Crossref journal-article
Elsevier BV
Neuropharmacology (78)
Bibliography

Gasparini, F., Lingenhöhl, K., Stoehr, N., Flor, P. J., Heinrich, M., Vranesic, I., Biollaz, M., Allgeier, H., Heckendorn, R., Urwyler, S., Varney, M. A., Johnson, E. C., Hess, S. D., Rao, S. P., Sacaan, A. I., Santori, E. M., Veliçelebi, G., & Kuhn, R. (1999). 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology, 38(10), 1493–1503.

Authors 18
  1. Fabrizio Gasparini (first)
  2. Kurt Lingenhöhl (additional)
  3. Natacha Stoehr (additional)
  4. Peter J Flor (additional)
  5. Micheline Heinrich (additional)
  6. Ivo Vranesic (additional)
  7. Michel Biollaz (additional)
  8. Hans Allgeier (additional)
  9. Roland Heckendorn (additional)
  10. Stephan Urwyler (additional)
  11. Mark A Varney (additional)
  12. Edwin C Johnson (additional)
  13. Stephen D Hess (additional)
  14. Sara P Rao (additional)
  15. Aida I Sacaan (additional)
  16. Emily M Santori (additional)
  17. Gönul Veliçelebi (additional)
  18. Rainer Kuhn (additional)
References 45 Referenced 620
  1. Annoura, H., Fukunaga, A., Vesugi, M., Tatsuoku, T., Horikawa, Y., 1996. A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorganic Med. Chem Letters. 6, 763–766. (10.1016/0960-894X(96)00104-7)
  2. Baker, R., Clark, B.P., Harris, J.R., Griffey, K.I., Kingston, A.E., Tizzano, J.P., 1998. LY393675, an a-substituted-cyclobutylglycine, is a potent group I metabotropic glutamate receptor antagonist. Soc. Neurosci. Abstr. 229.16.
  3. 10.1016/0306-4522(93)90400-A / Neuroscience / Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system by Birse (1993)
  4. Bowes, M., Panesar, M., Gentry, C., et al., 1999. Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist, methylphenylethynylpyridine, in rat models of inflammatory pain. Br. J. Pharm. (in press).
  5. 10.1038/347765a0 / Nature / Potassium conductances in hippocampal neurons blocked by excitatory amino acid transmitters by Charpak (1990)
  6. {'key': '10.1016/S0028-3908(99)00082-9_BIB6', 'first-page': '83', 'article-title': 'Receptors responsive to extracellular pyridine nucleotides', 'volume': '18', 'author': 'Communi', 'year': '1997', 'journal-title': 'TiPS'} / TiPS / Receptors responsive to extracellular pyridine nucleotides by Communi (1997)
  7. 10.1146/annurev.pharmtox.37.1.205 / Annu. Rev. Pharmacol. Toxicol. / Pharmacology and functions of metabotropic glutamate receptors by Conn (1997)
  8. 10.1016/0028-3908(95)00085-K / Neuropharmacology / Molecular and functional characterization of recombinant human glutamate receptor subtype 5 by Daggett (1995)
  9. Daggett, L.P., Jachec, C., Lin, F.F., et al., 1996. Functional characterization of two isoforms of the human GluR6 receptor and distribution of GluR6 RNA editing sites. Soc. Neurosci. Abstr. 236.11.
  10. 10.1152/jn.1991.66.1.40 / J. Neurophys. / Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition by Desai (1991)
  11. 10.1016/S0028-3908(97)00001-4 / Neuropharmacology / (R,S)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus by Doherty (1997)
  12. 10.1016/S0028-3908(96)00176-1 / Neuropharmacology / A novel splice variant of a metabotropic glutamate receptor, human mGluR7b by Flor (1997)
  13. Flor, P.J., Bruno, V., Battaglia, G., et al., 1998. Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist. Soc. Neurosci. Abstr. 431.11.
  14. {'key': '10.1016/S0028-3908(99)00082-9_BIB14', 'first-page': '1678', 'article-title': '(R,S)-4-Phosphophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist is anticonvulsive and neuroprotective in vivo', 'volume': '290', 'author': 'Gasparini', 'year': '1999', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / (R,S)-4-Phosphophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist is anticonvulsive and neuroprotective in vivo by Gasparini (1999)
  15. Gasparini, F., Lingenhoehl, K., Flor, P.J., et al., 1999b. Methylphenylethynylpyridine (MPEP): a novel potent, subtype-selective and systemically active antagonist at metabotropic glutamate receptor subtype 5. Br. J. Pharm. (in press).
  16. 10.1523/JNEUROSCI.15-10-06879.1995 / J. Neurosci. / Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 by Gereau IV (1995)
  17. 10.1016/S0028-3908(98)00132-4 / Neuropharmacology / Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1a metabotropic glutamate receptor by Hermans (1998)
  18. {'key': '10.1016/S0028-3908(99)00082-9_BIB18', 'first-page': '808', 'article-title': 'Cloning and functional characterization of human heteromeric N-methyl-d-aspartate receptors', 'volume': '278', 'author': 'Hess', 'year': '1996', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Cloning and functional characterization of human heteromeric N-methyl-d-aspartate receptors by Hess (1996)
  19. 10.1126/science.1709304 / Science / Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition by Hollmann (1991)
  20. 10.1097/00001756-199211000-00017 / NeuroReport / 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors by Ito (1992)
  21. 10.1021/jm00009a001 / J. Med. Chem. / Metabotropic glutamate receptors: novel targets for drug development by Knöpfel (1995)
  22. 10.1016/0922-4106(95)90054-3 / Eur. J. Pharmacol. / Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a by Knöpfel (1995)
