DOI: 10.1016/s0014-5793(99)01075-3. Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum

Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum

10.1016/s0014-5793(99)01075-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Proteins involved in protein translocation across the membrane of the endoplasmic reticulum assemble into different oligomeric complexes depending on their state of function. To analyse such membrane protein complexes we fractionated proteins of mammalian rough microsomes and analysed them using blue native PAGE and immunoblotting. Among the proteins characterised are the Sec61p complex, the oligosaccharyl transferase (OST) complex, the translocon‐associated protein (TRAP) complex, the TRAM and RAMP4 proteins, the signal recognition particle (SRP) and the SRP receptor (SR). Interestingly, the RAMP4 protein, SR and OST complex display more than one oligomeric form.

Bibliography

Wang, L., & Dobberstein, B. (1999). Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Letters, 457(3), 316â322. Portico.

Authors 2

Lin Wang (first)
Bernhard Dobberstein (additional)

References 36 Referenced 58

10.1146/annurev.cb.10.110194.000511
10.1146/annurev.bi.65.070196.001415
10.1111/j.1432-1033.1995.0531m.x
10.1038/340482a0
10.1016/0092-8674(89)90129-3
10.1038/340478a0
10.1126/science.252.5009.1171
10.1038/381248a0
10.1016/0092-8674(92)90517-G
10.1016/S0092-8674(00)81391-4
10.1126/science.278.5346.2123
10.1016/S0092-8674(00)80235-4
10.1016/S0092-8674(00)80445-6
10.1016/S0092-8674(00)81130-7
10.1096/fasebj.10.8.8666161
10.1111/j.1432-1033.1993.tb17933.x
10.1016/0092-8674(93)90483-7
10.1073/pnas.83.3.581
10.1016/0003-2697(91)90094-A
10.1006/abio.1994.1112
{'key': 'e_1_2_6_22_1', 'first-page': '535', 'volume': '377', 'author': 'Dekker P.J.', 'year': '1996', 'journal-title': 'Biol. Chem.'} / Biol. Chem. by Dekker P.J. (1996)
10.1093/emboj/16.24.7342
10.1016/S0076-6879(83)96010-X
10.1002/j.1460-2075.1995.tb00235.x
10.1016/S0076-6879(83)96057-3
10.1038/227680a0
10.1002/elps.1150090106
Harlow E.A.L.D. (1988) in: A Laboratory Manual Cold Spring Harbor Laboratory Press Cold Spring Harbor NY.
10.1038/357047a0
10.1038/297647a0
10.1083/jcb.108.3.797
10.1083/jcb.103.4.1167
10.1016/S0092-8674(00)81403-8
10.1016/0092-8674(92)90118-V
10.1111/j.1432-1033.1995.0689m.x
10.1038/366351a0

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:52 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:44 a.m.)
Indexed	1 month ago (July 26, 2025, 5:11 a.m.)
Issued	25 years, 11 months ago (Sept. 2, 1999)
Published	25 years, 11 months ago (Sept. 2, 1999)
Published Online	25 years, 11 months ago (Sept. 2, 1999)
Published Print	25 years, 11 months ago (Sept. 3, 1999)

