DOI: 10.1016/s0021-9258(17)34875-5. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

10.1016/s0021-9258(17)34875-5

Crossref journal-article

Elsevier BV

Journal of Biological Chemistry (78)

Bibliography

Alt, F. W., Kellems, R. E., Bertino, J. R., & Schimke, R. T. (1978). Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. Journal of Biological Chemistry, 253(5), 1357â1370.

Authors 4

F.W. Alt (first)
R.E. Kellems (additional)
J.R. Bertino (additional)
R.T. Schimke (additional)

References 81 Referenced 702

10.1172/JCI104735 / J. Clin. Invest. by Bertino (1963)
10.1016/0006-2952(61)90128-9 / Biochem. Pharmacol. by Fischer (1961)
10.1016/S0021-9258(18)64337-6 / J. Biol. Chem. by Hakala (1961)
10.1021/bi00900a024 / Biochemistry by Kashet (1964)
10.1073/pnas.62.1.88 / Proc. Natl. Acad. Sci. U. S. A. by Littlefield (1969)
{'key': '10.1016/S0021-9258(17)34875-5_bib6', 'first-page': '600', 'volume': '22', 'author': 'Friedkin', 'year': '1962', 'journal-title': 'Cancer Res.'} / Cancer Res. by Friedkin (1962)
10.1016/S0021-9258(18)99522-0 / J. Biol. Chem. by Perkins (1967)
10.1016/0003-9861(64)90354-6 / Arch. Biochem. Biophys. by Sartorelli (1964)
10.1016/0003-9861(73)90048-9 / Arch. Biochem. Biophys. by Jackson (1973)
{'key': '10.1016/S0021-9258(17)34875-5_bib10', 'first-page': '45', 'volume': '49', 'author': 'Courtenay', 'year': '1972', 'journal-title': 'J. Natl. Cancer Inst.'} / J. Natl. Cancer Inst. by Courtenay (1972)
{'key': '10.1016/S0021-9258(17)34875-5_bib11', 'first-page': '153', 'volume': '32', 'author': 'Biedler', 'year': '1972', 'journal-title': 'Cancer Res.'} / Cancer Res. by Biedler (1972)
10.1016/S0021-9258(17)33500-7 / J. Biol. Chem. by Alt (1976)
10.1016/S0021-9258(17)32931-9 / J. Biol. Chem. by Kellems (1976)
{'key': '10.1016/S0021-9258(17)34875-5_bib14', 'first-page': '117a', 'volume': '70', 'author': 'Biedler', 'year': '1976', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. by Biedler (1976)
10.1016/S0021-9258(19)45772-4 / J. Biol. Chem. by Nakamura (1972)
10.1016/S0021-9258(17)33501-9 / J. Biol. Chem. by Hanggi (1976)
10.1016/0092-8674(76)90168-9 / Cell by Chang (1976)
10.1016/S0091-679X(08)60052-7 / Methods Cell Physiol. by Thompson (1973)
10.1016/0027-5107(74)90180-8 / Mutat. Res. by Demars (1974)
10.1073/pnas.69.6.1408 / Proc. Natl. Acad. Sci. U. S. A. by Aviv (1972)
10.1016/S0021-9258(19)45431-8 / J. Biol. Chem. by Palacios (1972)
