DOI: 10.1016/s0092-8674(00)80365-7. Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

10.1016/s0092-8674(00)80365-7

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., Saez, C., Pugsley, T. A., Gershanik, O., Low, M. J., & Grandy, D. K. (1997). Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine. Cell, 90(6), 991â1001.

Authors 15

Marcelo Rubinstein (first)
Tamara J. Phillips (additional)
James R. Bunzow (additional)
Tomás L. Falzone (additional)
Gustavo Dziewczapolski (additional)
Ge Zhang (additional)
Yuan Fang (additional)
Jennifer L. Larson (additional)
John A. McDougall (additional)
Julia A. Chester (additional)
Carmen Saez (additional)
Thomas A. Pugsley (additional)
Oscar Gershanik (additional)
Malcolm J. Low (additional)
David K. Grandy (additional)

References 60 Referenced 380

10.1073/pnas.93.5.1945 / Proc. Natl. Acad. Sci. USA / A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice by Accili (1996)
10.1016/S0006-8993(96)01422-9 / Brain Res. / Cellular distribution of the rat D-4 dopamine receptor protein in the CNS using antireceptor antisera by Ariano (1997)
10.1016/0014-2999(95)00292-S / Eur. J. Pharmacol. / Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine by Arnt (1995)
10.1038/ng0196-81 / Nat. Genet. / Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking by Benjamin (1996)
10.1523/JNEUROSCI.15-12-07821.1995 / J. Neurosci. / Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain by Bergson (1995)
10.1016/0922-4106(95)90011-X / Eur. J. Pharmacol. / Functional characterization of the human D4.2 dopamine receptor using vaccinia virus as an expression system by Bouvier (1995)
10.1016/0006-8993(94)90523-1 / Brain Res. / The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats by Camp (1994)
10.1007/BF01250562 / J. Neural Transm. / Agonist antagonist interaction on dopamine receptors in brain as reflected in the rates of tyrosine and tryptophan hydroxylation by Carlsson (1975)
10.1016/0028-3908(82)90019-3 / Neuropharmacology / Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats by Carter (1982)
10.1016/0306-4522(95)00047-M / Neuroscience / Evidence for N-methyl-D-aspartate and AMPA subtypes of the glutamate receptor on substantia nigra dopamine neurons by Christoffersen (1995)
10.1146/annurev.pa.33.040193.001433 / Annu. Rev. Pharmacol. Toxicol. / Molecular diversity of the dopamine receptors by Civelli (1993)
10.1002/syn.890010408 / Synapse / D1 dopamine receptor—the search for a function by Clark (1987)
10.1126/science.8209252 / Science / Genetic animal models of alcohol and drug abuse by Crabbe (1994)
10.1007/BF01249100 / J. Neural Transm. / The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice by Dar (1984)
10.1016/0376-8716(95)01118-I / Drug Alcoh. Depend. / The role of dopamine in drug abuse viewed from the perspective of its role in motivation by Di Chiara (1995)
10.1038/ng0196-78 / Nat. Genet. / Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking by Ebstein (1996)
{'key': '10.1016/S0092-8674(00)80365-7_BIB17', 'first-page': '439', 'article-title': 'Genetic sensitivity to the effect of ethanol on the dopaminergic system in alcohol-preferring rats', 'volume': '1', 'author': 'Fadda', 'year': '1991', 'journal-title': 'Alcohol. Alcohol. Suppl.'} / Alcohol. Alcohol. Suppl. / Genetic sensitivity to the effect of ethanol on the dopaminergic system in alcohol-preferring rats by Fadda (1991)
10.1016/0014-5793(95)00168-9 / FEBS Lett. / Molecular cloning and characterization of the gene encoding the murine D4 dopamine receptor by Fishburn (1995)
10.1126/science.4012312 / Science / Regional brain dopamine metabolism by Freed (1985)
10.1111/j.1530-0277.1997.tb03725.x / Alcoh. Clin. Exp. Res. / Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandanavian chronic alcoholics by Geijer (1997)
10.1006/bbrc.1993.2222 / Biochem. Biophys. Res. Comm. / Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism by George (1993)
10.1016/0166-2236(90)90104-I / Trends Neurosci. / Neurotransmitters and neuromodulators in the basal ganglia by Graybiel (1990)
10.1126/science.8091209 / Science / The basal ganglia and adaptive motor control by Graybiel (1994)
10.1126/science.6610213 / Science / Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice by Heikkila (1984)
{'key': '10.1016/S0092-8674(00)80365-7_BIB25', 'first-page': '925', 'article-title': 'Dopamine (3-hydroxytyramine) and brain function', 'volume': '18', 'author': 'Hornykiewicz', 'year': '1966', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. / Dopamine (3-hydroxytyramine) and brain function by Hornykiewicz (1966)
{'key': '10.1016/S0092-8674(00)80365-7_BIB26', 'first-page': '219', 'article-title': 'Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol', 'volume': '239', 'author': 'Imperato', 'year': '1986', 'journal-title': 'J. Pharmacol. Exp. Therap.'} / J. Pharmacol. Exp. Therap. / Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol by Imperato (1986)
10.1016/0006-291X(91)90389-O / Biochem. Biophys. Res. Comm. / A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat phaeochromocytoma PC12h cells by Ishii (1991)
