DOI: 10.1016/s0028-3908(01)00132-0. Mutation of the 9′ leucine in the GABAA receptor γ2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states

Mutation of the 9′ leucine in the GABAA receptor γ2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states

10.1016/s0028-3908(01)00132-0

Crossref journal-article

Elsevier BV

Neuropharmacology (78)

Bibliography

Bianchi, M. T., & Macdonald, R. L. (2001). Mutation of the 9â² leucine in the GABAA receptor Î³2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. Neuropharmacology, 41(6), 737â744.

Authors 2

Matt T. Bianchi (first)
Robert L. Macdonald (additional)

References 20 Referenced 42

10.1523/JNEUROSCI.13-04-01418.1993 / Journal of Neuroscience / Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique by Angelotti (1993)
10.1523/JNEUROSCI.21-04-01127.2001 / Journal of Neuroscience / Structural determinants of fast desensitization and desensitization–deactivation coupling in GABAA receptors by Bianchi (2001)
10.1016/S0006-3495(94)80885-9 / Biophysical Journal / Multiphasic desensitization of the GABAA receptor in outside-out patches by Celentano (1994)
10.1523/JNEUROSCI.16-17-05415.1996 / Journal of Neuroscience / Stoichiometry of a recombinant GABAA receptor by Chang (1996)
10.1016/S0006-3495(99)77089-X / Biophysical Journal / Allosteric activation mechanism of the α1β2γ2 γ-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine by Chang (1999)
10.1038/sj.bjp.0702164 / British Journal of Pharmacology / Binding, gating, affinity and efficacy: The interpretation of structure–activity relationships for agonists and the effects of mutating receptors by Colquhoun (1998)
10.1113/jphysiol.1996.sp021756 / Journal of Physiology (Lond.) / Recombinant GABAA receptor desensitization: the role of the gamma2 subunit and its physiological significance by Dominguez-Perrot (1997)
{'key': '10.1016/S0028-3908(01)00132-0_BIB8', 'first-page': '379', 'article-title': 'The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating', 'volume': '48', 'author': 'Filatov', 'year': '1995', 'journal-title': 'Molecular Pharmacology'} / Molecular Pharmacology / The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating by Filatov (1995)
10.1111/j.1469-7793.1997.283bb.x / Journal of Physiology (Lond.) / Single channel properties of recombinant GABAA receptors containing γ2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 cells by Fisher (1997)
10.1016/S0028-3908(96)00150-5 / Neuropharmacology / Expression of functional GABAA receptors in the transfected L929 cells isolated by immunomagnetic bead separation by Greenfield (1997)
10.1111/j.1469-7793.1999.027af.x / Journal of Physiology (Lond.) / GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptors in mouse fibroblasts by Haas (1999)
10.1016/0896-6273(95)90075-6 / Neuron / Desensitized states prolong GABAA channel responses to brief agonist pulses by Jones (1995)
10.1016/S0166-2236(96)80037-3 / Trends in Neuroscience / The impact of receptor desensitization on fast synaptic transmission by Jones (1996)
10.1038/376514a0 / Nature / Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors by Labarca (1995)
10.1016/0896-6273(94)90152-X / Neuron / How quickly can GABAA receptors open? by Maconochie (1994)
10.1038/353846a0 / Nature / Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor by Revah (1991)
10.1523/JNEUROSCI.21-15-05574.2001 / Journal of Neuroscience / Subunit interactions and AMPA receptor desensitization by Robert (2001)
10.1038/sj.bjp.0702687 / British Journal of Pharmacology / Mutation at the putative GABA ion channel gate reveals changes in allosteric modulation by Thompson (1999)
10.1038/373037a0 / Nature / Acetylcholine receptor channel imaged in the open state by Unwin (1995)
10.1073/pnas.90.11.5030 / Proceedings of the National Academy of Sciences of the USA / Single amino acid substitution affects desensitization kinetics of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes by Yakel (1993)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:16 p.m.)
Deposited	5 years, 7 months ago (Jan. 12, 2020, 10:21 p.m.)
Indexed	2 months, 2 weeks ago (June 20, 2025, 8:25 a.m.)
Issued	23 years, 10 months ago (Nov. 1, 2001)
Published	23 years, 10 months ago (Nov. 1, 2001)
Published Print	23 years, 10 months ago (Nov. 1, 2001)

Funders 0

None

BibTeX

@article{Bianchi_2001, title={Mutation of the 9′ leucine in the GABAA receptor γ2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states}, volume={41}, ISSN={0028-3908}, url={http://dx.doi.org/10.1016/s0028-3908(01)00132-0}, DOI={10.1016/s0028-3908(01)00132-0}, number={6}, journal={Neuropharmacology}, publisher={Elsevier BV}, author={Bianchi, Matt T. and Macdonald, Robert L.}, year={2001}, month=nov, pages={737–744} }

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