic fibroblast growth factor",
      "volume": "10",
      "author": "Zhu",
      "year": "1997",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1016/S0092-8674(00)80851-X_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "937",
      "DOI": "10.1093/protein/11.10.937",
      "article-title": "Identification of two new hydrophobic residues on basic fibroblast growth factor important for fibroblast growth factor receptor binding",
      "volume": "11",
      "author": "Zhu",
      "year": "1998",
      "journal-title": "Protein Eng."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S009286740080851X?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S009286740080851X?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        15
      ]
    ],
    "date-time": "2021-06-15T13:45:33Z",
    "timestamp": 1623764733000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S009286740080851X"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  },
  "references-count": 44,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2000,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "S009286740080851X"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(00)80851-X",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        2000,
        5
      ]
    ]
  }
}