DOI: 10.1016/s0070-2153(06)76003-3. Aggregate‐Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications

Aggregate‐Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications

10.1016/s0070-2153(06)76003-3

Crossref book-chapter

Elsevier

Current Topics in Developmental Biology (78)

Bibliography

Williams, A., Jahreiss, L., Sarkar, S., Saiki, S., Menzies, F. M., Ravikumar, B., & Rubinsztein, D. C. (2006). AggregateâProne Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications. Current Topics in Developmental Biology, 89â101.

Authors 7

Andrea Williams (first)
Luca Jahreiss (additional)
Sovan Sarkar (additional)
Shinji Saiki (additional)
Fiona M. Menzies (additional)
Brinda Ravikumar (additional)
David C. Rubinsztein (additional)

References 41 Referenced 231

10.1038/nature02998 / Nature / Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death by Arrasate (2004)
10.1093/hmg/ddi458 / Hum. Mol. Genet. / Rapamycin alleviates toxicity of different aggregate‐prone proteins by Berger (2006)
10.1016/0092-8674(89)90026-3 / Cell / Neural and developmental actions of lithium: A unifying hypothesis by Berridge (1989)
10.1038/nrc1362 / Nat. Rev. Cancer / The TOR pathway: A target for cancer therapy by Bjornsti (2004)
10.1200/JCO.2005.23.622 / J. Clin. Oncol. / Phase II trial of temsirolimus (CCI‐779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study by Galanis (2005)
10.1038/nature02263 / Nature / Protein degradation and protection against misfolded or damaged proteins by Goldberg (2003)
10.1146/annurev.biochem.67.1.425 / Annu. Rev. Biochem. / The ubiquitin system by Hershko (1998)
10.1146/annurev.cellbio.19.110701.154617 / Annu. Rev. Cell Dev. Biol. / Regulation of membrane protein transport by ubiquitin and ubiquitin‐binding proteins by Hicke (2003)
10.1038/sj.emboj.7600426 / EMBO J. / Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg (2004)
10.1016/0092-8674(93)90585-E / Cell / A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes (1993)
10.1073/pnas.0505801102 / Proc. Natl. Acad. Sci. USA / Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation by Iwata (2005)
10.1146/annurev.biochem.69.1.303 / Annu. Rev. Biochem. / Autophagy, cytoplasm‐to‐vacuole targeting pathway, and pexophagy in yeast and mammalian cells by Kim (2000)
10.1146/annurev.cellbio.15.1.1 / Annu. Rev. Cell Dev. Biol. / Vacuolar import of proteins and organelles from the cytoplasm by Klionsky (1999)
10.1111/j.1440-1797.2005.00493.x / Nephrology (Carlton) / Sirolimus: Its role in nephrology by Lee (2005)
10.1016/S1534-5807(04)00099-1 / Dev. Cell / Development by self‐digestion: Molecular mechanisms and biological functions of autophagy by Levine (2004)
10.1016/S1097-2765(02)00602-0 / Mol. Cell / Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions by Lunkes (2002)
10.1083/jcb.200412071 / J. Cell Biol. / Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: Implications for mutant huntingtin toxicity by Luo (2005)
{'key': '10.1016/S0070-2153(06)76003-3_bib0017', 'first-page': '8458', 'article-title': 'Purification, structure, and catalytic properties of L‐myo‐inositol‐1‐phosphate synthase from rat testis', 'volume': '255', 'author': 'Maeda', 'year': '1980', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / Purification, structure, and catalytic properties of L‐myo‐inositol‐1‐phosphate synthase from rat testis by Maeda (1980)
