DOI: 10.1016/s0022-3565(24)37646-3. Blockade of HERG and Kv1.5 by Ketoconazole

Blockade of HERG and Kv1.5 by Ketoconazole

10.1016/s0022-3565(24)37646-3

Crossref journal-article

Elsevier BV

The Journal of Pharmacology and Experimental Therapeutics (78)

Bibliography

Dumaine, R., Roy, M.-L., & Brown, A. M. (1998). Blockade of HERG and Kv1.5 by Ketoconazole. The Journal of Pharmacology and Experimental Therapeutics, 286(2), 727â735.

Authors 3

Robert Dumaine (first)
Mary-Louise Roy (additional)
Arthur M. Brown (additional)

References 37 Referenced 55

{'key': '10.1016/S0022-3565(24)37646-3_bib1', 'first-page': 'I', 'article-title': 'Differences in outward currents of human atrial and ventricular myocytes.', 'volume': '4', 'author': 'Amos', 'year': '1994', 'journal-title': 'Circulation'} / Circulation / Differences in outward currents of human atrial and ventricular myocytes. by Amos (1994)
10.1161/01.CIR.91.8.2220 / Circulation / Regulation of potassium channels by non-sedating antihistamines. by Berul (1995)
10.1111/j.1540-8159.1997.tb06198.x / PACE / Heterogeneity in K+ channel transcript expression detected in isolated ferret cardiac myocytes. by Brahmajothi (1997)
{'issue': '4', 'key': '10.1016/S0022-3565(24)37646-3_bib4', 'first-page': 'I', 'article-title': 'Ketoconazole blocks potassium currents in feline heart.', 'volume': '88', 'author': 'Chen', 'year': '1993', 'journal-title': 'Circulation'} / Circulation / Ketoconazole blocks potassium currents in feline heart. by Chen (1993)
10.1038/301248a0 / Nature (Lond) / Caffeine induces a transient inward current in cultured cardiac cells. by Clusin (1983)
10.1056/NEJM199401273300407 / New Engl J Med / Oral azole drugs as systemic antifungal therapy. by Como (1994)
10.1016/0092-8674(95)90358-5 / Cell / A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. by Curran (1995)
10.2165/00003088-198308010-00002 / Clin Pharmacokinet / Clinical pharmacokinetics of systemic antifungal drugs. by Daneshmend (1983)
10.1136/bmj.298.6669.325 / Br Med J / Cardiotoxic effect with convulsions in terfenadine overdose. by Davies (1989)
10.1161/01.RES.73.1.210 / Circ Res / Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current. by Fedida (1993)
{'issue': '(I) 2', 'key': '10.1016/S0022-3565(24)37646-3_bib11', 'first-page': '149', 'article-title': 'Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsades de pointes.', 'volume': '41', 'author': 'Hey', 'year': '1996', 'journal-title': 'Arzneim-Forsh/Drug Res'} / Arzneim-Forsh/Drug Res / Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsades de pointes. by Hey (1996)
10.1001/jama.1993.03500120051025 / JAMA / Terfenadine-ketoconazole interaction. by Honig (1993)
10.1016/S0090-9556(25)08427-2 / Drug Metab Dispos / Terfenadine metabolism in human liver. In-vitro inhibition by macrolide antibiotics and azole antifungals. by Jurima-Romet (1994)
10.1161/01.CIR.85.6.2227 / Circulation / Early afterdepolarizations and triggered activity induced by cocaine. A possible mechanism of cocaine arrhythmogenesis. by Kimura (1992)
10.1161/01.RES.76.3.351 / Circ Res / Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial and endocardial myocytes: A weaker IKs contributes to the longer action potential of the M cell. by Liu (1995)
10.1172/JCI110903 / J Clin Invest / Ketoconazole blocks adrenal steriodogenesis by inhibiting cytochrome P450-dependent enzymes. by Loose (1983)
