DOI: 10.1016/s0021-9258(18)99049-6. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

10.1016/s0021-9258(18)99049-6

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., & Abraham, J. A. (1991). The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. Journal of Biological Chemistry, 266(18), 11947â11954.

Authors 7

E. Tischer (first)
R. Mitchell (additional)
T. Hartman (additional)
M. Silva (additional)
D. Gospodarowicz (additional)
J.C. Fiddes (additional)
J.A. Abraham (additional)

References 42 Referenced 1,436

10.1002/j.1460-2075.1986.tb04530.x / EMBO J by Abraham (1986)
10.1126/science.2842868 / Science by Beckman (1988)
10.1038/320695a0 / Nature by Betsholtz (1986)
10.1038/344299a0 / Nature by Betsholtz (1990)
10.1016/0092-8674(86)90789-0 / Cell by Bienz (1986)
10.1073/pnas.85.5.1492 / Proc. Natl. Acad. Sei. U. S. A by Bonthron (1988)
10.1146/annurev.bi.50.070181.002025 / Annu. Rev. Biochem by Breathnach (1981)
10.1021/bi00591a005 / Biochemistry by Chirgwin (1979)
10.1038/328621a0 / Nature by Collins (1987)
10.1073/pnas.87.4.1323 / Proc. Natl. Acad. Sei. U. S. A by Conn (1990)
10.1073/pnas.87.7.2628 / Proc. Natl. Acad. Sei. U. S. A by Conn (1990)
10.1016/S0021-9258(19)47212-8 / J. Biol. Chem by Connolly (1989)
10.1172/JCI114322 / J. Clin. Invest by Connolly (1989)
10.1126/science.6251548 / Science by Corden (1980)
10.1016/0092-8674(88)90024-4 / Cell by Curran (1988)
10.1038/316701a0 / Nature by Derynck (1985)
10.1016/0006-291X(89)92678-8 / Biochem. Biophys. Res. Commun by Ferrara (1989)
10.1038/312409a0 / Nature by Gidoni (1984)
{'key': '10.1016/S0021-9258(18)99049-6_bib951', 'first-page': '15', 'volume': '114', 'author': 'Gospodarowicz', 'year': '1990', 'journal-title': 'UCLA Symp. Mol. Cell. Biol'} / UCLA Symp. Mol. Cell. Biol by Gospodarowicz (1990)
10.1002/jcp.1040910307 / J. Cell. Physiol by Gospodarowicz (1977)
{'key': '10.1016/S0021-9258(18)99049-6_bib953', 'first-page': '144', 'volume': '46', 'author': 'Gospodarowicz', 'year': '1988', 'journal-title': 'Eur. J. Cell Biol'} / Eur. J. Cell Biol by Gospodarowicz (1988)
10.1073/pnas.86.19.7311 / Proc. Natl. Acad. Sei. U. S. A by Gospodarowicz (1989)
10.1016/0092-8674(87)90152-8 / Cell by Imagawa (1987)
10.1146/annurev.bi.58.070189.004055 / Annu. Rev. Biochem by Johnson (1989)
10.1016/0968-0004(86)90226-4 / Trends Biochem. Sei by Kadonaga (1986)
10.1126/science.2479987 / Science by Keck (1989)
10.1038/227680a0 / Nature by Laemmli (1970)
10.1021/bi00640a033 / Biochemistry by Lehrach (1977)
10.1126/science.2479986 / Science by Leung (1989)
10.3109/08977198909069077 / Growth Factors by Levy (1989)
10.1126/science.2667136 / Science by Mitchell (1989)
10.1002/j.1460-2075.1989.tb08557.x / EMBO J by Plouët (1989)
10.1073/pnas.83.8.2392 / Proc. Natl. Acad. Sei. U. S. A by Rao (1986)
10.1126/science.2448875 / Science by Saiki (1988)
10.1016/0022-2836(80)90196-5 / J. Mol. Biol by Sanger (1980)
10.1126/science.6823562 / Science by Senger (1983)
{'key': '10.1016/S0021-9258(18)99049-6_bib969', 'first-page': '5629', 'volume': '46', 'author': 'Senger', 'year': '1986', 'journal-title': 'Cancer Res'} / Cancer Res by Senger (1986)
10.1002/jcp.1041360212 / J. Cell. Physiol by Sternfeld (1988)
10.1016/0006-291X(89)92729-0 / Biochem. Biophys. Res. Commun by Tischer (1989)
10.1038/328619a0 / Nature by Tong (1987)
10.1073/pnas.84.8.2292 / Proc. Natl. Acad. Sei. U. S. A by Vlodavsky (1987)
10.1016/0378-1119(85)90120-9 / Gene (Amst.) by Yanisch-Perron (1985)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 6, 2021, 3:50 a.m.)
Deposited	3 years, 8 months ago (Dec. 18, 2021, 4:25 a.m.)
Indexed	1 hour, 29 minutes ago (Aug. 30, 2025, 1:41 a.m.)
Issued	34 years, 2 months ago (June 1, 1991)
Published	34 years, 2 months ago (June 1, 1991)
Published Print	34 years, 2 months ago (June 1, 1991)