10.1016/j.biocel.2004.04.010 / Int. J. Biochem. Cell Biol. / Pathophysiology of chaperone‐mediated autophagy by Massey (2004)
10.1093/hmg/9.14.2197 / Hum. Mol. Genet. / CREB‐binding protein sequestration by expanded polyglutamine by McCampbell (2000)
10.1016/j.biocel.2004.02.005 / Int. J. Biochem. Cell Biol. / Methods for monitoring autophagy by Mizushima (2004)
10.1093/hmg/10.14.1441 / Hum. Mol. Genet. / SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA‐binding protein by Nakamura (2001)
10.1126/science.1056784 / Science / Interference by huntingtin and atrophin‐1 with cbp‐mediated transcription leading to cellular toxicity by Nucifora (2001)
10.1093/hmg/ddg346 / Hum. Mol. Genet. / Autophagy regulates the processing of amino terminal huntingtin fragments by Qin (2003)
10.1093/hmg/11.9.1107 / Hum. Mol. Genet. / Aggregate‐prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy by Ravikumar (2002)
10.1038/ng1362 / Nat. Genet. / Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease by Ravikumar (2004)
10.1093/hmg/ddl036 / Hum. Mol. Genet. / Rapamycin pre‐treatment protects against apoptosis by Ravikumar (2006)
10.1128/EC.01.1.11-21.2002 / Eukaryot. Cell / Autophagy in the eukaryotic cell by Reggiori (2002)
{'key': '10.1016/S0070-2153(06)76003-3_bib0028', 'first-page': '16', 'article-title': 'Phenotypic characterization of individuals with 30–40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36–39 repeats', 'volume': '59', 'author': 'Rubinsztein', 'year': '1996', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Phenotypic characterization of individuals with 30–40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36–39 repeats by Rubinsztein (1996)
10.1002/ana.410420411 / Ann. Neurol. / Huntingtin localization in brains of normal and Huntington's disease patients by Sapp (1997)
10.1083/jcb.200504035 / J. Cell Biol. / Lithium induces autophagy by inhibiting inositol monophosphatase by Sarkar (2005)
10.1074/jbc.M600364200 / J. Biol. Chem. / Regulation of intracellular accumulation of mutant huntingtin by Beclin 1 by Shibata (2006)
10.1034/j.1600-0854.2001.20802.x / Traffic / Approaching the molecular mechanism of autophagy by Stromhaug (2001)
10.1016/S1097-2765(04)00151-0 / Mol. Cell / Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine‐containing proteins by Venkatraman (2004)
10.1093/hmg/11.22.2689 / Hum. Mol. Genet. / Aggregate formation inhibits proteasomal degradation of polyglutamine proteins by Verhoef (2002)
10.1074/jbc.M300227200 / J. Biol. Chem. / Alpha‐synuclein is degraded by both autophagy and the proteasome by Webb (2003)
10.1523/JNEUROSCI.22-18-07862.2002 / J. Neurosci. / Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease by Wellington (2002)
10.1038/417292a / Nature / A common mechanism of action for three mood‐stabilizing drugs by Williams (2002)
10.1016/j.cell.2006.01.016 / Cell / TOR signaling in growth and metabolism by Wullschleger (2006)
10.1038/sj.cdd.4401765 / Cell. Death Differ. / Autophagy: Molecular machinery for self‐eating by Yorimitsu (2005)
10.1146/annurev.neuro.23.1.217 / Annu. Rev. Neurosci. / Glutamine repeats and neurodegeneration by Zoghbi (2000)

