DOI: 10.1016/s0014-5793(99)01027-3. Rotenone and pyruvate prevent the <i>tert</i>‐butylhydroperoxide‐induced necrosis of U937 cells and allow them to proliferate

Rotenone and pyruvate prevent the tert‐butylhydroperoxide‐induced necrosis of U937 cells and allow them to proliferate

10.1016/s0014-5793(99)01027-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Exposure of U937 cells to tert‐butylhydroperoxide (tB‐OOH) led to cyclosporin A‐sensitive mitochondrial membrane permeability transition and necrosis. Pyruvate and rotenone, which increase mitochondrial NADH via different mechanisms, prevented these responses and the cells which received these treatments proliferated with kinetics similar to those observed in untreated cells. In contrast with these results, cells rescued by cyclosporin A were unable to proliferate. Thus, mitochondrial NADH plays a pivotal role in preventing upstream events which result in the onset of mitochondrial membrane permeability transition and death in cells exposed to tB‐OOH. These events appear to be critical for recovery of the ability of the cells to proliferate.

Bibliography

Sestili, P., Brambilla, L., & Cantoni, O. (1999). Rotenone and pyruvate prevent the tertâbutylhydroperoxideâinduced necrosis of U937 cells and allow them to proliferate. FEBS Letters, 457(1), 139â143. Portico.

Authors 3

Piero Sestili (first)
Liliana Brambilla (additional)
Orazio Cantoni (additional)

References 28 Referenced 12

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 8:18 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 3:22 a.m.)
Indexed	1 year ago (Sept. 1, 2024, 2:32 a.m.)
Issued	26 years ago (Aug. 20, 1999)
Published	26 years ago (Aug. 20, 1999)
Published Online	26 years ago (Aug. 30, 1999)
Published Print	26 years ago (Aug. 20, 1999)

Funders 0

None

BibTeX

@article{Sestili_1999, title={Rotenone and pyruvate prevent the tert‐butylhydroperoxide‐induced necrosis of U937 cells and allow them to proliferate}, volume={457}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)01027-3}, DOI={10.1016/s0014-5793(99)01027-3}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Sestili, Piero and Brambilla, Liliana and Cantoni, Orazio}, year={1999}, month=aug, pages={139–143} }

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