10.1038/sj.mp.4000248 / Mol. Psych. / Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects by Kotler (1997)
{'key': '10.1016/S0092-8674(00)80365-7_BIB29', 'first-page': '343', 'article-title': 'Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841', 'volume': '271', 'author': 'Krisch', 'year': '1994', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. / Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841 by Krisch (1994)
10.1016/0166-2236(91)90141-G / Trends Neurosci. / The dopamine hypothesis of the reinforcing properties of cocaine by Kuhar (1991)
10.1007/BF02245006 / Psychopharmacology / Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects by Leysen (1993)
Lindvall, O., and Bjorland, A. (1983). Dopamine and norepinephrine-containing neuron systems: their anatomy in the rat brain. In Chemical Neuroanatomy, P.C. Emson, ed. (New York: Raven Press), pp. 229–255.
10.1016/0006-8993(90)91604-F / Brain Res. / Similar effects of D-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats by Maisonneuve (1990)
10.1038/npp.1994.27 / Neuropsychopharmacology / Dopamine receptor gene expression in the human medial temporal lobe by Meador-Woodruff (1994)
10.1038/381245a0 / Nature / Localization of dopamine D4 receptors in GABAergic neurons of the primate brain by Mrzljak (1996)
10.1136/jmg.33.2.113 / J. Med. Genet. / Association between alcoholism and the dopamine D4 receptor gene by Muramatsu (1996)
10.1007/BF02257617 / J. Neural Transm. / Electrophysiological evidence that intrastriatally administered N-methyl-D-aspartate augments striatal dopamine tone in the rat by Overton (1992)
10.1016/S0074-7742(08)60669-8 / Int. Rev. Neurobiol. / Neurochemical bases of locomotion and ethanol stimulant effects by Phillips (1996)
10.1007/BF02244259 / Psychopharmacology / Response to selection for ethanol-induced locomotor activation by Phillips (1991)
10.1111/j.1530-0277.1994.tb00062.x / Alcohol. Clin. Exp. Res. / Localization of genes affecting alcohol drinking in mice by Phillips (1994)
10.1111/j.1530-0277.1995.tb01502.x / Alcohol. Clin. Exp. Res. / Effects of acute and repeated ethanol exposures on the locomotor activity of B × D recombinant inbred mice by Phillips (1995)
{'key': '10.1016/S0092-8674(00)80365-7_BIB42', 'first-page': '1355', 'article-title': 'Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907', 'volume': '275', 'author': 'Pugsley', 'year': '1995', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. / Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907 by Pugsley (1995)
10.1007/BF02245485 / Psychopharmacology / Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens by Rassnick (1992)
10.1046/j.1471-4159.1994.63041576.x / J. Neurochem. / Are striatal dopamine D4 receptors increased in schizophrenia? by Reynolds (1994)
10.1073/pnas.89.20.9593 / Proc. Natl. Acad. Sci., USA / Regulation of recombinant rat tyrosine hydroxylase by dopamine by Ribeiro (1992)
10.1016/0165-0173(93)90013-P / Brain Res. Rev. / The neural basis of drug craving by Robinson (1993)
10.1073/pnas.93.9.3995 / Proc. Natl. Acad. Sci. USA / Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis by Rubinstein (1996)
10.1038/365441a0 / Nature / Dopamine D4 receptors are elevated in schizophrenia by Seeman (1993)
10.1016/0165-6147(94)90323-9 / Trends Pharmacol. Sci. / Dopamine receptor pharmacology by Seeman (1994)
10.1523/JNEUROSCI.16-20-06579.1996 / J. Neurosci. / Coordinated expression of dopamine receptors in neostriatal medium spinal neurons by Surmeier (1996)
10.1038/358149a0 / Nature / Multiple dopamine D4 receptor variants in the human population by Van Tol (1992)
Waddington, J.L., and Daly, S.A. (1993). Regulation of unconditioned motor behavior by D1:D2 dopamine receptor interactions. J.L. Waddington, ed. (San Diego, CA: Academic Press), pp. 51–78.
10.1523/JNEUROSCI.12-11-04372.1992 / J. Neurosci. / Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels by Weiss (1992)
{'key': '10.1016/S0092-8674(00)80365-7_BIB54', 'first-page': '656', 'article-title': 'D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes', 'volume': '49', 'author': 'Werner', 'year': '1996', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes by Werner (1996)
10.1007/BF00168943 / Naunyn-Schmiedeberg's Arch. Pharmacol. / The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat by Westerink (1992)
10.1146/annurev.ne.19.030196.002201 / Annu. Rev. Neurosci. / Synaptic regulation of mesocorticolimbic dopamine neurons by White (1996)
10.1016/S0959-4388(96)80024-9 / Curr. Opin. Neurobiol. / Functional and pathophysiological models of the basal ganglia by Wichmann (1996)
10.1037/0033-295X.94.4.469 / Psychol. Rev. / A psychomotor stimulant theory of addiction by Wise (1987)
10.1146/annurev.ne.12.030189.002215 / Annu. Rev. Neurosci. / Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation by Zigmond (1989)
10.1016/0922-4106(94)90047-7 / Eur. J. Pharmacol. / Clozapine is a potent and selective muscarinic M4 receptor agonist by Zorn (1994)

