DOI: 10.1016/s0014-5793(97)00575-9. High expression of the yeast syntaxin‐related Vam3 protein suppresses the protein transport defects of a <i>pep12</i> null mutant

High expression of the yeast syntaxin‐related Vam3 protein suppresses the protein transport defects of a pep12 null mutant

10.1016/s0014-5793(97)00575-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The Pep12 protein of Saccharomyces cerevisiae is a member of the syntaxin family thought to function as target membrane receptor (t‐SNARE) for vesicular intermediates travelling between the Golgi apparatus and the vacuole. Exploiting the temperature‐sensitive growth phenotype of pep12 deletion strains, we identified VAM3 as a multicopy suppressor. Vam3p is another syntaxin‐related protein which on high expression restored vacuole acidification of pep12 null mutants and effectively suppressed their sorting and maturation defects of vacuolar hydrolases. We conclude that Vam3p acts either as a bypass suppressor or by functionally replacing Pep12p at an endosomal, prevacuolar compartment.

Bibliography

GÃ¶tte, M., & Gallwitz, D. (1997). High expression of the yeast syntaxinârelated Vam3 protein suppresses the protein transport defects of a pep12 null mutant. FEBS Letters, 411(1), 48â52. Portico.

Authors 2

M. Götte (first)
D. Gallwitz (additional)

References 46 Referenced 36

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:54 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 4:42 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 3:54 p.m.)
Issued	28 years, 1 month ago (July 7, 1997)
Published	28 years, 1 month ago (July 7, 1997)
Published Online	27 years ago (Aug. 28, 1998)
Published Print	28 years, 1 month ago (July 7, 1997)

Funders 0

None

BibTeX

@article{G_tte_1997, title={High expression of the yeast syntaxin‐related Vam3 protein suppresses the protein transport defects of a pep12 null mutant}, volume={411}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)00575-9}, DOI={10.1016/s0014-5793(97)00575-9}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Götte, M. and Gallwitz, D.}, year={1997}, month=jul, pages={48–52} }

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