Funders 0

None

BibTeX

@article{Wang_1999, title={Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum}, volume={457}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)01075-3}, DOI={10.1016/s0014-5793(99)01075-3}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Wang, Lin and Dobberstein, Bernhard}, year={1999}, month=sep, pages={316–322} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        26
      ]
    ],
    "date-time": "2025-07-26T09:11:07Z",
    "timestamp": 1753521067769
  },
  "reference-count": 36,
  "publisher": "Wiley",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            9,
            2
          ]
        ],
        "date-time": "1999-09-02T00:00:00Z",
        "timestamp": 936230400000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        9,
        3
      ]
    ]
  },
  "abstract": "<jats:p>Proteins involved in protein translocation across the membrane of the endoplasmic reticulum assemble into different oligomeric complexes depending on their state of function. To analyse such membrane protein complexes we fractionated proteins of mammalian rough microsomes and analysed them using blue native PAGE and immunoblotting. Among the proteins characterised are the Sec61p complex, the oligosaccharyl transferase (OST) complex, the translocon\u2010associated protein (TRAP) complex, the TRAM and RAMP4 proteins, the signal recognition particle (SRP) and the SRP receptor (SR). Interestingly, the RAMP4 protein, SR and OST complex display more than one oligomeric form.</jats:p>",
  "DOI": "10.1016/s0014-5793(99)01075-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T17:52:28Z",
    "timestamp": 1027619548000
  },
  "page": "316-322",
  "source": "Crossref",
  "is-referenced-by-count": 58,
  "title": "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum",
  "prefix": "10.1002",
  "volume": "457",
  "author": [
    {
      "given": "Lin",
      "family": "Wang",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Bernhard",
      "family": "Dobberstein",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        1999,
        9,
        2
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_6_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cb.10.110194.000511"
    },
    {
      "key": "e_1_2_6_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.65.070196.001415"
    },
    {
      "key": "e_1_2_6_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1995.0531m.x"
    },
    {
      "key": "e_1_2_6_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/340482a0"
    },
    {
      "key": "e_1_2_6_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90129-3"
    },
    {
      "key": "e_1_2_6_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/340478a0"
    },
    {
      "key": "e_1_2_6_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.252.5009.1171"
    },
    {
      "key": "e_1_2_6_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/381248a0"
    },
    {
      "key": "e_1_2_6_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90517-G"
    },
    {
      "key": "e_1_2_6_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81391-4"
    },
    {
      "key": "e_1_2_6_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5346.2123"
    },
    {
      "key": "e_1_2_6_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80235-4"
    },
    {
      "key": "e_1_2_6_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80445-6"
    },
    {
      "key": "e_1_2_6_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81130-7"
    },
    {
      "key": "e_1_2_6_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.10.8.8666161"
    },
    {
      "key": "e_1_2_6_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1993.tb17933.x"
    },
    {
      "key": "e_1_2_6_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90483-7"
    },
    {
      "key": "e_1_2_6_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.83.3.581"
    },
    {
      "key": "e_1_2_6_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-2697(91)90094-A"
    },
    {
      "key": "e_1_2_6_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/abio.1994.1112"
    },
    {
      "key": "e_1_2_6_22_1",
      "first-page": "535",
      "volume": "377",
      "author": "Dekker P.J.",
      "year": "1996",
      "journal-title": "Biol. Chem."
    },
    {
      "key": "e_1_2_6_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.24.7342"
    },
    {
      "key": "e_1_2_6_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0076-6879(83)96010-X"
    },
    {
      "key": "e_1_2_6_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1995.tb00235.x"
    },
    {
      "key": "e_1_2_6_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0076-6879(83)96057-3"
    },
    {
      "key": "e_1_2_6_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/227680a0"
    },
    {
      "key": "e_1_2_6_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/elps.1150090106"
    },
    {
      "key": "e_1_2_6_29_1",
      "unstructured": "Harlow E.A.L.D. (1988) in: A Laboratory Manual Cold Spring Harbor Laboratory Press Cold Spring Harbor NY."
    },
    {
      "key": "e_1_2_6_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/357047a0"
    },
    {
      "key": "e_1_2_6_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/297647a0"
    },
    {
      "key": "e_1_2_6_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.108.3.797"
    },
    {
      "key": "e_1_2_6_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.103.4.1167"
    },
    {
      "key": "e_1_2_6_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81403-8"
    },
    {
      "key": "e_1_2_6_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90118-V"
    },
    {
      "key": "e_1_2_6_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1995.0689m.x"
    },
    {
      "key": "e_1_2_6_37_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/366351a0"
    }
  ],
  "container-title": "FEBS Letters",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2899%2901075-3",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(99)01075-3",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2899%2901075-3",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        16
      ]
    ],
    "date-time": "2023-09-16T05:44:10Z",
    "timestamp": 1694843050000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793%2899%2901075-3"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        9,
        2
      ]
    ]
  },
  "references-count": 36,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1999,
          9,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1016/S0014-5793(99)01075-3"
  ],
  "URL": "http://dx.doi.org/10.1016/S0014-5793(99)01075-3",
  "relation": {},
  "ISSN": [
    "0014-5793",
    "1873-3468"
  ],
  "subject": [],
  "container-title-short": "FEBS Letters",
  "published": {
    "date-parts": [
      [
        1999,
        9,
        2
      ]
    ]
  }
}