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 1:47 p.m.)
Deposited	2 years, 6 months ago (Jan. 28, 2023, 8:22 a.m.)
Indexed	2 months ago (June 26, 2025, 8:30 a.m.)
Issued	27 years, 11 months ago (Sept. 1, 1997)
Published	27 years, 11 months ago (Sept. 1, 1997)
Published Print	27 years, 11 months ago (Sept. 1, 1997)

Funders 0

None

BibTeX

@article{Rubinstein_1997, title={Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine}, volume={90}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80365-7}, DOI={10.1016/s0092-8674(00)80365-7}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Rubinstein, Marcelo and Phillips, Tamara J. and Bunzow, James R. and Falzone, Tomás L. and Dziewczapolski, Gustavo and Zhang, Ge and Fang, Yuan and Larson, Jennifer L. and McDougall, John A. and Chester, Julia A. and Saez, Carmen and Pugsley, Thomas A. and Gershanik, Oscar and Low, Malcolm J. and Grandy, David K.}, year={1997}, month=sep, pages={991–1001} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        26
      ]
    ],
    "date-time": "2025-06-26T12:30:17Z",
    "timestamp": 1750941017540
  },
  "reference-count": 60,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1997,
            9,
            1
          ]
        ],
        "date-time": "1997-09-01T00:00:00Z",
        "timestamp": 873072000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 5798,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        9
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(00)80365-7",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        24
      ]
    ],
    "date-time": "2004-06-24T17:47:39Z",
    "timestamp": 1088099259000
  },
  "page": "991-1001",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 380,
  "title": "Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine",
  "prefix": "10.1016",
  "volume": "90",
  "author": [
    {
      "given": "Marcelo",
      "family": "Rubinstein",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Tamara J.",
      "family": "Phillips",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "James R.",
      "family": "Bunzow",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Tom\u00e1s L.",
      "family": "Falzone",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gustavo",
      "family": "Dziewczapolski",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ge",
      "family": "Zhang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yuan",
      "family": "Fang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jennifer L.",
      "family": "Larson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "John A.",
      "family": "McDougall",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Julia A.",
      "family": "Chester",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carmen",
      "family": "Saez",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Thomas A.",
      "family": "Pugsley",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Oscar",
      "family": "Gershanik",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Malcolm J.",
      "family": "Low",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David K.",
      "family": "Grandy",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1945",
      "DOI": "10.1073/pnas.93.5.1945",
      "article-title": "A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice",
      "volume": "93",
      "author": "Accili",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "26",
      "DOI": "10.1016/S0006-8993(96)01422-9",
      "article-title": "Cellular distribution of the rat D-4 dopamine receptor protein in the CNS using antireceptor antisera",
      "volume": "752",
      "author": "Ariano",
      "year": "1997",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/0014-2999(95)00292-S",
      "article-title": "Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine",
      "volume": "283",
      "author": "Arnt",
      "year": "1995",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1038/ng0196-81",
      "article-title": "Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking",
      "volume": "12",
      "author": "Benjamin",
      "year": "1996",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "7821",
      "DOI": "10.1523/JNEUROSCI.15-12-07821.1995",
      "article-title": "Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain",
      "volume": "15",
      "author": "Bergson",
      "year": "1995",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1016/0922-4106(95)90011-X",
      "article-title": "Functional characterization of the human D4.2 dopamine receptor using vaccinia virus as an expression system",
      "volume": "290",
      "author": "Bouvier",
      "year": "1995",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "180",
      "DOI": "10.1016/0006-8993(94)90523-1",
      "article-title": "The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats",
      "volume": "668",
      "author": "Camp",
      "year": "1994",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1007/BF01250562",
