DOI: 10.1016/s0014-5793(01)03241-0. The Eps15 homology (EH) domain

10.1016/s0014-5793(01)03241-0

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The Eps15 homology (EH) domain was originally identified as a motif present in three copies at the NH2‐termini of Eps15 and of the related molecule Eps15R. Both of these molecules are substrates for the tyrosine kinase activity of the epidermal growth factor receptor and hence the name ‘Eps15 homology’ or EH domain [Wong et al. (1994) Oncogene 9, 1591–1597; Wong et al. (1995) Proc. Natl. Acad. Sci. USA 92, 9530–9534; Fazioli et al. (1993) Mol. Cell. Biol. 13, 5814–5828] was derived. The motif was subsequently found in several proteins from yeast to nematode, thus establishing its evolutionary conservation. Initial studies with filter‐binding assays and phage‐displayed libraries demonstrated its protein:protein interaction abilities and identified specific ligands. Subsequently, structural analyses established the molecular bases of recognition between EH domains and cognate peptides. To date, several EH‐containing and EH‐binding proteins have been identified, which establish in the cell a network of protein:protein interactions, defined as the EH network. This network coordinates cellular functions connected with endocytosis, actin remodeling and intracellular transduction of signals.

Bibliography

Confalonieri, S., & Di Fiore, P. P. (2001). The Eps15 homology (EH) domain. FEBS Letters, 513(1), 24â29. Portico.

Authors 2

Stefano Confalonieri (first)
Pier Paolo Di Fiore (additional)

References 53 Referenced 89

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 14, 2002, 11:56 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 1:06 a.m.)
Indexed	2 weeks ago (Aug. 22, 2025, 12:44 a.m.)
Issued	23 years, 8 months ago (Dec. 7, 2001)
Published	23 years, 8 months ago (Dec. 7, 2001)
Published Online	23 years, 8 months ago (Dec. 7, 2001)
Published Print	23 years, 6 months ago (Feb. 20, 2002)

Funders 0

None

BibTeX

@article{Confalonieri_2001, title={The Eps15 homology (EH) domain}, volume={513}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(01)03241-0}, DOI={10.1016/s0014-5793(01)03241-0}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Confalonieri, Stefano and Di Fiore, Pier Paolo}, year={2001}, month=dec, pages={24–29} }

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