10.1016/S0021-9258(19)42526-X / J. Biol. Chem. by Shapiro (1974)
10.1016/S0021-9258(19)42615-X / J. Biol. Chem. by Taylor (1974)
10.1111/j.1432-1033.1976.tb10656.x / Eur. J. Biochem. by Pelham (1976)
{'journal-title': 'J. Biol. Chem.', 'year': '1978', 'author': 'Buell', 'key': '10.1016/S0021-9258(17)34875-5_bib25'} / J. Biol. Chem. by Buell (1978)
10.1016/0076-6879(74)29033-5 / Methods Enzymol. by Britten (1974)
10.1016/0003-2697(74)90343-1 / Anal. Biochem. by McCarty (1974)
10.1016/S0022-2836(65)80064-X / J. Mol. Biol. by Studier (1965)
10.1016/S0021-9258(19)44182-3 / J. Biol. Chem. by Rhoads (1973)
10.1016/0022-2836(73)90235-0 / J. Mol. Biol. by Fan (1973)
10.1073/pnas.72.4.1550 / Proc. Natl. Acad. Sci. U. S. A. by Ramirez (1975)
10.1016/0022-2836(76)90152-2 / J. Mol. Biol. by Stehelin (1976)
10.1146/annurev.ge.09.120175.001513 / Ann. Rev. Genet. by Hood (1975)
10.1016/S0021-9258(18)64324-8 / J. Biol. Chem. by Werkeiser (1961)
10.1021/bi00901a027 / Biochemistry by Huennekens (1963)
{'key': '10.1016/S0021-9258(17)34875-5_bib36', 'series-title': 'The Biochemistry of Folic Acid and Related Pteridines', 'first-page': '139', 'author': 'Blakeley', 'year': '1969'} / The Biochemistry of Folic Acid and Related Pteridines by Blakeley (1969)
10.1016/0926-6585(65)90213-X / Biochim. Biophys. Acta by Hakala (1965)
{'key': '10.1016/S0021-9258(17)34875-5_bib38', 'first-page': '987', 'volume': '22', 'author': 'Hakala', 'year': '1962', 'journal-title': 'Cancer Res.'} / Cancer Res. by Hakala (1962)
{'key': '10.1016/S0021-9258(17)34875-5_bib39', 'first-page': '246', 'volume': '25', 'author': 'Biedler', 'year': '1965', 'journal-title': 'Cancer Res.'} / Cancer Res. by Biedler (1965)
10.1038/169628a0 / Nature by Law (1952)
{'key': '10.1016/S0021-9258(17)34875-5_bib41', 'first-page': '2209', 'volume': '37', 'author': 'Benedict', 'year': '1977', 'journal-title': 'Cancer Res.'} / Cancer Res. by Benedict (1977)
10.1126/science.942798 / Science by Biedler (1976)
10.1016/0022-2836(76)90107-8 / J. Mol. Biol. by Anderson (1976)
10.1016/0022-2836(71)90374-3 / J. Mol. Biol. by Folk (1971)
10.1007/BF00333760 / Mol. & Gen. Genet. by Hill (1973)
10.1093/genetics/48.2.157 / Genetics by Hariuchi (1963)
10.1016/0022-2836(75)90154-0 / J. Mol. Biol. by Emmons (1975)
10.1093/genetics/10.2.117 / Genetics by Sturtevant (1925)
10.1126/science.83.2148.210 / Science by Bridges (1936)