Funders 0

None

BibTeX

@article{Tischer_1991, title={The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing}, volume={266}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(18)99049-6}, DOI={10.1016/s0021-9258(18)99049-6}, number={18}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Tischer, E. and Mitchell, R. and Hartman, T. and Silva, M. and Gospodarowicz, D. and Fiddes, J.C. and Abraham, J.A.}, year={1991}, month=jun, pages={11947–11954} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T05:41:29Z",
    "timestamp": 1756532489947
  },
  "reference-count": 42,
  "publisher": "Elsevier BV",
  "issue": "18",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1991,
            6,
            1
          ]
        ],
        "date-time": "1991-06-01T00:00:00Z",
        "timestamp": 675734400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            27
          ]
        ],
        "date-time": "2020-10-27T00:00:00Z",
        "timestamp": 1603756800000
      },
      "content-version": "vor",
      "delay-in-days": 10741,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1991,
        6
      ]
    ]
  },
  "DOI": "10.1016/s0021-9258(18)99049-6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        1,
        6
      ]
    ],
    "date-time": "2021-01-06T08:50:11Z",
    "timestamp": 1609923011000
  },
  "page": "11947-11954",
  "source": "Crossref",
  "is-referenced-by-count": 1436,
  "title": "The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing",
  "prefix": "10.1016",
  "volume": "266",
  "author": [
    {
      "given": "E.",
      "family": "Tischer",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Mitchell",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Hartman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "Silva",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.",
      "family": "Gospodarowicz",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.C.",
      "family": "Fiddes",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.A.",
      "family": "Abraham",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib933",
      "doi-asserted-by": "crossref",
      "first-page": "25232528",
      "DOI": "10.1002/j.1460-2075.1986.tb04530.x",
      "volume": "5",
      "author": "Abraham",
      "year": "1986",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib934",
      "doi-asserted-by": "crossref",
      "first-page": "1346",
      "DOI": "10.1126/science.2842868",
      "volume": "241",
      "author": "Beckman",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib935",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1038/320695a0",
      "volume": "320",
      "author": "Betsholtz",
      "year": "1986",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib936",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1038/344299a0",
      "volume": "344",
      "author": "Betsholtz",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib937",
      "doi-asserted-by": "crossref",
      "first-page": "753",
      "DOI": "10.1016/0092-8674(86)90789-0",
      "volume": "45",
      "author": "Bienz",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib938",
      "doi-asserted-by": "crossref",
      "first-page": "1492",
      "DOI": "10.1073/pnas.85.5.1492",
      "volume": "85",
      "author": "Bonthron",
      "year": "1988",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib939",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1146/annurev.bi.50.070181.002025",
      "volume": "50",
      "author": "Breathnach",
      "year": "1981",
      "journal-title": "Annu. Rev. Biochem"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib940",
      "doi-asserted-by": "crossref",
      "first-page": "5294",
      "DOI": "10.1021/bi00591a005",
      "volume": "18",
      "author": "Chirgwin",
      "year": "1979",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib941",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1038/328621a0",
      "volume": "328",
      "author": "Collins",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib942",
      "doi-asserted-by": "crossref",
      "first-page": "1323",
      "DOI": "10.1073/pnas.87.4.1323",
      "volume": "87",
      "author": "Conn",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib943",
      "doi-asserted-by": "crossref",
      "first-page": "2628",
      "DOI": "10.1073/pnas.87.7.2628",
      "volume": "87",
      "author": "Conn",
      "year": "1990",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib944",
      "doi-asserted-by": "crossref",
      "first-page": "20017",
      "DOI": "10.1016/S0021-9258(19)47212-8",
      "volume": "264",
      "author": "Connolly",
      "year": "1989",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib945",
      "doi-asserted-by": "crossref",
      "first-page": "1470",
      "DOI": "10.1172/JCI114322",
      "volume": "84",
      "author": "Connolly",
      "year": "1989",
      "journal-title": "J. Clin. Invest"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib946",
      "doi-asserted-by": "crossref",
      "first-page": "1406",
      "DOI": "10.1126/science.6251548",
      "volume": "209",
      "author": "Corden",
      "year": "1980",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib947",
      "doi-asserted-by": "crossref",
      "first-page": "395",
      "DOI": "10.1016/0092-8674(88)90024-4",
      "volume": "55",
      "author": "Curran",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib948",
      "doi-asserted-by": "crossref",
      "first-page": "701",
      "DOI": "10.1038/316701a0",
      "volume": "316",
      "author": "Derynck",
      "year": "1985",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib949",
      "doi-asserted-by": "crossref",
      "first-page": "851",
      "DOI": "10.1016/0006-291X(89)92678-8",
      "volume": "161",
      "author": "Ferrara",
      "year": "1989",
      "journal-title": "Biochem. Biophys. Res. Commun"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib950",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1038/312409a0",
      "volume": "312",
      "author": "Gidoni",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib951",
      "first-page": "15",
