DOI: 10.1016/s0014-5793(03)00451-4. MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation

MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation

10.1016/s0014-5793(03)00451-4

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

That signalling pathways, particularly the mitogen‐activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re‐evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.

Bibliography

Clayton, A. L., & Mahadevan, L. C. (2003). MAP kinaseâmediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Letters, 546(1), 51â58. Portico.

Authors 2

Alison L. Clayton (first)
Louis C. Mahadevan (additional)

References 98 Referenced 153

Dates

Type	When
Created	22 years, 3 months ago (May 12, 2003, 9:07 p.m.)
Deposited	1 year, 11 months ago (Sept. 12, 2023, 2:24 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:45 p.m.)
Issued	22 years, 3 months ago (May 6, 2003)
Published	22 years, 3 months ago (May 6, 2003)
Published Online	22 years, 3 months ago (May 6, 2003)
Published Print	22 years, 1 month ago (July 3, 2003)

Funders 0

None

BibTeX

@article{Clayton_2003, title={MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation}, volume={546}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(03)00451-4}, DOI={10.1016/s0014-5793(03)00451-4}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Clayton, Alison L. and Mahadevan, Louis C.}, year={2003}, month=may, pages={51–58} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        2
      ]
    ],
    "date-time": "2025-07-02T18:45:39Z",
    "timestamp": 1751481939271
  },
  "reference-count": 98,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            5,
            6
          ]
        ],
        "date-time": "2003-05-06T00:00:00Z",
        "timestamp": 1052179200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        7,
        3
      ]
    ]
  },
  "abstract": "<jats:p>That signalling pathways, particularly the mitogen\u2010activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re\u2010evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.</jats:p>",
  "DOI": "10.1016/s0014-5793(03)00451-4",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        5,
        13
      ]
    ],
    "date-time": "2003-05-13T01:07:27Z",
    "timestamp": 1052788047000
  },
  "page": "51-58",
  "source": "Crossref",
  "is-referenced-by-count": 153,
  "title": "MAP kinase\u2010mediated phosphoacetylation of histone H3 and inducible gene regulation",
  "prefix": "10.1002",
  "volume": "546",
  "author": [
    {
      "given": "Alison L.",
      "family": "Clayton",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Louis C.",
      "family": "Mahadevan",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2003,
        5,
        6
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_13_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0968-0004(00)01777-1"
    },
    {
      "key": "e_1_2_13_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0959-437X(02)00279-4"
    },
    {
      "key": "e_1_2_13_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.biochem.67.1.545"
    },
    {
      "key": "e_1_2_13_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0959-437X(00)00068-X"
    },
    {
      "key": "e_1_2_13_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.biochem.71.110601.135400"
    },
    {
      "key": "e_1_2_13_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/47412"
    },
    {
      "key": "e_1_2_13_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X"
    },
    {
      "key": "e_1_2_13_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1063127"
    },
    {
      "key": "e_1_2_13_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.2741/Dyson"
    },
    {
      "key": "e_1_2_13_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(01)03309-9"
    },
    {
      "key": "e_1_2_13_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E"
    },
    {
      "key": "e_1_2_13_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0022-2836(87)90698-X"
    },
    {
      "key": "e_1_2_13_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.15.5252"
    },
    {
      "key": "e_1_2_13_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.11.4781"
    },
    {
      "key": "e_1_2_13_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(02)00649-8"
    },
    {
      "key": "e_1_2_13_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1201403"
    },
    {
      "key": "e_1_2_13_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/18.17.4779"
    },
    {
      "key": "e_1_2_13_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/19.14.3714"
    },
    {
      "key": "e_1_2_13_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80256-7"
    },
    {
      "key": "e_1_2_13_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(01)00404-X"
    },
    {
      "key": "e_1_2_13_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.277.5332.1630"
    },
    {
      "key": "e_1_2_13_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81318-5"
    },
    {
      "key": "e_1_2_13_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35065000"
    },
    {
      "key": "e_1_2_13_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/physrev.2001.81.2.807"
    },
    {
      "key": "e_1_2_13_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.35.24914"
    },
    {
      "key": "e_1_2_13_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M300269200"
    },
    {
      "key": "e_1_2_13_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrm715"
    },
    {
      "key": "e_1_2_13_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0955-0674(96)80067-6"
    },
    {
      "key": "e_1_2_13_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/384641a0"
    },
    {
      "key": "e_1_2_13_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)82001-2"
    },
    {
      "key": "e_1_2_13_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/scdb.1999.0302"
    },
    {
      "key": "e_1_2_13_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/382319a0"
    },
    {
      "key": "e_1_2_13_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.12.5.627"
    },
    {
      "key": "e_1_2_13_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)00129-5"
    },
    {
      "key": "e_1_2_13_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80941-1"
    },
    {
      "key": "e_1_2_13_37_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80054-9"
    },
    {
      "key": "e_1_2_13_38_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80740-0"
    },
    {
      "key": "e_1_2_13_39_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.13.11.1412"
    },
    {
      "key": "e_1_2_13_40_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00169-0"
    },
    {
      "key": "e_1_2_13_41_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(02)01077-2"
    },
    {
      "key": "e_1_2_13_42_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1978.tb12135.x"
    },
    {
      "key": "e_1_2_13_43_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(20)65105-5"
    },
    {
