DOI: 10.1016/s0021-9258(19)76559-4. Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

10.1016/s0021-9258(19)76559-4

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Black, R. A., Kronheim, S. R., Cantrell, M., Deeley, M. C., March, C. J., Prickett, K. S., Wignall, J., Conlon, P. J., Cosman, D., & Hopp, T. P. (1988). Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. Journal of Biological Chemistry, 263(19), 9437â9442.

Authors 10

R A Black (first)
S R Kronheim (additional)
M Cantrell (additional)
M C Deeley (additional)
C J March (additional)
K S Prickett (additional)
J Wignall (additional)
P J Conlon (additional)
D Cosman (additional)
T P Hopp (additional)

References 32 Referenced 290

10.1038/315641a0 / Nature by March (1985)
10.1016/0167-5699(86)90124-6 / Immunol. Today by Oppenheim (1986)
10.1073/pnas.84.15.5267 / Proc. Natl. Acad. Sci. U. S. A. by Mochizuki (1987)
10.1073/pnas.81.24.7907 / Proc. Natl. Acad. Sci. U. S.A. by Auron (1984)
10.4049/jimmunol.134.1.343 / J. Immunol. by Giri (1985)
10.1084/jem.163.5.1267 / J. Exp. Med. by Bayne (1986)
10.4049/jimmunol.138.5.1447 / J. Immunol. by Auron (1987)
10.4049/jimmunol.136.8.2883 / J. Immunol. by Matsushima (1986)
10.1016/0161-5890(85)90061-6 / Mol. Immunol. by Lepe-Zuniga (1985)
10.1016/S0021-9258(18)61450-4 / J. Biol. Chem. by Mosley (1987)
10.1016/0092-8674(75)90018-5 / Cell by Maniatis (1975)
{'key': '10.1016/S0021-9258(19)76559-4_bib12', 'first-page': '1078', 'volume': '4', 'author': 'Kronheim', 'year': '1986', 'journal-title': 'Biotechnology'} / Biotechnology by Kronheim (1986)
10.1038/254034a0 / Nature by Shine (1975)
10.1038/227680a0 / Nature by Laemmli (1970)
10.1073/pnas.82.1.88 / Proc. Natl. Acad. Sci. U. S. A. by Mott (1985)
{'key': '10.1016/S0021-9258(19)76559-4_bib16', 'series-title': 'Recombinant Lymphokines and Their Receptors', 'first-page': '187', 'author': 'Cantrell', 'year': '1987'} / Recombinant Lymphokines and Their Receptors by Cantrell (1987)
10.1084/jem.161.3.490 / J. Exp. Med. by Kronheim (1985)
10.4049/jimmunol.131.3.1280 / J. Immunol. by Conlon (1983)
10.4049/jimmunol.135.6.3944 / J. Immunol. by MacDonald (1985)
10.1038/270347a0 / Nature by Collins (1977)
10.1126/science.306682 / Science by Koeffler (1978)
10.1111/j.1432-1033.1985.tb09157.x / Eur. J. Biochem. by Vandekerckhove (1985)
{'key': '10.1016/S0021-9258(19)76559-4_bib23', 'series-title': 'The Peptides', 'first-page': '1', 'volume': 'Vol. 2', 'author': 'Barany', 'year': '1979'} / The Peptides by Barany (1979)
10.1016/0161-5890(84)90084-1 / Mol. Immunol. by Hopp (1984)
10.4049/jimmunol.126.5.1978 / J. Immunol. by Gillis (1981)
10.1016/0006-291X(66)90162-8 / Biochem. Biophys. Res. Commun. by Mikes (1966)
10.1021/bi00329a036 / Biochemistry by Tanaka (1985)
10.1021/bi00379a015 / Biochemistry by Stein (1987)
10.1172/JCI110462 / J. Clin. Invest. by Senior (1982)
10.4049/jimmunol.132.5.2547 / J. Immunol. by Senior (1984)
10.1016/0014-5793(80)81128-8 / FEBS Lett. by Kargel (1980)
10.1016/S0021-9258(18)66927-3 / J. Biol. Chem. by Portnoy (1986)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 6, 2021, 4:53 p.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 11:04 p.m.)
Indexed	4 weeks, 2 days ago (July 26, 2025, 5:05 a.m.)
Issued	37 years, 1 month ago (July 1, 1988)
Published	37 years, 1 month ago (July 1, 1988)
Published Print	37 years, 1 month ago (July 1, 1988)

