DOI: 10.1016/s0014-5793(97)01525-1. YDL142c encodes cardiolipin synthase (Cls1p) and is non‐essential for aerobic growth of <i>Saccharomyces cerevisiae</i>

YDL142c encodes cardiolipin synthase (Cls1p) and is non‐essential for aerobic growth of Saccharomyces cerevisiae

10.1016/s0014-5793(97)01525-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The unassigned open reading frame YDL142c was identified to code for cardiolipin synthase, Cls1p. A cls1 deletion strain is viable on glucose, galactose, ethanol, glycerol and lactate containing media, although the growth rate on non‐fermentable carbon sources is decreased. Mitochondria of the cls1 mutant are devoid of cardiolipin but accumulate the cardiolipin precursor phosphatidylglycerol when grown on non‐fermentable carbon sources. Specific activity of phosphatidylglycerolphosphate synthase in cls1 is reduced to 30–75% of the wild‐type level. Amounts of mitochondrial cytochromes and activity of cytochrome c oxidase, however, are not affected in the cls1 deletion strain. Collectively, these data indicate that cardiolipin is not essential for aerobic growth of Saccharomyces cerevisiae.

Bibliography

Tuller, G., Hrastnik, C., Achleitner, G., Schiefthaler, U., Klein, F., & Daum, G. (1998). YDL142c encodes cardiolipin synthase (Cls1p) and is nonâessential for aerobic growth of Saccharomyces cerevisiae. FEBS Letters, 421(1), 15â18. Portico.

Authors 6

Gabriele Tuller (first)
Claudia Hrastnik (additional)
Georg Achleitner (additional)
Ursula Schiefthaler (additional)
Franz Klein (additional)
Günther Daum (additional)

References 22 Referenced 131

10.1016/0304-4157(85)90002-4
Trivedi A. Wearring A.V. Kohlwein S.D. Paltauf F. and Tustanoff E.R. (1988) in: Integration of Mitochondrial Function (Lemasters J.J. Hackenbrock C.R. Thurman R.G. and Weterhoff H.V. Eds.) pp. 87–94 Plenum Publ. Corp. New York. (10.1007/978-1-4899-2551-0_9)
10.1016/S0021-9258(19)81704-0
10.1016/S0021-9258(18)32849-7
10.1007/BF00762857
10.1016/0014-5793(82)80498-5
Paltauf F. Kohlwein S.D. and Henry S.A. (1992) in: The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression pp. 415–500 Cold Spring Harbor Laboratory Press Cold Spring Harbor NY.
10.1016/S0005-2760(97)00117-3
10.1139/m83-222
10.1016/0378-1119(94)90048-5
10.1016/0005-2760(90)90181-V
10.1016/0005-2760(90)90192-Z
10.1016/0168-9525(96)30053-X
10.1002/yea.320101310
10.1016/S0021-9258(18)33617-2
10.1016/S0021-9258(18)64849-5
{'key': 'e_1_2_5_18_1', 'first-page': '449', 'volume': '260', 'author': 'Broekhuyse R.M', 'year': '1968', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Broekhuyse R.M (1968)
10.1016/S0021-9258(19)52451-6
10.1042/bj1460409
10.1016/S0021-9258(19)44305-6
10.1128/jb.173.19.6124-6131.1991
10.1046/j.1365-2958.1997.5841950.x

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 11:03 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:29 a.m.)
Indexed	2 months ago (July 2, 2025, 3:07 p.m.)
Issued	27 years, 8 months ago (Jan. 2, 1998)
Published	27 years, 8 months ago (Jan. 2, 1998)
Published Online	27 years, 6 months ago (Feb. 10, 1998)
Published Print	27 years, 8 months ago (Jan. 2, 1998)

Funders 0

None

BibTeX

@article{Tuller_1998, title={YDL142c encodes cardiolipin synthase (Cls1p) and is non‐essential for aerobic growth of Saccharomyces cerevisiae}, volume={421}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)01525-1}, DOI={10.1016/s0014-5793(97)01525-1}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Tuller, Gabriele and Hrastnik, Claudia and Achleitner, Georg and Schiefthaler, Ursula and Klein, Franz and Daum, Günther}, year={1998}, month=jan, pages={15–18} }

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