DOI: 10.1016/s0092-8674(00)80324-4. The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

10.1016/s0092-8674(00)80324-4

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. (1997). The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation. Cell, 90(1), 181â192.

Authors 10

Li Zeng (first)
François Fagotto (additional)
Tong Zhang (additional)
Wei Hsu (additional)
Thomas J Vasicek (additional)
William L Perry (additional)
James J Lee (additional)
Shirley M Tilghman (additional)
Barry M Gumbiner (additional)
Frank Costantini (additional)

References 56 Referenced 755

{'key': '10.1016/S0092-8674(00)80324-4_BIB1', 'first-page': '147', 'article-title': 'Anterior–posterior polarization and mesoderm inducing factors in the pregastrula mouse embryo. Comparison to chick and frog embryos', 'volume': '4', 'author': 'Bachvarova', 'year': '1996', 'journal-title': 'Adv. Dev. Biol.'} / Adv. Dev. Biol. / Anterior–posterior polarization and mesoderm inducing factors in the pregastrula mouse embryo. Comparison to chick and frog embryos by Bachvarova (1996)
10.1242/dev.120.3.613 / Development / Induction of a second neural axis by the mouse node by Beddington (1994)
10.1016/S0092-8674(00)80117-8 / Cell / GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein α subunits by Berman (1996)
10.1242/dev.122.10.3055 / Development / The homeobox gene Siamois is a target of the Wnt dorsalization pathway and triggers organizer activity in the absence of mesoderm by Carnac (1996)
{'key': '10.1016/S0092-8674(00)80324-4_BIB5', 'first-page': '5', 'article-title': 'Marathon cDNA amplification', 'volume': '10', 'author': 'Chenchik', 'year': '1995', 'journal-title': 'CLONETECHniques'} / CLONETECHniques / Marathon cDNA amplification by Chenchik (1995)
10.1101/gad.7.1.13 / Genes Dev. / Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus by Christian (1993)
10.1016/S1044-5781(06)80050-2 / Semin. Dev. Biol. / Mouse gastrulation from a frog's perspective by Conlon (1995)
{'key': '10.1016/S0092-8674(00)80324-4_BIB8', 'first-page': '27', 'article-title': 'Properties of the primary organization field in the embryo of Xenopus laevis. II. Positional information for axial organization in embryos with two head organizers', 'volume': '28', 'author': 'Cooke', 'year': '1972', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. / Properties of the primary organization field in the embryo of Xenopus laevis. II. Positional information for axial organization in embryos with two head organizers by Cooke (1972)
10.1073/pnas.92.25.11916 / Proc. Natl. Acad. Sci. USA / GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain by De Vries (1995)
10.1016/0968-0004(91)90184-W / Trends Biochem. Sci. / Nuclear targeting sequences—a consensus? by Dingwall (1991)
10.1074/jbc.272.7.3871 / J. Biol. Chem. / RSG proteins and signaling by heterotrimeric G proteins by Dohlman (1997)
10.1128/MCB.16.9.5194 / Mol. Cell. Biol. / Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae by Dohlman (1996)
10.1038/379742a0 / Nature / Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family by Druey (1996)
10.1242/dev.120.12.3667 / Development / Beta-catenin localization during Xenopus embryogenesis by Fagotto (1994)
10.1083/jcb.132.6.1105 / J. Cell Biol. / Binding to cadherins antagonizes the signaling activity of betacatenin during axis formation in Xenopus by Fagotto (1996)
10.1242/dev.124.2.453 / Development / Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/β-catenin signaling pathway, but not by Vg1, Activin, or Noggin by Fagotto (1997)
10.1083/jcb.128.5.959 / J. Cell Biol. / Embryonic axis induction by the armadillo repeat domain of beta-catenin by Funayama (1995)
10.1002/jez.1402640409 / J. Exp. Zool. / Is the anterior–posterior axis of the fetus specified before implantation in the mouse? by Gardner (1992)
10.1002/jez.1401100105 / J. Exp. Zool. / The effects of a lethal mutation responsible for duplications and twinning in mouse embryos by Gluecksohn-Schoenheimer (1949)
10.1073/pnas.83.12.4413 / Proc. Natl. Acad. Sci. USA / Genetic analysis of mutations at the fused locus in the mouse by Greenspan (1986)
10.1242/dev.121.11.3529 / Development / Lack of beta-catenin affects mouse development at gastrulation by Haegel (1995)
10.1016/0092-8674(94)90069-8 / Cell / Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos by Heasman (1994)
