DOI: 10.1016/s0014-5793(97)01188-5. Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin

Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin

10.1016/s0014-5793(97)01188-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Stathmin is a regulator of microtubule dynamics which undergoes extensive phosphorylation during the cell cycle as well as in response to various extracellular factors. Four serine residues are targets for protein kinases: Ser‐25 and Ser‐38 for proline‐directed kinases such as mitogen‐activated protein kinase and cyclin‐dependent protein kinase, and Ser‐16 and Ser‐63 for cAMP‐dependent protein kinase. We studied the effect of phosphorylation on the microtubule‐destabilizing activity of stathmin and on its interaction with tubulin in vitro. We show that triple phosphorylation on Ser‐16, Ser‐25, and Ser‐38 efficiently inhibits its activity and prevents its binding to tubulin.

Bibliography

Di Paolo, G., Antonsson, B., Kassel, D., Riederer, B. M., & Grenningloh, G. (1997). Phosphorylation regulates the microtubuleâdestabilizing activity of stathmin and its interaction with tubulin. FEBS Letters, 416(2), 149â152. Portico.

Authors 5

Gilbert Di Paolo (first)
Bruno Antonsson (additional)
Daniel Kassel (additional)
Beat M Riederer (additional)
Gabriele Grenningloh (additional)

References 27 Referenced 79

10.1016/0955-0674(94)90119-8
10.1247/csf.21.369
10.1111/j.1471-4159.1983.tb09060.x
10.1091/mbc.6.12.1887
10.1016/S0092-8674(00)81037-5
10.1002/j.1460-2075.1996.tb00914.x
10.1073/pnas.94.2.741
10.1016/0968-0004(91)90123-D
10.1111/j.1432-1033.1994.tb18632.x
10.1016/S0021-9258(17)34062-0
10.1111/j.1471-4159.1989.tb11783.x
Di Paolo G. Lutjens R. Osen-Sand A. Sobel A. Catsicas S. and Grenningloh G. (1997) J. Neurosci. Res. (in press).
10.1083/jcb.133.6.1383
10.1111/j.1432-1033.1994.00053.x
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10.1007/BF01625193
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10.1074/jbc.270.23.14175

Dates

Type	When
Created	23 years ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 6:08 a.m.)
Indexed	3 weeks, 3 days ago (July 30, 2025, 10:04 a.m.)
Issued	27 years, 10 months ago (Oct. 20, 1997)
Published	27 years, 10 months ago (Oct. 20, 1997)
Published Online	27 years, 8 months ago (Nov. 25, 1997)
Published Print	27 years, 10 months ago (Oct. 20, 1997)

Funders 0

None

BibTeX

@article{Di_Paolo_1997, title={Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin}, volume={416}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)01188-5}, DOI={10.1016/s0014-5793(97)01188-5}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Di Paolo, Gilbert and Antonsson, Bruno and Kassel, Daniel and Riederer, Beat M and Grenningloh, Gabriele}, year={1997}, month=oct, pages={149–152} }

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