DOI: 10.1016/s0014-5793(99)00322-1. Effects of IL‐1 receptor‐associated kinase (IRAK) expression on IL‐1 signaling are independent of its kinase activity

Effects of IL‐1 receptor‐associated kinase (IRAK) expression on IL‐1 signaling are independent of its kinase activity

10.1016/s0014-5793(99)00322-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Interleukin‐1 (IL‐1) stimulates the association of the IL‐1 receptor‐associated protein kinase (IRAK) with the heterodimer of IL‐1RI and IL‐1RAcP via the adapter protein MyD88. In the receptor complex IRAK becomes heavily phosphorylated and concomitantly activated. Here we show that overexpression of a kinase‐inactive mutant of IRAK (K239S) inhibits neither IL‐1‐stimulated activation of the transcription factor NF‐κB, nor that of the c‐Jun N‐terminal kinase nor IL‐2 production in murine EL‐4 cells, but enhances these effects in a manner comparable to wild type IRAK. This strongly suggests that the intrinsic kinase activity is not required for downstream signaling via IRAK.

Bibliography

Knop, J., & Martin, M. U. (1999). Effects of ILâ1 receptorâassociated kinase (IRAK) expression on ILâ1 signaling are independent of its kinase activity. FEBS Letters, 448(1), 81â85. Portico.

Authors 2

J. Knop (first)
M.U. Martin (additional)

References 24 Referenced 90

10.1182/blood.V87.6.2095.bloodjournal8762095
10.1002/jlb.63.6.650
10.1002/eji.1830270139
10.1074/jbc.272.12.7727
10.1016/S0021-9258(18)82225-6
10.1016/S0021-9258(17)42061-8
10.1073/pnas.94.24.12829
10.1002/eji.1830240717
10.1074/jbc.270.28.16514
10.1172/JCI119549
10.1126/science.271.5252.1128
10.1126/science.278.5343.1612
10.1016/S1074-7613(00)80402-1
10.1074/jbc.273.20.12203
10.1038/383443a0
10.1074/jbc.272.34.21540
10.1016/0092-8674(94)90380-8
10.1002/(SICI)1521-4141(199810)28:10<3100::AID-IMMU3100>3.0.CO;2-7
10.1016/0003-2697(76)90527-3
10.1084/jem.187.12.2073
Li X. Commane M. Burns C. Vithalani K. Cao Z. and Stark G.R. (1998) Eur. Cytokine Network 9 379 (Abstract 43).
10.1074/jbc.272.51.32606
10.1016/S0014-5793(98)01270-8
10.1074/jbc.272.46.29167

Dates

Type	When
Created	23 years ago (July 25, 2002, 1:52 p.m.)
Deposited	1 year, 11 months ago (Sept. 15, 2023, 10:43 p.m.)
Indexed	4 months, 3 weeks ago (March 28, 2025, 6:57 a.m.)
Issued	26 years, 4 months ago (April 1, 1999)
Published	26 years, 4 months ago (April 1, 1999)
Published Online	26 years, 4 months ago (April 1, 1999)
Published Print	26 years, 4 months ago (April 2, 1999)

Funders 0

None

BibTeX

@article{Knop_1999, title={Effects of IL‐1 receptor‐associated kinase (IRAK) expression on IL‐1 signaling are independent of its kinase activity}, volume={448}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(99)00322-1}, DOI={10.1016/s0014-5793(99)00322-1}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Knop, J. and Martin, M.U.}, year={1999}, month=apr, pages={81–85} }

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