DOI: 10.1016/s0014-5793(99)00514-1. Inhibition of virulence factor expression in <i>Staphylococcus aureus</i> by the <i>Staphylococcus epidermidis</i> agr pheromone and derivatives

Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives

10.1016/s0014-5793(99)00514-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The agr quorum‐sensing system in Staphylococci controls the production of surface proteins and exoproteins. In the pathogenic species Staphylococcus aureus, these proteins include many virulence factors. The extracellular signal of the quorum‐sensing system is a thiolactone‐containing peptide pheromone, whose sequence varies among the different staphylococcal strains. We demonstrate that a synthetic Staphylococcus epidermidis pheromone is a competent inhibitor of the Staphylococcus aureus agr system. Derivatives of the pheromone, in which the N‐terminus or the cyclic bond structure was changed, were synthesized and their biological activity was determined. The presence of a correct N‐terminus and a thiolactone were absolute prerequisites for an agr‐activating effect in S. epidermidis, whereas inhibition of the S. aureus agr system was less dependent on the original structure. Our results show that effective quorum‐sensing blockers that suppress the expression of virulence factors in S. aureus can be designed based on the S. epidermidis pheromone.

Bibliography

Otto, M., SÃ¼Ãmuth, R., Vuong, C., Jung, G., & GÃ¶tz, F. (1999). Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives. FEBS Letters, 450(3), 257â262. Portico.

Authors 5

Michael Otto (first)
Roderich Süßmuth (additional)
Cuong Vuong (additional)
Günther Jung (additional)
Friedrich Götz (additional)

References 31 Referenced 146

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 8:18 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:49 p.m.)
Indexed	4 days, 14 hours ago (Aug. 26, 2025, 3:13 a.m.)
Issued	26 years, 3 months ago (May 7, 1999)
Published	26 years, 3 months ago (May 7, 1999)
Published Online	26 years, 1 month ago (July 13, 1999)
Published Print	26 years, 3 months ago (May 7, 1999)

Funders 0

None

BibTeX

@article{Otto_1999, title={Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives}, volume={450}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)00514-1}, DOI={10.1016/s0014-5793(99)00514-1}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Otto, Michael and Süßmuth, Roderich and Vuong, Cuong and Jung, Günther and Götz, Friedrich}, year={1999}, month=may, pages={257–262} }

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