DOI: 10.1016/s0014-5793(98)00210-5. Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the <i>IFN‐β</i> gene

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

10.1016/s0014-5793(98)00210-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The virus‐induced activation of interferon α/β (IFN‐α/β) gene transcription is essential for host defense. The IFN‐β promoter is controlled primarily by the virus‐inducible enhancer elements, the IRF‐Es. Here we show that IRF‐3, an IRF family transcription factor, translocates to the nucleus from the cytoplasm upon virus infection in NIH/3T3 cells. The nuclear IRF‐3 is phosphorylated, interacts with the co‐activators CBP/p300, and binds specifically to the IFN‐β IRF‐E. Furthermore, overexpression of IRF‐3 causes a marked increase in virus‐induced IFN‐β mRNA expression. Thus, IRF‐3 is a candidate transcription factor mediating the activation of the IFN‐β gene.

Bibliography

Sato, M., Tanaka, N., Hata, N., Oda, E., & Taniguchi, T. (1998). Involvement of the IRF family transcription factor IRFâ3 in virusâinduced activation of the IFNâÎ² gene. FEBS Letters, 425(1), 112â116. Portico.

Authors 5

Mitsuharu Sato (first)
Nobuyuki Tanaka (additional)
Naoki Hata (additional)
Eri Oda (additional)
Tadatsugu Taniguchi (additional)

References 30 Referenced 222

DeMaeyer E. and DeMaeyer-Guignard J. (1988) John Wiley and Sons New York.
Vilcek J. and Sen G.S. (1996) in: Fields Virology 3rd edn. (Fields D.M. Knipe P.M. and Howley P.M. Eds.) pp. 375–399 Lippincott-Raven Philadelphia PA.
Tanaka N. et al. (1998) Genes Cells (in press).
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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 12:33 a.m.)
Indexed	2 months, 4 weeks ago (May 26, 2025, 5:41 p.m.)
Issued	27 years, 5 months ago (March 20, 1998)
Published	27 years, 5 months ago (March 20, 1998)
Published Online	27 years, 2 months ago (June 24, 1998)
Published Print	27 years, 5 months ago (March 20, 1998)

Funders 0

None

BibTeX

@article{Sato_1998, title={Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene}, volume={425}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)00210-5}, DOI={10.1016/s0014-5793(98)00210-5}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Sato, Mitsuharu and Tanaka, Nobuyuki and Hata, Naoki and Oda, Eri and Taniguchi, Tadatsugu}, year={1998}, month=mar, pages={112–116} }

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