DOI: 10.1016/s0014-5793(97)01588-3. Rat brain contains multiple mRNAs for calpastatin<sup>1</sup>

Rat brain contains multiple mRNAs for calpastatin1

10.1016/s0014-5793(97)01588-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

This work was undertaken to establish the forms of the calpain inhibitor, calpastatin, expressed in the brain tissue. Five cDNA clones were obtained and the corresponding amino acid sequences were deduced. Three of these proteins contain an N‐terminal domain (domain L) and four inhibitory repeats typical of the calpastatin molecule. The other two are truncated forms, containing the domain L, free or associated with a single inhibitory repeat. Other differences, due to exon skipping, produce calpastatin forms with different susceptibility to posttranslational modifications. The more represented mRNA form corresponds to a calpastatin molecule containing the four inhibitory domains. These results may be useful to understand the involvement of calpain in the onset of acute and degenerative disorders of the central nervous system.

Bibliography

De Tullio, R., Sparatore, B., Salamino, F., Melloni, E., & Pontremoli, S. (1998). Rat brain contains multiple mRNAs for calpastatin1. FEBS Letters, 422(1), 113â117. Portico.

Authors 5

Roberta De Tullio (first)
Bianca Sparatore (additional)
Franca Salamino (additional)
Edon Melloni (additional)
Sandro Pontremoli (additional)

References 34 Referenced 35

10.1016/0014-5793(80)81326-3
{'key': 'e_1_2_6_3_1', 'first-page': '263', 'volume': '18', 'author': 'Murachi T.', 'year': '1989', 'journal-title': 'Biochem. Int.'} / Biochem. Int. by Murachi T. (1989)
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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 12:14 a.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 11:10 a.m.)
Issued	27 years, 7 months ago (Jan. 23, 1998)
Published	27 years, 7 months ago (Jan. 23, 1998)
Published Online	27 years, 6 months ago (Feb. 10, 1998)
Published Print	27 years, 7 months ago (Jan. 23, 1998)

Funders 0

None

BibTeX

@article{De_Tullio_1998, title={Rat brain contains multiple mRNAs for calpastatin1}, volume={422}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)01588-3}, DOI={10.1016/s0014-5793(97)01588-3}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={De Tullio, Roberta and Sparatore, Bianca and Salamino, Franca and Melloni, Edon and Pontremoli, Sandro}, year={1998}, month=jan, pages={113–117} }

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