Funders 0

None

BibTeX

@article{Black_1988, title={Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.}, volume={263}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(19)76559-4}, DOI={10.1016/s0021-9258(19)76559-4}, number={19}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Black, R A and Kronheim, S R and Cantrell, M and Deeley, M C and March, C J and Prickett, K S and Wignall, J and Conlon, P J and Cosman, D and Hopp, T P}, year={1988}, month=jul, pages={9437–9442} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        26
      ]
    ],
    "date-time": "2025-07-26T09:05:01Z",
    "timestamp": 1753520701003
  },
  "reference-count": 32,
  "publisher": "Elsevier BV",
  "issue": "19",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1988,
            7,
            1
          ]
        ],
        "date-time": "1988-07-01T00:00:00Z",
        "timestamp": 583718400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            10
          ]
        ],
        "date-time": "2020-10-10T00:00:00Z",
        "timestamp": 1602288000000
      },
      "content-version": "vor",
      "delay-in-days": 11789,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1988,
        7
      ]
    ]
  },
  "DOI": "10.1016/s0021-9258(19)76559-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        1,
        6
      ]
    ],
    "date-time": "2021-01-06T21:53:56Z",
    "timestamp": 1609970036000
  },
  "page": "9437-9442",
  "source": "Crossref",
  "is-referenced-by-count": 290,
  "title": "Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.",
  "prefix": "10.1016",
  "volume": "263",
  "author": [
    {
      "given": "R A",
      "family": "Black",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "S R",
      "family": "Kronheim",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M",
      "family": "Cantrell",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M C",
      "family": "Deeley",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C J",
      "family": "March",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K S",
      "family": "Prickett",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J",
      "family": "Wignall",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "P J",
      "family": "Conlon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D",
      "family": "Cosman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T P",
      "family": "Hopp",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1038/315641a0",
      "volume": "315",
      "author": "March",
      "year": "1985",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/0167-5699(86)90124-6",
      "volume": "7",
      "author": "Oppenheim",
      "year": "1986",
      "journal-title": "Immunol. Today"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "5267",
      "DOI": "10.1073/pnas.84.15.5267",
      "volume": "84",
      "author": "Mochizuki",
      "year": "1987",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "7907",
      "DOI": "10.1073/pnas.81.24.7907",
      "volume": "81",
      "author": "Auron",
      "year": "1984",
      "journal-title": "Proc. Natl. Acad. Sci. U. S.A."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.4049/jimmunol.134.1.343",
      "volume": "134",
      "author": "Giri",
      "year": "1985",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "1267",
      "DOI": "10.1084/jem.163.5.1267",
      "volume": "163",
      "author": "Bayne",
      "year": "1986",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1447",
      "DOI": "10.4049/jimmunol.138.5.1447",
      "volume": "138",
      "author": "Auron",
      "year": "1987",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "2883",
      "DOI": "10.4049/jimmunol.136.8.2883",
      "volume": "136",
      "author": "Matsushima",
      "year": "1986",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "1387",
      "DOI": "10.1016/0161-5890(85)90061-6",
      "volume": "22",
      "author": "Lepe-Zuniga",
      "year": "1985",
      "journal-title": "Mol. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "2941",
      "DOI": "10.1016/S0021-9258(18)61450-4",
      "volume": "262",
      "author": "Mosley",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1016/0092-8674(75)90018-5",
      "volume": "5",
      "author": "Maniatis",
      "year": "1975",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib12",
      "first-page": "1078",
      "volume": "4",
      "author": "Kronheim",
      "year": "1986",
      "journal-title": "Biotechnology"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "34",
      "DOI": "10.1038/254034a0",
      "volume": "254",
      "author": "Shine",
      "year": "1975",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "680",
      "DOI": "10.1038/227680a0",
      "volume": "227",
      "author": "Laemmli",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1073/pnas.82.1.88",
      "volume": "82",
      "author": "Mott",
      "year": "1985",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib16",
      "series-title": "Recombinant Lymphokines and Their Receptors",
      "first-page": "187",
      "author": "Cantrell",
      "year": "1987"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "490",
      "DOI": "10.1084/jem.161.3.490",
      "volume": "161",
      "author": "Kronheim",
      "year": "1985",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1280",
      "DOI": "10.4049/jimmunol.131.3.1280",
      "volume": "131",
      "author": "Conlon",
      "year": "1983",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "3944",
      "DOI": "10.4049/jimmunol.135.6.3944",
      "volume": "135",
      "author": "MacDonald",
      "year": "1985",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1038/270347a0",
      "volume": "270",
      "author": "Collins",
      "year": "1977",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1153",
      "DOI": "10.1126/science.306682",
      "volume": "200",
      "author": "Koeffler",
      "year": "1978",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1111/j.1432-1033.1985.tb09157.x",
      "volume": "152",
      "author": "Vandekerckhove",
      "year": "1985",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib23",
      "series-title": "The Peptides",
      "first-page": "1",
      "volume": "Vol. 2",
      "author": "Barany",
      "year": "1979"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/0161-5890(84)90084-1",
      "volume": "21",
      "author": "Hopp",
      "year": "1984",
      "journal-title": "Mol. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1978",
      "DOI": "10.4049/jimmunol.126.5.1978",
      "volume": "126",
      "author": "Gillis",
      "year": "1981",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1016/0006-291X(66)90162-8",
      "volume": "24",
      "author": "Mikes",
      "year": "1966",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "2040",
      "DOI": "10.1021/bi00329a036",
      "volume": "24",
      "author": "Tanaka",
      "year": "1985",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "1301",
      "DOI": "10.1021/bi00379a015",
      "volume": "26",
      "author": "Stein",
      "year": "1987",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "384",
      "DOI": "10.1172/JCI110462",
      "volume": "69",
      "author": "Senior",
      "year": "1982",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "2547",
      "DOI": "10.4049/jimmunol.132.5.2547",
      "volume": "132",
      "author": "Senior",
      "year": "1984",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1016/0014-5793(80)81128-8",
      "volume": "114",
      "author": "Kargel",
      "year": "1980",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/S0021-9258(19)76559-4_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "14697",
      "DOI": "10.1016/S0021-9258(18)66927-3",
      "volume": "261",
      "author": "Portnoy",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819765594?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819765594?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        17
      ]
    ],
    "date-time": "2023-10-17T03:04:17Z",
    "timestamp": 1697511857000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925819765594"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1988,
        7
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "19",
    "published-print": {
      "date-parts": [
        [
          1988,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925819765594"
  ],
  "URL": "http://dx.doi.org/10.1016/S0021-9258(19)76559-4",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1988,
        7
      ]
    ]
  }
}