DOI: 10.1016/s0092-8674(00)80596-6. Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice

Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice

10.1016/s0092-8674(00)80596-6

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Supattapone, S., Bosque, P., Muramoto, T., Wille, H., Aagaard, C., Peretz, D., Nguyen, H.-O. B., Heinrich, C., Torchia, M., Safar, J., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., & Scott, M. (1999). Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice. Cell, 96(6), 869â878.

Authors 14

Surachai Supattapone (first)
Patrick Bosque (additional)
Tamaki Muramoto (additional)
Holger Wille (additional)
Claus Aagaard (additional)
David Peretz (additional)
Hoang-Oanh B Nguyen (additional)
Cornelia Heinrich (additional)
Marilyn Torchia (additional)
Jiri Safar (additional)
Fred E Cohen (additional)
Stephen J DeArmond (additional)
Stanley B Prusiner (additional)
Michael Scott (additional)

References 41 Referenced 179

10.1016/0092-8674(86)90662-8 / Cell / Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene by Basler (1986)
10.1128/JVI.68.12.7859-7868.1994 / J. Virol. / Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy by Bessen (1994)
10.1007/BF03403528 / Mol. Med. / High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene by Büeler (1994)
10.1002/bip.360250307 / Biopolymers / Examination of the secondary structure of proteins by deconvolved FTIR spectra by Byler (1986)
10.1016/0092-8674(86)90875-5 / Cell / Linkage of prion protein and scrapie incubation time genes by Carlson (1986)
10.1073/pnas.91.12.5690 / Proc. Natl. Acad. Sci. USA / Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice by Carlson (1994)
10.1016/S0140-6736(61)92008-6 / Lancet / Encephalopathy in mice produced by inoculation with scrapie brain material by Chandler (1961)
10.1073/pnas.94.25.13452 / Proc. Natl. Acad. Sci. USA / Structure of the recombinant full-length hamster prion protein PrP(29–231) by Donne (1997)
10.1002/j.1460-2075.1996.tb00467.x / EMBO J. / Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie by Fischer (1996)
10.1073/pnas.90.1.1 / Proc. Natl. Acad. Sci. USA / Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity by Gasset (1993)
10.1073/pnas.91.15.7139 / Proc. Natl. Acad. Sci. USA / Proposed three-dimensional structure for the cellular prion protein by Huang (1994)
10.1073/pnas.94.19.10086 / Proc. Natl. Acad. Sci. USA / Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform by James (1997)
10.1073/pnas.94.19.10069 / Proc. Natl. Acad. Sci. USA / Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation by Kaneko (1997)
10.1074/jbc.271.3.1633 / J. Biol. Chem. / Mutant and infectious prion proteins display common biochemical properties in cultured cells by Lehmann (1996)
10.1073/pnas.93.11.5610 / Proc. Natl. Acad. Sci. USA / Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform by Lehmann (1996)
10.1093/brain/101.2.333 / Brain / Subacute spongiform encephalopathy Creutzfeldt-Jakob disease—the nature and progression of spongiform change by Masters (1978)
10.1021/bi952965e / Biochemistry / High-level expression and characterization of a purified 142-residue polypeptide of the prion protein by Mehlhorn (1996)