10.1001/archinte.1984.04400020052007 / Arch Intern Med / High-dose ketoconazole therapy and adrenal and testicular function in humans. by Pont (1984)
10.1016/S0002-8703(96)90525-6 / Am Heart J / Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: Distinguishing a drug effect from spontaneous variability. by Pratt (1996)
10.1016/S0026-895X(25)13362-2 / Molec Pharmacol / Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart. by Rampe (1993)
10.1161/01.CIR.94.4.817 / Circulation / HERG: A primary human ventricular target of the nonsedating antihistamine terfenadine. by Roy (1996)
10.1016/0092-8674(95)90340-2 / Cell / A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. by Sanguinetti (1995)
10.1085/jgp.96.1.195 / J Gen Physiol / Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by Class III antiarrhythmic agents. by Sanguinetti (1990)
10.1210/jcem-57-4-732 / J Clin Endocrinol Metab / Site of action of low dose ketoconazole on androgen biosynthesis in men. by Santen (1983)
10.1113/jphysiol.1987.sp016571 / J Physiol (Lond.) / Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. by Shibasaki (1987)
{'key': '10.1016/S0022-3565(24)37646-3_bib25', 'first-page': '1663', 'article-title': 'The pharmacology and use of H1 receptor-antagonist drugs.', 'volume': '330', 'author': 'Simons', 'year': '1997', 'journal-title': 'New England J Med'} / New England J Med / The pharmacology and use of H1 receptor-antagonist drugs. by Simons (1997)
10.1038/379833a0 / Nature / The inward rectification of the HERG cardiac potassium channel. by Smith (1996)
10.2165/00003495-198529010-00002 / Drugs / Terfenadine: A review of its pharmaco-dynamic properties and therapeutic efficacy. by Sorkin (1985)
10.1085/jgp.107.5.611 / J Gen Physiol / Fast inactivation causes rectification of the IKr channel. by Spector (1996)
10.1016/0014-5793(96)00355-9 / FEBS Lett / Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizoles. by Suessbrich (1996)
10.1126/science.8171340 / Science (Wash DC) / Specification of pore properties by the carboxyl terminus of inward rectifying K+ channels. by Taglialatela (1994)
10.1096/fasebj.5.3.2001794 / FASEB J / Molecular cloning of two voltage gated K+ channel cDNAs from human ventricle. by Tamkun (1991)
10.1126/science.7604285 / Science (Wash DC) / HERG, a human inward rectifier in the voltage-gated potassium channel family. by Trudeau (1995)
10.1002/j.1552-4604.1994.tb04735.x / J Clin Pharmacol / In-vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction. by Von Moltke (1994)
10.1161/01.RES.73.6.1061 / Circ Res / Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents. by Wang (1993)
10.1146/annurev.pa.36.040196.001313 / Annu Rev Pharmacol Toxicol / Cardiac action of antihistamines. by Woosley (1996)
{'issue': '2', 'key': '10.1016/S0022-3565(24)37646-3_bib36', 'first-page': '329A', 'article-title': 'Synergistic effects of ketoconazole and terfenadine on cardiac repolarization.', 'volume': '42', 'author': 'Woosley', 'year': '1994', 'journal-title': 'Circ Res'} / Circ Res / Synergistic effects of ketoconazole and terfenadine on cardiac repolarization. by Woosley (1994)
10.1161/01.RES.77.1.140 / Circ Res / Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. by Zeng (1995)

Dates

Type	When
Created	7 months, 3 weeks ago (Jan. 4, 2025, 11:09 a.m.)
Deposited	6 months, 1 week ago (Feb. 19, 2025, 8:01 p.m.)
Indexed	2 months, 1 week ago (June 18, 2025, 2:09 p.m.)
Issued	27 years ago (Aug. 1, 1998)
Published	27 years ago (Aug. 1, 1998)
Published Print	27 years ago (Aug. 1, 1998)

