10.1016/s0027-5107(02)00224-5
Crossref journal-article
Elsevier BV
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (78)
Bibliography

Thompson, L. H., & Schild, D. (2002). Recombinational DNA repair and human disease. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 509(1–2), 49–78.

Authors 2
  1. Larry H Thompson (first)
  2. David Schild (additional)
References 379 Referenced 305
  1. 10.1182/blood.V99.7.2554 / Blood / Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma by Nanjangud (2002)
  2. 10.1016/S0168-9525(00)02022-9 / Trends Genet. / Partners and pathways repairing a double-strand break by Haber (2000)
  3. 10.1016/S0960-9822(01)00279-2 / Curr. Biol. / Non-homologous end joining as a mechanism of DNA repair by Barnes (2001)
  4. 10.1016/S1097-2765(01)00424-5 / Mol. Cell. / NHEJ deficiency and disease by Pierce (2001)
  5. 10.1016/S0027-5107(01)00115-4 / Mutat. Res. / Homologous recombinational repair of DNA ensures mammalian chromosome stability by Thompson (2001)
  6. 10.1038/85798 / Nat. Genet. / DNA double-strand breaks: signaling, repair and the cancer connection by Khanna (2001)
  7. 10.1093/carcin/23.5.687 / Carcinogenesis / Sensing and repairing DNA double-strand breaks by Jackson (2002)
  8. 10.1038/sj.onc.1204767 / Oncogene / DNA double strand break repair and chromosomal translocation: lessons from animal models by Ferguson (2001)
  9. 10.1080/02841860152619115 / Acta Oncol. / The inherited basis of human radiosensitivity by Gatti (2001)
  10. 10.1073/pnas.95.9.5172 / Proc. Natl. Acad. Sci. U.S.A. / Homology-directed repair is a major double-strand break repair pathway in mammalian cells by Liang (1998)
  11. 10.1073/pnas.96.26.14899 / Proc. Natl. Acad. Sci. U.S.A. / DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes by Bailey (1999)
  12. 10.1128/MCB.21.11.3642-3651.2001 / Mol. Cell. Biol. / The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang by Goytisolo (2001)
  13. 10.1073/pnas.261574698 / Proc. Natl. Acad. Sci. U.S.A. / DNA-PKcs is critical for telomere capping by Gilley (2001)
  14. 10.1016/S0960-9822(01)00328-1 / Curr. Biol. / Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells by d’Adda di Fagagna (2001)
  15. 10.1016/S0960-9822(00)80123-2 / Curr. Biol. / The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts by Karanjawala (1999)
  16. 10.1038/35006670 / Nature / DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation by Difilippantonio (2000)
  17. 10.1073/pnas.110152897 / Proc. Natl. Acad. Sci. U.S.A. / The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations by Ferguson (2000)
  18. 10.1016/S0952-7915(00)00203-X / Curr. Opin. Immunol. / How to make ends meet in V(D)J recombination by Grawunder (2001)
  19. 10.1016/S0300-9084(99)80042-X / Biochimie / The contribution of homologous recombination in preserving genome integrity in mammalian cells by Thompson (1999)
  20. 10.1016/S0300-9084(99)80041-8 / Biochimie / The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells by Thacker (1999)
  21. {'key': '10.1016/S0027-5107(02)00224-5_BIB21', 'first-page': '71', 'article-title': 'Chromosome instability syndromes: lessons for carcinogenesis', 'volume': '221', 'author': 'Meyn', 'year': '1997', 'journal-title': 'Curr. Top. Microbiol. Immunol.'} / Curr. Top. Microbiol. Immunol. / Chromosome instability syndromes: lessons for carcinogenesis by Meyn (1997)
  22. {'key': '10.1016/S0027-5107(02)00224-5_BIB22', 'first-page': '4561', 'article-title': 'Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636de19 common mutation exhibit a variant phenotype', 'volume': '61', 'author': 'Spring', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636de19 common mutation exhibit a variant phenotype by Spring (2001)
  23. 10.1080/095530099139359 / Int. J. Radiat. Biol. / ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia by Lavin (1999)
  24. 10.1016/S0065-230X(01)83007-4 / Adv. Cancer Res. / ATM: genome stability, neuronal development, and cancer cross paths by Shiloh (2001)
  25. 10.1038/sj.cdd.4400874 / Cell Death Differ. / ATM, a central controller of cellular responses to DNA damage by Khanna (2001)
  26. 10.1038/sj.onc.1205060 / Oncogene / ATM function and telomere stability by Pandita (2002)
  27. 10.1038/258427a0 / Nature / Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity by Taylor (1975)
  28. 10.1002/bies.950110205 / Bioessays / Inherited sensitivity to X-rays in man by Thacker (1989)
  29. {'key': '10.1016/S0027-5107(02)00224-5_BIB29', 'first-page': '402', 'article-title': 'Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia telangiectasia', 'volume': '44', 'author': 'Bigbee', 'year': '1989', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia telangiectasia by Bigbee (1989)
  30. 10.1080/09553009414551951 / Int. J. Radiat. Biol. / Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients by Cole (1994)
  31. 10.1080/09553009114552601 / Int. J. Radiat. Biol. / Fibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate gamma-irradiation as assayed by pulsed field gel electrophoresis by Blocher (1991)
  32. 10.1126/science.3975628 / Science / On the nature of a defect in cells from individuals with ataxia-telangiectasia by Cornforth (1985)
  33. 10.1080/095530097143266 / Int. J. Radiat. Biol. / Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks by Foray (1997)
  34. 10.1093/hmg/4.11.2025 / Hum. Mol. Genet. / The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species by Savitsky (1995)
  35. 10.1016/S0968-0004(00)89083-0 / Trends Biochem. Sci. / Relationship of the ataxiatelangiectasia protein ATM to phosphoinositide 3-kinase by Lavin (1995)
  36. 10.1074/jbc.274.48.34277 / J. Biol. Chem. / Localization of a portion of extranuclear ATM to peroxisomes by Watters (1999)
  37. 10.1073/pnas.97.2.871 / Proc. Natl. Acad. Sci. U.S.A. / ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation by Barlow (2000)
  38. 10.1073/pnas.94.5.1840 / Proc. Natl. Acad. Sci. U.S.A. / The ataxiatelangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage by Brown (1997)
  39. 10.1038/sj.onc.1203124 / Oncogene / ATM: a mediator of multiple responses to genotoxic stress by Rotman (1999)
  40. 10.1016/S0959-437X(00)00159-3 / Curr. Opin. Genet. Dev. / ATM and ATR: networking cellular responses to DNA damage by Shiloh (2001)
  41. 10.1038/sj.onc.1203185 / Oncogene / MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases by Theodosiou (1999)
  42. 10.1038/sj.onc.1205127 / Oncogene / ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage by Bar-Shira (2002)
  43. 10.1038/542 / Nat. Genet. / ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins by Waterman (1998)
  44. 10.1002/j.1460-2075.1996.tb01054.x / EMBO J. / The Schizosaccharomyces pombe rad3 checkpoint gene by Bentley (1996)
  45. 10.1101/gad.14.4.397 / Genes Dev. / ATR disruption leads to chromosomal fragmentation and early embryonic lethality by Brown (2000)
  46. 10.1016/S0960-9822(00)00447-4 / Curr. Biol. / Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice by de Klein (2000)
  47. 10.1101/gad.914401 / Genes Dev. / Cell cycle checkpoint signaling through the ATM and ATR kinases by Abraham (2001)