      "article-title": "Agonist antagonist interaction on dopamine receptors in brain as reflected in the rates of tyrosine and tryptophan hydroxylation",
      "volume": "40",
      "author": "Carlsson",
      "year": "1975",
      "journal-title": "J. Neural Transm."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1016/0028-3908(82)90019-3",
      "article-title": "Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats",
      "volume": "21",
      "author": "Carter",
      "year": "1982",
      "journal-title": "Neuropharmacology"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1016/0306-4522(95)00047-M",
      "article-title": "Evidence for N-methyl-D-aspartate and AMPA subtypes of the glutamate receptor on substantia nigra dopamine neurons",
      "volume": "67",
      "author": "Christoffersen",
      "year": "1995",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1146/annurev.pa.33.040193.001433",
      "article-title": "Molecular diversity of the dopamine receptors",
      "volume": "33",
      "author": "Civelli",
      "year": "1993",
      "journal-title": "Annu. Rev. Pharmacol. Toxicol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1002/syn.890010408",
      "article-title": "D1 dopamine receptor\u2014the search for a function",
      "volume": "1",
      "author": "Clark",
      "year": "1987",
      "journal-title": "Synapse"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1715",
      "DOI": "10.1126/science.8209252",
      "article-title": "Genetic animal models of alcohol and drug abuse",
      "volume": "264",
      "author": "Crabbe",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1007/BF01249100",
      "article-title": "The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice",
      "volume": "60",
      "author": "Dar",
      "year": "1984",
      "journal-title": "J. Neural Transm."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1016/0376-8716(95)01118-I",
      "article-title": "The role of dopamine in drug abuse viewed from the perspective of its role in motivation",
      "volume": "38",
      "author": "Di Chiara",
      "year": "1995",
      "journal-title": "Drug Alcoh. Depend."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1038/ng0196-78",
      "article-title": "Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking",
      "volume": "12",
      "author": "Ebstein",
      "year": "1996",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB17",
      "first-page": "439",
      "article-title": "Genetic sensitivity to the effect of ethanol on the dopaminergic system in alcohol-preferring rats",
      "volume": "1",
      "author": "Fadda",
      "year": "1991",
      "journal-title": "Alcohol. Alcohol. Suppl."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/0014-5793(95)00168-9",
      "article-title": "Molecular cloning and characterization of the gene encoding the murine D4 dopamine receptor",
      "volume": "361",
      "author": "Fishburn",
      "year": "1995",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1126/science.4012312",
      "article-title": "Regional brain dopamine metabolism",
      "volume": "229",
      "author": "Freed",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "DOI": "10.1111/j.1530-0277.1997.tb03725.x",
      "article-title": "Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandanavian chronic alcoholics",
      "volume": "21",
      "author": "Geijer",
      "year": "1997",
      "journal-title": "Alcoh. Clin. Exp. Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1006/bbrc.1993.2222",
      "article-title": "Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism",
      "volume": "196",
      "author": "George",
      "year": "1993",
      "journal-title": "Biochem. Biophys. Res. Comm."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "244",
      "DOI": "10.1016/0166-2236(90)90104-I",
      "article-title": "Neurotransmitters and neuromodulators in the basal ganglia",
      "volume": "13",
      "author": "Graybiel",
      "year": "1990",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1826",
      "DOI": "10.1126/science.8091209",
      "article-title": "The basal ganglia and adaptive motor control",
      "volume": "265",
      "author": "Graybiel",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1451",
      "DOI": "10.1126/science.6610213",
      "article-title": "Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice",
      "volume": "224",
      "author": "Heikkila",
      "year": "1984",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB25",
      "first-page": "925",
      "article-title": "Dopamine (3-hydroxytyramine) and brain function",
      "volume": "18",
      "author": "Hornykiewicz",
      "year": "1966",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB26",
      "first-page": "219",
      "article-title": "Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol",
      "volume": "239",
      "author": "Imperato",
      "year": "1986",
      "journal-title": "J. Pharmacol. Exp. Therap."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "1051",
