DOI: 10.1016/s0014-5793(96)01197-0. Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

10.1016/s0014-5793(96)01197-0

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Apoptotic cells activate homologous complement and are opsonized with iC3b. We assessed the effect of iC3b opsonization upon phagocytosis of apoptotic Jurkat cells by macrophages, which were differentiated from THP‐1 cells by treatment with retinoic acid. Macrophage phagocytosis of apoptotic Jurkat cells was enhanced upon incubation of the apoptotic cells with normal human serum. The enhanced macrophage phagocytosis of normal serum‐treated apoptotic cells was decreased by anti‐human C3 F(ab′)2 and anti‐CR3 and anti‐CR4 mAbs to the level of phagocytosis of those treated with complement‐blocked serum. These results suggest that interaction between iC3b on apoptotic cells and complement receptor type 3 (CR3) and/or complement receptor type 4 (CR4) on macrophages could play an important role for the clearance of apoptotic cells by macrophages in vivo.

Bibliography

Takizawa, F., Tsuji, S., & Nagasawa, S. (1996). Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells. FEBS Letters, 397(2â3), 269â272. Portico.

Authors 3

Fumitake Takizawa (first)
Shoutaro Tsuji (additional)
Shigeharu Nagasawa (additional)

References 20 Referenced 123

10.1016/0167-5699(93)90215-7
10.1016/0014-5793(92)80373-O
10.1038/343170a0
10.4049/jimmunol.148.7.2207
10.1016/0952-7915(91)90081-B
10.1146/annurev.bi.57.070188.001541
10.4049/jimmunol.123.3.1388
10.1016/0019-2791(77)90345-7
10.1093/oxfordjournals.jbchem.a124598
10.1016/0014-5793(94)00897-3
10.1016/S0076-6879(86)32008-1
10.1093/oxfordjournals.jbchem.a124838
{'key': 'e_1_2_1_14_1', 'first-page': '345', 'volume': '76', 'author': 'Hemmi H.', 'year': '1985', 'journal-title': 'Jpn J. Cancer Res.'} / Jpn J. Cancer Res. by Hemmi H. (1985)
10.1002/eji.1830160306
10.1172/JCI113643
10.1016/0006-291X(90)91155-L
10.1084/jem.169.5.1747
{'key': 'e_1_2_1_19_1', 'first-page': '426', 'volume': '115', 'author': 'Morris R.G.', 'year': '1984', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. by Morris R.G. (1984)
10.1172/JCI114328
10.1016/0014-5793(95)01036-E

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 9:50 p.m.)
Indexed	1 month, 3 weeks ago (July 1, 2025, 9:48 a.m.)
Issued	28 years, 9 months ago (Nov. 18, 1996)
Published	28 years, 9 months ago (Nov. 18, 1996)
Published Online	25 years, 8 months ago (Dec. 2, 1999)
Published Print	28 years, 9 months ago (Nov. 18, 1996)

Funders 0

None

BibTeX

@article{Takizawa_1996, title={Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells}, volume={397}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(96)01197-0}, DOI={10.1016/s0014-5793(96)01197-0}, number={2–3}, journal={FEBS Letters}, publisher={Wiley}, author={Takizawa, Fumitake and Tsuji, Shoutaro and Nagasawa, Shigeharu}, year={1996}, month=nov, pages={269–272} }

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