10.1016/s0092-8674(00)80675-3
Crossref journal-article
Elsevier BV
Cell (78)
Bibliography

Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L. (2000). Regulated Intramembrane Proteolysis. Cell, 100(4), 391–398.

Authors 4
  1. Michael S Brown (first)
  2. Jin Ye (additional)
  3. Robert B Rawson (additional)
  4. Joseph L Goldstein (additional)
References 55 Referenced 1,160
  1. 10.1128/JB.181.19.5915-5921.1999 / J. Bacteriol. / Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1 by An (1999)
  2. 10.1016/S0166-2236(99)01455-1 / Trends Neurosci. / Presenilins by Annaert (1999)
  3. {'key': '10.1016/S0092-8674(00)80675-3_BIB3', 'article-title': 'A novel proteolytic cleavage involved in Notch signaling', 'volume': 'in press', 'author': 'Brou', 'year': '2000', 'journal-title': 'Mol. Cell'} / Mol. Cell / A novel proteolytic cleavage involved in Notch signaling by Brou (2000)
  4. 10.1016/S0092-8674(00)80213-5 / Cell / The SREBP pathway by Brown (1997)
  5. 10.1073/pnas.96.20.11041 / Proc. Natl. Acad. Sci. USA / A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood by Brown (1999)
  6. 10.1074/jbc.273.43.27765 / J. Biol. Chem. / Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor by Buxbaum (1998)
  7. 10.1016/S0896-6273(00)80771-0 / Neuron / Presenilins, processing of β-amyloid precursor protein, and Notch signaling by Chan (1999)
  8. 10.1146/annurev.cellbio.14.1.459 / Annu. Rev. Cell Biol. / Intracellular signaling from the endoplasmic reticulum to the nucleus by Chapman (1998)
  9. 10.1016/S0092-8674(00)81360-4 / Cell / A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response by Cox (1996)
  10. 10.1016/0092-8674(93)90648-A / Cell / Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase by Cox (1993)
  11. 10.1016/S0092-8674(00)81668-2 / Cell / Transport-dependent proteolysis of SREBP by DeBose-Boyd (1999)
  12. 10.1038/34910 / Nature / Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein by De Strooper (1998)
  13. 10.1038/19083 / Nature / A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain by De Strooper (1999)
  14. 10.1074/jbc.273.28.17801 / J. Biol. Chem. / Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning by Duncan (1998)
  15. 10.1146/annurev.micro.51.1.527 / Annu. Rev. Microbiol. / Cell-cell communication in gram-positive bacteria by Dunny (1997)
  16. 10.1074/jbc.274.32.22795 / J. Biol. Chem. / Autocatalytic processing of Site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins by Espenshade (1999)
  17. 10.1128/jb.176.18.5871-5873.1994 / J. Bacteriol. / A lipoprotein signal peptide encoded by the staphylococcal conjugative plasmid pSK41 exhibits an activity resembling that of Enterococcus faecalis pheromone cAD1 by Firth (1994)
  18. 10.1038/355033a0 / Nature / Protein folding in the cell by Gething (1992)
  19. 10.1091/mbc.10.11.3787 / Mol. Biol. Cell / Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in reponse to endoplasmic reticulum stress by Haze (1999)
  20. 10.1074/jbc.270.49.29422 / J. Biol. Chem. / Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection by Hua (1995)
  21. 10.1002/pro.5560030505 / Protein Sci. / Modeling studies of the change in conformation required for cleavage of limited proteolytic sites by Hubbard (1994)
  22. 10.1126/science.281.5373.64 / Science / Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex by Iwata (1998)
  23. 10.1038/70265 / Nat. Cell Biol. / Presenilin-1 mutations downregulate the signaling pathway of the unfolded-protein response by Katayama (1999)
  24. 10.1016/0022-2836(82)90515-0 / J. Mol. Biol. / A simple method for displaying the hydropathic character of a protein by Kyte (1982)
  25. 10.1038/377351a0 / Nature / Facilitation of lin-12-mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene by Levitan (1995)
  26. 10.1110/ps.8.2.439 / Protein Sci. / A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties by Lewis (1999)
  27. 10.1021/ar00153a003 / Acc. Chem. Res. / Structural basis of the action of thermolysin and related zinc peptidases by Matthews (1988)
  28. 10.1016/0092-8674(93)90521-Q / Cell / A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus by Mori (1993)