      "volume": "114",
      "author": "Gospodarowicz",
      "year": "1990",
      "journal-title": "UCLA Symp. Mol. Cell. Biol"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib952",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1002/jcp.1040910307",
      "volume": "91",
      "author": "Gospodarowicz",
      "year": "1977",
      "journal-title": "J. Cell. Physiol"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib953",
      "first-page": "144",
      "volume": "46",
      "author": "Gospodarowicz",
      "year": "1988",
      "journal-title": "Eur. J. Cell Biol"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib954",
      "doi-asserted-by": "crossref",
      "first-page": "7311",
      "DOI": "10.1073/pnas.86.19.7311",
      "volume": "86",
      "author": "Gospodarowicz",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib955",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1016/0092-8674(87)90152-8",
      "volume": "51",
      "author": "Imagawa",
      "year": "1987",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib956",
      "doi-asserted-by": "crossref",
      "first-page": "799",
      "DOI": "10.1146/annurev.bi.58.070189.004055",
      "volume": "58",
      "author": "Johnson",
      "year": "1989",
      "journal-title": "Annu. Rev. Biochem"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib957",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/0968-0004(86)90226-4",
      "volume": "11",
      "author": "Kadonaga",
      "year": "1986",
      "journal-title": "Trends Biochem. Sei"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib958",
      "doi-asserted-by": "crossref",
      "first-page": "1309",
      "DOI": "10.1126/science.2479987",
      "volume": "246",
      "author": "Keck",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib959",
      "doi-asserted-by": "crossref",
      "first-page": "680",
      "DOI": "10.1038/227680a0",
      "volume": "227",
      "author": "Laemmli",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib960",
      "doi-asserted-by": "crossref",
      "first-page": "4743",
      "DOI": "10.1021/bi00640a033",
      "volume": "16",
      "author": "Lehrach",
      "year": "1977",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib961",
      "doi-asserted-by": "crossref",
      "first-page": "1306",
      "DOI": "10.1126/science.2479986",
      "volume": "246",
      "author": "Leung",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib962",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.3109/08977198909069077",
      "volume": "2",
      "author": "Levy",
      "year": "1989",
      "journal-title": "Growth Factors"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib963",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1126/science.2667136",
      "volume": "245",
      "author": "Mitchell",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib964",
      "doi-asserted-by": "crossref",
      "first-page": "3801",
      "DOI": "10.1002/j.1460-2075.1989.tb08557.x",
      "volume": "8",
      "author": "Plou\u00ebt",
      "year": "1989",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib965",
      "doi-asserted-by": "crossref",
      "first-page": "2392",
      "DOI": "10.1073/pnas.83.8.2392",
      "volume": "83",
      "author": "Rao",
      "year": "1986",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib966",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1126/science.2448875",
      "volume": "239",
      "author": "Saiki",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib967",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1016/0022-2836(80)90196-5",
      "volume": "143",
      "author": "Sanger",
      "year": "1980",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib968",
      "doi-asserted-by": "crossref",
      "first-page": "983",
      "DOI": "10.1126/science.6823562",
      "volume": "219",
      "author": "Senger",
      "year": "1983",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib969",
      "first-page": "5629",
      "volume": "46",
      "author": "Senger",
      "year": "1986",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib970",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1002/jcp.1041360212",
      "volume": "136",
      "author": "Sternfeld",
      "year": "1988",
      "journal-title": "J. Cell. Physiol"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib971",
      "doi-asserted-by": "crossref",
      "first-page": "1198",
      "DOI": "10.1016/0006-291X(89)92729-0",
      "volume": "165",
      "author": "Tischer",
      "year": "1989",
      "journal-title": "Biochem. Biophys. Res. Commun"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib972",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1038/328619a0",
      "volume": "328",
      "author": "Tong",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib973",
      "doi-asserted-by": "crossref",
      "first-page": "2292",
      "DOI": "10.1073/pnas.84.8.2292",
      "volume": "84",
      "author": "Vlodavsky",
      "year": "1987",
      "journal-title": "Proc. Natl. Acad. Sei. U. S. A"
    },
    {
      "key": "10.1016/S0021-9258(18)99049-6_bib974",
      "doi-asserted-by": "crossref",
      "first-page": "103",
      "DOI": "10.1016/0378-1119(85)90120-9",
      "volume": "33",
      "author": "Yanisch-Perron",
      "year": "1985",
      "journal-title": "Gene (Amst.)"
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925818990496?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925818990496?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        18
      ]
    ],
    "date-time": "2021-12-18T09:25:05Z",
    "timestamp": 1639819505000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925818990496"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1991,
        6
      ]
    ]
  },
  "references-count": 42,
  "journal-issue": {
    "issue": "18",
    "published-print": {
      "date-parts": [
        [
          1991,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925818990496"
  ],
  "URL": "http://dx.doi.org/10.1016/S0021-9258(18)99049-6",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1991,
        6
      ]
    ]
  }
}