DOI: 10.1016/s0021-9258(18)45892-9. Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.

Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.

10.1016/s0021-9258(18)45892-9

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Sauer, U. H., San, D. P., & Matthews, B. W. (1992). Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. Journal of Biological Chemistry, 267(4), 2393â2399.

Authors 3

U H Sauer (first)
D P San (additional)
B W Matthews (additional)

References 44 Referenced 50

10.1016/0076-6879(87)54093-9 / Methods Enzymol. by Alber (1987)
10.1126/science.3277275 / Science by Alber (1988)
10.1021/bi00461a025 / Biochemistry by Anderson (1990)
10.1016/0022-2836(81)90398-3 / J. Mol. Biol. by Anderson (1981)
10.1016/0022-2836(88)90641-9 / J. Mol. Biol. by Barlow (1988)
10.1002/bip.360261104 / Biopolymers by Becktel (1987)
10.1002/prot.340100103 / Proteins Struct. Funct. Genet. by Bell (1991)
10.1021/bi00219a019 / Biochemistry by Consler (1991)
10.1002/prot.340070208 / Proteins Struct. Funct. Genet. by Dao-pin (1990)
10.1016/0022-2836(91)80079-A / J. Mol. Biol. by Dao-pin (1991)
10.1016/0022-2836(91)80181-S / J. Mol. Biol. by Dao-pin (1991)
10.1016/0005-2795(75)90273-1 / Biochim. Biophys. Acta by Elwell (1975)
10.1038/348263a0 / Nature by Faber (1990)
10.1038/277667a0 / Nature by Grütter (1979)
10.1016/0022-2836(87)90126-4 / J. Mol. Biol. by Grütter (1987)
10.1016/0022-2836(84)90474-1 / J. Mol. Biol. by Hawkes (1984)
{'key': '10.1016/S0021-9258(18)45892-9_bib17', 'series-title': 'Catalysis in Chemistry and Enzymology', 'author': 'Jenks', 'year': '1969'} / Catalysis in Chemistry and Enzymology by Jenks (1969)
10.1107/S0021889878013308 / J. Appl. Crystallogr. by Jones (1978)
10.1073/pnas.88.12.5307 / Proc. Natl. Acad. Sci. U. S. A. by Karle (1991)
10.1038/350121a0 / Nature by Knowles (1991)
10.1073/pnas.82.2.488 / Proc. Natl. Acad. Sci. U. S. A. by Kunkel (1985)
10.1016/0076-6879(87)54085-X / Methods Enzymol. by Kunkel (1987)
10.1016/0022-2836(74)90599-3 / J. Mol. Biol. by Levitt (1974)
10.1016/0022-2836(91)90721-H / J. Mol. Biol. by MacArthur (1991)
10.1126/science.2916125 / Science by Matsumura (1989)
10.1021/bi00396a001 / Biochemistry by Matthews (1987)
10.1073/pnas.84.19.6663 / Proc. Natl. Acad. Sci. U. S. A. by Matthews (1987)
10.1016/0076-6879(89)77005-1 / Methods Enzymol. by Muchmore (1989)
10.1143/JPSJ.32.1331 / J. Physiol. Soc. Jpn. by Nishikawa (1972)
10.1126/science.2237415 / Science by O'Neil (1990)
10.1021/bi00462a023 / Biochemistry by Pjura (1990)
10.1021/bi00219a037 / Biochemistry by Poteete (1991)
10.1126/science.3388019 / Science by Reidhaar-Olson (1988)
10.1002/prot.340070402 / Proteins Struct. Funct. Genet. by Sondek (1990)
10.1073/pnas.66.2.445 / Proc. Natl. Acad. Sci. U. S. A. by Storm (1970)
10.1021/bi00237a026 / Biochemistry by Strehlow (1991)
10.1101/SQB.1961.026.01.007 / Cold Spring Harbor Symp. Quant. Biol. by Streisinger (1961)
10.1107/S0108767387099124 / Acta Crystallogr. A by Tronrud (1987)
10.1016/S0021-9258(18)99306-3 / J. Biol. Chem. by Tsugita (1968)
10.1016/0022-2836(87)90636-X / J. Mol. Biol. by Weaver (1987)
10.1021/bi00435a025 / Biochemistry by Weaver (1989)
10.1073/pnas.85.2.401 / Proc. Natl. Acad. Sci. U. S. A. by Wetzel (1988)
10.1002/prot.340100306 / Proteins Struct. Funct. Genet. by Yun (1991)
10.1021/bi00222a001 / Biochemistry by Zhang (1991)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 5, 2021, 4:32 a.m.)
Deposited	3 years, 7 months ago (Jan. 1, 2022, 6:34 a.m.)
Indexed	1 month ago (July 30, 2025, 9:58 a.m.)
Issued	33 years, 7 months ago (Feb. 1, 1992)
Published	33 years, 7 months ago (Feb. 1, 1992)
Published Print	33 years, 7 months ago (Feb. 1, 1992)

Funders 0

None

BibTeX

@article{Sauer_1992, title={Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.}, volume={267}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(18)45892-9}, DOI={10.1016/s0021-9258(18)45892-9}, number={4}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Sauer, U H and San, D P and Matthews, B W}, year={1992}, month=feb, pages={2393–2399} }

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      "DOI": "10.1107/S0021889878013308",
      "volume": "11",
      "author": "Jones",
      "year": "1978",
      "journal-title": "J. Appl. Crystallogr."
    },
    {
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      "first-page": "5307",
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      "DOI": "10.1073/pnas.82.2.488",
      "volume": "82",
      "author": "Kunkel",
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      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
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      "author": "Kunkel",
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    },
    {
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      "first-page": "393",
      "DOI": "10.1016/0022-2836(74)90599-3",
      "volume": "82",
      "author": "Levitt",
      "year": "1974",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(18)45892-9_bib24",
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      "author": "MacArthur",
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      "author": "Matsumura",
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      "journal-title": "Science"
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      "DOI": "10.1016/0076-6879(89)77005-1",
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      "author": "Muchmore",
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      "key": "10.1016/S0021-9258(18)45892-9_bib29",
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      "first-page": "1331",
      "DOI": "10.1143/JPSJ.32.1331",
      "volume": "32",
      "author": "Nishikawa",
      "year": "1972",
      "journal-title": "J. Physiol. Soc. Jpn."
    },
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      "first-page": "646",
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      "author": "Sondek",
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      "volume": "243",
      "author": "Tsugita",
      "year": "1968",
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