DOI: 10.1016/s0014-5793(97)00724-2. BIT, an immune antigen receptor‐like molecule in the brain<sup>1</sup>

BIT, an immune antigen receptor‐like molecule in the brain1

10.1016/s0014-5793(97)00724-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We previously found a brain‐specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V‐type immunoglobulin domain, two C1‐type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine‐based activation motifs (TAM) that are variants of the antigen receptor signaling motifs. The overall structure is similar to those of immune antigen receptors. This molecule, BIT (brain immunoglobulin‐like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro. Cerebral cortical neurons could extend their neurites on BIT‐coated substrate and anti‐BIT monoclonal antibody specifically inhibited the effect. These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor‐like molecule of the brain, functions as a membrane signaling molecule that may participate in cell–cell interaction.

Bibliography

Sano, S., Ohnishi, H., Omori, A., Hasegawa, J., & Kubota, M. (1997). BIT, an immune antigen receptorâlike molecule in the brain1. FEBS Letters, 411(2â3), 327â334. Portico.

Authors 5

Shin-ichiro Sano (first)
Hiroshi Ohnishi (additional)
Akira Omori (additional)
Junko Hasegawa (additional)
Misae Kubota (additional)

References 26 Referenced 71

L. Du Pasquier in: W.E. Paul (Ed.) Fundamental Immunology Raven Press New York 1993 pp. 199–233.
10.1093/oxfordjournals.jbchem.a122686
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10.1016/S0021-9258(19)73981-7
10.1016/0092-8674(93)90221-B
10.1074/jbc.271.41.25569
10.1073/pnas.84.21.7753
10.1073/pnas.90.16.7789
10.1146/annurev.iy.06.040188.002121
10.1073/pnas.84.12.4210
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10.1002/j.1460-2075.1992.tb05481.x
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10.1002/j.1460-2075.1993.tb06205.x
10.1074/jbc.270.7.2897
10.1038/379277a0
10.1084/jem.177.4.1093
10.1146/annurev.cb.07.110191.001001
10.1128/MCB.16.12.6887
10.1038/386181a0
10.1073/pnas.80.12.3686

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 11:03 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 3:32 a.m.)
Indexed	5 months, 1 week ago (March 27, 2025, 4:16 a.m.)
Issued	28 years, 1 month ago (July 14, 1997)
Published	28 years, 1 month ago (July 14, 1997)
Published Online	24 years, 8 months ago (Dec. 14, 2000)
Published Print	28 years, 1 month ago (July 14, 1997)

Funders 0

None

BibTeX

@article{Sano_1997, title={BIT, an immune antigen receptor‐like molecule in the brain1}, volume={411}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)00724-2}, DOI={10.1016/s0014-5793(97)00724-2}, number={2–3}, journal={FEBS Letters}, publisher={Wiley}, author={Sano, Shin-ichiro and Ohnishi, Hiroshi and Omori, Akira and Hasegawa, Junko and Kubota, Misae}, year={1997}, month=jul, pages={327–334} }

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