DOI: 10.1016/s0092-8674(00)80720-5. The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling

The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling

10.1016/s0092-8674(00)80720-5

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Gritsman, K., Zhang, J., Cheng, S., Heckscher, E., Talbot, W. S., & Schier, A. F. (1999). The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling. Cell, 97(1), 121â132.

Authors 6

Kira Gritsman (first)
Jiaojiao Zhang (additional)
Simon Cheng (additional)
Elizabeth Heckscher (additional)
William S Talbot (additional)
Alexander F Schier (additional)

References 48 Referenced 626

10.1101/gad.10.15.1880 / Genes Dev. / A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway by Baker (1996)
10.1016/S0092-8674(00)80560-7 / Cell / Axis development and early asymmetry in mammals by Beddington (1999)
10.1126/science.278.5345.1937 / Science / Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid by Blader (1997)
10.1242/dev.124.4.827 / Development / A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis by Chang (1997)
10.1242/dev.120.7.1919 / Development / A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse by Conlon (1994)
10.1038/27215 / Nature / Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo by Ding (1998)
10.1126/science.282.5394.1654 / Science / The when and where of floor plate induction by Dodd (1998)
10.1016/S0960-9822(06)00030-3 / Curr. Biol. / Activin signaling has a necessary function in Xenopus early development by Dyson (1997)
10.1006/dbio.1998.9097 / Dev. Biol. / Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer by Erter (1998)
10.1242/dev.126.7.1427 / Development / The zebrafish bozozok locus encodes the homeodomain protein Dharma sufficient in the extraembryonic yolk syncytial layer for gastrula organizer formation by Fekany (1999)
10.1038/26013 / Nature / Zebrafish organizer development and germ-layer formation require nodal-related signals by Feldman (1998)
10.1242/dev.114.3.583 / Development / Localized enhancement and repression of the activity of the TGF-β family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo by Ferguson (1992)
10.1101/gad.12.6.844 / Genes Dev. / The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse by Gu (1998)
10.1242/dev.123.1.143 / Development / Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio by Hammerschmidt (1996)
10.1146/annurev.cellbio.13.1.611 / Annu. Rev. Cell Dev. Biol. / Formation and function of Spemann’s organizer by Harland (1997)
10.1038/350339a0 / Nature / The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system by Hatta (1991)
10.1006/dbio.1997.8511 / Dev. Biol. / The function of silberblick in the positioning of the eye anlage in the zebrafish embryo by Heisenberg (1997)
10.1007/BF00848335 / Wilhelm Roux’s Arch. / Maternal effects of zygotic mutants affecting early neurogenesis in Drosophila by Jimenez (1982)
10.1016/S0092-8674(00)81311-2 / Cell / GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF by Jing (1996)
10.1002/aja.1002030302 / Dev. Dyn. / Stages of embryonic development of the zebrafish by Kimmel (1995)
10.1016/0092-8674(95)90102-7 / Cell / The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development by Kinoshita (1995)
10.1016/S0960-9822(07)00509-X / Curr. Biol. / The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish by Koos (1998)
10.1016/S0092-8674(00)80425-0 / Cell / Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins by Marqués (1997)
10.1146/annurev.biochem.67.1.753 / Annu. Rev. Biochem. / TGF-β signal transduction by Massagué (1998)
10.1038/31693 / Nature / Smad2 role in mesoderm formation, left-right patterning and craniofacial development by Nomura (1998)
10.1101/gad.11.14.1812 / Genes Dev. / The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse by Oh (1997)
10.1016/0012-1606(84)90297-5 / Dev. Biol. / The effects of zygotic lethal mutations on female germ-line functions in Drosophila by Perrimon (1984)
10.1016/S0092-8674(00)80424-9 / Cell / Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity by Piccolo (1997)
10.1073/pnas.95.17.9932 / Proc. Natl. Acad. Sci. USA / cyclops encodes a nodal-related factor involved in midline signaling by Rebagliati (1998)
10.1006/dbio.1998.8935 / Dev. Biol. / Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry by Rebagliati (1998)
10.1002/(SICI)1521-1878(199901)21:1<61::AID-BIES8>3.0.CO;2-H / Bioessays / Cripto by Salomon (1999)
10.1038/26020 / Nature / Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signaling by Sampath (1998)
10.1016/S0959-437X(98)80119-6 / Curr. Opin. Genet. Dev. / The zebrafish organizer by Schier (1998)
10.1242/dev.123.1.165 / Development / Mutations affecting the development of the embryonic zebrafish brain by Schier (1996)
10.1242/dev.124.2.327 / Development / The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail by Schier (1997)
10.1242/dev.124.2.429 / Development / A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation by Shen (1997)
10.1016/0092-8674(91)90069-B / Cell / Injected Wnt RNA induces a complete body axis in Xenopus embryos by Sokol (1991)
10.1046/j.1365-4624.1997.00010.x / Genes Funct. / One-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube by Strähle (1997)
10.1242/dev.121.2.383 / Development / Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish by Toyama (1995)
10.1038/382080a0 / Nature / Characterization of a multicomponent receptor for GDNF by Treanor (1996)
10.1101/SQB.1997.062.01.015 / Cold Spring Harbor Symp. Quant. Biol. / Nodal signaling and axis formation in the mouse by Varlet (1997)
10.1016/S0092-8674(00)81407-5 / Cell / Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo by Waldrip (1998)
10.1073/pnas.95.16.9378 / Proc. Natl. Acad. Sci. USA / Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2 by Weinstein (1998)
10.1101/gad.12.16.2445 / Genes Dev. / Smads and early developmental signaling by the TGF-β superfamily by Whitman (1998)
10.1038/357252a0 / Nature / Involvement of p21ras in Xenopus mesoderm induction by Whitman (1992)
10.1101/gad.12.15.2345 / Genes Dev. / A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner by Yamanaka (1998)
10.1016/S0092-8674(00)80918-6 / Cell / Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation by Zhang (1998)
10.1038/361543a0 / Nature / Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation by Zhou (1993)

Dates

Type	When
Created	21 years, 2 months ago (June 30, 2004, 8:27 a.m.)
Deposited	2 years, 7 months ago (Jan. 28, 2023, 10:16 a.m.)
Indexed	1 week, 6 days ago (Aug. 23, 2025, 9:55 p.m.)
Issued	26 years, 5 months ago (April 1, 1999)
Published	26 years, 5 months ago (April 1, 1999)
Published Print	26 years, 5 months ago (April 1, 1999)

Funders 0

None

BibTeX

@article{Gritsman_1999, title={The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling}, volume={97}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80720-5}, DOI={10.1016/s0092-8674(00)80720-5}, number={1}, journal={Cell}, publisher={Elsevier BV}, author={Gritsman, Kira and Zhang, Jiaojiao and Cheng, Simon and Heckscher, Elizabeth and Talbot, William S and Schier, Alexander F}, year={1999}, month=apr, pages={121–132} }

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      "author": "Sampath",
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      "author": "Schier",
      "year": "1998",
      "journal-title": "Curr. Opin. Genet. Dev."
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      "author": "Sokol",
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      "author": "Str\u00e4hle",
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      "journal-title": "Genes Funct."
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      "author": "Treanor",
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      "author": "Varlet",
      "year": "1997",
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      "author": "Waldrip",
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      "article-title": "Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2",
      "volume": "95",
      "author": "Weinstein",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "volume": "12",
      "author": "Whitman",
      "year": "1998",
      "journal-title": "Genes Dev."
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      "volume": "12",
      "author": "Yamanaka",
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      "author": "Zhang",
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