  48. 10.1074/jbc.273.10.5858 / J. Biol. Chem. / DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 by Rogakou (1998)
  49. 10.1083/jcb.146.5.905 / J. Cell. Biol. / Megabase chromatin domains involved in DNA double-strand breaks in vivo by Rogakou (1999)
  50. 10.1016/S0960-9822(00)00610-2 / Curr. Biol. / A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage by Paull (2000)
  51. 10.1074/jbc.C100466200 / J. Biol. Chem. / ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks by Burma (2001)
  52. 10.1074/jbc.M102986200 / J. Biol. Chem. / Nuclear retention of ATM at sites of DNA double strand breaks by Andegeko (2001)
  53. 10.1126/science.281.5383.1674 / Science / Enhanced phosphorylation of p53 by ATM in response to DNA damage by Banin (1998)
  54. 10.1126/science.281.5383.1677 / Science / Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 by Canman (1998)
  55. 10.1073/pnas.012329699 / Proc. Natl. Acad. Sci. U.S.A. / Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer by Scott (2002)
  56. 10.1126/science.1069398 / Science / Genomic instability in mice lacking histone H2AX by Celeste (2002)
  57. 10.1073/pnas.122228699 / Proc. Natl. Acad. Sci. U.S.A. / Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX by Bassing (2002)
  58. 10.1093/emboj/19.3.463 / EMBO J. / The controlling role of ATM in homologous recombinational repair of DNA damage by Morrison (2000)
  59. 10.1101/gad.10.19.2411 / Genes Dev. / Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma by Xu (1996)
  60. 10.1016/S0092-8674(00)80086-0 / Cell / Atm-deficient mice: a paradigm of ataxia telangiectasia by Barlow (1996)
  61. 10.1038/7684 / Nat. Genet. / Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice by Barlow (1999)
  62. 10.1073/pnas.162349699 / Proc. Natl. Acad. Sci. U.S.A. / Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts by Worgul (2002)
  63. 10.1128/MCB.18.7.4385 / Mol. Cell. Biol. / Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm−/− mice by Xu (1998)
  64. {'key': '10.1016/S0027-5107(02)00224-5_BIB64', 'first-page': '1664', 'article-title': 'Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints', 'volume': '57', 'author': 'Westphal', 'year': '1997', 'journal-title': 'Cancer Res.'} / Cancer Res. / Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints by Westphal (1997)
  65. 10.1073/pnas.94.26.14590 / Proc. Natl. Acad. Sci. U.S.A. / Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice by Wang (1997)
  66. 10.1074/jbc.M009809200 / J. Biol. Chem. / ATM Is Required for Ikappa B Kinase (IKK) Activation in Response to DNA Double Strand Breaks by Li (2001)
  67. 10.1074/jbc.273.7.3799 / J. Biol. Chem. / Regulation of Rad51 function by c-Ab1 in response to DNA damage by Yuan (1998)
  68. 10.1074/jbc.274.18.12748 / J. Biol. Chem. / Radiation-induced assembly of Rad5l and Rad52 recombination complex requires ATM and c-Ab1 by Chen (1999)
  69. 10.1074/jbc.275.2.725 / J. Biol. Chem. / c-Ab1 tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance by Takao (2000)
  70. 10.1093/jnci/92.10.795 / J. Natl. Cancer Inst. / Cancer risk and the ATM gene: a continuing debate by Khanna (2000)
  71. 10.1093/jnci/93.2.84 / J. Natl. Cancer. Inst. / Public health burden of cancer in ataxia-telangiectasia heterozygotes by Swift (2001)
  72. 10.1093/jnci/94.3.205 / J. Natl. Cancer Inst. / Dominant negative ATM mutations in breast cancer families by Chenevix-Trench (2002)
  73. 10.1073/pnas.96.20.11134 / Proc. Natl. Acad. Sci. U.S.A. / Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM by Smith (1999)
  74. 10.1667/0033-7587(2002)157[0312:ROATAN]2.0.CO;2 / Radiat. Res. / Radiosensitivity of ataxia telangiectasia and Nijmegen breakage syndrome homozygotes and heterozygotes as determined by three-color FISH chromosome painting by Neubauer (2002)
  75. 10.1111/j.1651-2227.1981.tb05740.x / Acta Paediatr. Scand. / A new chromosomal instability disorder: the Nijmegen breakage syndrome by Weemaes (1981)
  76. 10.1016/S0092-8674(00)81175-7 / Cell / The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response by Carney (1998)
  77. 10.1016/S0092-8674(00)81174-5 / Cell / Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen Breakage syndrome by Varon (1998)
  78. 10.1038/549 / Nat. Genet. / Positional cloning of the gene for Nijmegen breakage syndrome by Matsuura (1998)
  79. 10.1146/annurev.genet.31.1.635 / Annu. Rev. Genet. / Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart by Shiloh (1997)
  80. 10.1002/(SICI)1521-1878(199908)21:8<649::AID-BIES4>3.0.CO;2-O / Bioessays / Nijmegen breakage syndrome: consequences of defective DNA double strand break repair by Digweed (1999)
  81. {'key': '10.1016/S0027-5107(02)00224-5_BIB81', 'first-page': '4881', 'article-title': 'Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects', 'volume': '60', 'author': 'Girard', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects by Girard (2000)
  82. 10.1093/emboj/21.6.1447 / EMBO J. / Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair by Kang (2002)
  83. 10.1006/clin.1996.4275 / Clin. Immunol. Immunopathol. / Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome by Sullivan (1997)
  84. 10.1128/MCB.17.9.5016 / Mol. Cell. Biol. / Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation by Jongmans (1997)
  85. {'key': '10.1016/S0027-5107(02)00224-5_BIB85', 'first-page': '2316', 'article-title': 'Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells', 'volume': '58', 'author': 'Yamazaki', 'year': '1998', 'journal-title': 'Cancer Res.'} / Cancer Res. / Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells by Yamazaki (1998)
  86. 10.1006/bbrc.1997.7924 / Biochem. Biophys. Res. Commun. / Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia by Matsuura (1998)
  87. 10.1080/095530099140221 / Int. J. Radiat. Biol. / Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines by Antoccia (1999)
  88. 10.1038/ng845 / Nat. Genet. / The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways by Falck (2002)
  89. 10.1128/MCB.21.15.5214-5222.2001 / Mol. Cell. Biol. / Chk2 activation dependence on NBS1 after DNA damage by Buscemi (2001)
  90. 10.1006/bbrc.1999.1737 / Biochem. Biophys. Res. Commun. / Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients by Ito (1999)
  91. 10.1016/S0198-8859(01)00345-7 / Hum. Immunol. / Decreased immunoglobulin class switching in Nijmegen breakage syndrome due to the DNA repair defect by van Engelen (2001)
  92. 10.1016/S0960-9822(01)00267-6 / Curr. Biol. / Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit by Ranganathan (2001)
  93. 10.1128/MCB.16.9.4832 / Mol. Cell. Biol. / Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair by Dolganov (1996)
  94. 10.1126/science.280.5363.590 / Science / In situ visualization of DNA double-strand break repair in human fibroblasts by Nelms (1998)
  95. 10.1128/MCB.17.10.6087 / Mol. Cell. Biol. / hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks by Maser (1997)
  96. 10.1128/MCB.21.6.2184-2191.2001 / Mol. Cell. Biol. / Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization by Desai-Mehta (2001)
  97. 10.1128/MCB.21.1.281-288.2001 / Mol. Cell. Biol. / DNA damage-dependent nuclear dynamics of the mre11 complex by Mirzoeva (2001)