      "DOI": "10.1016/0006-291X(91)90389-O",
      "article-title": "A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat phaeochromocytoma PC12h cells",
      "volume": "176",
      "author": "Ishii",
      "year": "1991",
      "journal-title": "Biochem. Biophys. Res. Comm."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1038/sj.mp.4000248",
      "article-title": "Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects",
      "volume": "2",
      "author": "Kotler",
      "year": "1997",
      "journal-title": "Mol. Psych."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB29",
      "first-page": "343",
      "article-title": "Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841",
      "volume": "271",
      "author": "Krisch",
      "year": "1994",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1016/0166-2236(91)90141-G",
      "article-title": "The dopamine hypothesis of the reinforcing properties of cocaine",
      "volume": "14",
      "author": "Kuhar",
      "year": "1991",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "S40",
      "DOI": "10.1007/BF02245006",
      "article-title": "Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects",
      "volume": "112",
      "author": "Leysen",
      "year": "1993",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB32",
      "unstructured": "Lindvall, O., and Bjorland, A. (1983). Dopamine and norepinephrine-containing neuron systems: their anatomy in the rat brain. In Chemical Neuroanatomy, P.C. Emson, ed. (New York: Raven Press), pp. 229\u2013255."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1016/0006-8993(90)91604-F",
      "article-title": "Similar effects of D-amphetamine and cocaine on extracellular dopamine levels in medial prefrontal cortex of rats",
      "volume": "535",
      "author": "Maisonneuve",
      "year": "1990",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1038/npp.1994.27",
      "article-title": "Dopamine receptor gene expression in the human medial temporal lobe",
      "volume": "10",
      "author": "Meador-Woodruff",
      "year": "1994",
      "journal-title": "Neuropsychopharmacology"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1038/381245a0",
      "article-title": "Localization of dopamine D4 receptors in GABAergic neurons of the primate brain",
      "volume": "381",
      "author": "Mrzljak",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1136/jmg.33.2.113",
      "article-title": "Association between alcoholism and the dopamine D4 receptor gene",
      "volume": "33",
      "author": "Muramatsu",
      "year": "1996",
      "journal-title": "J. Med. Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1007/BF02257617",
      "article-title": "Electrophysiological evidence that intrastriatally administered N-methyl-D-aspartate augments striatal dopamine tone in the rat",
      "volume": "4",
      "author": "Overton",
      "year": "1992",
      "journal-title": "J. Neural Transm."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/S0074-7742(08)60669-8",
      "article-title": "Neurochemical bases of locomotion and ethanol stimulant effects",
      "volume": "39",
      "author": "Phillips",
      "year": "1996",
      "journal-title": "Int. Rev. Neurobiol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1007/BF02244259",
      "article-title": "Response to selection for ethanol-induced locomotor activation",
      "volume": "103",
      "author": "Phillips",
      "year": "1991",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "931",
      "DOI": "10.1111/j.1530-0277.1994.tb00062.x",
      "article-title": "Localization of genes affecting alcohol drinking in mice",
      "volume": "18",
      "author": "Phillips",
      "year": "1994",
      "journal-title": "Alcohol. Clin. Exp. Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1111/j.1530-0277.1995.tb01502.x",
      "article-title": "Effects of acute and repeated ethanol exposures on the locomotor activity of B \u00d7 D recombinant inbred mice",
      "volume": "19",
      "author": "Phillips",
      "year": "1995",
      "journal-title": "Alcohol. Clin. Exp. Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB42",
      "first-page": "1355",
      "article-title": "Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907",
      "volume": "275",
      "author": "Pugsley",
      "year": "1995",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "92",
      "DOI": "10.1007/BF02245485",
      "article-title": "Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens",
      "volume": "109",
      "author": "Rassnick",
      "year": "1992",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1576",
      "DOI": "10.1046/j.1471-4159.1994.63041576.x",
      "article-title": "Are striatal dopamine D4 receptors increased in schizophrenia?",
      "volume": "63",
      "author": "Reynolds",
      "year": "1994",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "9593",
      "DOI": "10.1073/pnas.89.20.9593",