Funders 0

None

BibTeX

@article{Dumaine_1998, title={Blockade of HERG and Kv1.5 by Ketoconazole}, volume={286}, ISSN={0022-3565}, url={http://dx.doi.org/10.1016/s0022-3565(24)37646-3}, DOI={10.1016/s0022-3565(24)37646-3}, number={2}, journal={The Journal of Pharmacology and Experimental Therapeutics}, publisher={Elsevier BV}, author={Dumaine, Robert and Roy, Mary-Louise and Brown, Arthur M.}, year={1998}, month=aug, pages={727–735} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        18
      ]
    ],
    "date-time": "2025-06-18T18:09:47Z",
    "timestamp": 1750270187928,
    "version": "3.37.3"
  },
  "reference-count": 37,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            8,
            1
          ]
        ],
        "date-time": "1998-08-01T00:00:00Z",
        "timestamp": 901929600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            1998,
            8,
            1
          ]
        ],
        "date-time": "1998-08-01T00:00:00Z",
        "timestamp": 901929600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    }
  ],
  "content-domain": {
    "domain": [
      "jpet.aspetjournals.org",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  },
  "DOI": "10.1016/s0022-3565(24)37646-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2025,
        1,
        4
      ]
    ],
    "date-time": "2025-01-04T16:09:42Z",
    "timestamp": 1736006982000
  },
  "page": "727-735",
  "update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 55,
  "title": "Blockade of HERG and Kv1.5 by Ketoconazole",
  "prefix": "10.1016",
  "volume": "286",
  "author": [
    {
      "given": "Robert",
      "family": "Dumaine",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mary-Louise",
      "family": "Roy",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Arthur M.",
      "family": "Brown",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib1",
      "first-page": "I",
      "article-title": "Differences in outward currents of human atrial and ventricular myocytes.",
      "volume": "4",
      "author": "Amos",
      "year": "1994",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "2220",
      "DOI": "10.1161/01.CIR.91.8.2220",
      "article-title": "Regulation of potassium channels by non-sedating antihistamines.",
      "volume": "91",
      "author": "Berul",
      "year": "1995",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1111/j.1540-8159.1997.tb06198.x",
      "article-title": "Heterogeneity in K+ channel transcript expression detected in isolated ferret cardiac myocytes.",
      "volume": "20",
      "author": "Brahmajothi",
      "year": "1997",
      "journal-title": "PACE"
    },
    {
      "issue": "4",
      "key": "10.1016/S0022-3565(24)37646-3_bib4",
      "first-page": "I",
      "article-title": "Ketoconazole blocks potassium currents in feline heart.",
      "volume": "88",
      "author": "Chen",
      "year": "1993",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1038/301248a0",
      "article-title": "Caffeine induces a transient inward current in cultured cardiac cells.",
      "volume": "301",
      "author": "Clusin",
      "year": "1983",
      "journal-title": "Nature (Lond)"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1056/NEJM199401273300407",
      "article-title": "Oral azole drugs as systemic antifungal therapy.",
      "volume": "330",
      "author": "Como",
      "year": "1994",
      "journal-title": "New Engl J Med"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "795",
      "DOI": "10.1016/0092-8674(95)90358-5",
      "article-title": "A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.",
      "volume": "80",
      "author": "Curran",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.2165/00003088-198308010-00002",
      "article-title": "Clinical pharmacokinetics of systemic antifungal drugs.",
      "volume": "8",
      "author": "Daneshmend",
      "year": "1983",
      "journal-title": "Clin Pharmacokinet"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib9",
      "doi-asserted-by": "crossref",
      "DOI": "10.1136/bmj.298.6669.325",
      "article-title": "Cardiotoxic effect with convulsions in terfenadine overdose.",
      "volume": "298",
      "author": "Davies",
      "year": "1989",
      "journal-title": "Br Med J"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "210",
      "DOI": "10.1161/01.RES.73.1.210",
      "article-title": "Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.",
      "volume": "73",
      "author": "Fedida",
      "year": "1993",
      "journal-title": "Circ Res"
    },
    {
      "issue": "(I) 2",
      "key": "10.1016/S0022-3565(24)37646-3_bib11",