  98. 10.1038/35007091 / Nature / ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway by Lim (2000)
  99. 10.1038/35013089 / Nature / ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response by Wu (2000)
  100. 10.1038/75508 / Nat. Genet. / ATM-dependent phosphorylation of nibrin in response to radiation exposure by Gatei (2000)
  101. 10.1038/35013083 / Nature / Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products by Zhao (2000)
  102. 10.1038/86920 / Nat. Genet. / An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele by Maser (2001)
  103. 10.1016/S0960-9822(02)00763-7 / Curr. Biol. / A murine model of Nijmegen breakage syndrome by Williams (2002)
  104. 10.1016/S0960-9822(01)00019-7 / Curr. Biol. / Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice by Zhu (2001)
  105. 10.1016/S0165-4608(00)00390-3 / Cancer Genet. Cytogenet. / No evidence for deletions of the NBS1 gene in lymphomas by Stumm (2001)
  106. 10.1016/S0092-8674(00)81547-0 / Cell / The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder by Stewart (1999)
  107. 10.1086/302391 / Am. J. Hum. Genet. / The mammalian Mre11–Rad50–nbs1 protein complex: integration of functions in the cellular DNA-damage response by Petrini (1999)
  108. 10.1016/S0955-0674(00)00091-0 / Curr. Opin. Cell Biol. / The Mre11 complex and ATM: collaborating to navigate S phase by Petrini (2000)
  109. 10.1093/nar/25.15.2985 / Nucl. Acids Res. / Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells by Xiao (1997)
  110. 10.1093/emboj/18.23.6619 / EMBO J. / Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells by Yamaguchi-Iwai (1999)
  111. 10.1073/pnas.96.13.7376 / Proc. Natl. Acad. Sci. U.S.A. / Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation by Luo (1999)
  112. 10.1074/jbc.273.34.21447 / J. Biol. Chem. / Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95 by Trujillo (1998)
  113. 10.1016/S1097-2765(00)80097-0 / Mol. Cell. / The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks by Paull (1998)
  114. 10.1101/gad.13.10.1276 / Genes Dev. / Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex by Paull (1999)
  115. 10.1093/nar/30.3.667 / Nucl. Acids Res. / Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction by Huang (2002)
  116. 10.1097/00005792-199311000-00003 / Medicine / Bloom syndrome: a Mendelian prototype of somatic mutational disease by German (1993)
  117. 10.1146/annurev.genom.1.1.409 / Annu. Rev. Genomics Hum. Genet. / DNA helicases, genomic instability, and human genetic disease by van Brabant (2000)
  118. 10.1042/bst0290201 / Biochem. Soc. Trans. / Role of the Bloom’s syndrome helicase in maintenance of genome stability by Hickson (2001)
  119. 10.1073/pnas.71.11.4508 / Proc. Natl. Acad. Sci. U.S.A. / A manyfold increase in sister chromatid exchanges in Bloom’s syndrome lymphocytes by Chaganti (1974)
  120. 10.1073/pnas.78.5.3133 / Proc. Natl. Acad. Sci. U.S.A. / Elevated spontaneous mutation rate in Bloom syndrome fibroblasts by Warren (1981)
  121. 10.1073/pnas.86.2.670 / Proc. Natl. Acad. Sci. U.S.A. / Evidence for increased in vivo mutation and somatic recombination in Bloom’s syndrome by Langlois (1989)
  122. 10.1083/jcb.200110009 / J. Cell. Biol. / Bloom’s syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest by Franchitto (2002)
  123. 10.1074/jbc.M203801200 / J. Biol. Chem. / Functional link between BLM defective in Bloom’s syndrome and the ataxia-telangiectasia mutated protein, ATM by Beamish (2002)
  124. 10.1016/0092-8674(95)90105-1 / Cell / The Bloom’s syndrome gene product is homologous to RecQ helicases by Ellis (1995)
  125. 10.1016/S0959-437X(99)00039-8 / Curr. Opin. Genet. Dev. / RecQ family helicases: roles in cancer and aging by Karow (2000)
  126. 10.1101/gad.12.21.3382 / Genes Dev. / Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom’s syndrome gene by Chester (1998)
  127. 10.1074/jbc.M009471200 / J. Biol. Chem. / Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51 by Wu (2001)
  128. 10.1083/jcb.153.2.367 / J. Cell. Biol. / Regulation and localization of the Bloom syndrome protein in response to DNA damage by Bischof (2001)
  129. 10.1038/sj.onc.1204003 / Oncogene / ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation by Ababou (2000)
  130. 10.1074/jbc.M009664200 / J. Biol. Chem. / The Bloom’s syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair by Langland (2001)
  131. 10.1093/nar/29.21.4378 / Nucl. Acids Res. / Direct association of Bloom’s syndrome gene product with the human mismatch repair protein MLH1 by Pedrazzi (2001)
  132. 10.1093/nar/29.13.2843 / Nucl. Acids Res. / The Bloom’s and Werner’s syndrome proteins are DNA structure-specific helicases by Mohaghegh (2001)
  133. 10.1093/emboj/19.13.3428 / EMBO J. / Possible association of BLM in decreasing DNA double strand breaks during DNA replication by Wang (2000)
  134. 10.1093/emboj/19.13.3398 / EMBO J. / Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells by Johnson (2000)
  135. 10.1074/jbc.M103298200 / J. Biol. Chem. / Functional interaction of p53 and BLM DNA helicase in apoptosis by Wang (2001)
  136. 10.1038/sj.onc.1205120 / Oncogene / The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control by Garkavtsev (2001)
  137. 10.1074/jbc.M006462200 / J. Biol. Chem. / Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death by Bischof (2001)
  138. 10.1093/nar/29.15.3172 / Nucl. Acids Res. / Cleavage of the Bloom’s syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha by Freire (2001)
  139. 10.1016/S0047-6374(01)00248-2 / Mech. Ageing Dev. / Unwinding the molecular basis of the Werner syndrome by Shen (2001)
  140. {'key': '10.1016/S0027-5107(02)00224-5_BIB140', 'first-page': '762', 'article-title': 'Sister chromatid exchange frequencies in Progeria and Werner syndrome patients', 'volume': '33', 'author': 'Darlington', 'year': '1981', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Sister chromatid exchange frequencies in Progeria and Werner syndrome patients by Darlington (1981)
  141. 10.1038/sj.onc.1205143 / Oncogene / Werner and Bloom helicases are involved in DNA repair in a complementary fashion by Imamura (2002)
  142. 10.1073/pnas.95.22.13097 / Proc. Natl. Acad. Sci. U.S.A. / A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity by Lebel (1998)
  143. 10.1016/S0027-5107(00)00109-3 / Mutat. Res. / Werner’s syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage by Pichierri (2000)
  144. 10.1096/fj.00-0611fje / FASEB J. / Werner syndrome cells are sensitive to DNA cross-linking drugs by Poot (2001)
  145. 10.1074/jbc.M101913200 / J. Biol. Chem. / Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase by Yannone (2001)
  146. 10.1091/mbc.12.8.2412 / Mol. Biol. Cell / Werner’s syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle by Pichierri (2001)
  147. 10.1007/s004390050903 / Hum. Genet. / Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase by Poot (1999)
  148. 10.1126/science.272.5259.258 / Science / Positional cloning of the Werner’s syndrome gene by Yu (1996)
  149. 10.1038/2410 / Nat. Genet. / The premature ageing syndrome protein, WRN, is a 3′ → 5′ exonuclease by Huang (1998)