10.1101/gad.10.13.1580 / Genes Dev. / Bone morphogenetic proteins by Hogan (1996)
10.1101/gad.10.21.2805 / Genes Dev. / Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos by Hoppler (1996)
10.1242/dev.119.4.1147 / Development / Cwnt-8C by Hume (1993)
10.1038/383175a0 / Nature / RGS10 is a selective activator of Gαi GTPase activity by Hunt (1996)
10.1017/S0016672300025702 / Genet. Res. / Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization by Jacobs-Cohen (1984)
10.1016/0012-1606(88)90189-3 / Dev. Biol. / The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos by Kao (1988)
10.1016/0012-1606(89)90090-0 / Dev. Biol. / The chick's marginal zone and primitive streak formation. I. Coordinative effect of induction and inhibition by Khaner (1989)
10.1101/gad.8.1.118 / Genes Dev. / The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal by Klingensmith (1994)
10.1016/S0092-8674(00)80998-8 / Cell / EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins by Koelle (1996)
10.1016/0092-8674(86)90762-2 / Cell / Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes by Kozak (1986)
10.1242/dev.113.3.891 / Development / Clonal analysis of epiblast fate during germ layer formation in the mouse embryo by Lawson (1991)
10.1016/0092-8674(95)90373-9 / Cell / Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis by Lemaire (1995)
{'year': '1996', 'series-title': 'Genetic Variants and Strains of the Laboratory Mouse', 'author': 'Lyon', 'key': '10.1016/S0092-8674(00)80324-4_BIB35'} / Genetic Variants and Strains of the Laboratory Mouse by Lyon (1996)
10.1101/gad.10.20.2527 / Genes Dev. / Signal transduction through β-catenin and specification of cell fate during embryogenesis by Miller (1996)
10.1016/S0168-9525(97)01093-7 / Trends Genet. / WNTs modulate cell fate and behavior during vertebrate development by Moon (1997)
10.1016/0959-437X(94)90067-D / Curr. Opin. Genet. Dev. / Wnt genes and vertebrate development by Parr (1994)
10.1093/genetics/141.1.321 / Genetics / Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus by Perry (1995)
10.1242/dev.121.3.755 / Development / Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3 by Pierce (1995)
10.1101/gad.8.11.1311 / Genes Dev. / Xenopus embryos regulate the nuclear localization of XMyoD by Rupp (1994)
10.1242/dev.118.1.47 / Development / Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo by Sasaki (1993)
10.1016/0092-8674(94)90176-7 / Cell / HNF-3β as a regulator of floor plate development by Sasaki (1994)
10.1016/S0960-9822(94)00027-8 / Curr. Biol. / Inducing factors in Xenopus early embryos by Slack (1994)
10.1016/S0960-9822(96)00750-6 / Curr. Biol. / Analysis of Dishevelled signaling pathways during Xenopus development by Sokol (1996)
10.1016/S0959-437X(96)80065-7 / Curr. Opin. Genet. Dev. / Early mouse development by St-Jacques (1996)
10.1006/dbio.1994.1297 / Dev. Biol. / Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled by Sussman (1994)
10.1073/pnas.91.22.10255 / Proc. Natl. Acad. Sci. USA / A truncated bone morphogenetic protein receptor affects dorsal–ventral patterning in the early Xenopus embryo by Suzuki (1994)
10.1101/gr.6.9.773 / Genome Res. / Lessons learned, promises kept by Tilghman (1996)
10.1101/gad.9.24.3038 / Genes Dev. / Molecular mechanisms of Spemann's organizer formation by Watabe (1995)
10.1038/383172a0 / Nature / RGS family members by Watson (1996)
Wilkinson, D.G. (1992). Whole mount in situ hybridization of vertebrate embryos. In In Situ Hybridization: a Practical Approach, D.G. Wilkinson, ed. (Oxford: IRL Press), pp. 75–83.
10.1242/dev.122.10.2987 / Development / Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos by Wylie (1996)
10.1101/gad.9.9.1087 / Genes Dev. / The dishevelled protein is modified by wingless signaling in Drosophila by Yanagawa (1995)
10.1101/gad.10.12.1443 / Genes Dev. / The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3 by Yost (1996)
10.1242/dev.115.3.689 / Development / Activin can generate ectopic axial structures in chick blastoderm explants by Ziv (1992)

Dates

Type	When
Created	21 years, 2 months ago (June 9, 2004, 4:23 p.m.)
Deposited	1 year, 9 months ago (Oct. 30, 2023, 7:29 p.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 9:53 a.m.)
Issued	28 years, 1 month ago (July 1, 1997)
Published	28 years, 1 month ago (July 1, 1997)
Published Print	28 years, 1 month ago (July 1, 1997)

