DOI: 10.1016/s0021-9258(19)44395-0. Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

10.1016/s0021-9258(19)44395-0

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Authors 7

Anthony Y.H. Lu (first)
Wayne Levin (additional)
Susan B. West (additional)
Martin Jacobson (additional)
Dene Ryan (additional)
Ronald Kuntzman (additional)
A.H. Conney (additional)

References 35 Referenced 108

10.1016/0006-291X(69)90339-8 / Biochem. Biophys. Res. Commun. by Lu (1969)
{'key': '10.1016/S0021-9258(19)44395-0_bib2', 'first-page': '213', 'volume': '6', 'author': 'Lu', 'year': '1970', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Lu (1970)
10.1016/S0021-9258(19)45536-1 / J. Biol. Chem. by Lu (1972)
10.1016/S0021-9258(18)62872-8 / J. Biol. Chem. by Strobel (1970)
10.1016/0006-291X(67)90515-3 / Biochem. Biophys. Res. Commun. by Alvares (1967)
10.1016/0006-291X(66)90376-7 / Biochem. Biophys. Res. Commun. by Sladek (1966)
10.1016/0006-291X(68)90555-X / Biochem. Biophys. Res. Commun. by Hildebrandt (1968)
{'key': '10.1016/S0021-9258(19)44395-0_bib8', 'first-page': '317', 'volume': '19', 'author': 'Conney', 'year': '1967', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Conney (1967)
10.1146/annurev.pa.09.040169.000321 / Annu. Rev. Pharmacol. by Kuntzman (1969)
10.1016/0026-0495(71)90094-1 / Metab. (Clin. Exp.) by Mannering (1971)
10.1016/S0021-9258(19)56992-7 / J. Biol. Chem. by Lu (1968)
10.1016/S0021-9258(18)83427-5 / J. Biol. Chem. by Lu (1969)
10.1016/0006-291X(71)90033-7 / Biochem. Biophys. Res. Commun. by Lu (1971)
10.1016/0006-2952(69)90059-8 / Biochem. Pharmacol. by Levin (1969)
10.1016/S0006-291X(72)80121-9 / Biochem. Biophys. Res. Commun. by Lu (1972)
10.1016/S0021-9258(20)82245-5 / J. Biol. Chem. by Omura (1964)
{'key': '10.1016/S0021-9258(19)44395-0_bib17', 'first-page': '490', 'volume': '8', 'author': 'Lu', 'year': '1972', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Lu (1972)
10.1016/0039-128X(69)90042-7 / Steroids by Jacobson (1969)
10.1016/S0021-9258(18)94484-4 / J. Biol. Chem. by Nebert (1968)
10.1016/0009-2797(72)90053-1 / Chem.-Biol. Interactions by Jacobson (1972)
10.1016/0003-9861(71)90456-5 / Arch. Biochem. Biophys. by Wiebel (1971)
10.1016/0003-9861(72)90447-X / Arch. Biochem. Biophys. by Lu (1972)
10.1016/S0021-9258(18)92030-2 / J. Biol. Chem. by Conney (1968)
{'key': '10.1016/S0021-9258(19)44395-0_bib23', 'series-title': 'Microsomes and Drug Oxidations', 'first-page': '279', 'author': 'Conney', 'year': '1969'} / Microsomes and Drug Oxidations by Conney (1969)
10.1016/0006-2952(71)90335-2 / Biochem. Pharmacol. by Aust (1971)
10.1016/0006-2952(70)90121-8 / Biochem. Pharmacol. by Pederson (1970)
10.1007/BF00997298 / Naunyn-Schmiedebergsarchiv Pharmakol. by Bohn (1971)
10.1515/bchm2.1969.350.1.547 / Hoppe-Seyler's Z. Physiol. Chem. by Degkwitz (1969)
10.1016/0024-3205(63)90137-1 / Life Sci. by Smith (1963)
{'key': '10.1016/S0021-9258(19)44395-0_bib29', 'first-page': '131', 'volume': '5', 'author': 'Guarino', 'year': '1969', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Guarino (1969)
{'key': '10.1016/S0021-9258(19)44395-0_bib30', 'first-page': '206', 'volume': '6', 'author': 'Alvares', 'year': '1970', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Alvares (1970)
10.1093/oxfordjournals.jbchem.a128854 / J. Biochem. (Tokyo) by Wada (1968)
10.3109/00498257209036237 / Xenobiotica by Von Bahr (1972)
{'key': '10.1016/S0021-9258(19)44395-0_bib33', 'first-page': '499', 'volume': '5', 'author': 'Levin', 'year': '1969', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Levin (1969)
{'key': '10.1016/S0021-9258(19)44395-0_bib34', 'first-page': '4', 'volume': '175', 'author': 'Alvares', 'year': '1970', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Alvares (1970)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 6, 2021, 9:17 a.m.)
Deposited	3 years, 8 months ago (Jan. 2, 2022, 12:47 p.m.)
Indexed	17 hours, 38 minutes ago (Sept. 4, 2025, 10:11 a.m.)
Issued	52 years, 8 months ago (Jan. 1, 1973)
Published	52 years, 8 months ago (Jan. 1, 1973)
Published Print	52 years, 8 months ago (Jan. 1, 1973)