  150. 10.1093/nar/28.12.2396 / Nucl. Acids Res. / Characterization of the human and mouse WRN 3′ → 5′ exonuclease by Huang (2000)
  151. 10.1093/nar/28.2.648 / Nucl. Acids Res. / WRN helicase expression in Werner syndrome cell lines by Moser (2000)
  152. 10.1128/MCB.20.9.3286-3291.2000 / Mol. Cell. Biol. / Mutations in the WRN gene in mice accelerate mortality in a p53-null background by Lombard (2000)
  153. {'key': '10.1016/S0027-5107(02)00224-5_BIB153', 'first-page': '1816', 'article-title': 'Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase', 'volume': '61', 'author': 'Lebel', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase by Lebel (2001)
  154. 10.1016/S0531-5565(01)00227-3 / Exp. Gerontol. / Roles of the Werner syndrome protein in pathways required for maintenance of genome stability by Brosh (2002)
  155. 10.1074/jbc.M111523200 / J. Biol. Chem. / Werner protein is a target of DNA-PK in vivo and in vitro, and its catalytic activities are regulated by phosphorylation by Karmakar (2002)
  156. 10.1093/emboj/20.20.5791 / EMBO J. / Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity by Brosh (2001)
  157. {'key': '10.1016/S0027-5107(02)00224-5_BIB157', 'first-page': '547', 'article-title': 'Lack of WRN results in extensive deletion at nonhomologous joining ends', 'volume': '62', 'author': 'Oshima', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Lack of WRN results in extensive deletion at nonhomologous joining ends by Oshima (2002)
  158. 10.1101/gad.877001 / Genes Dev. / Loss of Werner syndrome protein function promotes aberrant mitotic recombination by Prince (2001)
  159. 10.1128/MCB.22.20.6971-6978.2002 / Mol. Cell. Biol. / Homologous recombination resolution defect in Werner syndrome by Saintigny (2002)
  160. 10.1093/embo-reports/kvd004 / EMBO Rep. / Werner’s syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest by Constantinou (2000)
  161. 10.1046/j.1365-2443.2001.00433.x / Genes Cells / Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51 by Sakamoto (2001)
  162. 10.1002/(SICI)1096-8628(20000131)90:3<223::AID-AJMG7>3.0.CO;2-Z / Am. J. Med. Genet. / Rothmund–Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome by Lindor (2000)
  163. 10.1006/geno.1999.5959 / Genomics / Rothmund–Thomson syndrome responsible gene. RECQ4: genomic structure and products by Kitao (1999)
  164. 10.1038/8788 / Nat. Genet. / Mutations in RECQL4 cause a subset of cases of Rothmund–Thomson syndrome by Kitao (1999)
  165. 10.1016/S0921-8777(98)00024-X / Mutat. Res. / Is Fanconi anemia caused by a defect in the processing of DNA damage? by Buchwald (1998)
  166. 10.1093/hmg/10.20.2253 / Hum. Mol. Genet. / Fanconi anemia and DNA repair by Grompe (2001)
  167. 10.1038/35076590 / Nat. Rev. Genet. / The emerging genetic and molecular basis of Fanconi anaemia by Joenje (2001)
  168. 10.1007/BF02982547 / Int. J. Hematol. / Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes by Yamashita (2001)
  169. 10.1542/peds.67.1.128 / Pediatrics / Prenatal and postnatal diagnosis and carrier detection of Fanconi anemia by a cytogenetic method by Auerbach (1981)
  170. 10.1093/hmg/9.12.1805 / Hum. Mol. Genet. / Mice with a targeted disruption of the fanconi anemia homolog Fanca by Cheng (2000)
  171. 10.1016/S0301-472X(02)00838-X / Exp. Hematol. / Fanconi anemia group A and C double-mutant mice. Functional evidence for a multi-protein Fanconi anemia complex by Noll (2002)
  172. 10.1182/blood.V88.1.49.49 / Blood / Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene by Whitney (1996)
  173. 10.1038/ng0496-448 / Nat. Genet. / Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia by Chen (1996)
  174. 10.1182/blood.V98.12.3435 / Blood / Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9 by Yang (2001)
  175. 10.1093/hmg/11.3.273 / Hum. Mol. Genet. / Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice by Koomen (2002)
  176. 10.1038/ng1297-487 / Nat. Genet. / The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex by Kupfer (1997)
  177. 10.1128/MCB.19.7.4866 / Mol. Cell. Biol. / Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex by Garcia-Higuera (1999)
  178. 10.1093/hmg/9.18.2665 / Hum. Mol. Genet. / The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG by de Winter (2000)
  179. 10.1093/emboj/cdf355 / EMBO J. / FANCE: the link between Fanconi anaemia complex assembly and activity by Pace (2002)
  180. 10.1016/S1097-2765(01)00173-3 / Mol. Cell. / Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway by Garcia-Higuera (2001)
  181. 10.1016/S0092-8674(02)00747-X / Cell / Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways by Taniguchi (2002)
  182. 10.1016/S1097-2765(02)00580-4 / Mol. Cell. / The two faces of BRCA2, a FANCtastic discovery by Stewart (2002)
  183. 10.1126/science.1073834 / Science / Biallelic inactivation of BRCA2 in Fanconi anemia by Howlett (2002)
  184. 10.1093/carcin/22.12.1939 / Carcinogenesis / The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquinated form of the FAND2 protein, is hypersensitive to a range of DNA damaging agents, and exhibits a normal level of spontaneous sister chromatid exchange by Wilson (2001)
  185. 10.1038/87876 / Nat. Med. / Breast cancer genetics: what we know and what we need by Nathanson (2001)
  186. 10.1126/science.281.5379.1009 / Science / BRCA1 required for transcription-coupled repair of oxidative DNA damage by Gowen (1998)
  187. {'key': '10.1016/S0027-5107(02)00224-5_BIB187', 'first-page': '5548', 'article-title': 'BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells', 'volume': '60', 'author': 'Le Page', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells by Le Page (2000)
  188. 10.1016/S1097-2765(00)80276-2 / Mol. Cell. / Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells by Chen (1998)
  189. 10.1038/sj.onc.1203968 / Oncogene / Lessons learned from BRCA1 and BRCA2 by Zheng (2000)
  190. 10.1016/S0168-9525(99)01930-7 / Trends Genet. / Insights into the functions of BRCA1 and BRCA2 by Welcsh (2000)
  191. 10.1038/35044000 / Nature / In search of the tumour-suppressor functions of BRCA1 and BRCA2 by Scully (2000)
  192. 10.1093/hmg/10.7.705 / Hum. Mol. Genet. / BRCA1 and BRCA2 and the genetics of breast and ovarian cancer by Welcsh (2001)
  193. 10.1016/S0960-9822(01)00389-X / Curr. Biol. / New complexities for BRCA1 and BRCA2 by Kerr (2001)
  194. 10.1186/bcr417 / Breast Cancer Res. / Distinct functions of BRCA1 and BRCA2 in double-strand break repair by Liu (2002)
  195. 10.1016/S0092-8674(02)00615-3 / Cell / Cancer susceptibility and the functions of BRCA1 and BRCA2 by Venkitaraman (2002)
  196. 10.1074/jbc.C000276200 / J. Biol. Chem. / The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin by Bhattacharyya (2000)
  197. {'key': '10.1016/S0027-5107(02)00224-5_BIB197', 'first-page': '3547', 'article-title': 'BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo', 'volume': '59', 'author': 'Yuan', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo by Yuan (1999)
  198. 10.1016/S1097-2765(00)80202-6 / Mol. Cell. / Brca1 controls homology-directed DNA repair by Moynahan (1999)
