DOI: 10.1016/s0092-8674(00)80762-x. p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

10.1016/s0092-8674(00)80762-x

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999). p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis. Cell, 97(4), 527â538.

Authors 8

Lynda Chin (first)
Steven E Artandi (additional)
Qiong Shen (additional)
Alice Tam (additional)
Shwu-Luan Lee (additional)
Geoffrey J Gottlieb (additional)
Carol W Greider (additional)
Ronald A DePinho (additional)

References 44 Referenced 808

10.1016/S0092-8674(01)80006-4 / Cell / Telomere shortening and tumor formation by mouse cells lacking telomerase RNA by Blasco (1997)
10.1126/science.279.5349.349 / Science / Extension of life-span by introduction of telomerase into normal human cells by Bodnar (1998)
10.1038/377552a0 / Nature / Radiation-induced cell cycle arrest compromised by p21 deficiency by Brugarolas (1995)
10.1002/j.1460-2075.1995.tb00098.x / EMBO / Telomere elongation in immortal human cells without detectable telomerase activity by Bryan (1995)
10.1126/science.282.5393.1497 / Science / Requirement for p53 and p21 to sustain G2 arrest after DNA damage by Bunz (1998)
10.1002/j.1460-2075.1992.tb05245.x / EMBO / Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity by Counter (1992)
10.1073/pnas.95.25.14723 / Proc. Natl. Acad. Sci. USA / Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization by Counter (1998)
10.1016/0092-8674(95)90039-X / Cell / Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control by Deng (1995)
10.1093/emboj/16.6.1381 / EMBO / Transgenic mouse model for studying the transcriptional activity of the p53 protein by Gottlieb (1997)
10.1016/S0092-8674(00)80761-8 / Cell / Short dysfunctional telomeres impair tumorigenesis in the INK4aΔ2/3 cancer-prone mouse by Greenberg (1999)
10.1016/S0960-9822(98)70105-8 / Curr. Biol. / Telomeres and senescence by Greider (1998)
10.1038/337331a0 / Nature / A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis by Greider (1989)
10.1016/0006-291X(91)91403-Y / Biochem. Biophys. Res. Comm. / Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1 by Hara (1991)
{'key': '10.1016/S0092-8674(00)80762-X_BIB14', 'first-page': '2457', 'article-title': 'In vitro gowth characteristics of embryo fibroblasts isolated from p53-deficient mice', 'volume': '8', 'author': 'Harvey', 'year': '1993', 'journal-title': 'Oncogene'} / Oncogene / In vitro gowth characteristics of embryo fibroblasts isolated from p53-deficient mice by Harvey (1993)
10.1016/0014-4827(61)90192-6 / Exp. Cell. Res. / The serial cultivation of human diploid cell strains by Hayflick (1961)
10.1093/emboj/18.5.1172 / EMBO J. / Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube by Herrera (1999)
10.1016/S0092-8674(00)80452-3 / Cell / Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19 ARF by Kamijo (1997)
10.1126/science.283.5406.1321 / Science / p53 and ATM dependent apoptosis induced by telomeres lacking TRF2 by Karleseder (1999)
10.1126/science.1589764 / Science / Oncogenic forms of p53 inhibit p53-regulated gene expression by Kern (1992)
10.1126/science.7605428 / Science / Specific association of human telomerase activity with immortal cells and cancer by Kim (1994)
10.1038/23962 / Nature / Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells by Kiyono (1998)
10.1038/304596a0 / Nature / Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes by Land (1983)
10.1038/33345 / Nature / Essential role of mouse telomerase in highly proliferative organs by Lee (1998)
10.1016/S0092-8674(00)81871-1 / Cell / p53, the cellular gatekeeper for growth and division by Levine (1997)
10.1016/0092-8674(93)90719-7 / Cell / p53-dependent apoptosis modulates the cytotoxicity of anticancer agents by Lowe (1993)
10.1016/0092-8674(93)90234-H / Cell / An alternative pathway for yeast telomere maintenance rescues est1- senescence by Lundblad (1993)
10.1101/gad.10.14.1822 / Genes Dev. / Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase by McEachern (1996)
10.1101/gad.6.8.1480 / Genes Dev. / Myc family oncoproteins function through a common pathway to transform normal cells in culture by Mukherjee (1992)
10.1038/580 / Nat. Genet. / Severe growth defect in mouse cells lacking the telomerase RNA component by Niida (1998)
10.1016/S0092-8674(00)81400-2 / Cell / The INK4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2’s inhibition of p53 by Pomerantz (1998)
10.1016/S0092-8674(00)81774-2 / Cell / Signaling to p53 by Prives (1998)
10.1016/S0092-8674(00)80580-2 / Cell / Longevity, stress response, and cancer in aging telomerase deficient mice by Rudolph (1999)
10.1038/nbt0898-743 / Nat. Biotechnol. / Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry by Rufer (1998)
10.1038/ng0695-175 / Nat. Genet. / A subset of p53-deficient embryos exhibit exencephaly by Sah (1995)
10.1016/0092-8674(93)90493-A / Cell / Loss of a yeast telomere by Sandell (1993)
10.1016/S0092-8674(00)81902-9 / Cell / Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a by Serrano (1997)
10.1016/0014-4827(91)90453-2 / Exp. Cell Res. / A role for both RB and p53 in the regulation of human cellular senescence by Shay (1991)
10.1016/S0092-8674(00)80416-X / Cell / DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 by Shieh (1997)
10.1101/gad.11.24.3471 / Genes Dev. / DNA damage induces phosphorylation of the amino terminus of p53 by Siliciano (1997)
10.1038/385740a0 / Nature / Control of telomere length by the human telomeric protein TRF1 by van Steensel (1997)
10.1016/S0092-8674(00)80932-0 / Cell / TRF2 protects human telomeres from end-to-end fusions by van Steensel (1998)
10.1016/S0960-9822(98)70109-5 / Curr. Biol. / Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span by Vaziri (1998)
10.1093/emboj/17.16.4657 / EMBO / Retention of wild-type p53 in tumors from p53 heterozygous mice by Venkatachalam (1998)
10.1038/344126a0 / Nature / In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase by Yu (1990)

Dates

Type	When
Created	21 years, 4 months ago (April 10, 2004, 5:39 a.m.)
Deposited	5 years, 4 months ago (March 31, 2020, 7:07 p.m.)
Indexed	3 days, 16 hours ago (Aug. 20, 2025, 8:40 a.m.)
Issued	26 years, 3 months ago (May 1, 1999)
Published	26 years, 3 months ago (May 1, 1999)
Published Print	26 years, 3 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Chin_1999, title={p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis}, volume={97}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80762-x}, DOI={10.1016/s0092-8674(00)80762-x}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Chin, Lynda and Artandi, Steven E and Shen, Qiong and Tam, Alice and Lee, Shwu-Luan and Gottlieb, Geoffrey J and Greider, Carol W and DePinho, Ronald A}, year={1999}, month=may, pages={527–538} }

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      "author": "Sah",
      "year": "1995",
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      "volume": "196",
      "author": "Shay",
      "year": "1991",
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