DOI: 10.1016/s0014-5793(99)01475-1. Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo‐microscopy

Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo‐microscopy

10.1016/s0014-5793(99)01475-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The three‐dimensional structures of the complete haemagglutinin (HA) of influenza virus A/Japan/305/57 (H2N2) in its native (neutral pH) and membrane fusion‐competent (low pH) form by electron cryo‐microscopy at a resolution of 10 Å and 14 Å, respectively, have been determined. In the fusion‐competent form the subunits remain closely associated preserving typical overall features of the trimeric ectodomain at neutral pH. Rearrangements of the tertiary structure in the distal and the stem parts are associated with the formation of a central cavity through the entire ectodomain. We suggest that the cavity is essential for relocation of the so‐called fusion sequence of HA towards the target membrane.

Bibliography

BÃ¶ttcher, C., Ludwig, K., Herrmann, A., van Heel, M., & Stark, H. (1999). Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryoâmicroscopy. FEBS Letters, 463(3), 255â259. Portico.

Authors 5

Christoph Böttcher (first)
Kai Ludwig (additional)
Andreas Herrmann (additional)
Marin van Heel (additional)
Holger Stark (additional)

References 43 Referenced 88

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{'key': 'e_1_2_6_20_1', 'first-page': '114', 'volume': '82', 'author': 'van Heel M.', 'year': '1989', 'journal-title': 'Optik'} / Optik by van Heel M. (1989)
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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:44 p.m.)
Indexed	1 month, 1 week ago (July 19, 2025, 11:26 p.m.)
Issued	25 years, 8 months ago (Dec. 17, 1999)
Published	25 years, 8 months ago (Dec. 17, 1999)
Published Online	25 years, 7 months ago (Jan. 18, 2000)
Published Print	25 years, 8 months ago (Dec. 17, 1999)

Funders 0

None

BibTeX

@article{B_ttcher_1999, title={Structure of influenza haemagglutinin at neutral and at fusogenic pH by electron cryo‐microscopy}, volume={463}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)01475-1}, DOI={10.1016/s0014-5793(99)01475-1}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Böttcher, Christoph and Ludwig, Kai and Herrmann, Andreas and van Heel, Marin and Stark, Holger}, year={1999}, month=dec, pages={255–259} }

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