  199. {'key': '10.1016/S0027-5107(02)00224-5_BIB199', 'first-page': '4842', 'article-title': 'Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation', 'volume': '61', 'author': 'Moynahan', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brca1 mutation by Moynahan (2001)
  200. 10.1073/pnas.111125998 / Proc. Natl. Acad. Sci. U.S.A. / Direct DNA binding by Brca1 by Paull (2001)
  201. 10.1074/jbc.M200748200 / J. Biol. Chem. / BRCA1 facilitates micro-homology mediated end-joining of DNA double-strand breaks by Zhong (2002)
  202. {'key': '10.1016/S0027-5107(02)00224-5_BIB202', 'first-page': '3966', 'article-title': 'Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts', 'volume': '62', 'author': 'Zhong', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts by Zhong (2002)
  203. 10.1126/science.286.5442.1162 / Science / Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks by Cortez (1999)
  204. 10.1074/jbc.M011681200 / J. Biol. Chem. / Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies by Gatei (2001)
  205. 10.1038/35004614 / Nature / hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response by Lee (2000)
  206. 10.1101/gad.851000 / Genes Dev. / Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress by Tibbetts (2000)
  207. 10.1038/35018134 / Nature / Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response by Li (2000)
  208. 10.1016/S1097-2765(00)80466-9 / Mol. Cell. / Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells by Xu (1999)
  209. 10.1128/MCB.21.10.3445-3450.2001 / Mol. Cell. Biol. / Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation by Xu (2001)
  210. 10.1038/ng837 / Nat. Genet. / BRCA1 regulates the G2/M checkpoint by activating Chkl kinase upon DNA damage by Yarden (2002)
  211. 10.1073/pnas.221430898 / Proc. Natl. Acad. Sci. U.S.A. / The human decatenation checkpoint by Deming (2001)
  212. 10.1073/pnas.95.22.12983 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1 is associated with the centrosome during mitosis by Hsu (1998)
  213. {'key': '10.1016/S0027-5107(02)00224-5_BIB213', 'first-page': '7713', 'article-title': 'Identification of a gamma-tubulin-binding domain in BRCA1', 'volume': '61', 'author': 'Hsu', 'year': '2001', 'journal-title': 'Cancer Res.'} / Cancer Res. / Identification of a gamma-tubulin-binding domain in BRCA1 by Hsu (2001)
  214. 10.1126/science.285.5428.747 / Science / Association of BRCA1 with the hRad50–hMre11–p95 complex and the DNA damage response by Zhong (1999)
  215. 10.1073/pnas.070452397 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and Hrpb10alpha in activated transcription by Schlegel (2000)
  216. 10.1101/gad.14.8.927 / Genes Dev. / BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures by Wang (2000)
  217. 10.1074/jbc.M105227200 / J. Biol. Chem. / Redistribution of BRCA1 among four different protein complexes following replication blockage by Chiba (2001)
  218. {'key': '10.1016/S0027-5107(02)00224-5_BIB218', 'first-page': '4222', 'article-title': 'The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme', 'volume': '62', 'author': 'Chiba', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme by Chiba (2002)
  219. 10.1074/jbc.M112231200 / J. Biol. Chem. / A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer by Li (2002)
  220. 10.1126/science.289.5476.11a / Science / Independence of R/M/N focus formation and the presence of intact BRCA1 by Wu (2000)
  221. 10.1038/nsb1001-833 / Nat. Struct. Biol. / Structure of a BRCA1-BARD1 heterodimeric RING–RING complex by Brzovic (2001)
  222. 10.1074/jbc.M109249200 / J. Biol. Chem. / Identification of residues required for the interaction of BARD1 with BRCA1 by Morris (2002)
  223. 10.1074/jbc.C000881200 / J. Biol. Chem. / The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation by Hashizume (2001)
  224. 10.1074/jbc.M201252200 / J. Biol. Chem. / Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase by Chen (2002)
  225. 10.1074/jbc.273.14.7795 / J. Biol. Chem. / The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain by Brzovic (1998)
  226. 10.1074/jbc.M106551200 / J. Biol. Chem. / BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein–protein interactions by Brzovic (2001)
  227. 10.1073/pnas.081068398 / Proc. Natl. Acad. Sci. U.S.A. / Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity by Ruffner (2001)
  228. 10.1016/S0092-8674(01)00270-7 / Cell / The BARD1–CstF-50 interaction links mRNA 3′ end formation to DNA damage and tumor suppression by Kleiman (2001)
  229. 10.1038/sj.onc.1201861 / Oncogene / BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression by Jensen (1998)
  230. 10.1038/930 / Nat. Genet. / BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A by Anderson (1998)
  231. 10.1073/pnas.94.11.5605 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1 is a component of the RNA polymerase II holoenzyme by Scully (1997)
  232. 10.1016/S0092-8674(00)00030-1 / Cell / BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer by Bochar (2000)
  233. 10.1038/sj.onc.1202323 / Oncogene / The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter by Chai (1999)
  234. 10.1074/jbc.275.4.2777 / J. Biol. Chem. / BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression by MacLachlan (2000)
  235. 10.1128/MCB.22.12.4280-4292.2002 / Mol. Cell. Biol. / BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets by MacLachlan (2002)
  236. 10.1074/jbc.M002539200 / J. Biol. Chem. / BRCA1 physically and functionally interacts with ATF1 by Houvras (2000)
  237. 10.1074/jbc.273.39.25388 / J. Biol. Chem. / The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression by Yu (1998)
  238. 10.1074/jbc.274.16.11334 / J. Biol. Chem. / Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage by Li (1999)
  239. 10.1074/jbc.M909494199 / J. Biol. Chem. / Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor by Yu (2000)
  240. 10.1074/jbc.M110603200 / J. Biol. Chem. / The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity by Sum (2002)
  241. 10.1016/S1097-2765(00)00075-7 / Mol. Cell. / Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1 by Zheng (2000)
  242. 10.1016/S0014-5793(96)01312-9 / FEBS Lett. / From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair by Callebaut (1997)
  243. 10.1096/fasebj.11.1.9034168 / FASEB J. / A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins by Bork (1997)
  244. 10.1016/S0921-8777(00)00034-3 / Mutat. Res. / The BRCA1 C-terminal domain: structure and function by Huyton (2000)
  245. 10.1073/pnas.96.9.4983 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1 interacts with components of the histone deacetylase complex by Yarden (1999)
  246. 10.1016/S0092-8674(01)00304-X / Cell / BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function by Cantor (2001)
  247. 10.1073/pnas.97.3.1020 / Proc. Natl. Acad. Sci. U.S.A. / CBP/p300 interact with and function as transcriptional coactivators of BRCA1 by Pao (2000)
  248. 10.1038/ng0296-191 / Nat. Genet. / Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities by Gowen (1996)
  249. 10.1101/gad.10.14.1835 / Genes Dev. / Inactivation of the mouse Brca1 gene leads to failure in the moiphogenesis of the egg cylinder in early postimplantation development by Liu (1996)
