DOI: 10.1016/s0014-5793(03)00565-9. Control of glycogen deposition

10.1016/s0014-5793(03)00565-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Traditionally, glycogen synthase (GS) has been considered to catalyze the key step of glycogen synthesis and to exercise most of the control over this metabolic pathway. However, recent advances have shown that other factors must be considered. Moreover, the control of glycogen deposition does not follow identical mechanisms in muscle and liver. Glucose must be phosphorylated to promote activation of GS. Glucose‐6‐phosphate (Glc‐6‐P) binds to GS, causing the allosteric activation of the enzyme probably through a conformational rearrangement that simultaneously converts it into a better substrate for protein phosphatases, which can then lead to the covalent activation of GS. The potency of Glc‐6‐P for activation of liver GS is determined by its source, since Glc‐6‐P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I). As a result, hepatic glycogen deposition from glucose is subject to a system of control in which the ‘controller’, GS, is in turn controlled by GK. In contrast, in skeletal muscle, the control of glycogen synthesis is shared between glucose transport and GS. The characteristics of the two pairs of isoenzymes, liver GS/GK and muscle GS/HK I, and the relationships that they establish are tailored to suit specific metabolic roles of the tissues in which they are expressed. The key enzymes in glycogen metabolism change their intracellular localization in response to glucose. The changes in the intracellular distribution of liver GS and GK triggered by glucose correlate with stimulation of glycogen synthesis. The translocation of GS, which constitutes an additional mechanism of control, causes the orderly deposition of hepatic glycogen and probably represents a functional advantage in the metabolism of the polysaccharide.

Bibliography

Ferrer, J. C., Favre, C., Gomis, R. R., FernÃ¡ndez-Novell, J. M., GarcÄ±Ìa-Rocha, M., de la Iglesia, N., Cid, E., & Guinovart, J. J. (2003). Control of glycogen deposition. FEBS Letters, 546(1), 127â132. Portico.

Authors 8

Juan C. Ferrer (first)
Cristián Favre (additional)
Roger R. Gomis (additional)
Josep M. Fernández-Novell (additional)
Mar Garcı́a-Rocha (additional)
Núria de la Iglesia (additional)
Emili Cid (additional)
Joan J. Guinovart (additional)

References 52 Referenced 170

Dates

Type	When
Created	22 years, 3 months ago (June 2, 2003, 7:15 p.m.)
Deposited	1 year, 11 months ago (Sept. 12, 2023, 2:24 p.m.)
Indexed	5 days ago (Aug. 30, 2025, 12:48 p.m.)
Issued	22 years, 3 months ago (May 27, 2003)
Published	22 years, 3 months ago (May 27, 2003)
Published Online	22 years, 3 months ago (May 27, 2003)
Published Print	22 years, 2 months ago (July 3, 2003)

Funders 0

None

BibTeX

@article{Ferrer_2003, title={Control of glycogen deposition}, volume={546}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(03)00565-9}, DOI={10.1016/s0014-5793(03)00565-9}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Ferrer, Juan C. and Favre, Cristián and Gomis, Roger R. and Fernández-Novell, Josep M. and Garcı́a-Rocha, Mar and de la Iglesia, Núria and Cid, Emili and Guinovart, Joan J.}, year={2003}, month=may, pages={127–132} }

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