Dates

Type	When
Created	18 years, 9 months ago (Nov. 20, 2006, 1:46 p.m.)
Deposited	6 years, 4 months ago (April 22, 2019, 7:56 a.m.)
Indexed	5 days, 15 hours ago (Aug. 28, 2025, 8:38 a.m.)
Issued	19 years, 8 months ago (Jan. 1, 2006)
Published	19 years, 8 months ago (Jan. 1, 2006)
Published Print	19 years, 8 months ago (Jan. 1, 2006)

Funders 0

None

BibTeX

@inbook{Williams_2006, title={Aggregate‐Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications}, ISSN={0070-2153}, url={http://dx.doi.org/10.1016/s0070-2153(06)76003-3}, DOI={10.1016/s0070-2153(06)76003-3}, booktitle={Current Topics in Developmental Biology}, publisher={Elsevier}, author={Williams, Andrea and Jahreiss, Luca and Sarkar, Sovan and Saiki, Shinji and Menzies, Fiona M. and Ravikumar, Brinda and Rubinsztein, David C.}, year={2006}, pages={89–101} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        28
      ]
    ],
    "date-time": "2025-08-28T12:38:16Z",
    "timestamp": 1756384696138
  },
  "reference-count": 41,
  "publisher": "Elsevier",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006
      ]
    ]
  },
  "DOI": "10.1016/s0070-2153(06)76003-3",
  "type": "book-chapter",
  "created": {
    "date-parts": [
      [
        2006,
        11,
        20
      ]
    ],
    "date-time": "2006-11-20T18:46:55Z",
    "timestamp": 1164048415000
  },
  "page": "89-101",
  "source": "Crossref",
  "is-referenced-by-count": 231,
  "title": "Aggregate\u2010Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications",
  "prefix": "10.1016",
  "author": [
    {
      "given": "Andrea",
      "family": "Williams",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Luca",
      "family": "Jahreiss",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Sovan",
      "family": "Sarkar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shinji",
      "family": "Saiki",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fiona M.",
      "family": "Menzies",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Brinda",
      "family": "Ravikumar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David C.",
      "family": "Rubinsztein",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0001",
      "doi-asserted-by": "crossref",
      "first-page": "805",
      "DOI": "10.1038/nature02998",
      "article-title": "Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death",
      "volume": "431",
      "author": "Arrasate",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0002",
      "doi-asserted-by": "crossref",
      "first-page": "433",
      "DOI": "10.1093/hmg/ddi458",
      "article-title": "Rapamycin alleviates toxicity of different aggregate\u2010prone proteins",
      "volume": "15",
      "author": "Berger",
      "year": "2006",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0003",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1016/0092-8674(89)90026-3",
      "article-title": "Neural and developmental actions of lithium: A unifying hypothesis",
      "volume": "59",
      "author": "Berridge",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0004",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1038/nrc1362",
      "article-title": "The TOR pathway: A target for cancer therapy",
      "volume": "4",
      "author": "Bjornsti",
      "year": "2004",
      "journal-title": "Nat. Rev. Cancer"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0005",
      "doi-asserted-by": "crossref",
      "first-page": "5294",
      "DOI": "10.1200/JCO.2005.23.622",
      "article-title": "Phase II trial of temsirolimus (CCI\u2010779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study",
      "volume": "23",
      "author": "Galanis",
      "year": "2005",
      "journal-title": "J. Clin. Oncol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0006",
      "doi-asserted-by": "crossref",
      "first-page": "895",
      "DOI": "10.1038/nature02263",
      "article-title": "Protein degradation and protection against misfolded or damaged proteins",
      "volume": "426",
      "author": "Goldberg",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0007",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1146/annurev.biochem.67.1.425",
      "article-title": "The ubiquitin system",
      "volume": "67",
      "author": "Hershko",
      "year": "1998",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0008",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1146/annurev.cellbio.19.110701.154617",
      "article-title": "Regulation of membrane protein transport by ubiquitin and ubiquitin\u2010binding proteins",
      "volume": "19",
      "author": "Hicke",
      "year": "2003",
      "journal-title": "Annu. Rev. Cell Dev. Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0009",
      "doi-asserted-by": "crossref",
      "first-page": "4307",
      "DOI": "10.1038/sj.emboj.7600426",
      "article-title": "Inefficient degradation of truncated polyglutamine proteins by the proteasome",
      "volume": "23",
      "author": "Holmberg",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib9001",
      "doi-asserted-by": "crossref",
      "first-page": "971",
      "DOI": "10.1016/0092-8674(93)90585-E",
      "article-title": "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes",
      "volume": "72",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0010",