      "first-page": "149",
      "article-title": "Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsades de pointes.",
      "volume": "41",
      "author": "Hey",
      "year": "1996",
      "journal-title": "Arzneim-Forsh/Drug Res"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "1513",
      "DOI": "10.1001/jama.1993.03500120051025",
      "article-title": "Terfenadine-ketoconazole interaction.",
      "volume": "269",
      "author": "Honig",
      "year": "1993",
      "journal-title": "JAMA"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "849",
      "DOI": "10.1016/S0090-9556(25)08427-2",
      "article-title": "Terfenadine metabolism in human liver. In-vitro inhibition by macrolide antibiotics and azole antifungals.",
      "volume": "22",
      "author": "Jurima-Romet",
      "year": "1994",
      "journal-title": "Drug Metab Dispos"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "2227",
      "DOI": "10.1161/01.CIR.85.6.2227",
      "article-title": "Early afterdepolarizations and triggered activity induced by cocaine. A possible mechanism of cocaine arrhythmogenesis.",
      "volume": "85",
      "author": "Kimura",
      "year": "1992",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1161/01.RES.76.3.351",
      "article-title": "Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial and endocardial myocytes: A weaker IKs contributes to the longer action potential of the M cell.",
      "volume": "76",
      "author": "Liu",
      "year": "1995",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1495",
      "DOI": "10.1172/JCI110903",
      "article-title": "Ketoconazole blocks adrenal steriodogenesis by inhibiting cytochrome P450-dependent enzymes.",
      "volume": "71",
      "author": "Loose",
      "year": "1983",
      "journal-title": "J Clin Invest"
    },
    {
      "issue": "11",
      "key": "10.1016/S0022-3565(24)37646-3_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "2150",
      "DOI": "10.1001/archinte.1984.04400020052007",
      "article-title": "High-dose ketoconazole therapy and adrenal and testicular function in humans.",
      "volume": "144",
      "author": "Pont",
      "year": "1984",
      "journal-title": "Arch Intern Med"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1016/S0002-8703(96)90525-6",
      "article-title": "Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: Distinguishing a drug effect from spontaneous variability.",
      "volume": "131",
      "author": "Pratt",
      "year": "1996",
      "journal-title": "Am Heart J"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1240",
      "DOI": "10.1016/S0026-895X(25)13362-2",
      "article-title": "Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart.",
      "volume": "44",
      "author": "Rampe",
      "year": "1993",
      "journal-title": "Molec Pharmacol"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1161/01.CIR.94.4.817",
      "article-title": "HERG: A primary human ventricular target of the nonsedating antihistamine terfenadine.",
      "volume": "94",
      "author": "Roy",
      "year": "1996",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1016/0092-8674(95)90340-2",
      "article-title": "A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.",
      "volume": "81",
      "author": "Sanguinetti",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1085/jgp.96.1.195",
      "article-title": "Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by Class III antiarrhythmic agents.",
      "volume": "96",
      "author": "Sanguinetti",
      "year": "1990",
      "journal-title": "J Gen Physiol"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "732",
      "DOI": "10.1210/jcem-57-4-732",
      "article-title": "Site of action of low dose ketoconazole on androgen biosynthesis in men.",
      "volume": "57",
      "author": "Santen",
      "year": "1983",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1113/jphysiol.1987.sp016571",
      "article-title": "Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.",
      "volume": "387",
      "author": "Shibasaki",
      "year": "1987",
      "journal-title": "J Physiol (Lond.)"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib25",
      "first-page": "1663",
      "article-title": "The pharmacology and use of H1 receptor-antagonist drugs.",
      "volume": "330",
      "author": "Simons",
      "year": "1997",
      "journal-title": "New England J Med"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "833",
      "DOI": "10.1038/379833a0",
      "article-title": "The inward rectification of the HERG cardiac potassium channel.",
      "volume": "379",
