DOI: 10.1016/s0049-3848(00)00258-9. Secretion, γ-carboxylation, and Endoplasmic Reticulum-associated Degradation of Chimeras with Mutually Exchanged Gla Domain Between Human Protein C and Prothrombin

Secretion, γ-carboxylation, and Endoplasmic Reticulum-associated Degradation of Chimeras with Mutually Exchanged Gla Domain Between Human Protein C and Prothrombin

10.1016/s0049-3848(00)00258-9

Crossref journal-article

Elsevier BV

Thrombosis Research (78)

Bibliography

Tokunaga, F., Takeuchi, S., Omura, S., Arvan, P., & Koide, T. (2000). Secretion, Î³-carboxylation, and Endoplasmic Reticulum-associated Degradation of Chimeras with Mutually Exchanged Gla Domain Between Human Protein C and Prothrombin. Thrombosis Research, 99(5), 511â521.

Authors 5

F Tokunaga (first)
S Takeuchi (additional)
S Omura (additional)
P Arvan (additional)
T Koide (additional)

References 32 Referenced 5

10.1146/annurev.bi.54.070185.002331 / Ann Rev Biochem / Vitamin K-dependent carboxylase by Suttie (1985)
10.1096/fasebj.7.5.8462786 / FASEB J / Synthesis of vitamin K-dependent proteins by Suttie (1993)
10.1172/JCI108712 / J Clin Invest / Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B by Thompson (1977)
10.1182/blood.V62.4.784.784 / Blood / Quantitation of factor VII in the plasma of normal and warfarin-treated individuals by radioimmunoassay by Fair (1983)
10.1111/j.1365-2141.1984.tb08523.x / British J Haematol / Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy by Vigano (1984)
10.1073/pnas.82.14.4673 / Proc Natl Acad Sci USA / The nucleotide sequence of the gene for human protein C by Foster (1985)
10.1021/bi00278a008 / Biochemistry / Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin by Degen (1983)
10.3181/00379727-148-38492 / Proc Soc Exp Biol Med / Plasma abnormal prothrombin and microsomal prothrombin precursor in various species by Carlisle (1975)
10.1182/blood.V84.1.169.169 / Blood / Prothrombin synthesis and degradation in rat hepatoma (H-35) cells by Zhang (1994)
10.1055/s-0038-1650520 / Thromb Haemostas / Differential effects of warfarin on the intracellular processing of vitamin K-dependent proteins by Wu (1996)
10.1073/pnas.94.25.13654 / Proc Natl Acad Sci USA / Structural features of the kringle domain determine the intracellular degradation of under-gamma-carboxylated prothrombin by Wu (1997)
10.1182/blood.V64.1.194.194 / Blood / Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III by Fair (1984)
10.1055/s-0038-1656315 / Thromb Haemostas / The effects of vitamin K1 and warfarin on prothrombin expression in human hepatoblastoma (HepG2) cells by Jamison (1992)
10.1016/S0021-9258(19)38606-5 / J Biol Chem / βprotein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites by Miletich (1990)
10.1016/S0021-9258(18)41833-9 / J Biol Chem / Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor by McClure (1992)
10.1021/bi00004a009 / Biochemistry / Warfarin causes the degradation of protein C precursor in the endoplasmic reticulum by Tokunaga (1995)
10.7164/antibiotics.44.113 / J Antibiotics / Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells by Omura (1991)
{'key': '10.1016/S0049-3848(00)00258-9_BIB18', 'first-page': '874', 'article-title': 'A PCR-based method for site-specific domain replacement that does not require restriction recognition sequences', 'volume': '15', 'author': 'Zhong', 'year': '1993', 'journal-title': 'Biotechniques'} / Biotechniques / A PCR-based method for site-specific domain replacement that does not require restriction recognition sequences by Zhong (1993)
{'key': '10.1016/S0049-3848(00)00258-9_BIB19', 'first-page': '2745', 'article-title': 'High-efficiency transformation of mammalian cells by plasmid DNA', 'volume': '7', 'author': 'Chen', 'year': '1987', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / High-efficiency transformation of mammalian cells by plasmid DNA by Chen (1987)
10.1111/j.1432-1033.1979.tb12956.x / Eur J Biochem / Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin by Seglen (1979)
10.1093/oxfordjournals.jbchem.a021922 / J Biochem (Tokyo) / Proteasomes by Tanaka (1998)
10.1074/jbc.270.23.13652 / J Biol Chem / Thermal stability and domain-domain interactions in natural and recombinant protein C by Medved (1995)
10.1016/S0021-9258(18)92888-7 / J Biol Chem / Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin by Grinnell (1991)
10.1016/S0962-8924(97)01032-5 / Trends Cell Biol / Calnexin, calreticulin and the folding of glycoproteins by Helenius (1997)
10.1021/bi00185a030 / Biochemistry / Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein C. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium by Christiansen (1994)
10.1055/s-0038-1656079 / Thromb Haemostas / Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII by Geng (1997)
10.1016/S0021-9258(18)68208-0 / J Biol Chem / Phospholipid binding properties of bovine prothrombin peptide residues 1–45 by Pollock (1988)
10.1021/bi00124a016 / Biochemistry / The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1 by Soriano-Garcia (1992)
10.1016/S0014-5793(97)00745-X / FEBS Lett / Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors by Tokunaga (1997)
10.1016/S0092-8674(00)81881-4 / Cell / ER quality control by Kopito (1997)
10.1126/science.286.5446.1882 / Science / Setting the standards by Ellgaard (1999)
10.1016/S0962-8924(97)01020-9 / Trends Cell Biol / ER-associated and proteasome-mediated protein degradation. How two topologically restricted events came together by Brodsky (1997)