  250. 10.1016/S0092-8674(00)81302-1 / Cell / The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse by Hakem (1996)
  251. 10.1101/gad.11.10.1226 / Genes Dev. / Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos by Ludwig (1997)
  252. 10.1038/90108 / Nat. Genet. / Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumoriginesis by Xu (2001)
  253. {'key': '10.1016/S0027-5107(02)00224-5_BIB253', 'first-page': '3789', 'article-title': 'Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%', 'volume': '62', 'author': 'Murphy', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17% by Murphy (2002)
  254. 10.1038/386804a0 / Nature / Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 by Sharan (1997)
  255. 10.1074/jbc.272.51.31941 / J. Biol. Chem. / RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene Brca2 by Wong (1997)
  256. 10.1073/pnas.95.23.13869 / Proc. Natl. Acad. Sci. U.S.A. / The BRCA2 gene product functionally interacts with p53 and RAD51 by Marmorstein (1998)
  257. 10.1073/pnas.95.9.5287 / Proc. Natl. Acad. Sci. U.S.A. / The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment by Chen (1998)
  258. 10.1016/S1097-2765(01)00175-7 / Mol. Cell. / Role of BRCA2 in control of the RAD51 recombination and DNA repair protein by Davies (2001)
  259. {'key': '10.1016/S0027-5107(02)00224-5_BIB259', 'first-page': '1752s', 'article-title': 'BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway', 'volume': '59', 'author': 'Chen', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway by Chen (1999)
  260. 10.1101/gad.14.11.1400 / Genes Dev. / Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation by Yu (2000)
  261. {'key': '10.1016/S0027-5107(02)00224-5_BIB261', 'first-page': '3441', 'article-title': 'Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence', 'volume': '58', 'author': 'Morimatsu', 'year': '1998', 'journal-title': 'Cancer Res.'} / Cancer Res. / Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence by Morimatsu (1998)
  262. 10.1073/pnas.151253498 / Proc. Natl. Acad. Sci. U.S.A. / Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining by Xia (2001)
  263. 10.1128/MCB.22.2.669-679.2002 / Mol. Cell. Biol. / Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions by Kraakman-van der Zwet (2002)
  264. 10.1038/ng0596-22 / Nat. Genet. / Internal repeats in the BRCA2 protein sequence by Bork (1996)
  265. 10.1093/hmg/6.1.53 / Hum. Mol. Genet. / The BRC repeats are conserved in mammalian BRCA2 proteins by Bignell (1997)
  266. 10.1074/jbc.274.46.32931 / J. Biol. Chem. / Expression of BRC repeats in breast cancer cells disrupts the BRCA2–Rad5l complex and leads to radiation hypersensitivity and loss of G(2)IM checkpoint control by Chen (1999)
  267. 10.1038/ng1297-423 / Nat. Genet. / Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation by Connor (1997)
  268. 10.1016/S1097-2765(00)80035-0 / Mol. Cell. / Involvement of Brca2 in DNA repair by Patel (1998)
  269. {'key': '10.1016/S0027-5107(02)00224-5_BIB269', 'first-page': '990', 'article-title': 'Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene', 'volume': '62', 'author': 'McAllister', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene by McAllister (2002)
  270. 10.1093/hmg/11.7.841 / Hum. Mol. Genet. / Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations by Warren (2002)
  271. {'key': '10.1016/S0027-5107(02)00224-5_BIB271', 'first-page': '1311', 'article-title': 'Inhibition of cancer cell growth by BRCA2', 'volume': '62', 'author': 'Wang', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Inhibition of cancer cell growth by BRCA2 by Wang (2002)
  272. {'key': '10.1016/S0027-5107(02)00224-5_BIB272', 'first-page': '5485', 'article-title': 'Nuclear location and cell cycle regulation of the BRCA2 protein', 'volume': '57', 'author': 'Bertwistle', 'year': '1997', 'journal-title': 'Cancer Res.'} / Cancer Res. / Nuclear location and cell cycle regulation of the BRCA2 protein by Bertwistle (1997)
  273. 10.1073/pnas.93.23.13078 / Proc. Natl. Acad. Sci. U.S.A. / Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells by Rajan (1996)
  274. 10.1038/sj.onc.1201506 / Oncogene / Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice by Blackshear (1998)
  275. 10.1006/bbrc.1997.6544 / Biochem. Biophys. Res. Commun. / Changes in BRCA2 expression during progression of the cell cycle by Wang (1997)
  276. {'key': '10.1016/S0027-5107(02)00224-5_BIB276', 'first-page': '4590', 'article-title': 'Cell cycle control of BRCA2', 'volume': '56', 'author': 'Vaughn', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. / Cell cycle control of BRCA2 by Vaughn (1996)
  277. 10.1016/S0960-9822(99)80479-5 / Curr. Biol. / Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification by Tutt (1999)
  278. 10.1016/S1097-2765(00)80182-3 / Mol. Cell. / Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2 by Lee (1999)
  279. 10.1016/S1097-2765(00)80078-7 / Mol. Cell. / XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA crosslinks and other damages by Liu (1998)
  280. 10.1093/nar/26.13.3084 / Nucl. Acids Res. / The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family by Cartwright (1998)
  281. 10.1101/gad.13.20.2633 / Genes Dev. / XRCC3 promotes homology-directed repair of DNA damage in mammalian cells by Pierce (1999)
  282. 10.1038/43932 / Nature / Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination by Johnson (1999)
  283. 10.1038/35036399 / Nat. Cell. Biol. / Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation by Griffin (2000)
  284. 10.1128/MCB.20.17.6476-6482.2000 / Mol. Cell. Biol. / The Rad51 paralog Rad51B promotes homologous recombinational repair by Takata (2000)
  285. 10.1128/MCB.21.8.2858-2866.2001 / Mol. Cell. Biol. / Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs by Takata (2001)
  286. 10.1016/S0027-5107(00)00152-4 / Mutat. Res. / Chromosomal instability in BRCA1- or BRCA2-defective human cancer cells detected by spontaneous micronucleus assay by Ban (2001)
  287. 10.1038/sj.onc.1205656 / Oncogene / Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1 by Godthelp (2002)
  288. 10.1038/sj.onc.1205636 / Oncogene / Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer by Weaver (2002)
  289. 10.1016/S1097-2765(01)00174-5 / Mol. Cell. / BRCA2 is required for homology-directed repair of chromosomal breaks by Moynahan (2001)
  290. 10.1093/emboj/20.17.4704 / EMBO J. / Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences by Tutt (2001)
  291. 10.1128/MCB.19.7.5166 / Mol. Cell. Biol. / Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells by Sonoda (1999)
  292. 10.1038/sj.onc.1205168 / Oncogene / Conserved domains in the chicken homologue of BRCA2 by Takata (2002)
  293. 10.1038/386772a0 / Nature / Transcriptional activation functions in BRCA2 by Milner (1997)
  294. 10.1038/sj.onc.1202475 / Oncogene / BRCA2 associates with acetyltransferase activity when bound to P/CAF by Fuks (1998)
  295. 10.1038/sj.onc.1204098 / Oncogene / Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 by Liu (2001)
  296. 10.1016/S0092-8674(01)00209-4 / Cell / A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression by Marmorstein (2001)
