DOI: 10.1016/s0014-5793(98)00205-1. Proteasome function is dispensable under normal but not under heat shock conditions in <i>Thermoplasma acidophilum</i>

Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum

10.1016/s0014-5793(98)00205-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Hitherto the biology of proteolysis in prokaryotes, particularly in archaea, is only poorly understood. We have used the tri‐peptide vinyl sulfone inhibitor carboxybenzyl‐leucyl‐leucyl‐leucine vinyl sulfone (Z‐L3VS) to study the in vivo function of proteasomes in Thermoplasma acidophilum. Z‐L3VS is a potent inhibitor of the Thermoplasma proteasome and is capable of modifying 75 to 80% of the proteasomal β‐subunits in cell cultures. Inhibition of proteasomes has only marginal effects under normal growth conditions. Under heat shock conditions, however, the effects of proteasome inhibition are much more severe, to the extent of complete cell growth arrest. These data suggest that other proteolytic systems may exist that can compensate for the loss of proteasome function in T. acidophilum.

Bibliography

Ruepp, A., Eckerskorn, C., Bogyo, M., & Baumeister, W. (1998). Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum. FEBS Letters, 425(1), 87â90. Portico.

Authors 4

Andreas Ruepp (first)
Christoph Eckerskorn (additional)
Matthew Bogyo (additional)
Wolfgang Baumeister (additional)

References 25 Referenced 45

10.1146/annurev.bi.65.070196.004101
Baumeister W. Walz J. Zuehl F. and Seemueller E. (1998) Cell in press.
{'key': 'e_1_2_5_4_1', 'first-page': '121', 'volume': '378', 'author': 'Baumeister W.', 'year': '1997', 'journal-title': 'Biol. Chem.'} / Biol. Chem. by Baumeister W. (1997)
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Dates

Type	When
Created	23 years ago (July 25, 2002, 1:53 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 12:32 a.m.)
Indexed	3 months ago (May 15, 2025, 5:24 p.m.)
Issued	27 years, 5 months ago (March 20, 1998)
Published	27 years, 5 months ago (March 20, 1998)
Published Online	27 years, 1 month ago (June 24, 1998)
Published Print	27 years, 5 months ago (March 20, 1998)

Funders 0

None

BibTeX

@article{Ruepp_1998, title={Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum}, volume={425}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)00205-1}, DOI={10.1016/s0014-5793(98)00205-1}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Ruepp, Andreas and Eckerskorn, Christoph and Bogyo, Matthew and Baumeister, Wolfgang}, year={1998}, month=mar, pages={87–90} }

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