10.1073/pnas.93.26.15457 / Proc. Natl. Acad. Sci. USA / Recombinant scrapie-like prion protein of 106 amino acids is soluble by Muramoto (1996)
10.1038/nm0797-750 / Nat. Med. / Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α helix by Muramoto (1997)
{'key': '10.1016/S0092-8674(00)80596-6_BIB20', 'series-title': 'Slow, Latent and Temperate Virus Infections, NINDB Monograph 2', 'article-title': 'Experiments with scrapie with special reference to the nature of the agent and the pathology of the disease', 'author': 'Pattison', 'year': '1965'} / Slow, Latent and Temperate Virus Infections, NINDB Monograph 2 / Experiments with scrapie with special reference to the nature of the agent and the pathology of the disease by Pattison (1965)
10.1006/jmbi.1997.1328 / J. Mol. Biol. / A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform by Peretz (1997)
10.1021/bi00269a050 / Biochemistry / Further purification and characterization of scrapie prions by Prusiner (1982)
10.1016/0092-8674(83)90168-X / Cell / Scrapie prions aggregate to form amyloid-like birefringent rods by Prusiner (1983)
10.1016/0092-8674(84)90533-6 / Cell / Purification and structural studies of a major scrapie prion protein by Prusiner (1984)
10.1016/0092-8674(90)90134-Z / Cell / Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication by Prusiner (1990)
10.1073/pnas.90.22.10608 / Proc. Natl. Acad. Sci. USA / Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies by Prusiner (1993)
10.1016/S0092-8674(00)81163-0 / Cell / Prion protein biology by Prusiner (1998)
10.1038/382180a0 / Nature / NMR structure of the mouse prion protein domain PrP(121–231) by Riek (1996)
10.1128/JVI.70.3.1714-1722.1996 / J. Virol. / Disruption of prion rods generates 10-nm spherical particles having high α-helical content and lacking scrapie infectivity by Riesner (1996)
10.1073/pnas.90.8.3182 / Proc. Natl. Acad. Sci. USA / Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells by Rogers (1993)
10.1038/2654 / Nat. Med. / Eight prion strains have PrPSc molecules with different conformations by Safar (1998)
10.1016/0092-8674(89)90608-9 / Cell / Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques by Scott (1989)
10.1016/0092-8674(93)90275-U / Cell / Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes by Scott (1993)
10.1128/JVI.71.12.9032-9044.1997 / J. Virol. / Propagation of prion strains through specific conformers of the prion protein by Scott (1997)
10.1016/S0092-8674(00)81572-X / Cell / Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions by Shmerling (1998)
10.1073/pnas.89.16.7620 / Proc. Natl. Acad. Sci. USA / Regional mapping of prion proteins in brains by Taraboulos (1992)
10.1016/0092-8674(95)90236-8 / Cell / Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein by Telling (1995)
10.1101/gad.10.14.1736 / Genes Dev. / Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice by Telling (1996)
10.1126/science.274.5295.2079 / Science / Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity by Telling (1996)
10.1016/S0006-3495(99)77270-X / Biophys. J. / Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions by Wille (1999)
10.1128/JVI.72.11.9413-9418.1998 / J. Virol. / Mapping the prion protein using recombinant antibodies by Williamson (1998)

