DOI: 10.1016/s0014-5793(98)00583-3. Localization of fractalkine and CX<sub>3</sub>CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

10.1016/s0014-5793(98)00583-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Localization of the mRNAs for fractalkine, a CX3C chemokine, and for its receptor CX3CR1 was investigated in the rat brain. In situ hybridization study revealed that fractalkine mRNA was dominantly expressed in neuronal cells particularly in the olfactory bulb, cerebral cortex, hippocampus, caudate putamen and nucleus accumbens. In vitro study using enriched neuronal or glial culture supported the dominant expression of fractalkine mRNA in neurons. On the other hand, CX3CR1 mRNA was dominantly expressed in glial cells throughout the whole brain. The in vitro study suggested the cells expressing CX3CR1 mRNA are microglia, not astrocytes or neurons. Fractalkine appears to function as a signal molecule from neuron to microglia.

Bibliography

Nishiyori, A., Minami, M., Ohtani, Y., Takami, S., Yamamoto, J., Kawaguchi, N., Kume, T., Akaike, A., & Satoh, M. (1998). Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Letters, 429(2), 167â172. Portico.

Authors 9

Atsushi Nishiyori (first)
Masabumi Minami (additional)
Yoshikazu Ohtani (additional)
Shinya Takami (additional)
Junki Yamamoto (additional)
Nami Kawaguchi (additional)
Toshiaki Kume (additional)
Akinori Akaike (additional)
Masamichi Satoh (additional)

References 28 Referenced 289

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 12:08 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 2:21 p.m.)
Indexed	1 week, 1 day ago (Aug. 26, 2025, 2:46 a.m.)
Issued	27 years, 2 months ago (June 12, 1998)
Published	27 years, 2 months ago (June 12, 1998)
Published Online	26 years, 8 months ago (Dec. 10, 1998)
Published Print	27 years, 2 months ago (June 12, 1998)

Funders 0

None

BibTeX

@article{Nishiyori_1998, title={Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?}, volume={429}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)00583-3}, DOI={10.1016/s0014-5793(98)00583-3}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Nishiyori, Atsushi and Minami, Masabumi and Ohtani, Yoshikazu and Takami, Shinya and Yamamoto, Junki and Kawaguchi, Nami and Kume, Toshiaki and Akaike, Akinori and Satoh, Masamichi}, year={1998}, month=jun, pages={167–172} }

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