Funders 0

None

BibTeX

@article{Lu_1973, title={Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates}, volume={248}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(19)44395-0}, DOI={10.1016/s0021-9258(19)44395-0}, number={2}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Lu, Anthony Y.H. and Levin, Wayne and West, Susan B. and Jacobson, Martin and Ryan, Dene and Kuntzman, Ronald and Conney, A.H.}, year={1973}, month=jan, pages={456–460} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T14:11:44Z",
    "timestamp": 1756995104372
  },
  "reference-count": 35,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1973,
            1,
            1
          ]
        ],
        "date-time": "1973-01-01T00:00:00Z",
        "timestamp": 94694400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            30
          ]
        ],
        "date-time": "2020-10-30T00:00:00Z",
        "timestamp": 1604016000000
      },
      "content-version": "vor",
      "delay-in-days": 17469,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1973,
        1
      ]
    ]
  },
  "DOI": "10.1016/s0021-9258(19)44395-0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        1,
        6
      ]
    ],
    "date-time": "2021-01-06T14:17:48Z",
    "timestamp": 1609942668000
  },
  "page": "456-460",
  "source": "Crossref",
  "is-referenced-by-count": 108,
  "title": "Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates",
  "prefix": "10.1016",
  "volume": "248",
  "author": [
    {
      "given": "Anthony Y.H.",
      "family": "Lu",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Wayne",
      "family": "Levin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Susan B.",
      "family": "West",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Martin",
      "family": "Jacobson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dene",
      "family": "Ryan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ronald",
      "family": "Kuntzman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.H.",
      "family": "Conney",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "545",
      "DOI": "10.1016/0006-291X(69)90339-8",
      "volume": "36",
      "author": "Lu",
      "year": "1969",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib2",
      "first-page": "213",
      "volume": "6",
      "author": "Lu",
      "year": "1970",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "1727",
      "DOI": "10.1016/S0021-9258(19)45536-1",
      "volume": "247",
      "author": "Lu",
      "year": "1972",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "4851",
      "DOI": "10.1016/S0021-9258(18)62872-8",
      "volume": "245",
      "author": "Strobel",
      "year": "1970",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/0006-291X(67)90515-3",
      "volume": "29",
      "author": "Alvares",
      "year": "1967",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "668",
      "DOI": "10.1016/0006-291X(66)90376-7",
      "volume": "24",
      "author": "Sladek",
      "year": "1966",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "607",
      "DOI": "10.1016/0006-291X(68)90555-X",
      "volume": "30",
      "author": "Hildebrandt",
      "year": "1968",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib8",
      "first-page": "317",
      "volume": "19",
      "author": "Conney",
      "year": "1967",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1146/annurev.pa.09.040169.000321",
      "volume": "9",
      "author": "Kuntzman",
      "year": "1969",
      "journal-title": "Annu. Rev. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "228",
      "DOI": "10.1016/0026-0495(71)90094-1",
      "volume": "20",
      "author": "Mannering",
      "year": "1971",
      "journal-title": "Metab. (Clin. Exp.)"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "1331",
      "DOI": "10.1016/S0021-9258(19)56992-7",
      "volume": "243",
      "author": "Lu",
      "year": "1968",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "3714",
      "DOI": "10.1016/S0021-9258(18)83427-5",
      "volume": "244",
      "author": "Lu",
      "year": "1969",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "1200",
      "DOI": "10.1016/0006-291X(71)90033-7",
      "volume": "42",
      "author": "Lu",
      "year": "1971",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "883",
      "DOI": "10.1016/0006-2952(69)90059-8",
      "volume": "18",
      "author": "Levin",
      "year": "1969",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1334",