  297. 10.1128/MCB.19.7.4633 / Mol. Cell. Biol. / Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals by Marston (1999)
  298. 10.1074/jbc.M112132200 / J. Biol. Chem. / ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair by Stark (2002)
  299. 10.1038/34937 / Nature / Synergistic actions of Rad5l and Rad52 in recombination and DNA repair by Benson (1998)
  300. 10.1006/jmbi.2000.4180 / J. Mol. Biol. / Reconstitution of the strand invasion step of double-strand break repair using human Rad5l Rad52 and RPA proteins by Mcllwraith (2000)
  301. 10.1074/jbc.M104938200 / J. Biol. Chem. / Homologous pairing promoted by the human Rad52 protein by Kagawa (2001)
  302. 10.1093/emboj/20.19.5513 / EMBO J. / Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells by Fujimori (2001)
  303. 10.1093/nar/30.6.1346 / Nucl. Acids Res. / Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54 by Tanaka (2002)
  304. 10.1093/emboj/21.1.175 / EMBO J. / A role for RAD54B in homologous recombination in human cells by Miyagawa (2002)
  305. 10.1074/jbc.M910306199 / J. Biol. Chem. / A novel human Rad54 homologue, Rad54B, associates with Rad51 by Tanaka (2000)
  306. 10.1038/sj.onc.1202691 / Oncogene / Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer by Hiramoto (1999)
  307. 10.1016/S0962-8924(01)02149-3 / Trends Cell Biol. / Double-strand breaks and tumorigenesis by Pierce (2001)
  308. {'key': '10.1016/S0027-5107(02)00224-5_BIB308', 'first-page': '219', 'article-title': 'Elevated levels of Rad51 recombination protein in tumor cells', 'volume': '62', 'author': 'Raderschall', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Elevated levels of Rad51 recombination protein in tumor cells by Raderschall (2002)
  309. 10.1038/sj.onc.1203578 / Oncogene / DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma by Maacke (2000)
  310. 10.1002/1097-0215(20001001)88:1<28::AID-IJC5>3.0.CO;2-4 / Int. J. Cancer / Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas by Yoshikawa (2000)
  311. 10.1016/S1097-2765(01)00357-4 / Mol. Cell. / BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance by Slupianek (2001)
  312. 10.1093/nar/29.21.4352 / Nucl. Acids Res. / Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells by Kim (2001)
  313. 10.1093/nar/29.3.662 / Nucl. Acids Res. / RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors by Arnaudeau (2001)
  314. 10.1006/excr.2001.5265 / Exp. Cell Res. / Effects of HsRad51 overexpression on cell proliferation, cell cycle progression, and apoptosis by Flygare (2001)
  315. 10.1093/nar/30.3.740 / Nucl. Acids Res. / Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line by Yanez (2002)
  316. 10.1093/nar/30.10.2172 / Nucl. Acids Res. / Mammalian Rad51C contributes to DNA cross-link resistance by Godthelp (2002)
  317. 10.1074/jbc.M201402200 / J. Biol. Chem. / Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability by French (2002)
  318. 10.1101/gad.11.9.1111 / Genes Dev. / Yeast Rad55 and Rad57 proteins form a heterodimer that functions with RPA to promote DNA strand exchange by Rad51 recombinase by Sung (1997)
  319. 10.1101/gad.947001 / Genes Dev. / Identification and purification of two distinct complexes containing the five RAD51 paralogs by Masson (2001)
  320. 10.1093/nar/30.4.1001 / Nucl. Acids Res. / Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells by Wiese (2002)
  321. 10.1093/nar/30.4.1009 / Nucl. Acids Res. / Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells by Liu (2002)
  322. 10.1074/jbc.M108306200 / J. Biol. Chem. / RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51 by Miller (2002)
  323. {'key': '10.1016/S0027-5107(02)00224-5_BIB323', 'first-page': '19', 'article-title': 'Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas', 'volume': '59', 'author': 'Schoenmakers', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas by Schoenmakers (1999)
  324. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1078>3.0.CO;2-8 / Genes Chromosomes Cancer / Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma by Takahashi (2001)
  325. 10.1002/gcc.1197 / Genes Chromosomes Cancer / Cumulative dosage effect of a RAD51L1/HMGA2 fusion and RAD51L1 loss in a case of pseudo-Meigs syndrome by Amant (2001)
  326. {'key': '10.1016/S0027-5107(02)00224-5_BIB326', 'first-page': '5612', 'article-title': 'A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer', 'volume': '60', 'author': 'Winsey', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer by Winsey (2000)
  327. 10.1002/ijc.1228 / Int. J. Cancer / DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study by Matullo (2001)
  328. 10.1093/hmg/11.12.1399 / Hum. Mol. Genet. / Variants in DNA double-strand break repair genes and breast cancer susceptibility by Kuschel (2002)
  329. {'key': '10.1016/S0027-5107(02)00224-5_BIB329', 'first-page': '911', 'article-title': 'No association between the XPD (Lys751Gln) polymorphism or the XRCC3 (Thr241 Met) polymorphism and lung cancer risk', 'volume': '10', 'author': 'David-Beabes', 'year': '2001', 'journal-title': 'Cancer Epidemiol. Biomarkers Prev.'} / Cancer Epidemiol. Biomarkers Prev. / No association between the XPD (Lys751Gln) polymorphism or the XRCC3 (Thr241 Met) polymorphism and lung cancer risk by David-Beabes (2001)
  330. 10.1093/carcin/22.4.593 / Carcinogenesis / Genetic polymorphisms in DNA repair genes and risk of lung cancer by Butkiewicz (2001)
  331. 10.1038/sj.onc.1205539 / Oncogene / Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks by Araujo (2002)
  332. 10.1093/hmg/11.12.1433 / Hum. Mol. Genet. / A potential role for the XRCC2 RI88H polymorphic site in DNA-damage repair and breast cancer by Rafii (2002)
  333. {'key': '10.1016/S0027-5107(02)00224-5_BIB333', 'first-page': '5340', 'article-title': 'Multiple genes at 17q23 undergo amplification and overexpression in breast cancer', 'volume': '60', 'author': 'Barlund', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Multiple genes at 17q23 undergo amplification and overexpression in breast cancer by Barlund (2000)
  334. {'key': '10.1016/S0027-5107(02)00224-5_BIB334', 'first-page': '5371', 'article-title': '17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes', 'volume': '60', 'author': 'Wu', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / 17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes by Wu (2000)
  335. 10.1038/21447 / Nature / The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta by Masutani (1999)
  336. 10.1126/science.285.5425.263 / Science / hRAD30 mutations in the variant form of xeroderma pigmentosum by Johnson (1999)
  337. {'key': '10.1016/S0027-5107(02)00224-5_BIB337', 'first-page': '1102', 'article-title': 'Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant', 'volume': '59', 'author': 'Cleaver', 'year': '1999', 'journal-title': 'Cancer Res.'} / Cancer Res. / Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant by Cleaver (1999)
  338. 10.1073/pnas.130182897 / Proc. Natl. Acad. Sci. U.S.A. / Inaugural article: polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair by Limoli (2000)