      "key": "e_1_2_13_44_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s004120050256"
    },
    {
      "key": "e_1_2_13_45_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.13.7480"
    },
    {
      "key": "e_1_2_13_46_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00118-5"
    },
    {
      "key": "e_1_2_13_47_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.36.25543"
    },
    {
      "key": "e_1_2_13_48_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00034-9"
    },
    {
      "key": "e_1_2_13_49_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.152.4.669"
    },
    {
      "key": "e_1_2_13_50_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.3.874-885.2002"
    },
    {
      "key": "e_1_2_13_51_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1356-9597.2001.00498.x"
    },
    {
      "key": "e_1_2_13_52_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1062322"
    },
    {
      "key": "e_1_2_13_53_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90385-C"
    },
    {
      "key": "e_1_2_13_54_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06774.x"
    },
    {
      "key": "e_1_2_13_55_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M103973200"
    },
    {
      "key": "e_1_2_13_56_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M010931200"
    },
    {
      "key": "e_1_2_13_57_1",
      "unstructured": "Soloaga A. Thomson S. Wiggin G.R. Rampersaud N. Dyson M.H. Hazzalin C.A. Mahadevan L.C. and Arthur J.S.C. (2003) EMBO J. (in press)."
    },
    {
      "key": "e_1_2_13_58_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(97)01105-7"
    },
    {
      "key": "e_1_2_13_59_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3510095"
    },
    {
      "key": "e_1_2_13_60_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0165-6147(00)01865-4"
    },
    {
      "key": "e_1_2_13_61_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.17.7686"
    },
    {
      "key": "e_1_2_13_62_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.29.18623"
    },
    {
      "key": "e_1_2_13_63_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/372739a0"
    },
    {
      "key": "e_1_2_13_64_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0303-7207(99)00061-1"
    },
    {
      "key": "e_1_2_13_65_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/geno.1999.6004"
    },
    {
      "key": "e_1_2_13_66_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00840.x"
    },
    {
      "key": "e_1_2_13_67_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.21.20.7089-7096.2001"
    },
    {
      "key": "e_1_2_13_68_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M004615200"
    },
    {
      "key": "e_1_2_13_69_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/384567a0"
    },
    {
      "key": "e_1_2_13_70_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.21.12202"
    },
    {
      "key": "e_1_2_13_71_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.285.5429.886"
    },
    {
      "key": "e_1_2_13_72_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.97.6.2462"
    },
    {
      "key": "e_1_2_13_73_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(00)02031-7"
    },
    {
      "key": "e_1_2_13_74_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.8.2871-2881.2002"
    },
    {
      "key": "e_1_2_13_75_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.15.4426"
    },
    {
      "key": "e_1_2_13_76_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80195-1"
    },
    {
      "key": "e_1_2_13_77_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(01)00325-7"
    },
    {
      "key": "e_1_2_13_78_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M106710200"
    },
    {
      "key": "e_1_2_13_79_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(20)65104-3"
    },
    {
      "key": "e_1_2_13_80_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80257-9"
    },
    {
      "key": "e_1_2_13_81_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(01)00301-X"
    },
    {
      "key": "e_1_2_13_82_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Shogren-Knaak M.A. Fry C.J. and Peterson C.L. (2003) J. Biol. Chem. 278 15744-15748.",
      "DOI": "10.1074/jbc.M301445200"
    },
    {
      "key": "e_1_2_13_83_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(02)01080-2"
    },
    {
      "key": "e_1_2_13_84_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M200651200"
    },
    {
      "key": "e_1_2_13_85_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ni748"
    },
    {
      "key": "e_1_2_13_86_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/383022a0"
    },
    {
      "key": "e_1_2_13_87_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(97)01048-9"
    },
    {
      "key": "e_1_2_13_88_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.21.23.8213-8224.2001"
    },
    {
      "key": "e_1_2_13_89_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M207836200"
    },
    {
      "key": "e_1_2_13_90_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00035-0"
    },
    {
      "key": "e_1_2_13_91_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M102701200"
    },
    {
      "key": "e_1_2_13_92_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.153.4.865"
    },
    {
      "key": "e_1_2_13_93_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M102288200"
    },
    {
      "key": "e_1_2_13_94_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-291X(02)00297-8"
    },
    {
      "key": "e_1_2_13_95_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/embo-reports/kvf157"
    },
    {
      "key": "e_1_2_13_96_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.848800"
    },
    {
      "key": "e_1_2_13_97_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/embo-reports/kvf066"
    },
    {
      "key": "e_1_2_13_98_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.22.22.7820-7830.2002"
    },
    {
      "key": "e_1_2_13_99_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.23.5.1808-1816.2003"
    }
  ],
  "container-title": "FEBS Letters",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2803%2900451-4",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(03)00451-4",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2803%2900451-4",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        12
      ]
    ],
    "date-time": "2023-09-12T18:24:20Z",
    "timestamp": 1694543060000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793%2803%2900451-4"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        5,
        6
      ]
    ]
  },
  "references-count": 98,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2003,
          7,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1016/S0014-5793(03)00451-4"
  ],
  "URL": "http://dx.doi.org/10.1016/S0014-5793(03)00451-4",
  "relation": {},
  "ISSN": [
    "0014-5793",
    "1873-3468"
  ],
  "subject": [],
  "container-title-short": "FEBS Letters",
  "published": {
    "date-parts": [
      [
        2003,
        5,
        6
      ]
    ]
  }
}