10.1093/genetics/21.6.625 / Genetics by Stern (1936)
10.1073/pnas.43.1.122 / Proc. Natl. Acad. Sci. U. S. A. by Taylor (1957)
10.1083/jcb.21.2.159 / J. Cell Biol. by Marin (1964)
10.1101/SQB.1941.009.01.010 / Cold Spring Harbor Symp. Quant. Biol. by McClintock (1941)
10.1073/pnas.50.1.126 / Proc. Natl. Acad. Sci. U. S. A. by Peterson (1963)
10.1093/genetics/63.1.133 / Genetics by Schalet (1969)
10.1126/science.1251186 / Science by Smith (1976)
10.1101/SQB.1974.038.01.055 / Cold Spring Harbor Symp. Quant. Biol. by Smith (1973)
10.1101/SQB.1974.038.01.053 / Cold Spring Harbor Symp. Quant. Biol. by Tartof (1973)
10.1073/pnas.71.4.1272 / Proc. Natl. Acad. Sci. U. S. A. by Tartof (1974)
10.1126/science.160.3825.272 / Science by Brown (1968)
10.1101/SQB.1974.038.01.058 / Cold Spring Harbor Symp. Quant. Biol. by Hourcade (1973)
10.1038/2261209a0 / Nature by Baltimore (1970)
10.1038/2261211a0 / Nature by Temin (1970)
10.1146/annurev.ge.09.120175.002035 / Ann. Rev. Genet. by Tartof (1975)
10.1016/0092-8674(77)90135-0 / Cell by Ringold (1977)
10.1073/pnas.73.4.1274 / Proc. Natl. Acad. Sci. U. S. A. by Willecke (1976)
10.1073/pnas.74.9.3937 / Proc. Natl. Acad. Sci. U. S. A. by Fournier (1977)
10.1073/pnas.70.4.1258 / Proc. Natl. Acad. Sci. U. S. A. by McBride (1973)
10.1073/pnas.72.5.1792 / Proc. Natl. Acad. Sci. U. S.A. by Willecke (1975)
10.1073/pnas.73.8.2838 / Proc. Natl. Acad. Sci. U. S. A. by Degnen (1976)
10.1073/pnas.74.8.3480 / Proc. Natl. Acad. Sci. U. S. A. by Spandidos (1977)
10.1038/263731a0 / Nature by Cohen (1976)
10.1016/0092-8674(77)90313-0 / Cell by Kleckner (1977)
10.1111/j.1749-6632.1971.tb30656.x / Ann. N. Y. Acad. Sci. by Rownd (1971)
10.1128/jb.123.3.1013-1034.1975 / J. Bacteriol. by Perlman (1975)
10.1016/0092-8674(76)90036-2 / Cell by Kempe (1976)
{'year': '1970', 'series-title': 'Evolution of Gene Duplication', 'author': 'Ohno', 'key': '10.1016/S0021-9258(17)34875-5_bib77'} / Evolution of Gene Duplication by Ohno (1970)
10.1016/0006-291X(72)90483-4 / Biochem. Biophys. Res. Commun. by Packman (1972)
10.1016/0022-2836(72)90563-3 / J. Mol. Biol. by Suzuki (1972)
10.1016/S0021-9258(19)43323-1 / J. Biol. Chem. by Sullivan (1973)
{'key': '10.1016/S0021-9258(17)34875-5_bib81', 'volume': '42', 'author': 'Schimke', 'year': '1977', 'journal-title': 'Cold Spring Harbor Symp. Quant. Biol.'} / Cold Spring Harbor Symp. Quant. Biol. by Schimke (1977)

