DOI: 10.1016/s0021-9258(18)53969-7. Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.

10.1016/s0021-9258(18)53969-7

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Leavitt, A. D., Shiue, L., & Varmus, H. E. (1993). Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. Journal of Biological Chemistry, 268(3), 2113â2119.

Authors 3

A.D. Leavitt (first)
L. Shiue (additional)
H.E. Varmus (additional)

References 35 Referenced 165

10.1016/0092-8674(85)90114-X / Cell by Colicelli (1985)
10.1016/0022-2836(88)90378-6 / J. Mol. Biol. by Colicelli (1988)
10.1073/pnas.86.9.3065 / Proc. Natl. Acad. Sci U. S. A. by Fujiwara (1989)
10.1038/306155a0 / Nature by Panganiban (1983)
10.1016/0092-8674(89)90401-7 / Cell by Roth (1989)
10.1073/pnas.81.20.6461 / Proc. Natl. Acad. Sci. U. S. A. by Donehower (1984)
10.1073/pnas.81.24.7885 / Proc. Natl. Acad. Sci. U. S. A. by Panganiban (1984)
10.1128/jvi.62.7.2307-2312.1988 / J. Virol. by Quinn (1988)
10.1016/0092-8674(84)90439-2 / Cell by Schwartzberg (1984)
{'key': '10.1016/S0021-9258(18)53969-7_bib10', 'first-page': '2526', 'volume': '86', 'author': 'Brown', 'year': '1989', 'journal-title': 'Proc. Natl. Acad. Sci U. S. A.'} / Proc. Natl. Acad. Sci U. S. A. by Brown (1989)
10.1016/0092-8674(90)90126-Y / Cell by Craigie (1990)
10.1128/jvi.63.12.5319-5327.1989 / J. Virol. by Katzman (1989)
10.1128/jvi.65.7.3906-3910.1991 / J. Virol. by Whitcomb (1991)
10.1128/jvi.66.4.2359-2368.1992 / J. Virol. by Leavitt (1992)
10.1016/0092-8674(92)90289-O / Cell by Pryciak (1992)
10.1073/pnas.89.12.5532 / Proc. Natl. Acad. Sci. U. S. A. by Kitamura (1992)
10.1126/science.1738845 / Science by Chow (1992)
10.1073/pnas.83.20.7648 / Proc. Natl. Acad. Sci. U. S. A. by Johnson (1986)
10.1093/nar/19.4.851 / Nucleic Acids Res. by Kahn (1991)
10.1111/j.1365-2958.1990.tb00555.x / Mol. Microbiol. by Fayet (1990)
10.1002/prot.340050210 / Proteins Struct. Funct. Genet. by Lin (1989)
10.1093/nar/19.24.6691 / Nucleic Acids Res. by Vink (1992)
10.1128/jvi.65.10.5624-5630.1991 / J. Virol. by LaFemina (1991)
10.1073/pnas.88.4.1339 / Proc. Natl. Acad. Sci U. S. A. by Bushman (1991)
10.1016/0092-8674(91)90297-C / Cell by Engelman (1991)
10.1016/0076-6879(87)54085-X / Methods Enzymol. by Kunkel (1987)
{'key': '10.1016/S0021-9258(18)53969-7_bib27', 'series-title': 'Expression Systems and Processes for Recombinant DNA Products', 'first-page': '51', 'author': 'Barr', 'year': '1991'} / Expression Systems and Processes for Recombinant DNA Products by Barr (1991)
{'key': '10.1016/S0021-9258(18)53969-7_bib28', 'first-page': '2331', 'volume': '12', 'author': 'Kulkosky', 'year': '1992', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. by Kulkosky (1992)
10.1128/jvi.65.4.2141-2145.1991 / J. Virol. by Roth (1991)
10.1128/jvi.64.10.4709-4717.1990 / J. Virol. by Roth (1990)
10.1128/jvi.62.11.3958-3964.1988 / J. Virol. by Donehower (1988)
10.1016/S0021-9258(19)50138-7 / J. Biol. Chem. by Burke (1992)
10.1089/aid.1992.8.297 / AIDS Res. Hum. Retroviruses by Woerner (1992)
10.1073/pnas.86.7.2433 / Proc. Natl. Acad. Sci. U. S. A. by Franchini (1989)
{'key': '10.1016/S0021-9258(18)53969-7_bib35', 'series-title': 'Human Retroviruses and AIDS 1991: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences', 'author': 'Myers', 'year': '1991'} / Human Retroviruses and AIDS 1991: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences by Myers (1991)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 5, 2021, 8:21 a.m.)
Deposited	3 years, 8 months ago (Dec. 16, 2021, 5:17 p.m.)
Indexed	3 weeks, 2 days ago (Aug. 2, 2025, 12:07 a.m.)
Issued	32 years, 7 months ago (Jan. 1, 1993)
Published	32 years, 7 months ago (Jan. 1, 1993)
Published Print	32 years, 7 months ago (Jan. 1, 1993)

Funders 0

None

BibTeX

@article{Leavitt_1993, title={Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.}, volume={268}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(18)53969-7}, DOI={10.1016/s0021-9258(18)53969-7}, number={3}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Leavitt, A.D. and Shiue, L. and Varmus, H.E.}, year={1993}, month=jan, pages={2113–2119} }

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