DOI: 10.1016/s0014-5793(98)01418-5. Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

10.1016/s0014-5793(98)01418-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

α‐Synuclein (α‐syn) protein and a fragment of it, called NAC, have been found in association with the pathological lesions of a number of neurodegenerative diseases. Recently, mutations in the α‐syn gene have been reported in families susceptible to an inherited form of Parkinson's disease. We have shown that human wild‐type α‐syn, mutant α‐syn(Ala30Pro) and mutant α‐syn(Ala53Thr) proteins can self‐aggregate and form amyloid‐like filaments. Here we report that aggregates of NAC and α‐syn proteins induced apoptotic cell death in human neuroblastoma SH‐SY5Y cells. These findings indicate that accumulation of α‐syn and its degradation products may play a major role in the development of the pathogenesis of these neurodegenerative diseases.

Bibliography

El-Agnaf, O. M. A., Jakes, R., Curran, M. D., Middleton, D., Ingenito, R., Bianchi, E., Pessi, A., Neill, D., & Wallace, A. (1998). Aggregates from mutant and wildâtype Î±âsynuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of Î²âsheet and amyloidâlike filaments. FEBS Letters, 440(1â2), 71â75. Portico.

Authors 9

Omar M.A El-Agnaf (first)
Ross Jakes (additional)
Martin D Curran (additional)
Derek Middleton (additional)
Raffaele Ingenito (additional)
Elisabetta Bianchi (additional)
Antonello Pessi (additional)
David Neill (additional)
Andrew Wallace (additional)

References 33 Referenced 314

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Dates

Type	When
Created	22 years, 3 months ago (May 12, 2003, 5:07 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 12:25 a.m.)
Indexed	2 days, 18 hours ago (Sept. 3, 2025, 6:30 a.m.)
Issued	26 years, 9 months ago (Nov. 27, 1998)
Published	26 years, 9 months ago (Nov. 27, 1998)
Published Online	26 years, 8 months ago (Dec. 9, 1998)
Published Print	26 years, 9 months ago (Nov. 27, 1998)

Funders 0

None

BibTeX

@article{El_Agnaf_1998, title={Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments}, volume={440}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)01418-5}, DOI={10.1016/s0014-5793(98)01418-5}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={El-Agnaf, Omar M.A and Jakes, Ross and Curran, Martin D and Middleton, Derek and Ingenito, Raffaele and Bianchi, Elisabetta and Pessi, Antonello and Neill, David and Wallace, Andrew}, year={1998}, month=nov, pages={71–75} }

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