Funders 0

None

BibTeX

@article{Zeng_1997, title={The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation}, volume={90}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/s0092-8674(00)80324-4}, DOI={10.1016/s0092-8674(00)80324-4}, number={1}, journal={Cell}, publisher={Elsevier BV}, author={Zeng, Li and Fagotto, François and Zhang, Tong and Hsu, Wei and Vasicek, Thomas J and Perry, William L and Lee, James J and Tilghman, Shirley M and Gumbiner, Barry M and Costantini, Frank}, year={1997}, month=jul, pages={181–192} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T13:53:21Z",
    "timestamp": 1754488401542
  },
  "reference-count": 56,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1997,
            7,
            1
          ]
        ],
        "date-time": "1997-07-01T00:00:00Z",
        "timestamp": 867715200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2001,
            4,
            11
          ]
        ],
        "date-time": "2001-04-11T00:00:00Z",
        "timestamp": 986947200000
      },
      "content-version": "vor",
      "delay-in-days": 1380,
      "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        7
      ]
    ]
  },
  "DOI": "10.1016/s0092-8674(00)80324-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        9
      ]
    ],
    "date-time": "2004-06-09T20:23:03Z",
    "timestamp": 1086812583000
  },
  "page": "181-192",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 755,
  "title": "The Mouse   Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation",
  "prefix": "10.1016",
  "volume": "90",
  "author": [
    {
      "given": "Li",
      "family": "Zeng",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Fran\u00e7ois",
      "family": "Fagotto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Tong",
      "family": "Zhang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wei",
      "family": "Hsu",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Thomas J",
      "family": "Vasicek",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "suffix": "Iii",
      "given": "William L",
      "family": "Perry",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "James J",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shirley M",
      "family": "Tilghman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Barry M",
      "family": "Gumbiner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Frank",
      "family": "Costantini",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB1",
      "first-page": "147",
      "article-title": "Anterior\u2013posterior polarization and mesoderm inducing factors in the pregastrula mouse embryo. Comparison to chick and frog embryos",
      "volume": "4",
      "author": "Bachvarova",
      "year": "1996",
      "journal-title": "Adv. Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1242/dev.120.3.613",
      "article-title": "Induction of a second neural axis by the mouse node",
      "volume": "120",
      "author": "Beddington",
      "year": "1994",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1016/S0092-8674(00)80117-8",
      "article-title": "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein \u03b1 subunits",
      "volume": "86",
      "author": "Berman",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "3055",
      "DOI": "10.1242/dev.122.10.3055",
      "article-title": "The homeobox gene Siamois is a target of the Wnt dorsalization pathway and triggers organizer activity in the absence of mesoderm",
      "volume": "122",
      "author": "Carnac",
      "year": "1996",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB5",
      "first-page": "5",
      "article-title": "Marathon cDNA amplification",
      "volume": "10",
      "author": "Chenchik",
      "year": "1995",
      "journal-title": "CLONETECHniques"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1101/gad.7.1.13",
      "article-title": "Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus",
      "volume": "7",
      "author": "Christian",
      "year": "1993",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1016/S1044-5781(06)80050-2",
      "article-title": "Mouse gastrulation from a frog's perspective",
      "volume": "6",
      "author": "Conlon",
      "year": "1995",
      "journal-title": "Semin. Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB8",
      "first-page": "27",
      "article-title": "Properties of the primary organization field in the embryo of Xenopus laevis. II. Positional information for axial organization in embryos with two head organizers",
      "volume": "28",
      "author": "Cooke",
      "year": "1972",
      "journal-title": "J. Embryol. Exp. Morphol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "11916",
      "DOI": "10.1073/pnas.92.25.11916",
      "article-title": "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain",
      "volume": "92",
      "author": "De Vries",
      "year": "1995",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "478",
      "DOI": "10.1016/0968-0004(91)90184-W",
      "article-title": "Nuclear targeting sequences\u2014a consensus?",
      "volume": "16",
      "author": "Dingwall",
      "year": "1991",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "3871",
      "DOI": "10.1074/jbc.272.7.3871",
      "article-title": "RSG proteins and signaling by heterotrimeric G proteins",
      "volume": "272",
      "author": "Dohlman",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "5194",
      "DOI": "10.1128/MCB.16.9.5194",
      "article-title": "Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae",
      "volume": "16",
      "author": "Dohlman",
      "year": "1996",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "742",
      "DOI": "10.1038/379742a0",
      "article-title": "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family",