Dates

Type	When
Created	4 years, 7 months ago (Jan. 18, 2021, 6:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 17, 2023, 7:33 p.m.)
Indexed	1 day, 19 hours ago (Aug. 27, 2025, 12:26 p.m.)
Issued	47 years, 5 months ago (March 1, 1978)
Published	47 years, 5 months ago (March 1, 1978)
Published Print	47 years, 5 months ago (March 1, 1978)

Funders 0

None

BibTeX

@article{Alt_1978, title={Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.}, volume={253}, ISSN={0021-9258}, url={http://dx.doi.org/10.1016/s0021-9258(17)34875-5}, DOI={10.1016/s0021-9258(17)34875-5}, number={5}, journal={Journal of Biological Chemistry}, publisher={Elsevier BV}, author={Alt, F.W. and Kellems, R.E. and Bertino, J.R. and Schimke, R.T.}, year={1978}, month=mar, pages={1357–1370} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        27
      ]
    ],
    "date-time": "2025-08-27T16:26:15Z",
    "timestamp": 1756311975773
  },
  "reference-count": 81,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1978,
            3,
            1
          ]
        ],
        "date-time": "1978-03-01T00:00:00Z",
        "timestamp": 257558400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2020,
            10,
            24
          ]
        ],
        "date-time": "2020-10-24T00:00:00Z",
        "timestamp": 1603497600000
      },
      "content-version": "vor",
      "delay-in-days": 15578,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1978,
        3
      ]
    ]
  },
  "DOI": "10.1016/s0021-9258(17)34875-5",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        1,
        18
      ]
    ],
    "date-time": "2021-01-18T23:02:44Z",
    "timestamp": 1611010964000
  },
  "page": "1357-1370",
  "source": "Crossref",
  "is-referenced-by-count": 702,
  "title": "Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.",
  "prefix": "10.1016",
  "volume": "253",
  "author": [
    {
      "given": "F.W.",
      "family": "Alt",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "R.E.",
      "family": "Kellems",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.R.",
      "family": "Bertino",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.T.",
      "family": "Schimke",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "466",
      "DOI": "10.1172/JCI104735",
      "volume": "42",
      "author": "Bertino",
      "year": "1963",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1016/0006-2952(61)90128-9",
      "volume": "7",
      "author": "Fischer",
      "year": "1961",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "952",
      "DOI": "10.1016/S0021-9258(18)64337-6",
      "volume": "236",
      "author": "Hakala",
      "year": "1961",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "1928",
      "DOI": "10.1021/bi00900a024",
      "volume": "3",
      "author": "Kashet",
      "year": "1964",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1073/pnas.62.1.88",
      "volume": "62",
      "author": "Littlefield",
      "year": "1969",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib6",
      "first-page": "600",
      "volume": "22",
      "author": "Friedkin",
      "year": "1962",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "4771",
      "DOI": "10.1016/S0021-9258(18)99522-0",
      "volume": "242",
      "author": "Perkins",
      "year": "1967",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1016/0003-9861(64)90354-6",
      "volume": "108",
      "author": "Sartorelli",
      "year": "1964",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "192",
      "DOI": "10.1016/0003-9861(73)90048-9",
      "volume": "154",
      "author": "Jackson",
      "year": "1973",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib10",
      "first-page": "45",
      "volume": "49",
      "author": "Courtenay",
      "year": "1972",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib11",
      "first-page": "153",
      "volume": "32",
      "author": "Biedler",
      "year": "1972",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "3063",
      "DOI": "10.1016/S0021-9258(17)33500-7",
      "volume": "251",
      "author": "Alt",
      "year": "1976",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "6987",
      "DOI": "10.1016/S0021-9258(17)32931-9",
      "volume": "251",
      "author": "Kellems",
      "year": "1976",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib14",
      "first-page": "117a",
      "volume": "70",
      "author": "Biedler",
      "year": "1976",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1016/S0021-9258(19)45772-4",
      "volume": "247",
      "author": "Nakamura",
      "year": "1972",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "3075",
      "DOI": "10.1016/S0021-9258(17)33501-9",
      "volume": "251",
      "author": "Hanggi",
      "year": "1976",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1016/0092-8674(76)90168-9",
      "volume": "7",
      "author": "Chang",
      "year": "1976",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/S0091-679X(08)60052-7",
      "volume": "6",
      "author": "Thompson",
      "year": "1973",
      "journal-title": "Methods Cell Physiol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1016/0027-5107(74)90180-8",
      "volume": "24",
      "author": "Demars",
      "year": "1974",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "1408",
      "DOI": "10.1073/pnas.69.6.1408",
      "volume": "69",
      "author": "Aviv",
      "year": "1972",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "2316",
