DOI: 10.1016/s0014-5793(03)00431-9. The <i>Drosophila</i> homolog of Aut1 is essential for autophagy and development

The Drosophila homolog of Aut1 is essential for autophagy and development

10.1016/s0014-5793(03)00431-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The Drosophila homolog of yeast Aut1, CG6877/Draut1, is a ubiquitously expressed cytosolic protein. Draut1 loss of function was achieved by expression of an inverted repeat transgene inducing RNA interference. The effect is temperature‐dependent and resembles an allelic series as described by Fortier, E. and Belote, J.M. (Genesis 26 (2000) 240–244). Draut1 loss of function larvae are unable to induce autophagy and heterophagy in fat body cells before pupariation and die during metamorphosis. To our knowledge, this is the first report of a multicellular animal lacking the function of a gene participating in the protein conjugation systems of autophagy.

Bibliography

JuhÃ¡sz, G., CsikÃ³s, G., Sinka, R., ErdÃ©lyi, M., & Sass, M. (2003). The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Letters, 543(1â3), 154â158. Portico.

Authors 5

Gábor Juhász (first)
György Csikós (additional)
Rita Sinka (additional)
Miklós Erdélyi (additional)
Miklós Sass (additional)

References 23 Referenced 81

Dates

Type	When
Created	22 years, 3 months ago (May 12, 2003, 9:07 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 2:07 p.m.)
Indexed	1 week ago (Aug. 23, 2025, 12:59 a.m.)
Issued	22 years, 4 months ago (April 30, 2003)
Published	22 years, 4 months ago (April 30, 2003)
Published Online	22 years, 4 months ago (April 30, 2003)
Published Print	22 years, 3 months ago (May 22, 2003)

Funders 0

None

BibTeX

@article{Juh_sz_2003, title={The Drosophila homolog of Aut1 is essential for autophagy and development}, volume={543}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(03)00431-9}, DOI={10.1016/s0014-5793(03)00431-9}, number={1–3}, journal={FEBS Letters}, publisher={Wiley}, author={Juhász, Gábor and Csikós, György and Sinka, Rita and Erdélyi, Miklós and Sass, Miklós}, year={2003}, month=apr, pages={154–158} }

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