Dates

Type	When
Created	21 years, 2 months ago (June 30, 2004, 4:27 a.m.)
Deposited	5 years, 5 months ago (April 2, 2020, 7:55 a.m.)
Indexed	2 months ago (July 2, 2025, 2:31 p.m.)
Issued	26 years, 6 months ago (March 1, 1999)
Published	26 years, 6 months ago (March 1, 1999)
Published Print	26 years, 6 months ago (March 1, 1999)

Funders 0

None

BibTeX

@article{Supattapone_1999, title={Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice}, volume={96}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80596-6}, DOI={10.1016/s0092-8674(00)80596-6}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Supattapone, Surachai and Bosque, Patrick and Muramoto, Tamaki and Wille, Holger and Aagaard, Claus and Peretz, David and Nguyen, Hoang-Oanh B and Heinrich, Cornelia and Torchia, Marilyn and Safar, Jiri and Cohen, Fred E and DeArmond, Stephen J and Prusiner, Stanley B and Scott, Michael}, year={1999}, month=mar, pages={869–878} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        2
      ]
    ],
    "date-time": "2025-07-02T18:31:57Z",
    "timestamp": 1751481117663
  },
  "reference-count": 41,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            3,
            1
          ]
        ],
        "date-time": "1999-03-01T00:00:00Z",
        "timestamp": 920246400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 5252,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(00)80596-6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        30
      ]
    ],
    "date-time": "2004-06-30T08:27:59Z",
    "timestamp": 1088584079000
  },
  "page": "869-878",
  "source": "Crossref",
  "is-referenced-by-count": 179,
  "title": "Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice",
  "prefix": "10.1016",
  "volume": "96",
  "author": [
    {
      "given": "Surachai",
      "family": "Supattapone",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Patrick",
      "family": "Bosque",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Tamaki",
      "family": "Muramoto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Holger",
      "family": "Wille",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Claus",
      "family": "Aagaard",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David",
      "family": "Peretz",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hoang-Oanh B",
      "family": "Nguyen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Cornelia",
      "family": "Heinrich",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marilyn",
      "family": "Torchia",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jiri",
      "family": "Safar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fred E",
      "family": "Cohen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stephen J",
      "family": "DeArmond",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Stanley B",
      "family": "Prusiner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Michael",
      "family": "Scott",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/0092-8674(86)90662-8",
      "article-title": "Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene",
      "volume": "46",
      "author": "Basler",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "7859",
      "DOI": "10.1128/JVI.68.12.7859-7868.1994",
      "article-title": "Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy",
      "volume": "68",
      "author": "Bessen",
      "year": "1994",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1007/BF03403528",
      "article-title": "High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene",
      "volume": "1",
      "author": "B\u00fceler",
      "year": "1994",
      "journal-title": "Mol. Med."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1002/bip.360250307",
      "article-title": "Examination of the secondary structure of proteins by deconvolved FTIR spectra",
      "volume": "25",
      "author": "Byler",
      "year": "1986",
      "journal-title": "Biopolymers"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1016/0092-8674(86)90875-5",
      "article-title": "Linkage of prion protein and scrapie incubation time genes",
      "volume": "46",
      "author": "Carlson",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "5690",
      "DOI": "10.1073/pnas.91.12.5690",
      "article-title": "Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice",
      "volume": "91",
      "author": "Carlson",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1378",
      "DOI": "10.1016/S0140-6736(61)92008-6",
      "article-title": "Encephalopathy in mice produced by inoculation with scrapie brain material",
      "volume": "1",
      "author": "Chandler",
      "year": "1961",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "13452",
      "DOI": "10.1073/pnas.94.25.13452",
      "article-title": "Structure of the recombinant full-length hamster prion protein PrP(29\u2013231)",
      "volume": "94",
      "author": "Donne",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1255",
      "DOI": "10.1002/j.1460-2075.1996.tb00467.x",
      "article-title": "Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie",
      "volume": "15",
      "author": "Fischer",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1073/pnas.90.1.1",
      "article-title": "Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity",
      "volume": "90",
      "author": "Gasset",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "7139",
      "DOI": "10.1073/pnas.91.15.7139",
      "article-title": "Proposed three-dimensional structure for the cellular prion protein",
      "volume": "91",
      "author": "Huang",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "10086",
      "DOI": "10.1073/pnas.94.19.10086",
      "article-title": "Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform",
      "volume": "94",
      "author": "James",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "10069",
      "DOI": "10.1073/pnas.94.19.10069",
      "article-title": "Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation",
      "volume": "94",
      "author": "Kaneko",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1633",
      "DOI": "10.1074/jbc.271.3.1633",
      "article-title": "Mutant and infectious prion proteins display common biochemical properties in cultured cells",
      "volume": "271",
      "author": "Lehmann",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "5610",
      "DOI": "10.1073/pnas.93.11.5610",
      "article-title": "Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform",
      "volume": "93",
      "author": "Lehmann",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1093/brain/101.2.333",
      "article-title": "Subacute spongiform encephalopathy Creutzfeldt-Jakob disease\u2014the nature and progression of spongiform change",
      "volume": "101",
      "author": "Masters",