  29. {'key': '10.1016/S0092-8674(00)80675-3_BIB29', 'article-title': 'Ligand-induced “ectodomain shedding” regulates γ-secretase-like proteolytic activation of Notch1', 'volume': 'in press', 'author': 'Mumm', 'year': '2000', 'journal-title': 'Mol. Cell'} / Mol. Cell / Ligand-induced “ectodomain shedding” regulates γ-secretase-like proteolytic activation of Notch1 by Mumm (2000)
  30. 10.1016/S0092-8674(00)81667-0 / Cell / A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response by Niwa (1999)
  31. 10.1074/jbc.273.27.17243 / J. Biol. Chem. / Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain by Nohturfft (1998)
  32. 10.1073/pnas.96.20.11235 / Proc. Natl. Acad. Sci. USA / Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi by Nohturfft (1999)
  33. 10.1038/25403 / Nature / Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor by Paetzel (1998)
  34. 10.1016/0076-6879(95)48015-3 / Methods Enzymol. / Evolutionary families of metallopeptidases by Rawlings (1995)
  35. 10.1016/S1097-2765(00)80006-4 / Mol. Cell / Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs by Rawson (1997)
  36. 10.1074/jbc.274.40.28549 / J. Biol. Chem. / Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein by Rawson (1999)
  37. 10.1074/jbc.274.51.36801 / J. Biol. Chem. / Cell surface presenilin-1 participates in the γ-secretase-like proteolysis of Notch by Ray (1999)
  38. 10.1073/pnas.96.26.14765 / Proc. Natl. Acad. Sci. USA / A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors by Rudner (1999)
  39. 10.1074/jbc.273.10.5785 / J. Biol. Chem. / Cleavage of sterol regulatory element binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies by Sakai (1998)
  40. 10.1016/S1097-2765(00)80150-1 / Mol. Cell / Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells by Sakai (1998)
  41. 10.1074/jbc.271.31.18295 / J. Biol. Chem. / Amyloid β-protein and the genetics of Alzheimer's disease by Selkoe (1996)
  42. 10.1038/375754a0 / Nature / Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease by Sherrington (1995)
  43. 10.1016/S0092-8674(00)80369-4 / Cell / The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response by Sidrauski (1997)
  44. 10.1038/990114 / Nature / Purification and cloning of amyloid precursor protein β-secretase from human brain by Sinha (1999)
  45. 10.1146/annurev.genet.30.1.297 / Annu. Rev. Genet. / Molecular genetics of sporulation in Bacillus subtilis by Stragier (1996)
  46. 10.1038/19091 / Nature / Presenilin is required for activity and nuclear access of Notch in Drosophila by Struhl (1999)
  47. 10.1101/gad.12.12.1812 / Genes Dev. / A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells by Tirasophon (1998)
  48. 10.1126/science.286.5440.735 / Science / β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE by Vassar (1999)
  49. 10.1016/0092-8674(94)90234-8 / Cell / SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis by Wang (1994)
  50. 10.1093/emboj/17.19.5708 / EMBO J. / Cloning of mammalian Ire1 reveals diversity in the ER stress responses by Wang (1998)
  51. 10.1038/19077 / Nature / Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and β-secretase activity by Wolfe (1999)
  52. 10.1038/990107 / Nature / Membrane-anchored aspartyl protease with Alzheimer's disease γ-secretase activity by Yan (1999)
  53. 10.1038/19096 / Nature / Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants by Ye (1999)
  54. 10.1074/jbc.273.50.33741 / J. Biol. Chem. / Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins by Yoshida (1998)
  55. 10.1074/jbc.274.31.21973 / J. Biol. Chem. / Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins by Zelenski (1999)
Dates
Type When
Created 21 years, 2 months ago (June 30, 2004, 4:27 a.m.)
Deposited 5 years, 4 months ago (April 2, 2020, 7:54 a.m.)
Indexed 1 week, 2 days ago (Aug. 23, 2025, 1 a.m.)
Issued 25 years, 7 months ago (Feb. 1, 2000)
Published 25 years, 7 months ago (Feb. 1, 2000)
Published Print 25 years, 7 months ago (Feb. 1, 2000)
Funders 0

None

@article{Brown_2000, title={Regulated Intramembrane Proteolysis}, volume={100}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80675-3}, DOI={10.1016/s0092-8674(00)80675-3}, number={4}, journal={Cell}, publisher={Elsevier BV}, author={Brown, Michael S and Ye, Jin and Rawson, Robert B and Goldstein, Joseph L}, year={2000}, month=feb, pages={391–398} }