DOI: 10.1016/s0014-5793(98)00501-8. Two immunoglobulin‐like domains of the Z‐disc portion of titin interact in a conformation‐dependent way with telethonin

Two immunoglobulin‐like domains of the Z‐disc portion of titin interact in a conformation‐dependent way with telethonin

10.1016/s0014-5793(98)00501-8

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The giant muscle protein titin/connectin plays a crucial role in myofibrillogenesis as a molecular ruler for sarcomeric protein sorting. We describe here that the N‐terminal titin immunoglobulin domains Z1 and Z2 interact specifically with telethonin in yeast two‐hybrid analysis and protein binding assays. Immunofluorescence with antibodies against the N‐terminal region of titin and telethonin detects both proteins at the Z‐disc of human myotubes. Longer titin fragments, comprising a serine‐proline‐rich phosphorylation site and the next domain, do not interact. The interaction of telethonin with titin is therefore conformation‐dependent, reflecting a possible phosphorylation regulation during myofibrillogenesis.

Bibliography

Mues, A., van der Ven, P. F. M., Young, P., FÃ¼rst, D. O., & Gautel, M. (1998). Two immunoglobulinâlike domains of the Zâdisc portion of titin interact in a conformationâdependent way with telethonin. FEBS Letters, 428(1â2), 111â114. Portico.

Authors 5

Alexander Mues (first)
Peter F.M van der Ven (additional)
Paul Young (additional)
Dieter O Fürst (additional)
Mathias Gautel (additional)

References 23 Referenced 137

10.1073/pnas.76.8.3698
{'key': 'e_1_2_6_3_1', 'first-page': '317', 'volume': '82', 'author': 'Maruyama K.', 'year': '1977', 'journal-title': 'J. Biochem.'} / J. Biochem. by Maruyama K. (1977)
10.1016/S0960-9822(02)00472-4
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Obermann W.M.J. van der Ven P.M.F. Steiner F. Weber K. and Fürst D.O. (1998) Mol. Biol. Cell (in press).
10.1128/MCB.3.2.182

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:53 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 10:47 p.m.)
Indexed	1 month ago (July 30, 2025, 9:55 a.m.)
Issued	27 years, 3 months ago (May 22, 1998)
Published	27 years, 3 months ago (May 22, 1998)
Published Online	27 years, 2 months ago (June 15, 1998)
Published Print	27 years, 3 months ago (May 22, 1998)

Funders 0

None

BibTeX

@article{Mues_1998, title={Two immunoglobulin‐like domains of the Z‐disc portion of titin interact in a conformation‐dependent way with telethonin}, volume={428}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)00501-8}, DOI={10.1016/s0014-5793(98)00501-8}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Mues, Alexander and van der Ven, Peter F.M and Young, Paul and Fürst, Dieter O and Gautel, Mathias}, year={1998}, month=may, pages={111–114} }

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