      "article-title": "Regulation of recombinant rat tyrosine hydroxylase by dopamine",
      "volume": "89",
      "author": "Ribeiro",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci., USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1016/0165-0173(93)90013-P",
      "article-title": "The neural basis of drug craving",
      "volume": "18",
      "author": "Robinson",
      "year": "1993",
      "journal-title": "Brain Res. Rev."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "3995",
      "DOI": "10.1073/pnas.93.9.3995",
      "article-title": "Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis",
      "volume": "93",
      "author": "Rubinstein",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1038/365441a0",
      "article-title": "Dopamine D4 receptors are elevated in schizophrenia",
      "volume": "365",
      "author": "Seeman",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "264",
      "DOI": "10.1016/0165-6147(94)90323-9",
      "article-title": "Dopamine receptor pharmacology",
      "volume": "15",
      "author": "Seeman",
      "year": "1994",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "6579",
      "DOI": "10.1523/JNEUROSCI.16-20-06579.1996",
      "article-title": "Coordinated expression of dopamine receptors in neostriatal medium spinal neurons",
      "volume": "16",
      "author": "Surmeier",
      "year": "1996",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "149",
      "DOI": "10.1038/358149a0",
      "article-title": "Multiple dopamine D4 receptor variants in the human population",
      "volume": "358",
      "author": "Van Tol",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB52",
      "unstructured": "Waddington, J.L., and Daly, S.A. (1993). Regulation of unconditioned motor behavior by D1:D2 dopamine receptor interactions. J.L. Waddington, ed. (San Diego, CA: Academic Press), pp. 51\u201378."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "4372",
      "DOI": "10.1523/JNEUROSCI.12-11-04372.1992",
      "article-title": "Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels",
      "volume": "12",
      "author": "Weiss",
      "year": "1992",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB54",
      "first-page": "656",
      "article-title": "D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes",
      "volume": "49",
      "author": "Werner",
      "year": "1996",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "523",
      "DOI": "10.1007/BF00168943",
      "article-title": "The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat",
      "volume": "345",
      "author": "Westerink",
      "year": "1992",
      "journal-title": "Naunyn-Schmiedeberg's Arch. Pharmacol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "405",
      "DOI": "10.1146/annurev.ne.19.030196.002201",
      "article-title": "Synaptic regulation of mesocorticolimbic dopamine neurons",
      "volume": "19",
      "author": "White",
      "year": "1996",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "751",
      "DOI": "10.1016/S0959-4388(96)80024-9",
      "article-title": "Functional and pathophysiological models of the basal ganglia",
      "volume": "6",
      "author": "Wichmann",
      "year": "1996",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1037/0033-295X.94.4.469",
      "article-title": "A psychomotor stimulant theory of addiction",
      "volume": "94",
      "author": "Wise",
      "year": "1987",
      "journal-title": "Psychol. Rev."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1146/annurev.ne.12.030189.002215",
      "article-title": "Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation",
      "volume": "12",
      "author": "Zigmond",
      "year": "1989",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/S0092-8674(00)80365-7_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "R1",
      "DOI": "10.1016/0922-4106(94)90047-7",
      "article-title": "Clozapine is a potent and selective muscarinic M4 receptor agonist",
      "volume": "269",
      "author": "Zorn",
      "year": "1994",
      "journal-title": "Eur. J. Pharmacol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400803657?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400803657?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        1,
        28
      ]
    ],
    "date-time": "2023-01-28T13:22:02Z",
    "timestamp": 1674912122000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867400803657"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        9
      ]
    ]
  },
  "references-count": 60,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1997,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867400803657"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(00)80365-7",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1997,
        9
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0092-8674(00)80365-7",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 1997 Cell Press. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}