      "year": "1978",
      "journal-title": "Brain"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "5528",
      "DOI": "10.1021/bi952965e",
      "article-title": "High-level expression and characterization of a purified 142-residue polypeptide of the prion protein",
      "volume": "35",
      "author": "Mehlhorn",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "15457",
      "DOI": "10.1073/pnas.93.26.15457",
      "article-title": "Recombinant scrapie-like prion protein of 106 amino acids is soluble",
      "volume": "93",
      "author": "Muramoto",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "750",
      "DOI": "10.1038/nm0797-750",
      "article-title": "Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an \u03b1 helix",
      "volume": "3",
      "author": "Muramoto",
      "year": "1997",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB20",
      "series-title": "Slow, Latent and Temperate Virus Infections, NINDB Monograph 2",
      "article-title": "Experiments with scrapie with special reference to the nature of the agent and the pathology of the disease",
      "author": "Pattison",
      "year": "1965"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "614",
      "DOI": "10.1006/jmbi.1997.1328",
      "article-title": "A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform",
      "volume": "273",
      "author": "Peretz",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "6942",
      "DOI": "10.1021/bi00269a050",
      "article-title": "Further purification and characterization of scrapie prions",
      "volume": "21",
      "author": "Prusiner",
      "year": "1982",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1016/0092-8674(83)90168-X",
      "article-title": "Scrapie prions aggregate to form amyloid-like birefringent rods",
      "volume": "35",
      "author": "Prusiner",
      "year": "1983",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/0092-8674(84)90533-6",
      "article-title": "Purification and structural studies of a major scrapie prion protein",
      "volume": "38",
      "author": "Prusiner",
      "year": "1984",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "673",
      "DOI": "10.1016/0092-8674(90)90134-Z",
      "article-title": "Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication",
      "volume": "63",
      "author": "Prusiner",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "10608",
      "DOI": "10.1073/pnas.90.22.10608",
      "article-title": "Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies",
      "volume": "90",
      "author": "Prusiner",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1016/S0092-8674(00)81163-0",
      "article-title": "Prion protein biology",
      "volume": "93",
      "author": "Prusiner",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "180",
      "DOI": "10.1038/382180a0",
      "article-title": "NMR structure of the mouse prion protein domain PrP(121\u2013231)",
      "volume": "382",
      "author": "Riek",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1714",
      "DOI": "10.1128/JVI.70.3.1714-1722.1996",
      "article-title": "Disruption of prion rods generates 10-nm spherical particles having high \u03b1-helical content and lacking scrapie infectivity",
      "volume": "70",
      "author": "Riesner",
      "year": "1996",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "3182",
      "DOI": "10.1073/pnas.90.8.3182",
      "article-title": "Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells",
      "volume": "90",
      "author": "Rogers",
      "year": "1993",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1038/2654",
      "article-title": "Eight prion strains have PrPSc molecules with different conformations",
      "volume": "4",
      "author": "Safar",
      "year": "1998",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1016/0092-8674(89)90608-9",
      "article-title": "Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques",
      "volume": "59",
      "author": "Scott",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "979",
      "DOI": "10.1016/0092-8674(93)90275-U",
      "article-title": "Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes",
      "volume": "73",
      "author": "Scott",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "9032",
      "DOI": "10.1128/JVI.71.12.9032-9044.1997",
      "article-title": "Propagation of prion strains through specific conformers of the prion protein",
      "volume": "71",
      "author": "Scott",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1016/S0092-8674(00)81572-X",
      "article-title": "Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions",
      "volume": "93",
      "author": "Shmerling",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "7620",
      "DOI": "10.1073/pnas.89.16.7620",
      "article-title": "Regional mapping of prion proteins in brains",
      "volume": "89",
      "author": "Taraboulos",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/0092-8674(95)90236-8",
      "article-title": "Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein",
      "volume": "83",
      "author": "Telling",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1736",
      "DOI": "10.1101/gad.10.14.1736",
      "article-title": "Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice",
      "volume": "10",
      "author": "Telling",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "2079",
      "DOI": "10.1126/science.274.5295.2079",
      "article-title": "Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity",
      "volume": "274",
      "author": "Telling",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1048",
      "DOI": "10.1016/S0006-3495(99)77270-X",
      "article-title": "Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions",
      "volume": "76",
      "author": "Wille",
      "year": "1999",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0092-8674(00)80596-6_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "9413",
      "DOI": "10.1128/JVI.72.11.9413-9418.1998",
      "article-title": "Mapping the prion protein using recombinant antibodies",
      "volume": "72",
      "author": "Williamson",
      "year": "1998",
      "journal-title": "J. Virol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400805966?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400805966?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        4,
        2
      ]
    ],
    "date-time": "2020-04-02T11:55:05Z",
    "timestamp": 1585828505000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867400805966"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1999,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867400805966"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(00)80596-6",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  }
}