  23. 10.1007/BF00171050 / Naunyn Schmiedebergs Arch. Pharmacol. / Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line by Laurie (1995)
  24. 10.1016/S0028-3908(96)00172-4 / Neuropharmacology / Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor by Laurie (1997)
  25. 10.1016/0024-3205(93)90301-I / Life Sci. / Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4 by Lazareno (1993)
  26. 10.1016/S0028-3908(97)00078-6 / Neuropharmacology / Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype by Lin (1997)
  27. 10.1016/S0028-3908(98)00062-8 / Neuropharmacology / Reevaluation of ACEA1021 as an antagonist at the strychnine-insensitive glycine site of the N-methyl-d-aspartate receptor by Lingenhöhl (1998)
  28. {'key': '10.1016/S0028-3908(99)00082-9_BIB28', 'first-page': '453', 'article-title': 'CPCCOEt, a non-competitive mGluR1 antagonist, inhibits receptor signaling without affecting glutamate binding', 'volume': '55', 'author': 'Litschig', 'year': '1999', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / CPCCOEt, a non-competitive mGluR1 antagonist, inhibits receptor signaling without affecting glutamate binding by Litschig (1999)
  29. 10.1152/jn.1993.69.3.1000 / J. Neurophys. / Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in the hippocampus by Liu (1993)
  30. 10.1016/0896-6273(92)90165-A / Neuron / Cellular localization of a metabotropic glutamate receptor in rat brain by Martin (1992)
  31. {'key': '10.1016/S0028-3908(99)00082-9_BIB31', 'first-page': '267', 'article-title': 'Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?', 'volume': '19', 'author': 'Nicoletti', 'year': '1997', 'journal-title': 'TiNS'} / TiNS / Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? by Nicoletti (1997)
  32. Pellicciari, R., Raimondo, M., Marinozzi, Natalini, B., Costantino, G., Thomsen, C., 1996. (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)glycine, a structurally new groupI metabotropic glutamate receptor antagonist. J. Med. Chem. 39, 2874–2876. (10.1021/jm960254o)
  33. 10.1002/cne.903550310 / J. Comp. Neurol. / Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain by Romano (1995)
  34. 10.1002/(SICI)1096-9861(19960408)367:3<403::AID-CNE6>3.0.CO;2-9 / J. Comp. Neurol. / Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in the rat brain: protein, mRNA splice variants, and regional distribution by Romano (1996)
  35. 10.1016/S0197-0186(97)00060-0 / Neurochem. Int. / (S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors: differential effects in neonatal rat brain regions by Sacaan (1998)
  36. 10.1248/cpb.36.3826 / Chem. Pharm. Bull. / Thermal rearrangements of cyclic amine ylides. VIII. Intramolecular cyclization of 2-ethynylpyridine N-ylides into indolizines and cycl[3.2.2]azines by Sashida (1988)
  37. 10.1046/j.1471-4159.1994.63020769.x / J. Neurochem. / 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus by Schoepp (1994)
  38. 10.1111/j.1476-5381.1996.tb15312.x / Br. J. Pharmacol. / Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes by Sekiyama (1996)
  39. 10.1016/0304-3940(93)90227-C / Neurosci. Lett. / Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5 in the brain by Shigemoto (1993)
  40. 10.1523/JNEUROSCI.17-19-07503.1997 / J. Neurosci. / Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus by Shigemoto (1997)
  41. 10.1016/S1044-5765(05)80002-8 / Semin. Neurosci. / Functional diversity of K+ currents in hippocampal pyramidal neurons by Storm (1993)
  42. Thomas, N.K., Woolley, M.L., Miller, J.C., et al., 1998. Novel phenylglycines as metabotropic glutamate receptor antagonist. Soc. Neurosci. Abstr. 229.15.
  43. Varney, M.A., Cosford, N., Jachec, C., et al., 1999. Characterization of SIB-1757 and SIB-1893: highly selective antagonists at metabotropic glutamate receptor subtype 5. Br. J. Pharm. (in press).
  44. 10.1016/S0076-6879(99)94005-3 / Meth. Enzymol. / Fluorescence techniques for measuring ion channel activity by Veliçelebi (1998)
  45. 10.1016/0165-6147(94)90028-0 / Trends Pharmacol. Sci. / Phenylglycine derivatives as antagonists of metabotropic glutamate receptors by Watkins (1994)
Dates
Type When
Created 23 years, 1 month ago (July 25, 2002, 2:55 p.m.)
Deposited 5 years, 7 months ago (Jan. 28, 2020, 2:46 p.m.)
Indexed 1 month, 1 week ago (July 20, 2025, 12:26 a.m.)
Issued 25 years, 11 months ago (Oct. 1, 1999)
Published 25 years, 11 months ago (Oct. 1, 1999)
Published Print 25 years, 11 months ago (Oct. 1, 1999)
Funders 0

None

@article{Gasparini_1999, title={2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist}, volume={38}, ISSN={0028-3908}, url={http://dx.doi.org/10.1016/s0028-3908(99)00082-9}, DOI={10.1016/s0028-3908(99)00082-9}, number={10}, journal={Neuropharmacology}, publisher={Elsevier BV}, author={Gasparini, Fabrizio and Lingenhöhl, Kurt and Stoehr, Natacha and Flor, Peter J and Heinrich, Micheline and Vranesic, Ivo and Biollaz, Michel and Allgeier, Hans and Heckendorn, Roland and Urwyler, Stephan and Varney, Mark A and Johnson, Edwin C and Hess, Stephen D and Rao, Sara P and Sacaan, Aida I and Santori, Emily M and Veliçelebi, Gönul and Kuhn, Rainer}, year={1999}, month=oct, pages={1493–1503} }