DOI: 10.1016/s0014-5793(99)01356-3. TRAF1 is a TNF inducible regulator of NF‐κB activation

TRAF1 is a TNF inducible regulator of NF‐κB activation

10.1016/s0014-5793(99)01356-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Tumor necrosis factor receptor (TNFR)‐associated factor TRAF1 was first identified as a component of the TNFR2 signalling complex. Unlike the other members of the TRAF family, TRAF1 lacks the N‐terminal ring finger motif and has a tissue specific expression. Here we demonstrate that expression of TRAF1 is induced by TNF and the protein kinase C (PKC) activator PMA, but not by interleukin‐1 (IL‐1). TNF‐induced upregulation of TRAF1 could be prevented by pretreatment of the cells with the proteasome inhibitor MG‐132, whereas the PKC inhibitor Ro31‐8220 was without effect. Interestingly, overexpression of TRAF1 in HEK293T completely prevented NF‐κB activation induced by TNF, IL‐1, or overexpression of TRAF2 or TRAF6. These data suggest that inducible expression of TRAF1 may serve a negative regulatory function in NF‐κB signalling pathways.

Bibliography

Carpentier, I., & Beyaert, R. (1999). TRAF1 is a TNF inducible regulator of NFâÎºB activation. FEBS Letters, 460(2), 246â250. Portico.

Authors 2

Isabelle Carpentier (first)
Rudi Beyaert (additional)

References 33 Referenced 78

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:52 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:09 a.m.)
Indexed	2 months, 3 weeks ago (June 10, 2025, 3:03 p.m.)
Issued	25 years, 10 months ago (Oct. 25, 1999)
Published	25 years, 10 months ago (Oct. 25, 1999)
Published Online	25 years, 10 months ago (Oct. 25, 1999)
Published Print	25 years, 10 months ago (Oct. 29, 1999)

Funders 0

None

BibTeX

@article{Carpentier_1999, title={TRAF1 is a TNF inducible regulator of NF‐κB activation}, volume={460}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)01356-3}, DOI={10.1016/s0014-5793(99)01356-3}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Carpentier, Isabelle and Beyaert, Rudi}, year={1999}, month=oct, pages={246–250} }

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