DOI: 10.1016/s0027-5107(97)00246-7. The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (χ2) not a gaussian distribution

The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (χ2) not a gaussian distribution

10.1016/s0027-5107(97)00246-7

Crossref journal-article

Elsevier BV

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (78)

Bibliography

Bauer, E., Recknagel, R.-D., Fiedler, U., Wollweber, L., Bock, C., & Greulich, K. O. (1998). The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (Ï2) not a gaussian distribution. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 398(1â2), 101â110.

Authors 6

Eckhard Bauer (first)
Rolf-Dieter Recknagel (additional)
Ursula Fiedler (additional)
Leo Wollweber (additional)
Claudia Bock (additional)
Karl Otto Greulich (additional)

References 30 Referenced 88

10.1016/0006-291X(84)90411-X / Biochem. Biophys. Res. Commun. / Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells by Östling (1984)
10.1016/0014-4827(88)90265-0 / Exp. Cell Res. / A simple technique for quantitation of low level of DNA damage in individual cells by Singh (1988)
10.1016/0921-8777(92)90075-E / Mut. Res., DNA Repair / UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and xeroderma pigmentosum donors in the comet assay: a potential diagnostic technique by Green (1992)
10.1080/09553009214552161 / Int. J. Radiat. Biol. / Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells by Gedik (1992)
10.1016/1011-1344(94)07007-5 / J. Photochem. Photobiol. B Biol. / UV-B-laser-induced DNA damages in lymphocytes observed by single-cell gel electrophoresis by de With (1994)
10.1016/1011-1344(95)07151-Q / J. Photochem. Photobiol. B Biol. / Wavelength dependence of laser-induced DNA damage in lymphocytes observed by single-cell gel electrophoresis by de With (1995)
R.R. Tice, P.W. Andrews, N.P. Singh, The single cell gel assay: a sensitive technique for evaluating intercellular differences in DNA damage and repair, in: B.M. Sutherland, A.D. Woodhead (Eds.), Methods for the Detection of DNA Damage in Human Tissues, Plenum, New York, 1990, pp. 291–301. (10.1007/978-1-4613-0637-5_23)
R.R. Tice, The single cell gel/comet assay: a microgel electrophoretic technique for the detection of DNA damage and repair in individual cells, in: D.H. Philips, Svenitt (Eds.), Environmental Mutagenesis, Bios Scientific Publishers, Oxford, 1994.
10.1016/0027-5107(93)90207-V / Mutation Res. / The single cell gel electrophoresis assay (comet assay): a European review by McKelvey-Martin (1993)
10.1016/0165-1110(94)00013-3 / Mut. Res. / The comet assay: a comprehensive review by Fairbairn (1995)
10.1080/09553009514550771 / Int. J. Radiat. Biol. / The comet moment as a measure of DNA damage in the comet assay by Kent (1995)
10.1097/00004032-199306000-00016 / Health Phys. / Single-cell gel technique supports hit probability calculations by Jostes (1993)
10.2307/3577587 / Radiat. Res. / Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the `Comet' Assay by Olive (1990)
10.1016/0921-8777(93)90010-E / Mut. Res., DNA Repair / Induction and rejoining of radiation-induced DNA single-strand breaks: `tail moment' as a function of position in the cycle by Olive (1993)
{'key': '10.1016/S0027-5107(97)00246-7_BIB15', 'first-page': '3939', 'article-title': 'Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines', 'volume': '54', 'author': 'Olive', 'year': '1994', 'journal-title': 'Cancer Res.'} / Cancer Res. / Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines by Olive (1994)
{'key': '10.1016/S0027-5107(97)00246-7_BIB16', 'first-page': '4460', 'article-title': 'Use of the comet assay to identify cells sensitive to Tirapazamine in multicell spheroids and tumors in mice', 'volume': '56', 'author': 'Olive', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Use of the comet assay to identify cells sensitive to Tirapazamine in multicell spheroids and tumors in mice by Olive (1996)
{'key': '10.1016/S0027-5107(97)00246-7_BIB17', 'first-page': '4671', 'article-title': 'DNA double-strand breaks measured in individual cells subjected to gel electrophoresis', 'volume': '51', 'author': 'Olive', 'year': '1991', 'journal-title': 'Cancer Res.'} / Cancer Res. / DNA double-strand breaks measured in individual cells subjected to gel electrophoresis by Olive (1991)
10.1016/0014-4827(92)90378-L / Exp. Cell Res. / Factors influencing DNA migration from individual cells subjected to gel electrophoresis by Olive (1992)
10.1002/cyto.990160404 / Cytometry / DNA strand breakage and DNA structure influence staining with propidium iodide using the alkaline comet assay by Olive (1994)
Komet Assay Software, version 3 edn., Kinetic Imaging, South Harrington Building, Sefton St., Liverpool L3 4BQ, UK, November, 1994.
10.1016/0300-483X(94)02910-M / Toxicology / Demonstration of chlorobenzene-induced DNA damage in mouse lymphocytes using the single cell gel electrophoresis assay by Vaghef (1995)
10.1080/095530096145922 / Int. J. Radiat. Biol. / Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UV C, UV B, UV A and γ-rays by Alapetite (1996)
10.1016/0027-5107(94)90306-9 / Mut. Res. / Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects by Betti (1994)
10.1080/09553009414550911 / Int. J. Radiat. Biol. / Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage by Singh (1994)
10.1093/mutage/10.2.85 / Mutagenesis / The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment by Ashby (1995)
10.1093/jnci/84.9.707 / J. Natl. Cancer Inst. / Detection of hypoxic cells in a murine tumor with the use of the comet assay by Olive (1992)
{'key': '10.1016/S0027-5107(97)00246-7_BIB27', 'first-page': '733', 'article-title': 'Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers', 'volume': '53', 'author': 'Olive', 'year': '1993', 'journal-title': 'Cancer Res.'} / Cancer Res. / Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers by Olive (1993)
10.2307/3578945 / Radiat. Res. / Detection of hypoxic fractions in murine tumors by comet assay: Comparison with other techniques by Hu (1995)
V.D. Barnett, Random Negative Exponential Deviates, Cambridge Univ. Press, London, 1965. (10.2307/2987400)
10.2307/2281704 / J. Am. Stat. Assoc. / Note on grouping by Cox (1957)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 2:52 p.m.)
Deposited	5 years, 6 months ago (Jan. 28, 2020, 2:24 p.m.)
Indexed	1 week ago (Aug. 20, 2025, 8:50 a.m.)
Issued	27 years, 6 months ago (Feb. 1, 1998)
Published	27 years, 6 months ago (Feb. 1, 1998)
Published Print	27 years, 6 months ago (Feb. 1, 1998)

Funders 0

None

BibTeX

@article{Bauer_1998, title={The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (χ2) not a gaussian distribution}, volume={398}, ISSN={0027-5107}, url={http://dx.doi.org/10.1016/s0027-5107(97)00246-7}, DOI={10.1016/s0027-5107(97)00246-7}, number={1–2}, journal={Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis}, publisher={Elsevier BV}, author={Bauer, Eckhard and Recknagel, Rolf-Dieter and Fiedler, Ursula and Wollweber, Leo and Bock, Claudia and Greulich, Karl Otto}, year={1998}, month=feb, pages={101–110} }

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  ],
  "URL": "http://dx.doi.org/10.1016/S0027-5107(97)00246-7",
  "relation": {},
  "ISSN": [
    "0027-5107"
  ],
  "subject": [],
  "container-title-short": "Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis",
  "published": {
    "date-parts": [
      [
        1998,
        2
      ]
    ]
  }
}