      "volume": "379",
      "author": "Druey",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "3667",
      "DOI": "10.1242/dev.120.12.3667",
      "article-title": "Beta-catenin localization during Xenopus embryogenesis",
      "volume": "120",
      "author": "Fagotto",
      "year": "1994",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "1105",
      "DOI": "10.1083/jcb.132.6.1105",
      "article-title": "Binding to cadherins antagonizes the signaling activity of betacatenin during axis formation in Xenopus",
      "volume": "132",
      "author": "Fagotto",
      "year": "1996",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1242/dev.124.2.453",
      "article-title": "Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/\u03b2-catenin signaling pathway, but not by Vg1, Activin, or Noggin",
      "volume": "124",
      "author": "Fagotto",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "959",
      "DOI": "10.1083/jcb.128.5.959",
      "article-title": "Embryonic axis induction by the armadillo repeat domain of beta-catenin",
      "volume": "128",
      "author": "Funayama",
      "year": "1995",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1002/jez.1402640409",
      "article-title": "Is the anterior\u2013posterior axis of the fetus specified before implantation in the mouse?",
      "volume": "264",
      "author": "Gardner",
      "year": "1992",
      "journal-title": "J. Exp. Zool."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1002/jez.1401100105",
      "article-title": "The effects of a lethal mutation responsible for duplications and twinning in mouse embryos",
      "volume": "110",
      "author": "Gluecksohn-Schoenheimer",
      "year": "1949",
      "journal-title": "J. Exp. Zool."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "4413",
      "DOI": "10.1073/pnas.83.12.4413",
      "article-title": "Genetic analysis of mutations at the fused locus in the mouse",
      "volume": "83",
      "author": "Greenspan",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "3529",
      "DOI": "10.1242/dev.121.11.3529",
      "article-title": "Lack of beta-catenin affects mouse development at gastrulation",
      "volume": "121",
      "author": "Haegel",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1016/0092-8674(94)90069-8",
      "article-title": "Overexpression of cadherins and underexpression of \u03b2-catenin inhibit dorsal mesoderm induction in early Xenopus embryos",
      "volume": "79",
      "author": "Heasman",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1580",
      "DOI": "10.1101/gad.10.13.1580",
      "article-title": "Bone morphogenetic proteins",
      "volume": "10",
      "author": "Hogan",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "2805",
      "DOI": "10.1101/gad.10.21.2805",
      "article-title": "Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos",
      "volume": "10",
      "author": "Hoppler",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1147",
      "DOI": "10.1242/dev.119.4.1147",
      "article-title": "Cwnt-8C",
      "volume": "119",
      "author": "Hume",
      "year": "1993",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1038/383175a0",
      "article-title": "RGS10 is a selective activator of G\u03b1i GTPase activity",
      "volume": "383",
      "author": "Hunt",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1017/S0016672300025702",
      "article-title": "Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization",
      "volume": "43",
      "author": "Jacobs-Cohen",
      "year": "1984",
      "journal-title": "Genet. Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1016/0012-1606(88)90189-3",
      "article-title": "The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos",
      "volume": "127",
      "author": "Kao",
      "year": "1988",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.1016/0012-1606(89)90090-0",
      "article-title": "The chick's marginal zone and primitive streak formation. I. Coordinative effect of induction and inhibition",
      "volume": "134",
      "author": "Khaner",
      "year": "1989",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "118",
      "DOI": "10.1101/gad.8.1.118",
      "article-title": "The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal",
      "volume": "8",
      "author": "Klingensmith",
      "year": "1994",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/S0092-8674(00)80998-8",
      "article-title": "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins",
      "volume": "84",
      "author": "Koelle",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/0092-8674(86)90762-2",
      "article-title": "Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes",
      "volume": "44",
      "author": "Kozak",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "891",
      "DOI": "10.1242/dev.113.3.891",
      "article-title": "Clonal analysis of epiblast fate during germ layer formation in the mouse embryo",
      "volume": "113",
      "author": "Lawson",
      "year": "1991",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/0092-8674(95)90373-9",
      "article-title": "Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis",
      "volume": "81",
      "author": "Lemaire",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "year": "1996",
      "series-title": "Genetic Variants and Strains of the Laboratory Mouse",
      "author": "Lyon",
      "key": "10.1016/S0092-8674(00)80324-4_BIB35"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "2527",
      "DOI": "10.1101/gad.10.20.2527",
      "article-title": "Signal transduction through \u03b2-catenin and specification of cell fate during embryogenesis",
      "volume": "10",
      "author": "Miller",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0168-9525(97)01093-7",