      "DOI": "10.1016/S0021-9258(19)45431-8",
      "volume": "247",
      "author": "Palacios",
      "year": "1972",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "3665",
      "DOI": "10.1016/S0021-9258(19)42526-X",
      "volume": "249",
      "author": "Shapiro",
      "year": "1974",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "3597",
      "DOI": "10.1016/S0021-9258(19)42615-X",
      "volume": "249",
      "author": "Taylor",
      "year": "1974",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1111/j.1432-1033.1976.tb10656.x",
      "volume": "67",
      "author": "Pelham",
      "year": "1976",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "journal-title": "J. Biol. Chem.",
      "year": "1978",
      "author": "Buell",
      "key": "10.1016/S0021-9258(17)34875-5_bib25"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1016/0076-6879(74)29033-5",
      "volume": "29",
      "author": "Britten",
      "year": "1974",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1016/0003-2697(74)90343-1",
      "volume": "61",
      "author": "McCarty",
      "year": "1974",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1016/S0022-2836(65)80064-X",
      "volume": "11",
      "author": "Studier",
      "year": "1965",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "2031",
      "DOI": "10.1016/S0021-9258(19)44182-3",
      "volume": "248",
      "author": "Rhoads",
      "year": "1973",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/0022-2836(73)90235-0",
      "volume": "80",
      "author": "Fan",
      "year": "1973",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1550",
      "DOI": "10.1073/pnas.72.4.1550",
      "volume": "72",
      "author": "Ramirez",
      "year": "1975",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1016/0022-2836(76)90152-2",
      "volume": "101",
      "author": "Stehelin",
      "year": "1976",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.1146/annurev.ge.09.120175.001513",
      "volume": "9",
      "author": "Hood",
      "year": "1975",
      "journal-title": "Ann. Rev. Genet."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "888",
      "DOI": "10.1016/S0021-9258(18)64324-8",
      "volume": "236",
      "author": "Werkeiser",
      "year": "1961",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1021/bi00901a027",
      "volume": "2",
      "author": "Huennekens",
      "year": "1963",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib36",
      "series-title": "The Biochemistry of Folic Acid and Related Pteridines",
      "first-page": "139",
      "author": "Blakeley",
      "year": "1969"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1016/0926-6585(65)90213-X",
      "volume": "102",
      "author": "Hakala",
      "year": "1965",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib38",
      "first-page": "987",
      "volume": "22",
      "author": "Hakala",
      "year": "1962",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib39",
      "first-page": "246",
      "volume": "25",
      "author": "Biedler",
      "year": "1965",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "628",
      "DOI": "10.1038/169628a0",
      "volume": "169",
      "author": "Law",
      "year": "1952",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib41",
      "first-page": "2209",
      "volume": "37",
      "author": "Benedict",
      "year": "1977",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "186",
      "DOI": "10.1126/science.942798",
      "volume": "191",
      "author": "Biedler",
      "year": "1976",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1016/0022-2836(76)90107-8",
      "volume": "105",
      "author": "Anderson",
      "year": "1976",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1016/0022-2836(71)90374-3",
      "volume": "58",
      "author": "Folk",
      "year": "1971",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1007/BF00333760",
      "volume": "127",
      "author": "Hill",
      "year": "1973",
      "journal-title": "Mol. & Gen. Genet."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1093/genetics/48.2.157",
      "volume": "48",
      "author": "Hariuchi",
      "year": "1963",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1016/0022-2836(75)90154-0",
      "volume": "91",
      "author": "Emmons",
      "year": "1975",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "117",
      "DOI": "10.1093/genetics/10.2.117",
      "volume": "10",
      "author": "Sturtevant",
      "year": "1925",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "210",
      "DOI": "10.1126/science.83.2148.210",
      "volume": "83",
      "author": "Bridges",
      "year": "1936",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "625",
      "DOI": "10.1093/genetics/21.6.625",
      "volume": "21",
      "author": "Stern",
      "year": "1936",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "122",
      "DOI": "10.1073/pnas.43.1.122",
      "volume": "43",
      "author": "Taylor",
      "year": "1957",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1083/jcb.21.2.159",
      "volume": "21",
      "author": "Marin",
      "year": "1964",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "72",
      "DOI": "10.1101/SQB.1941.009.01.010",
      "volume": "9",
      "author": "McClintock",
      "year": "1941",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "126",
      "DOI": "10.1073/pnas.50.1.126",
      "volume": "50",
