DOI: 10.1016/s0014-5793(97)00564-4. Heterogeneity of water‐soluble amyloid β‐peptide in Alzheimer's disease and Down's syndrome brains

Heterogeneity of water‐soluble amyloid β‐peptide in Alzheimer's disease and Down's syndrome brains

10.1016/s0014-5793(97)00564-4

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Water‐soluble amyloid β‐peptides (sAβ), ending at residue 42, precede amyloid plaques in Down's syndrome (DS). Here we report that sAβ consists of the full‐length Aβ1–42 and peptides truncated and modified by cyclization of the N‐terminal glutamates, Aβ3(pE)–42 and Aβ11(pE)–42. The Aβ3(pE)–42 peptide is the most abundant form of sAβ in Alzheimer's disease (AD) brains. In DS, sAβ3(pE)–42 concentration increases with age and the peptide becomes a dominant species in the presence of plaques. Both pyroglutamate‐modified peptides and the full‐length Aβ form a stable aggregate that is water soluble. The findings point to a crucial role of the aggregated and modified sAβ in the plaque formation and pathogenesis of AD.

Bibliography

Russo, C., Saido, T. C., DeBusk, L. M., Tabaton, M., Gambetti, P., & Teller, J. K. (1997). Heterogeneity of waterâsoluble amyloid Î²âpeptide in Alzheimerâs disease and Downâs syndrome brains. FEBS Letters, 409(3), 411â416. Portico.

Authors 6

Claudio Russo (first)
Takaomi C. Saido (additional)
Laura M. DeBusk (additional)
Massimo Tabaton (additional)
Pierluigi Gambetti (additional)
Jan K. Teller (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:51 p.m.)
Indexed	2 days, 9 hours ago (Sept. 4, 2025, 9:34 a.m.)
Issued	28 years, 2 months ago (June 16, 1997)
Published	28 years, 2 months ago (June 16, 1997)
Published Online	27 years, 9 months ago (Nov. 7, 1997)
Published Print	28 years, 2 months ago (June 16, 1997)

Funders 0

None

BibTeX

@article{Russo_1997, title={Heterogeneity of water‐soluble amyloid β‐peptide in Alzheimer’s disease and Down’s syndrome brains}, volume={409}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(97)00564-4}, DOI={10.1016/s0014-5793(97)00564-4}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Russo, Claudio and Saido, Takaomi C. and DeBusk, Laura M. and Tabaton, Massimo and Gambetti, Pierluigi and Teller, Jan K.}, year={1997}, month=jun, pages={411–416} }

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