      "DOI": "10.1016/S0006-291X(72)80121-9",
      "volume": "46",
      "author": "Lu",
      "year": "1972",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "2379",
      "DOI": "10.1016/S0021-9258(20)82245-5",
      "volume": "239",
      "author": "Omura",
      "year": "1964",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib17",
      "first-page": "490",
      "volume": "8",
      "author": "Lu",
      "year": "1972",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "327",
      "DOI": "10.1016/0039-128X(69)90042-7",
      "volume": "13",
      "author": "Jacobson",
      "year": "1969",
      "journal-title": "Steroids"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "6242",
      "DOI": "10.1016/S0021-9258(18)94484-4",
      "volume": "243",
      "author": "Nebert",
      "year": "1968",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1016/0009-2797(72)90053-1",
      "volume": "5",
      "author": "Jacobson",
      "year": "1972",
      "journal-title": "Chem.-Biol. Interactions"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1016/0003-9861(71)90456-5",
      "volume": "144",
      "author": "Wiebel",
      "year": "1971",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib21a",
      "doi-asserted-by": "crossref",
      "first-page": "294",
      "DOI": "10.1016/0003-9861(72)90447-X",
      "volume": "153",
      "author": "Lu",
      "year": "1972",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "3912",
      "DOI": "10.1016/S0021-9258(18)92030-2",
      "volume": "243",
      "author": "Conney",
      "year": "1968",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib23",
      "series-title": "Microsomes and Drug Oxidations",
      "first-page": "279",
      "author": "Conney",
      "year": "1969"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1061",
      "DOI": "10.1016/0006-2952(71)90335-2",
      "volume": "20",
      "author": "Aust",
      "year": "1971",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "2221",
      "DOI": "10.1016/0006-2952(70)90121-8",
      "volume": "19",
      "author": "Pederson",
      "year": "1970",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1007/BF00997298",
      "volume": "270",
      "author": "Bohn",
      "year": "1971",
      "journal-title": "Naunyn-Schmiedebergsarchiv Pharmakol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "547",
      "DOI": "10.1515/bchm2.1969.350.1.547",
      "volume": "350",
      "author": "Degkwitz",
      "year": "1969",
      "journal-title": "Hoppe-Seyler's Z. Physiol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "486",
      "DOI": "10.1016/0024-3205(63)90137-1",
      "volume": "2",
      "author": "Smith",
      "year": "1963",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib29",
      "first-page": "131",
      "volume": "5",
      "author": "Guarino",
      "year": "1969",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib30",
      "first-page": "206",
      "volume": "6",
      "author": "Alvares",
      "year": "1970",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1093/oxfordjournals.jbchem.a128854",
      "volume": "64",
      "author": "Wada",
      "year": "1968",
      "journal-title": "J. Biochem. (Tokyo)"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.3109/00498257209036237",
      "volume": "2",
      "author": "Von Bahr",
      "year": "1972",
      "journal-title": "Xenobiotica"
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib33",
      "first-page": "499",
      "volume": "5",
      "author": "Levin",
      "year": "1969",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(19)44395-0_bib34",
      "first-page": "4",
      "volume": "175",
      "author": "Alvares",
      "year": "1970",
      "journal-title": "J. Pharmacol. Exp. Ther."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819443950?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925819443950?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        1,
        2
      ]
    ],
    "date-time": "2022-01-02T17:47:13Z",
    "timestamp": 1641145633000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925819443950"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1973,
        1
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1973,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925819443950"
  ],
  "URL": "http://dx.doi.org/10.1016/S0021-9258(19)44395-0",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1973,
        1
      ]
    ]
  }
}