Dates

Type	When
Created	23 years ago (July 25, 2002, 10:21 a.m.)
Deposited	3 years, 1 month ago (June 25, 2022, 9:33 a.m.)
Indexed	1 year, 11 months ago (Sept. 13, 2023, 11:12 a.m.)
Issued	24 years, 11 months ago (Sept. 1, 2000)
Published	24 years, 11 months ago (Sept. 1, 2000)
Published Print	24 years, 11 months ago (Sept. 1, 2000)

Funders 0

None

BibTeX

@article{Tokunaga_2000, title={Secretion, γ-carboxylation, and Endoplasmic Reticulum-associated Degradation of Chimeras with Mutually Exchanged Gla Domain Between Human Protein C and Prothrombin}, volume={99}, ISSN={0049-3848}, url={http://dx.doi.org/10.1016/s0049-3848(00)00258-9}, DOI={10.1016/s0049-3848(00)00258-9}, number={5}, journal={Thrombosis Research}, publisher={Elsevier BV}, author={Tokunaga, F and Takeuchi, S and Omura, S and Arvan, P and Koide, T}, year={2000}, month=sep, pages={511–521} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        9,
        13
      ]
    ],
    "date-time": "2023-09-13T15:12:31Z",
    "timestamp": 1694617951603
  },
  "reference-count": 32,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            9,
            1
          ]
        ],
        "date-time": "2000-09-01T00:00:00Z",
        "timestamp": 967766400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  },
  "DOI": "10.1016/s0049-3848(00)00258-9",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T14:21:37Z",
    "timestamp": 1027606897000
  },
  "page": "511-521",
  "source": "Crossref",
  "is-referenced-by-count": 5,
  "title": "Secretion, \u03b3-carboxylation, and Endoplasmic Reticulum-associated Degradation of Chimeras with Mutually Exchanged Gla Domain Between Human Protein C and Prothrombin",
  "prefix": "10.1016",
  "volume": "99",
  "author": [
    {
      "given": "F",
      "family": "Tokunaga",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "S",
      "family": "Takeuchi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S",
      "family": "Omura",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "P",
      "family": "Arvan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T",
      "family": "Koide",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "459",
      "DOI": "10.1146/annurev.bi.54.070185.002331",
      "article-title": "Vitamin K-dependent carboxylase",
      "volume": "54",
      "author": "Suttie",
      "year": "1985",
      "journal-title": "Ann Rev Biochem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1096/fasebj.7.5.8462786",
      "article-title": "Synthesis of vitamin K-dependent proteins",
      "volume": "7",
      "author": "Suttie",
      "year": "1993",
      "journal-title": "FASEB J"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "900",
      "DOI": "10.1172/JCI108712",
      "article-title": "Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B",
      "volume": "59",
      "author": "Thompson",
      "year": "1977",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1182/blood.V62.4.784.784",
      "article-title": "Quantitation of factor VII in the plasma of normal and warfarin-treated individuals by radioimmunoassay",
      "volume": "62",
      "author": "Fair",
      "year": "1983",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1111/j.1365-2141.1984.tb08523.x",
      "article-title": "Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy",
      "volume": "57",
      "author": "Vigano",
      "year": "1984",
      "journal-title": "British J Haematol"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "4673",
      "DOI": "10.1073/pnas.82.14.4673",
      "article-title": "The nucleotide sequence of the gene for human protein C",
      "volume": "82",
      "author": "Foster",
      "year": "1985",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "2087",
      "DOI": "10.1021/bi00278a008",
      "article-title": "Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin",
      "volume": "22",
      "author": "Degen",
      "year": "1983",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.3181/00379727-148-38492",
      "article-title": "Plasma abnormal prothrombin and microsomal prothrombin precursor in various species",
      "volume": "148",
      "author": "Carlisle",
      "year": "1975",
      "journal-title": "Proc Soc Exp Biol Med"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1182/blood.V84.1.169.169",
      "article-title": "Prothrombin synthesis and degradation in rat hepatoma (H-35) cells",
      "volume": "84",
      "author": "Zhang",
      "year": "1994",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "46",
      "DOI": "10.1055/s-0038-1650520",
      "article-title": "Differential effects of warfarin on the intracellular processing of vitamin K-dependent proteins",
      "volume": "76",
      "author": "Wu",
      "year": "1996",
      "journal-title": "Thromb Haemostas"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "13654",
      "DOI": "10.1073/pnas.94.25.13654",
      "article-title": "Structural features of the kringle domain determine the intracellular degradation of under-gamma-carboxylated prothrombin",
      "volume": "94",
      "author": "Wu",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1182/blood.V64.1.194.194",
      "article-title": "Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III",
      "volume": "64",
      "author": "Fair",
      "year": "1984",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "40",
      "DOI": "10.1055/s-0038-1656315",
      "article-title": "The effects of vitamin K1 and warfarin on prothrombin expression in human hepatoblastoma (HepG2) cells",
      "volume": "68",
      "author": "Jamison",
      "year": "1992",
      "journal-title": "Thromb Haemostas"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "11397",
      "DOI": "10.1016/S0021-9258(19)38606-5",