  339. 10.1073/pnas.231611798 / Proc. Natl. Acad. Sci. U.S.A. / UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mrel1 relocalization by Limoli (2002)
  340. 10.1046/j.1432-1327.2001.02225.x / Eur. J. Biochem. / Post-translational modifications and activation of p53 by genotoxic stresses by Appella (2001)
  341. {'key': '10.1016/S0027-5107(02)00224-5_BIB341', 'first-page': '47', 'article-title': 'Activation of the p53 tumor suppressor protein', 'volume': '1602', 'author': 'Vousden', 'year': '2002', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta / Activation of the p53 tumor suppressor protein by Vousden (2002)
  342. 10.1074/jbc.C100569200 / J. Biol. Chem. / Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress by Ward (2001)
  343. {'key': '10.1016/S0027-5107(02)00224-5_BIB343', 'first-page': '5795', 'article-title': 'Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells', 'volume': '45', 'author': 'Pinkel', 'year': '1985', 'journal-title': 'Cancer Res.'} / Cancer Res. / Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells by Pinkel (1985)
  344. 10.1074/jbc.M102075200 / J. Biol. Chem. / Protective role for c-Jun in the cellular response to DNA damage by Potapova (2001)
  345. 10.1016/S1535-6108(02)00041-7 / Cancer Cell / The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients by Elledge (2002)
  346. 10.1101/gad.970702 / Genes Dev. / SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint by Yazdi (2002)
  347. 10.1101/gad.970602 / Genes Dev. / Involvement of the cohesin protein, Smcl, in Atm-dependent and independent responses to DNA damage by Kim (2002)
  348. 10.1074/jbc.M008871200 / J. Biol. Chem. / Atm-dependent phosphorylation of human rad9 is required for ionizing radiation-induced checkpoint activation by Chen (2001)
  349. 10.1073/pnas.190030497 / Proc. Natl. Acad. Sci. U.S.A. / Ataxia telangiectasia-mutated phosphorylates chk2 in vivo and in vitro by Matsuoka (2000)
  350. {'key': '10.1016/S0027-5107(02)00224-5_BIB350', 'first-page': '5934', 'article-title': 'Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation', 'volume': '60', 'author': 'Ahn', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation by Ahn (2000)
  351. 10.1038/35036406 / Nat. Cell. Biol. / Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 by Melchionna (2000)
  352. 10.1074/jbc.M104414200 / J. Biol. Chem. / The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation by Lee (2001)
  353. 10.1074/jbc.C100587200 / J. Biol. Chem. / Threonine 68 of Chk2 Is phosphorylated at sites of DNA strand breaks by Ward (2001)
  354. 10.1038/3882 / Nat. Genet. / ATM associates with and phosphorylates p53: mapping the region of interaction by Khanna (1998)
  355. 10.1074/jbc.C200093200 / J. Biol. Chem. / ATM mediates phosphorylation at multiple p53 sites, including Ser46, in response to ionizing radiation by Saito (2002)
  356. 10.1101/gad.886901 / Genes Dev. / ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage by Maya (2001)
  357. {'key': '10.1016/S0027-5107(02)00224-5_BIB357', 'first-page': '3299', 'article-title': 'Role for ATM in DNA damage-induced phosphorylation of BRCA1', 'volume': '60', 'author': 'Gatei', 'year': '2000', 'journal-title': 'Cancer Res.'} / Cancer Res. / Role for ATM in DNA damage-induced phosphorylation of BRCA1 by Gatei (2000)
  358. 10.1038/387520a0 / Nature / Interaction between ATM protein and c-Ab1 in response to DNA damage by Shafman (1997)
  359. 10.1038/387516a0 / Nature / Ataxia telangiectasia mutant protein activates c-Ab1 tyrosine kinase in response to ionizing radiation by Baskaran (1997)
  360. 10.1074/jbc.M011534200 / J. Biol. Chem. / Telomeric protein Pin2/TRFI as an important ATM target in response to double strand DNA breaks by Kishi (2001)
  361. 10.1101/gad.14.3.289 / Genes Dev. / The human homologs of checkpoint kinases chkl and cdsl (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites by Shieh (2000)
  362. 10.1126/science.287.5459.1824 / Science / DNA damage-induced activation of p53 by the checkpoint kinase Chk2 by Hirao (2000)
  363. 10.1101/gad.14.3.278 / Genes Dev. / Chk2/hCdsl functions as a DNA damage checkpoint in G(l) by stabilizing p53 by Chehab (2000)
  364. 10.1128/MCB.21.5.1719-1729.2001 / Mol. Cell. Biol. / Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage by Anderson (2001)
  365. 10.1083/jcb.153.3.613 / J. Cell. Biol. / Tumor suppressor p53 binding protein I (S3BP1) is involved in DNA damage-signaling pathways by Rappold (2001)
  366. 10.1073/pnas.231364598 / Proc. Natl. Acad. Sci. U.S.A. / Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G11/S checkpoint activation in response to DNA damage by Post (2001)
  367. 10.1038/35082110 / Nature / ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses by Bao (2001)
  368. 10.1101/gad.14.12.1448 / Genes Dev. / Chk1 is an essential kinase that is regulated by ATR and required for the G(2)/M DNA damage checkpoint by Liu (2000)
  369. 10.1128/MCB.21.13.4129-4139.2001 / Mol. Cell. Biol. / Atr-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 by Zhao (2001)
  370. 10.1128/MCB.22.12.4419-4432.2002 / Mol. Cell. Biol. / Chk2 activation and phosphorylation-dependent oligomerization by Xu (2002)
  371. 10.1073/pnas.96.21.11866 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1-associated growth arrest is RB-dependent by Aprelikova (1999)
  372. 10.1073/pnas.95.5.2302 / Proc. Natl. Acad. Sci. U.S.A. / BRCA1 regulates p53-dependent gene expression by Ouchi (1998)
  373. 10.1038/sj.onc.1201932 / Oncogene / BRCA1 physically associates with p53 and stimulates its transcriptional activity by Zhang (1998)
  374. 10.1073/pnas.080469697 / Proc. Natl. Acad. Sci. U.S.A. / Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes by Ouchi (2000)
  375. 10.1128/MCB.22.12.4020-4032.2002 / Mol. Cell. Biol. / Constitutive association of BRCA1 and c-Ab1 and its ATM-dependent disruption after irradiation by Foray (2002)
  376. 10.1038/sj.onc.1202403 / Oncogene / BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells by Wang (1998)
  377. 10.1074/jbc.M112231200 / J. Biol. Chem. / A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promotor activity in breast cancer by Li (2002)
  378. 10.1074/jbc.273.11.6183 / J. Biol. Chem. / Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs by Li (1998)
  379. 10.1074/jbc.271.51.32863 / J. Biol. Chem. / The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor by Chen (1996)
Dates
Type When
Created 22 years, 9 months ago (Nov. 11, 2002, 4:13 p.m.)
Deposited 2 years, 3 months ago (April 25, 2023, 12:02 a.m.)
Indexed 1 month, 3 weeks ago (July 2, 2025, 3:07 p.m.)
Issued 22 years, 9 months ago (Nov. 1, 2002)
Published 22 years, 9 months ago (Nov. 1, 2002)
Published Print 22 years, 9 months ago (Nov. 1, 2002)
Funders 0

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@article{Thompson_2002, title={Recombinational DNA repair and human disease}, volume={509}, ISSN={0027-5107}, url={http://dx.doi.org/10.1016/s0027-5107(02)00224-5}, DOI={10.1016/s0027-5107(02)00224-5}, number={1–2}, journal={Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis}, publisher={Elsevier BV}, author={Thompson, Larry H and Schild, David}, year={2002}, month=nov, pages={49–78} }