      "author": "Smith",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.2165/00003495-198529010-00002",
      "article-title": "Terfenadine: A review of its pharmaco-dynamic properties and therapeutic efficacy.",
      "volume": "29",
      "author": "Sorkin",
      "year": "1985",
      "journal-title": "Drugs"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1085/jgp.107.5.611",
      "article-title": "Fast inactivation causes rectification of the IKr channel.",
      "volume": "107",
      "author": "Spector",
      "year": "1996",
      "journal-title": "J Gen Physiol"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/0014-5793(96)00355-9",
      "article-title": "Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizoles.",
      "volume": "385",
      "author": "Suessbrich",
      "year": "1996",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "844",
      "DOI": "10.1126/science.8171340",
      "article-title": "Specification of pore properties by the carboxyl terminus of inward rectifying K+ channels.",
      "volume": "264",
      "author": "Taglialatela",
      "year": "1994",
      "journal-title": "Science (Wash DC)"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1096/fasebj.5.3.2001794",
      "article-title": "Molecular cloning of two voltage gated K+ channel cDNAs from human ventricle.",
      "volume": "5",
      "author": "Tamkun",
      "year": "1991",
      "journal-title": "FASEB J"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "92",
      "DOI": "10.1126/science.7604285",
      "article-title": "HERG, a human inward rectifier in the voltage-gated potassium channel family.",
      "volume": "269",
      "author": "Trudeau",
      "year": "1995",
      "journal-title": "Science (Wash DC)"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1222",
      "DOI": "10.1002/j.1552-4604.1994.tb04735.x",
      "article-title": "In-vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.",
      "volume": "34",
      "author": "Von Moltke",
      "year": "1994",
      "journal-title": "J Clin Pharmacol"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "1061",
      "DOI": "10.1161/01.RES.73.6.1061",
      "article-title": "Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.",
      "volume": "73",
      "author": "Wang",
      "year": "1993",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib35",
      "doi-asserted-by": "crossref",
      "DOI": "10.1146/annurev.pa.36.040196.001313",
      "article-title": "Cardiac action of antihistamines.",
      "volume": "36",
      "author": "Woosley",
      "year": "1996",
      "journal-title": "Annu Rev Pharmacol Toxicol"
    },
    {
      "issue": "2",
      "key": "10.1016/S0022-3565(24)37646-3_bib36",
      "first-page": "329A",
      "article-title": "Synergistic effects of ketoconazole and terfenadine on cardiac repolarization.",
      "volume": "42",
      "author": "Woosley",
      "year": "1994",
      "journal-title": "Circ Res"
    },
    {
      "key": "10.1016/S0022-3565(24)37646-3_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1161/01.RES.77.1.140",
      "article-title": "Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization.",
      "volume": "77",
      "author": "Zeng",
      "year": "1995",
      "journal-title": "Circ Res"
    }
  ],
  "container-title": "The Journal of Pharmacology and Experimental Therapeutics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022356524376463?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022356524376463?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        2,
        20
      ]
    ],
    "date-time": "2025-02-20T01:01:47Z",
    "timestamp": 1740013307000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022356524376463"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  },
  "references-count": 37,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1998,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022356524376463"
  ],
  "URL": "http://dx.doi.org/10.1016/S0022-3565(24)37646-3",
  "relation": {},
  "ISSN": [
    "0022-3565"
  ],
  "subject": [],
  "container-title-short": "The Journal of Pharmacology and Experimental Therapeutics",
  "published": {
    "date-parts": [
      [
        1998,
        8
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Blockade of HERG and Kv1.5 by Ketoconazole",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "The Journal of Pharmacology and Experimental Therapeutics",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/S0022-3565(24)37646-3",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "\u00a9 1998 The American Society for Pharmacology and Experimental Therapeutics",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}