      "doi-asserted-by": "crossref",
      "first-page": "13135",
      "DOI": "10.1073/pnas.0505801102",
      "article-title": "Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation",
      "volume": "102",
      "author": "Iwata",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0011",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1146/annurev.biochem.69.1.303",
      "article-title": "Autophagy, cytoplasm\u2010to\u2010vacuole targeting pathway, and pexophagy in yeast and mammalian cells",
      "volume": "69",
      "author": "Kim",
      "year": "2000",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0012",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1146/annurev.cellbio.15.1.1",
      "article-title": "Vacuolar import of proteins and organelles from the cytoplasm",
      "volume": "15",
      "author": "Klionsky",
      "year": "1999",
      "journal-title": "Annu. Rev. Cell Dev. Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0013",
      "doi-asserted-by": "crossref",
      "first-page": "606",
      "DOI": "10.1111/j.1440-1797.2005.00493.x",
      "article-title": "Sirolimus: Its role in nephrology",
      "volume": "10",
      "author": "Lee",
      "year": "2005",
      "journal-title": "Nephrology (Carlton)"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0014",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1016/S1534-5807(04)00099-1",
      "article-title": "Development by self\u2010digestion: Molecular mechanisms and biological functions of autophagy",
      "volume": "6",
      "author": "Levine",
      "year": "2004",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0015",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1016/S1097-2765(02)00602-0",
      "article-title": "Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions",
      "volume": "10",
      "author": "Lunkes",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0016",
      "doi-asserted-by": "crossref",
      "first-page": "647",
      "DOI": "10.1083/jcb.200412071",
      "article-title": "Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: Implications for mutant huntingtin toxicity",
      "volume": "169",
      "author": "Luo",
      "year": "2005",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0017",
      "first-page": "8458",
      "article-title": "Purification, structure, and catalytic properties of L\u2010myo\u2010inositol\u20101\u2010phosphate synthase from rat testis",
      "volume": "255",
      "author": "Maeda",
      "year": "1980",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0018",
      "doi-asserted-by": "crossref",
      "first-page": "2420",
      "DOI": "10.1016/j.biocel.2004.04.010",
      "article-title": "Pathophysiology of chaperone\u2010mediated autophagy",
      "volume": "36",
      "author": "Massey",
      "year": "2004",
      "journal-title": "Int. J. Biochem. Cell Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0019",
      "doi-asserted-by": "crossref",
      "first-page": "2197",
      "DOI": "10.1093/hmg/9.14.2197",
      "article-title": "CREB\u2010binding protein sequestration by expanded polyglutamine",
      "volume": "9",
      "author": "McCampbell",
      "year": "2000",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0020",
      "doi-asserted-by": "crossref",
      "first-page": "2491",
      "DOI": "10.1016/j.biocel.2004.02.005",
      "article-title": "Methods for monitoring autophagy",
      "volume": "36",
      "author": "Mizushima",
      "year": "2004",
      "journal-title": "Int. J. Biochem. Cell Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0021",
      "doi-asserted-by": "crossref",
      "first-page": "1441",
      "DOI": "10.1093/hmg/10.14.1441",
      "article-title": "SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA\u2010binding protein",
      "volume": "10",
      "author": "Nakamura",
      "year": "2001",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0022",
      "doi-asserted-by": "crossref",
      "first-page": "2423",
      "DOI": "10.1126/science.1056784",
      "article-title": "Interference by huntingtin and atrophin\u20101 with cbp\u2010mediated transcription leading to cellular toxicity",
      "volume": "291",
      "author": "Nucifora",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0023",
      "doi-asserted-by": "crossref",
      "first-page": "3231",
      "DOI": "10.1093/hmg/ddg346",
      "article-title": "Autophagy regulates the processing of amino terminal huntingtin fragments",
      "volume": "12",
      "author": "Qin",
      "year": "2003",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0024",
      "doi-asserted-by": "crossref",
      "first-page": "1107",
      "DOI": "10.1093/hmg/11.9.1107",
      "article-title": "Aggregate\u2010prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy",
      "volume": "11",
      "author": "Ravikumar",
      "year": "2002",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0025",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1038/ng1362",
      "article-title": "Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease",
      "volume": "36",
      "author": "Ravikumar",
      "year": "2004",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0026",
      "doi-asserted-by": "crossref",
      "first-page": "1209",