      "article-title": "WNTs modulate cell fate and behavior during vertebrate development",
      "volume": "13",
      "author": "Moon",
      "year": "1997",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "523",
      "DOI": "10.1016/0959-437X(94)90067-D",
      "article-title": "Wnt genes and vertebrate development",
      "volume": "4",
      "author": "Parr",
      "year": "1994",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1093/genetics/141.1.321",
      "article-title": "Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus",
      "volume": "141",
      "author": "Perry",
      "year": "1995",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1242/dev.121.3.755",
      "article-title": "Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3",
      "volume": "121",
      "author": "Pierce",
      "year": "1995",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1311",
      "DOI": "10.1101/gad.8.11.1311",
      "article-title": "Xenopus embryos regulate the nuclear localization of XMyoD",
      "volume": "8",
      "author": "Rupp",
      "year": "1994",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1242/dev.118.1.47",
      "article-title": "Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo",
      "volume": "118",
      "author": "Sasaki",
      "year": "1993",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1016/0092-8674(94)90176-7",
      "article-title": "HNF-3\u03b2 as a regulator of floor plate development",
      "volume": "76",
      "author": "Sasaki",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1016/S0960-9822(94)00027-8",
      "article-title": "Inducing factors in Xenopus early embryos",
      "volume": "4",
      "author": "Slack",
      "year": "1994",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "1456",
      "DOI": "10.1016/S0960-9822(96)00750-6",
      "article-title": "Analysis of Dishevelled signaling pathways during Xenopus development",
      "volume": "6",
      "author": "Sokol",
      "year": "1996",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1016/S0959-437X(96)80065-7",
      "article-title": "Early mouse development",
      "volume": "6",
      "author": "St-Jacques",
      "year": "1996",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "73",
      "DOI": "10.1006/dbio.1994.1297",
      "article-title": "Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled",
      "volume": "166",
      "author": "Sussman",
      "year": "1994",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "10255",
      "DOI": "10.1073/pnas.91.22.10255",
      "article-title": "A truncated bone morphogenetic protein receptor affects dorsal\u2013ventral patterning in the early Xenopus embryo",
      "volume": "91",
      "author": "Suzuki",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "773",
      "DOI": "10.1101/gr.6.9.773",
      "article-title": "Lessons learned, promises kept",
      "volume": "6",
      "author": "Tilghman",
      "year": "1996",
      "journal-title": "Genome Res."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "3038",
      "DOI": "10.1101/gad.9.24.3038",
      "article-title": "Molecular mechanisms of Spemann's organizer formation",
      "volume": "9",
      "author": "Watabe",
      "year": "1995",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "172",
      "DOI": "10.1038/383172a0",
      "article-title": "RGS family members",
      "volume": "383",
      "author": "Watson",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB52",
      "unstructured": "Wilkinson, D.G. (1992). Whole mount in situ hybridization of vertebrate embryos. In In Situ Hybridization: a Practical Approach, D.G. Wilkinson, ed. (Oxford: IRL Press), pp. 75\u201383."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "2987",
      "DOI": "10.1242/dev.122.10.2987",
      "article-title": "Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos",
      "volume": "122",
      "author": "Wylie",
      "year": "1996",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "1087",
      "DOI": "10.1101/gad.9.9.1087",
      "article-title": "The dishevelled protein is modified by wingless signaling in Drosophila",
      "volume": "9",
      "author": "Yanagawa",
      "year": "1995",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "1443",
      "DOI": "10.1101/gad.10.12.1443",
      "article-title": "The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3",
      "volume": "10",
      "author": "Yost",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/S0092-8674(00)80324-4_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1242/dev.115.3.689",
      "article-title": "Activin can generate ectopic axial structures in chick blastoderm explants",
      "volume": "115",
      "author": "Ziv",
      "year": "1992",
      "journal-title": "Development"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400803244?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0092867400803244?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        30
      ]
    ],
    "date-time": "2023-10-30T23:29:38Z",
    "timestamp": 1698708578000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0092867400803244"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        7
      ]
    ]
  },
  "references-count": 56,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1997,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "S0092867400803244"
  ],
  "URL": "http://dx.doi.org/10.1016/S0092-8674(00)80324-4",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1997,
        7
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Cell",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0092-8674(00)80324-4",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 1997 Cell Press. Published by Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}