      "author": "Peterson",
      "year": "1963",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1093/genetics/63.1.133",
      "volume": "63",
      "author": "Schalet",
      "year": "1969",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "528",
      "DOI": "10.1126/science.1251186",
      "volume": "191",
      "author": "Smith",
      "year": "1976",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1101/SQB.1974.038.01.055",
      "volume": "38",
      "author": "Smith",
      "year": "1973",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1101/SQB.1974.038.01.053",
      "volume": "38",
      "author": "Tartof",
      "year": "1973",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "1272",
      "DOI": "10.1073/pnas.71.4.1272",
      "volume": "71",
      "author": "Tartof",
      "year": "1974",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "272",
      "DOI": "10.1126/science.160.3825.272",
      "volume": "160",
      "author": "Brown",
      "year": "1968",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1101/SQB.1974.038.01.058",
      "volume": "38",
      "author": "Hourcade",
      "year": "1973",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "1209",
      "DOI": "10.1038/2261209a0",
      "volume": "226",
      "author": "Baltimore",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1211",
      "DOI": "10.1038/2261211a0",
      "volume": "226",
      "author": "Temin",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1146/annurev.ge.09.120175.002035",
      "volume": "9",
      "author": "Tartof",
      "year": "1975",
      "journal-title": "Ann. Rev. Genet."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1016/0092-8674(77)90135-0",
      "volume": "10",
      "author": "Ringold",
      "year": "1977",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "1274",
      "DOI": "10.1073/pnas.73.4.1274",
      "volume": "73",
      "author": "Willecke",
      "year": "1976",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "3937",
      "DOI": "10.1073/pnas.74.9.3937",
      "volume": "74",
      "author": "Fournier",
      "year": "1977",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1258",
      "DOI": "10.1073/pnas.70.4.1258",
      "volume": "70",
      "author": "McBride",
      "year": "1973",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "1792",
      "DOI": "10.1073/pnas.72.5.1792",
      "volume": "72",
      "author": "Willecke",
      "year": "1975",
      "journal-title": "Proc. Natl. Acad. Sci. U. S.A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "2838",
      "DOI": "10.1073/pnas.73.8.2838",
      "volume": "73",
      "author": "Degnen",
      "year": "1976",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "3480",
      "DOI": "10.1073/pnas.74.8.3480",
      "volume": "74",
      "author": "Spandidos",
      "year": "1977",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.1038/263731a0",
      "volume": "263",
      "author": "Cohen",
      "year": "1976",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1016/0092-8674(77)90313-0",
      "volume": "11",
      "author": "Kleckner",
      "year": "1977",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1111/j.1749-6632.1971.tb30656.x",
      "volume": "182",
      "author": "Rownd",
      "year": "1971",
      "journal-title": "Ann. N. Y. Acad. Sci."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "1013",
      "DOI": "10.1128/jb.123.3.1013-1034.1975",
      "volume": "123",
      "author": "Perlman",
      "year": "1975",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "541",
      "DOI": "10.1016/0092-8674(76)90036-2",
      "volume": "9",
      "author": "Kempe",
      "year": "1976",
      "journal-title": "Cell"
    },
    {
      "year": "1970",
      "series-title": "Evolution of Gene Duplication",
      "author": "Ohno",
      "key": "10.1016/S0021-9258(17)34875-5_bib77"
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1016/0006-291X(72)90483-4",
      "volume": "49",
      "author": "Packman",
      "year": "1972",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1016/0022-2836(72)90563-3",
      "volume": "70",
      "author": "Suzuki",
      "year": "1972",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "7530",
      "DOI": "10.1016/S0021-9258(19)43323-1",
      "volume": "248",
      "author": "Sullivan",
      "year": "1973",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/S0021-9258(17)34875-5_bib81",
      "volume": "42",
      "author": "Schimke",
      "year": "1977",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    }
  ],
  "container-title": "Journal of Biological Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925817348755?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0021925817348755?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        17
      ]
    ],
    "date-time": "2023-10-17T23:33:10Z",
    "timestamp": 1697585590000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0021925817348755"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1978,
        3
      ]
    ]
  },
  "references-count": 81,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1978,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "S0021925817348755"
  ],
  "URL": "http://dx.doi.org/10.1016/S0021-9258(17)34875-5",
  "relation": {},
  "ISSN": [
    "0021-9258"
  ],
  "subject": [],
  "container-title-short": "Journal of Biological Chemistry",
  "published": {
    "date-parts": [
      [
        1978,
        3
      ]
    ]
  }
}