      "DOI": "10.1093/hmg/ddl036",
      "article-title": "Rapamycin pre\u2010treatment protects against apoptosis",
      "volume": "15",
      "author": "Ravikumar",
      "year": "2006",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0027",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1128/EC.01.1.11-21.2002",
      "article-title": "Autophagy in the eukaryotic cell",
      "volume": "1",
      "author": "Reggiori",
      "year": "2002",
      "journal-title": "Eukaryot. Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0028",
      "first-page": "16",
      "article-title": "Phenotypic characterization of individuals with 30\u201340 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36\u201339 repeats",
      "volume": "59",
      "author": "Rubinsztein",
      "year": "1996",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0029",
      "doi-asserted-by": "crossref",
      "first-page": "604",
      "DOI": "10.1002/ana.410420411",
      "article-title": "Huntingtin localization in brains of normal and Huntington's disease patients",
      "volume": "42",
      "author": "Sapp",
      "year": "1997",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0030",
      "doi-asserted-by": "crossref",
      "first-page": "1101",
      "DOI": "10.1083/jcb.200504035",
      "article-title": "Lithium induces autophagy by inhibiting inositol monophosphatase",
      "volume": "170",
      "author": "Sarkar",
      "year": "2005",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0031",
      "doi-asserted-by": "crossref",
      "first-page": "14474",
      "DOI": "10.1074/jbc.M600364200",
      "article-title": "Regulation of intracellular accumulation of mutant huntingtin by Beclin 1",
      "volume": "281",
      "author": "Shibata",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0032",
      "doi-asserted-by": "crossref",
      "first-page": "524",
      "DOI": "10.1034/j.1600-0854.2001.20802.x",
      "article-title": "Approaching the molecular mechanism of autophagy",
      "volume": "2",
      "author": "Stromhaug",
      "year": "2001",
      "journal-title": "Traffic"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0033",
      "doi-asserted-by": "crossref",
      "first-page": "95",
      "DOI": "10.1016/S1097-2765(04)00151-0",
      "article-title": "Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine\u2010containing proteins",
      "volume": "14",
      "author": "Venkatraman",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0034",
      "doi-asserted-by": "crossref",
      "first-page": "2689",
      "DOI": "10.1093/hmg/11.22.2689",
      "article-title": "Aggregate formation inhibits proteasomal degradation of polyglutamine proteins",
      "volume": "11",
      "author": "Verhoef",
      "year": "2002",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0035",
      "doi-asserted-by": "crossref",
      "first-page": "25009",
      "DOI": "10.1074/jbc.M300227200",
      "article-title": "Alpha\u2010synuclein is degraded by both autophagy and the proteasome",
      "volume": "278",
      "author": "Webb",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0036",
      "doi-asserted-by": "crossref",
      "first-page": "7862",
      "DOI": "10.1523/JNEUROSCI.22-18-07862.2002",
      "article-title": "Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease",
      "volume": "22",
      "author": "Wellington",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0037",
      "doi-asserted-by": "crossref",
      "first-page": "292",
      "DOI": "10.1038/417292a",
      "article-title": "A common mechanism of action for three mood\u2010stabilizing drugs",
      "volume": "417",
      "author": "Williams",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0038",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1016/j.cell.2006.01.016",
      "article-title": "TOR signaling in growth and metabolism",
      "volume": "124",
      "author": "Wullschleger",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "issue": "Suppl. 2",
      "key": "10.1016/S0070-2153(06)76003-3_bib0039",
      "doi-asserted-by": "crossref",
      "first-page": "1542",
      "DOI": "10.1038/sj.cdd.4401765",
      "article-title": "Autophagy: Molecular machinery for self\u2010eating",
      "volume": "12",
      "author": "Yorimitsu",
      "year": "2005",
      "journal-title": "Cell. Death Differ."
    },
    {
      "key": "10.1016/S0070-2153(06)76003-3_bib0040",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1146/annurev.neuro.23.1.217",
      "article-title": "Glutamine repeats and neurodegeneration",
      "volume": "23",
      "author": "Zoghbi",
      "year": "2000",
      "journal-title": "Annu. Rev. Neurosci."
    }
  ],
  "container-title": "Current Topics in Developmental Biology",
  "original-title": [],
  "deposited": {
    "date-parts": [
      [
        2019,
        4,
        22
      ]
    ],
    "date-time": "2019-04-22T11:56:19Z",
    "timestamp": 1555934179000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0070215306760033"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006
      ]
    ]
  },
  "references-count": 41,
  "URL": "http://dx.doi.org/10.1016/S0070-2153(06)76003-3",
  "relation": {},
  "ISSN": [
    "0070-2153"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2006
      ]
    ]
  }
}