      "article-title": "\u03b2protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites",
      "volume": "265",
      "author": "Miletich",
      "year": "1990",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "19710",
      "DOI": "10.1016/S0021-9258(18)41833-9",
      "article-title": "Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor",
      "volume": "267",
      "author": "McClure",
      "year": "1992",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1163",
      "DOI": "10.1021/bi00004a009",
      "article-title": "Warfarin causes the degradation of protein C precursor in the endoplasmic reticulum",
      "volume": "34",
      "author": "Tokunaga",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.7164/antibiotics.44.113",
      "article-title": "Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells",
      "volume": "44",
      "author": "Omura",
      "year": "1991",
      "journal-title": "J Antibiotics"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB18",
      "first-page": "874",
      "article-title": "A PCR-based method for site-specific domain replacement that does not require restriction recognition sequences",
      "volume": "15",
      "author": "Zhong",
      "year": "1993",
      "journal-title": "Biotechniques"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB19",
      "first-page": "2745",
      "article-title": "High-efficiency transformation of mammalian cells by plasmid DNA",
      "volume": "7",
      "author": "Chen",
      "year": "1987",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1111/j.1432-1033.1979.tb12956.x",
      "article-title": "Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin",
      "volume": "95",
      "author": "Seglen",
      "year": "1979",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1093/oxfordjournals.jbchem.a021922",
      "article-title": "Proteasomes",
      "volume": "123",
      "author": "Tanaka",
      "year": "1998",
      "journal-title": "J Biochem (Tokyo)"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "13652",
      "DOI": "10.1074/jbc.270.23.13652",
      "article-title": "Thermal stability and domain-domain interactions in natural and recombinant protein C",
      "volume": "270",
      "author": "Medved",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "9778",
      "DOI": "10.1016/S0021-9258(18)92888-7",
      "article-title": "Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin",
      "volume": "266",
      "author": "Grinnell",
      "year": "1991",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/S0962-8924(97)01032-5",
      "article-title": "Calnexin, calreticulin and the folding of glycoproteins",
      "volume": "7",
      "author": "Helenius",
      "year": "1997",
      "journal-title": "Trends Cell Biol"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "5901",
      "DOI": "10.1021/bi00185a030",
      "article-title": "Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein C. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium",
      "volume": "33",
      "author": "Christiansen",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "926",
      "DOI": "10.1055/s-0038-1656079",
      "article-title": "Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII",
      "volume": "77",
      "author": "Geng",
      "year": "1997",
      "journal-title": "Thromb Haemostas"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "14216",
      "DOI": "10.1016/S0021-9258(18)68208-0",
      "article-title": "Phospholipid binding properties of bovine prothrombin peptide residues 1\u201345",
      "volume": "263",
      "author": "Pollock",
      "year": "1988",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "2554",
      "DOI": "10.1021/bi00124a016",
      "article-title": "The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1",
      "volume": "31",
      "author": "Soriano-Garcia",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1016/S0014-5793(97)00745-X",
      "article-title": "Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors",
      "volume": "412",
      "author": "Tokunaga",
      "year": "1997",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "427",
      "DOI": "10.1016/S0092-8674(00)81881-4",
      "article-title": "ER quality control",
      "volume": "88",
      "author": "Kopito",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1882",
      "DOI": "10.1126/science.286.5446.1882",
      "article-title": "Setting the standards",
      "volume": "286",
      "author": "Ellgaard",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0049-3848(00)00258-9_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/S0962-8924(97)01020-9",
      "article-title": "ER-associated and proteasome-mediated protein degradation. How two topologically restricted events came together",
      "volume": "7",
      "author": "Brodsky",
      "year": "1997",
      "journal-title": "Trends Cell Biol"
    }
  ],
  "container-title": "Thrombosis Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0049384800002589?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0049384800002589?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        6,
        25
      ]
    ],
    "date-time": "2022-06-25T13:33:09Z",
    "timestamp": 1656163989000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0049384800002589"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          2000,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "S0049384800002589"
  ],
  "URL": "http://dx.doi.org/10.1016/S0049-3848(00)00258-9",
  "relation": {},
  "ISSN": [
    "0049-3848"
  ],
  "subject": [],
  "container-title-short": "Thrombosis Research",
  "published": {
    "date-parts": [
      [
        2000,
        9
      ]
    ]
  }
}