DOI: 10.1016/s0014-5793(96)01506-2. The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family<sup>1</sup>

The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family1

10.1016/s0014-5793(96)01506-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Murine MyD88, an RNA with homology both to the interleukin‐1 receptor signaling domain and to ‘death‐domains’, is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re‐evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published. Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3‐p22 by fluorescence in situ hybridization (FISH). Overexpression of the death domain region leads to transcriptional activation of the IL‐8 promoter.

Bibliography

Bonnert, T. P., Garka, K. E., Parnet, P., Sonoda, G., Testa, J. R., & Sims, J. E. (1997). The cloning and characterization of human MyD88: a member of an ILâ1 receptor related family1. FEBS Letters, 402(1), 81â84. Portico.

Authors 6

Timothy P Bonnert (first)
Kirsten E Garka (additional)
Patricia Parnet (additional)
Gonosuke Sonoda (additional)
Joseph R Testa (additional)
John E Sims (additional)

References 25 Referenced 119

Dates

Type	When
Created	23 years ago (July 25, 2002, 1:54 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:17 p.m.)
Indexed	2 months ago (June 19, 2025, 1:50 a.m.)
Issued	28 years, 6 months ago (Feb. 3, 1997)
Published	28 years, 6 months ago (Feb. 3, 1997)
Published Online	27 years, 7 months ago (Jan. 14, 1998)
Published Print	28 years, 6 months ago (Feb. 3, 1997)

Funders 0

None

BibTeX

@article{Bonnert_1997, title={The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family1}, volume={402}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(96)01506-2}, DOI={10.1016/s0014-5793(96)01506-2}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Bonnert, Timothy P and Garka, Kirsten E and Parnet, Patricia and Sonoda, Gonosuke and Testa, Joseph R and Sims, John E}, year={1997}, month=feb, pages={81–84} }

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